http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shanti Marasini,Huan Yue,Son Long Ho,차현실,박지애,Ki-Hye Jung,Adibehalsadat Ghazanfari,Mohammad Yaseen Ahmad,Shuwen Liu,채권석,장용민,이강호 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.8
Until now, there have been limited studies on T2 magnetic resonance imaging (MRI) contrast agents (CAs) using paramagnetic nanoparticles (NPs). In this study, ultrafine dysprosium oxide (Dy2O3) NPs were synthesized as a T2 MRI CA. To obtain high biocompatibility and colloidal stability in aqueous medium for in vivo applications, they were grafted with polyacrylic acid. They displayed paramagnetism with an appreciable magnetization value at 300?K and consequently, an appreciable transverse water proton spin relaxivity (r2) value which increased as the applied MR field increased. Their potential as a T2 MRI CA was proved by taking in vivo T2 MR images in mice.
Ghazanfari, Adibehalsadat,Marasini, Shanti,Miao, Xu,Park, Ji Ae,Jung, Ki-Hye,Ahmad, Mohammad Yaseen,Yue, Huan,Ho, Son Long,Liu, Shuwen,Jang, Yeong Ji,Chae, Kwon Seok,Chang, Yongmin,Lee, Gang Ho Elsevier 2019 Colloids and surfaces. A, Physicochemical and engi Vol.576 No.-
<P><B>Abstract</B></P> <P>Ultrasmall heavy metal oxide nanoparticles are potential candidate materials for X-ray computed tomography (CT) contrast agents because they possess high X-ray attenuation powers owing to high X-ray attenuation coefficients of heavy metal atoms and high density of heavy metal atoms per nanoparticle. In this study, five kinds of polyacrylic acid (PAA)-coated ultrasmall heavy metal oxide (Bi<SUB>2</SUB>O<SUB>3</SUB>, Yb<SUB>2</SUB>O<SUB>3</SUB>, NaTaO<SUB>3</SUB>, Dy<SUB>2</SUB>O<SUB>3</SUB>, and Gd<SUB>2</SUB>O<SUB>3</SUB>) nanoparticles were synthesized and their X-ray attenuation properties were investigated. The estimated average particle diameters were 2.3 ± 0.1, 1.7 ± 0.1, 1.5 ± 0.1, 1.8 ± 0.1, and 1.9 ± 0.1 nm for PAA-coated ultrasmall Bi<SUB>2</SUB>O<SUB>3,</SUB> Yb<SUB>2</SUB>O<SUB>3</SUB>, NaTaO<SUB>3</SUB>, Dy<SUB>2</SUB>O<SUB>3</SUB>, and Gd<SUB>2</SUB>O<SUB>3</SUB> nanoparticles, respectively. All of the nanoparticle suspension samples exhibited a high colloidal stability, a high biocompatibility, and X-ray attenuation powers which were stronger than that of a commercial iodine contrast agent Ultravist<SUP>®</SUP> at the same atomic concentration and much stronger, at the same number density. The effectiveness of the nanoparticle suspension samples as CT contrast agents was demonstrated by acquiring in vivo CT images by using one of the samples (i.e., PAA-coated ultrasmall Bi<SUB>2</SUB>O<SUB>3</SUB> nanoparticles). After intravenous injection into the mouse tail vein, positive contrast enhancements in various organs were observed.</P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Adibehalsadat Ghazanfari,Shanti Marasini,Tirusew Tegafaw,Son Long Ho,Xu Miao,Mohammad Yaseen Ahmad,Huan Yue,이강호,박지애,정기혜,장용민,오인택,채권석 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.3
Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in com- puted tomography (CT). In this study, ultrasmall Yb2O3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the rst time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2:1 0:1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravistr) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb2O3 nanoparticles for use as a powerful CT contrast agent.
Mohammad Yaseen Ahmad,차현실,오인택,Tirusew Tegafaw,XUMIAO,Son Long Ho,Shanti Marasini,Adibehalsadat Ghazanfari,Huan Yue,채권석,장용민,이강호 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.4
We prepared gadolinium oxide (Gd2O3) nanoparticles (GNPs) coated with a trans‐activator of transcription (TAT) peptide with cell‐penetrating ability (i.e., TAT‐GNPs) through one‐pot process. We characterized the particle diameter, surface‐coating structure, water proton relaxivities, and in vitro cellular toxicities of the TAT‐GNPs. We measured in vivo T1 magnetic resonance images (MRI) in a model nude mouse with liver cancer prior and posterior to intravenous administration. The average particle diameter of the GNPs was 1.5 nm. The sample solution exhibited a longitudinal water proton relaxivity (r1) of 18.2/s/mM (r2/r1 = 1.6, r2 = transverse water proton relaxivity), which is four to five times higher than those of commercial Gd‐chelates. The in vivo T1 MRI exhibited positively (or T1) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT‐GNPs acted as an enhanced cancer‐imaging agent similar to the cancer‐targeting agent in T1 MRI.
Tegafaw, Tirusew,Oh, In Taek,Cha, Hyunsil,Yue, Huan,Miao, Xu,Ho, Son Long,Ahmad, Mohammad Yaseen,Marasini, Shanti,Ghazanfari, Adibehalsadat,Kim, Hee-Kyung,Chae, Kwon Seok,Chang, Yongmin,Lee, Gang Ho Elsevier 2018 The Journal of physics and chemistry of solids Vol.120 No.-
<P><B>Abstract</B></P> <P>In this study, amorphous carbon nanoparticles (CNPs) with an average diameter of 2.2 nm were synthesized by reducing dextrose (C<SUB>6</SUB>H<SUB>12</SUB>O<SUB>6</SUB>) with sodium hydroxide in an aqueous medium. The amorphous CNPs formed stable colloidal suspensions in water owing to the presence of hydrophilic functional groups on the nanoparticle surfaces. The amorphous CNPs exhibited ultraviolet (UV)-visible absorption (λ<SUB>abs</SUB>) at 267 nm and emission (λ<SUB>em</SUB>) at 453 nm under UV irradiation; thus, the colloidal suspension appeared sky-blue in color under UV irradiation. The amorphous CNPs were paramagnetic with weak magnetization at room temperature and exhibited small longitudinal (r<SUB>1</SUB>) and transverse (r<SUB>2</SUB>) water proton relaxivities of 0.036 and 0.068 s<SUP>−1</SUP>mM<SUP>−1</SUP>, respectively. The amorphous CNPs exhibited no cellular toxicity up to the measured carbon concentration of 500 μM and presented fluorescence microscopy images on a micrometer scale, thus demonstrating their utility in fluorescence bio-imaging applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The amorphous CNPs with an average diameter of 2.2 nm were synthesized in an aqueous medium. </LI> <LI> The CNPs were non-toxic and formed stable colloidal suspensions in water. </LI> <LI> The CNPs were paramagnetic and exhibited weak magnetization at room temperature. </LI> <LI> The CNPs exhibited small water proton relaxivities. </LI> <LI> Fluorescence microscopy demonstrated the utility of the CNPs in fluorescence bio-imaging applications. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>