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The Association Between Current Helicobacter pylori Infection and Coronary Artery Disease
( Seung Won Jin ),( Sung Ho Her ),( Jong Min Lee ),( Hee Jeoung Yoon ),( Su Jin Moon ),( Pum Joon Kim ),( Sang Hong Baek ),( Ki Bae Seung ),( Jae Hyung Kim ),( Sang Bum Kang ),( Jae Hi Kim ),( Keon Ye 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.3
Background: The role of Helicobacter pylori (H. pylori) in the pathogenesis of coronary artery disease (CAD) is still controversial, and the relation between current H. pylori infection and CAD has not been fully examined. This study evaluated the relation between H. pylori infection as confirmed by gastroduodenoscopic biopsy and CAD. Methods: We determined the presence of H. pylori infections, via gastroduodenoscopy, in 88 patients of the normal coronary angiographic group and also in 175 patients of the CAD group, and the latter patients had more than 50% coronary stenosis angiographically demonstrated. We excluded those patients with a history of previous H. pylori eradication and/or malignancy. A small piece of tissue from the antrum, which was obtained by gastroduodenoscopic biopsy, was stained by Warthin-starry silver stain. We defined a negative staining result that there was no stained tissue in the sample and the stained tissue was also positive for H. pylori infection. Results: There was no significant difference, except for gender, age, smoking and high density lipoprotein cholesterol (HDL-c), of the demographic and laboratory characteristics between the groups. Twenty seven (30.7%) patients of the normal control group and 71 (40.6%) patients of the CAD group were positive of H. pylori infection, yet there was no statistical difference. We angiographically followed up the 80 patients of the CAD group who were treated by percutaneous coronary intervention (PCI) at 6 to 9 months after their primary intervention. Twenty two (37.9%) of the 58 patients of the H. pylori negative group and 10 (45.5%) of the 22 patients of the H. pylori positive group were treated with reintervention, but reintervention was also not significantly different between the group with H. pylori infection and the group without the infection. Conclusions: These data indicated that H. pylori infection had a modest influence on CAD and progressive atheroma, but the showed a tendency to increase. Further studies are needed to evaluate the relationship between H. pylori infection and CAD.
Pseudomonas acidovorns의 5S rRNA의 구조 결정
이승주,박인원,고문주,남정이 생화학분자생물학회 1994 BMB Reports Vol.17 No.3
The primary structure of the 5S rRNA isolated from Pseudomonas acidovorans was determined by enzymatic and chemical degradation methods. It consists of 115 nucleotides and contains no modified nucleosides. Based on Knuc values calculated from the homology of sequences of ten 5S rRNAs from Pseudomonas species, a phylogenic tree was reconstructed. There exists 60 to 87% homology between the 5S rRNA of P. acidovorans and those of other Pseudomonas species. The highest homology of sequences was found between 5S rRNA of P. acidovorans and that of P. cepacia; the phylogenic tree shows that these two species are evolutionarily very close. The secondary structure of the 5S rRNA of P. acidovorans was analyzed by enzymatic and chemical modification methods. The secondary structure determined shows that it is very similar to the generalized models proposed by other workers (De Wachter et al., 1982; Wolters and Erdmann, 1988; Koh, 1989). The secondary structure of 5S rRNA from P. acidovorans consists of five helices, five loops and two bulges.
Tong Moon,Dong Hui Cho,Jung Min Youn,Jae Bok Lee,Jeoung Won Bae,Seung Pil Jung 한국유방암학회 2016 Journal of Breast Disease Vol.4 No.2
Purpose: In the treatment of breast cancer, neoadjuvant chemotherapy (NAC) is useful to reduce breast cancer size before surgical intervention. Patients who achieve a pathologic complete response (pCR) to NAC have improved overall survival (OS). However, the relationship between prognosis and partial response is yet unclear. In this study, we evaluated prognostic factors and the tumor response ratio (TRR) method among patients who received NAC. Methods: Clinicopathologic factors were evaluated to predict OS. The TRR was calculated by dividing pathologic tumor size by clinical tumor size. TRRs were then categorized into four groups, and the survival times for the different TRR groups were compared using statistical evaluation. Results: Clinical N stage (p=0.02), overall stage (p=0.04), pathologic N stage (p=0.03), hormone receptor status (p=0.01), and lymphovascular invasion (p=0.02) were significantly associated with OS. Pathologic overall stage and TRR did not correlate with OS. Patients with a pCR exhibited the best survival rates using the current staging system and the TRR method. Conclusion: Clinicopathologic factors can be easily applied to predict OS, and clinicians could use these parameters until an accurate, simple, and highly discriminatory methods is developed to assess breast cancer patients with a partial.
퍼머넌트 및 염색 시술 순서에 따른 모발 손상과 웨이브 효율에 관한 연구
문승재(Seung Jae Moon),나해윤(Hae Yun Na),배효정(Hyo Jeoung Bae),전아름(A Reum Jeun) 한국인체미용예술학회 2010 한국인체미용예술학회지 Vol.11 No.4
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