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Yun, Seok Joong,Jeong, Pildu,Kang, Ho Won,Kim, Ye-Hwan,Kim, Eun-Ah,Yan, Chunri,Choi, Young-Ki,Kim, Dongho,Kim, Jung Min,Kim, Seon-Kyu,Kim, Seon-Young,Kim, Sang Tae,Kim, Won Tae,Lee, Ok-Jun,Koh, Gou-Yo Korean Continence Society 2015 International Neurourology Journal Vol.19 No.2
<P><B>Purpose:</B></P><P>MicroRNAs (miRNAs) in biological fluids are potential biomarkers for the diagnosis and assessment of urological diseases such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The aim of the study was to identify and validate urinary cell-free miRNAs that can segregate patients with PCa from those with BPH. </P><P><B>Methods:</B></P><P>In total, 1,052 urine, 150 serum, and 150 prostate tissue samples from patients with PCa or BPH were used in the study. A urine-based miRNA microarray analysis suggested the presence of differentially expressed urinary miRNAs in patients with PCa, and these were further validated in three independent PCa cohorts, using a quantitative reverse transcriptionpolymerase chain reaction analysis. </P><P><B>Results:</B></P><P>The expression levels of hsa-miR-615-3p, hsv1-miR-H18, hsv2-miR-H9-5p, and hsa-miR-4316 were significantly higher in urine samples of patients with PCa than in those of BPH controls. In particular, herpes simplex virus (hsv)-derived hsv1-miR-H18 and hsv2-miR-H9-5p showed better diagnostic performance than did the serum prostate-specific antigen (PSA) test for patients in the PSA gray zone. Furthermore, a combination of urinary hsv2-miR-H9-5p with serum PSA showed high sensitivity and specificity, providing a potential clinical benefit by reducing unnecessary biopsies. </P><P><B>Conclusions:</B></P><P>Our findings showed that hsv-encoded hsv1-miR-H18 and hsv2-miR-H9-5p are significantly associated with PCa and can facilitate early diagnosis of PCa for patients within the serum PSA gray zone.</P>
Kim, Seon-Hee,Park, Jin lI,Choi, Soon-Kyu,Kim, Ji-A,Kim, Si-Hwan,Kim, Jack C.,Park, Won-Woo ]東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.1
Ten, heretofore unreported, 5¹-methyl-5¹-[2-(5-substituted uracil-1-yl)ethyl)]-2¹-oxo-3¹-methylenetetrahydrofurans (H, F, Cl, Br, I, CH₃, CF₃, CH₂CH₃, CH=CH₂, SePh) (7a-j) were synthesized and evaluated against four cell lines (K-562, FM-3A, P-388 and U-937). For the preparation of α-methylene-γ-butyrolactone-linked to 5-substituted uracils (7a-j), the convenient Reformasky type reaction was employed which involves the treatment of ethyl α-(bromomethyl)acrylate and zinc with the respective 1-(5-substituted uracil-1-yl)-3-butanone (6a-j). The 5-substituted uracil ketones (6a-j) were directly obtained by the respective Michael type reaction of vinyl methyl ketone with the K₂CO₃(or NaH)-treated 5-substituted uracils (5a-j) in the presence of acetic acid in the DMF solvent. The α-methylene-γ-butyrolactone compounds showing the most significant antitumor activity are 7e, 7f, 7h and 7j (inhibitory concentration (IC) ranging from 0.69 to 2.9 ㎍/ml), while 7b, 7g and 7i have shown moderate to significant activity. The compounds 7a, 7c and 7d were found to be inactive. The synthetic intermediate compounds 6a-j were also screened and found marginal to moderate activity where compounds 6b and 6g showed significant activity (IC:0.4∼2.8 ㎍/ml).
Kim, Ok-Tae,Hyun, Dong-Yun,Bang, Kyong-Hwan,Jung, Su-Jin,Kim, Young-Chang,Shin, Yu-Su,Kim, Dong-Hwi,Kim, Swon-Won,Seong, Nak-Sul,Cha, Seon-Woo,Park, Hee-Woon The Korean Society of Medicinal Crop Science 2007 한국약용작물학회지 Vol.15 No.2
The cost of conventional cultivation of ginseng (Panax ginseng C.A. Meyer) is very expensive, because shadow condition should be maintained during cultivation periods owing to inherently weak plant for high-temperature. Therefore, application of plant biotechnology may be possible to overcome these difficulties caused by conventional breeding of ginseng. Transgenic plants were produced via Agrobacterium tumefaciens Gv3101, both carrying the binary plasmid pBI121 mLPISO with nptII and Iso (isoprene synthase) gene. Integration of the transgenes into the P. ginseng nuclear genome was confirmed by PCR analysis using nptII primers and Iso primers. RT-PCR result also demonstrated the foreign isoprene synthase gene in three transgenic plant lines (T1, T3, and T5) which was expressed at the transcriptional level. When whole plants of transgenic ginseng were exposed to high temperature at $46^{\circ}C$ for 1 h, a non-transformed plant was wilted from heat shock, whereas a transgenic plant appeared to remain healthy. We suggest that the introduction of exogenous isoprene synthase is considered as alternative methods far generating thermotolerance ginseng.
Won, Dong-Seon,Kim, Jin-Hyang,No, Hyo Jin,Cho, You Jin,Lee, Ju-Yeon,Rhee, Bum Ku,Choi, Hee-Dok John Wiley Sons, Ltd. 2010 Polymer international Vol.59 No.2
<P>Stabilization of electrically induced dipole alignment is one of the important criteria in the development of nonlinear optical (NLO) polymers for electro-optic device applications. Polyurethanes for NLO applications have attracted attention because of their high thermal stability due to hydrogen bonding. In the work reported here, we designed and synthesized a new type of NLO polyurethane, in which the pendant NLO chromophores are part of the polymer backbone. This mid-type NLO polymer is expected to have the merits of both main-chain and side-chain NLO polymers, namely stable dipole alignment and good solubility. 1-[3,4-Di-(2-hydroxyethoxy)phenyl]-2-(2-thienyl)ethene was prepared and condensed with 3,3′-dimethoxy-4,4′-biphenylenediisocyanate to yield a polyurethane. This polyurethane was reacted with tetracyanoethylene to give a novel Y-type polyurethane (7) containing 1-(3,4-dioxyphenyl)-2-[5-(1,2,2-tricyanovinyl)-2-thienyl]ethenes as NLO chromophores, which constitute part of the polymer backbone. Polyurethane 7 is soluble in common organic solvents such as N,N-dimethylformamide and dimethylsulfoxide. It shows a thermal stability up to 280 °C from thermogravimetric analysis with a glass transition temperature obtained from differential scanning calorimetry of ca 162 °C. The second harmonic generation (SHG) coefficient (d<SUB>33</SUB>) of a poled polymer film of he polyurethane at 1560 nm fundamental wavelength is ca 1.11 × 10<SUP>−18</SUP> C. Polymer 7 exhibits an enhanced thermal stability and no significant SHG decay is observed below 150 °C, which is acceptable for NLO device applications. Copyright © 2009 Society of Chemical Industry</P> <B>Graphic Abstract</B> <P>A novel Y-type polyurethane containing 1-(3,4-dioxyphenyl)-2-{5-(1,2,2-tricyanovinyl)-2-thienyl}ethenes as NLO-chromophores exhibited SHG coefficient (d<SUB>33</SUB>) of 1.11 × 10<SUP>−18</SUP> C at 1560 nm fundamental wavelength with enhanced thermal stability of SHG up to 150°C, which is acceptable for nonlinear optical device applications. <img src='wiley_img/09598103-2010-59-2-PI2702-gra001.gif' alt='wiley_img/09598103-2010-59-2-PI2702-gra001'> </P>
Wavelet Based Multi-Bit Fingerprinting Against Geometric Distortions
Kim, Won Gyum,Seo, Yong Seok,Jung, Hye Won,Lee, Seon Hwa,Oh, Won Geun Trans Tech Publications, Ltd. 2006 Key Engineering Materials Vol.321 No.-
<P>This paper presents a new image fingerprinting scheme which embeds a multi-bits fingerprinting code and is robust against the geometric attack such as rotation, scaling and translation. We construct a 64 bits fingerprinting code and embed into wavelet subband of 512x512 images repeatedly. In order to restore an image from geometric distortion a noise reduction filter is performed and a rectilinear tiling pattern is used as a template. Results of experimental studies show that our method is robust against geometric distortions and JPEG compression.</P>
Syringo-Subarachnoid-Peritoneal Shunt Using T-Tube for Treatment of Post-Traumatic Syringomyelia
Kim, Seon-Hwan,Choi, Seung-Won,Youm, Jin-Young,Kwon, Hyon-Jo The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.52 No.1
Various surgical procedures for the treatment of post-traumatic syringomyelia have been introduced recently, but most surgical strategies have been unreliable. We introduce the concept and technique of a new shunting procedure, syringo-subarachnoid-peritoneal shunt. A 54-year-old patient presented to our hospital with a progressive impairment of motion and position sense on the right side. Sixteen years before this admission, he had been treated by decompressive laminectomy for a burst fracture of L1. On his recent admission, magnetic resonance (MR) imaging studies of the whole spine revealed the presence of a huge syrinx extending from the medulla to the L1 vertebral level. We performed a syringo-subarachnoid-peritoneal shunt, including insertion of a T-tube into the syrinx, subarachnoid space and peritoneal cavity. Clinical manifestations and radiological findings improved after the operation. The syringo-subarachnoid-peritoneal shunt has several advantages. First, fluid can communicate freely between the syrinx, the subarachnoid space, and the peritoneal cavity. Secondly, we can prevent shunt catheter from migrating because dural anchoring of the T-tube is easy. Finally, we can perform shunt revision easily, because only one arm of the T-tube is inserted into the intraspinal syringx cavity. We think that this procedure is the most beneficial method among the various shunting procedures.
Endoscopic Cryotherapy of Lung and Bronchial Tumors: A Systematic Review
( Seon Heui Lee ),( Won Jung Choi ),( Sook Whan Sung ),( Young Kyoon Kim ),( Chi Hong Kim ),( Jae Il Zo ),( Kwang Joo Park ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.2
Background/Aims: We made a systematic review and evaluation of endoscopic cryotherapy of endobronchial tumors, investigating safety and efficacy. Methods: Qualified studies regarding endoscopic cryotherapy of lung tumors were systemically evaluated using available databases according to predefined criteria. Results: In total, 16 publications were included in the final assessment. A narrative synthesis was performed because a formal meta-analysis was not viable due to the lack of controlled studies and study heterogeneity. Overall success rates for significant recanalization of the obstruction were approximately 80%, although they varied, depending on disease status in the patient population. Complications from the procedure developed in 0-11.1% of cases, most of which were minor and controlled by conservative management. Although limited data were available on comprehensive functional assessment, some studies showed that respiratory symptoms, pulmonary function tests, and performance status were significantly improved. Conclusions: Endoscopic cryotherapy was found to be a safe and useful procedure in the management of endobronchial tumors although its efficacy and appropriate indications have yet to be determined in well-designed controlled studies. (Korean J Intern Med 2011;26:137-144 )
Removal of Arsenic from Leachate of Tailing using Laboratory-synthesized Zerovalent Iron
Kim, Soon-Oh,Jung, Young-Il,Cho, Hyen-Goo,Park, Won-Jeong,Kim, In-Seon The Korean Society for Applied Biological Chemistr 2007 Journal of Applied Biological Chemistry (J. Appl. Vol.50 No.1
Feasibility of laboratory-synthesized zerovalent iron was investigated to remove arsenic from leachates of tailings taken from an Au-Ag abandoned mine. The tailings were seriously contaminated with arsenic, and its potential adverse effect on the ecosystems around the mine seems to be significantly high. Long-term column experiments were conducted for about 3.5 months to evaluate the effectiveness of the synthesized zerovalent iron for removal of arsenic. Over than 95% removal efficiency of As was observed in the zerovalent iron mediated tests. In addition, the XRD data suggest that the corrosion products of ZVI were identified magnetite, maghemite, goethite, and lepidocrocite, all of which support Fe(II) oxidation as an intermediate step in the zerovalent iron corrosion process. The results indicate that arsenic can be removed from the tailing-leachate by the mechanism of coprecipitation and/or adsorption onto those iron oxides formed from ZVI corrosion.