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( Naganathan Selvakumar ),( Selvakumar Naganathan ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Hepatic artery intimal dissection (HAD) followed by hepatic artery thrombosis (HAT) is serious complication of liver transplantation. There is paucity of information in literature on the management options for HAD encountered during surgery. In this study we describe a new classification and technique for the management of HAD during living donor liver transplant (LDLT). Methods: Based on the longitudinal extent of intimal dissection, HAD was classified into 4 types. Management was based on the availability of adequate length of hepatic artery and availability of alternate source of inflow. The dissected hepatic artery itself was used for arterial anastomosis in cases with preserved flow in the dissected artery and paucity of an alternative sources of arterial inflow. The technique of using the dissected artery is based on close approximation of tunica intima to media with the first two sutures of the arterial anastomosis. Patients with HAD were compared with those without HAD for evaluation of risk factors for intimal dissection. Results: 47 (2.4%) patients developed HAD during surgery. 22 (46.7%) patients had type II dissection for whom the other (right or the left) undissected hepatic artery was used for anastomosis. 20 (45%) patients were found to have major (type III or IV) dissection. The dissected artery was used for anastomosis in 9 of (45%) of these patients. Post-operative HAT developed in only one out of the 9 patients. Pre-existing portal vein thrombosis (PVT) and prior trans arterial embolization (TAE) were found to be major risk factors for development of intimal dissection. Conclusions: Classification
Generation of Anti-c-Met Single Domain Antibody Fragment Based on Human Stable Frameworks
Selvakumar Edwardraja,Sriram Sokalingam,Govindan Raghunathan,Bum-Yeol Hwang,이선구 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6
The size reduction is an important issue in the biomedical application of antibody and single domain antibody fragment is recognized as very attractive tool. However, it is very time-consuming and laborious to generate the fragment antibody with targeted binding function. Here,we investigated the possibility to prepare single domain antibody (sdAb) by a simple grafting method based on stable human consensus framework sequences. The complementarity determining region sequences in VH domain of anti-c-Met scFv from rabbit were grafted with the human VH3 consensus framework sequences, which generated the anti-c-Met single domain antibody showing almost same binding activity to its scFv form. The generated single domain antibody could be produced as functional form in oxidizing cytoplasm of E. coli, but produced as inactive form in reducing cytoplasm. The structural analysis of the homology models gave us the insight on the stability of the single domain antibody. In this report, we have demonstrated that the very stable human consensus framework sequence can be used for the generation of active anti-c-Met sdAb via complementarity determining regions grafting. We expect that this kind of grafting method for the generation of sdAb may provide us with the opportunities to prepare sdAbs based on the known antibody sequences.
Selvakumar Sasirekha,Sankaranarayanan Swamynathan 한국통신학회 2017 Journal of communications and networks Vol.19 No.4
The sensor nodes have limited sensing, computation,communication capabilities and are mostly operated by batteriesin a harsh environment with non-replenishable power sources. These restrictions make the sensor network prone to failures becausemost of the energy is spent on data transmission, sensing, andcomputing. Many applications such as habitat monitoring, militarysurveillance and forest fire detection expect the sensor nodes to lastfor a long time because they operate human unattended. Therefore,the major challenges in designing a wireless sensor network (WSN)are energy conservation, reducing data transmission delay and improvingthe network lifetime. In this context, data aggregation is anintelligent technique used in WSN, wherein the data from disparatesources are accumulated at intermediate nodes, thereby reducingthe number of packets to be sent to the sink. Literature studyshows that various routing algorithms are used to perform dataaggregation based on the network topology. In order to provide animproved performance amongst the existing, a routing algorithmcalled cluster-chain mobile agent routing (CCMAR) is proposedin this work. It makes full use of the advantages of both low energyadaptive clustering hierarchy (LEACH) and power-efficientgathering in sensor information systems (PEGASIS). CCMAR dividesthe WSN into a few clusters and runs in two phases.The proposedsystem is simulated and evaluated for the performance metricssuch as energy consumption, transmission delay and networklifetime. The results demonstrate that the proposed CCMAR outperformsLEACH, PEGASIS and other similar routing algorithm,energy efficient cluster-chain based protocol.
Selvakumar, Kanakaraj,Kim, Ae Rhan,Prabhu, Manimuthu Ramesh,Yoo, Dong Jin The Korean Society for Composite Materials 2021 Composites research Vol.34 No.6
A series of novel PBI/SrTiO<sub>3</sub> nanocomposite membranes composed of polybenzimidazole (PBI) and strontium titanate (SrTiO<sub>3</sub>) with a perovskite structure were fabricated with various concentrations of SrTiO<sub>3</sub> through a solution casting method. Various characterization techniques such as proton nuclear magnetic resonance, thermogravimetric analysis, atomic force microscopy (AFM) and AC impedance spectroscopy were used to investigate the chemical structure, thermal, phosphate absorption and morphological properties, and proton conductivity of the fabricated nanocomposite membranes. The optimized PBI/SrTiO<sub>3</sub>-8 polymer nanocomposite membrane containing 8wt% of SrTiO<sub>3</sub> showed a higher proton conductivity of 7.95 × 10<sup>-2</sup> S/cm at 160℃ compared to other nanocomposite membranes. The PBI/SrTiO<sub>3</sub>-8 composite membrane also showed higher thermal stability compared to pristine PBI. In addition, the roughness change of the polymer composite membrane was also investigated by AFM. Based on these results, nanocomposite membranes based on perovskite structures are expected to be considered as potential candidates for high-temperature PEM fuel cell applications.
Selvakumar Gopal,Murugesan Chandrasekaran,Charlotte Shagol,Kiyoon Kim,Tongmin Sa 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.4
Microorganisms present in the rhizosphere soil plays a vital role in improving the plant growth and soil fertility. Many kinds of fertilizers including chemical and organic has been approached to improve the productivity. Though some of them showed significant improvement in yield, they failed to maintain the soil properties. Rather they negatively affected soil eventually, the land became unsuitable for agricultural. To overcome these problems, microorganisms have been used as effective alternative. For past few decades, plant growth promoting rhizobacteria (PGPR) and arbuscular mycorrhizal fungi (AMF) have been used as effective inoculants to enhance the plant growth and productivity. PGPR improves the plant growth and helps the plant to withstand biotic and abiotic stresses. AM fungi are known to colonize roots of plants and they increase the plant nutrient uptake. Spore associated bacteria (SAB) are attached to spore wall or hyphae and known to increase the AMF germination and root colonization but their mechanism of interaction is poorly known. Better understanding the interactions among AMF, SAB and PGPR are necessary to enhance the quality of inoculants as a biofertilizers. In this paper, current knowledge about the interactions between fungi and bacteria are reviewed and discussed about AMF spore associated bacteria.