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Charge Transfer in Iridate-Manganite Superlattices
Okamoto, Satoshi,Nichols, John,Sohn, Changhee,Kim, So Yeun,Noh, Tae Won,Lee, Ho Nyung American Chemical Society 2017 NANO LETTERS Vol.17 No.4
<P>Charge transfer in superlattices consisting of SrIrO3 and SrMnO3 is investigated using density functional theory. Despite the nearly identical work function and nonpolar interfaces between SrIrO3 and SrMnO3, rather large charge transfer was experimentally reported at the interface between them. Here, we report a microscopic model that captures the mechanism behind this phenomenon, providing a qualitative understanding of the experimental observation. This leads to unique strain dependence of such charge transfer in iridate-manganite superlattices. The predicted behavior is consistently verified by experiment with soft X-ray and optical spectroscopy. Our work thus demonstrates a new route to control electronic states in nonpolar oxide heterostructures.</P>
Aikou Okamoto,Eiji Kondo,Toshiaki Nakamura,Satoshi Yanagida,Junzo Hamanishi,Kenichi Harano,Kosei Hasegawa,Takeshi Hirasawa,Kensuke Hori,Shinichi Komiyama,Motoki Matsuura,Hidekatsu Nakai,Hiroko Nakamur 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2
Objective: To evaluate the efficacy and safety of niraparib in Japanese women with heavilypretreated ovarian cancer. Methods: This Phase 2 open-label, single-arm study enrolled Japanese women withhomologous recombination deficiency-positive relapsed, high-grade serous ovarian,fallopian tube, or primary peritoneal cancer who had completed 3–4 lines of therapy. The starting dose of niraparib was 300 mg administered once daily in continuous 28-daycycles until objective progressive disease, unacceptable toxicity, consent withdrawal ordiscontinuation. The primary endpoint, objective response rate (ORR), was assessed bythe investigator using RECIST version 1.1. Safety evaluations included the incidence oftreatment-emergent adverse events (TEAEs), including serious TEAEs. Results: Twenty women were enrolled and the confirmed ORR in the full analysis set (FAS)was 35.0% (7/20), consisting of 1 complete response and 6 partial responses. Diseasecontrol rate in the FAS was 90.0%. The most frequently reported TEAEs (>50%) wereanemia, nausea, and platelet count decreased. One patient (5.0%) had TEAEs leadingto discontinuation of niraparib whereas reductions or interruptions were reported in 14(70.0%) and 15 (75.0%) patients, respectively. The median dose intensity (202.9 mg daily)corresponded to a relative dose intensity of 67.6%. Conclusion: Efficacy and safety of niraparib in heavily pretreated Japanese women wascomparable to that seen in an equivalent population of non-Japanese women. No new safetysignals were identified.Trial Registration: ClinicalTrials.gov Identifier: NCT03759600
Structural and Magnetic Properties in Annealed FePt-Bx (x = 0.05 and 0.33) Thin Films
Young-Min LEE,Chan-Gyu LEE,Bon-Heun KOO,Byeong-Seon LEE,Osamu Kitakami,Satoshi Okamoto,Takamichi Miyazaki,Yutaka Shimada 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.3
Multi-layer films of MgO20 nm/(FePt-Bx)50 nm/MgO20 nm were deposited on Si (100) substrates by RF magnetron sputtering. The B content (x) of the thin films was found to be about 5 and 33 at.% by using wavelength dispersive spectroscopy (WDX). In the (FePt)0.67B0.33 film an excess of B in the FePt film led to an amorphous structure in the as-deposited film, which changed to an ordered cubic structure on annealing. However, the (FePt)0.95B0.05 film started to show a phase transformation from the disordered fcc structure to the ordered L10 phase with an fct structure at 350 C and was remarkably transformed to a L10 structure at about 500 C on post-annealing. The maximum coercivities (Hc) of the (FePt)0.95B0.05 and the (FePt)0.67B0.33 films were found to be 9.1 and 2.9 kOe after annealing at 600 C for 1 hr, respectively.