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Auditory P300 after Taking Hypnotic Zolpidem
KyoungUk Lee,E Jin Park,ChinYang Kang,SangIck Han,KweonHaeng Lee,YangWhan Jeon 대한신경정신의학회 2007 PSYCHIATRY INVESTIGATION Vol.4 No.1
Objective-Although the hypnotic, zolpidem, is known to be free of any detrimental residual effects, its residual effects on cognitive function after its elimination half-life have not been sufficiently investigated. This study was designed to examine the residual effects of zolpidem on cognitive function using event-related potentials (ERPs). Methods-Twelve healthy right-handed men participated in this study. ERP recordings were conducted at baseline and 5 hours after taking 10 mg of zolpidem. The auditory oddball task included the presentation of a series of standard (1,000 Hz, 75 dB, 80%) and target tones (2,000 Hz, 75 dB, 20%) in a predetermined quasi-random order. The data were analyzed using analysis of variance (ANOVA). Results-On the behavioral task, the reaction time was significantly delayed in the post-drug condition compared to the baseline. The P300 amplitude was significantly decreased in the post-drug condition compared to the baseline. However, the P300 latency showed no difference between the pre- and post-drug conditions. Conclusions-The residual effects of zolpidem on cognitive function may persist after its elimination half-life. Further large placebo-controlled trials are needed to confirm the findings of this study.
박석윤,박래현,이석훈,정현용,한상익,전양환,김재문,정기영 충남대학교 기초과학연구소 1998 忠南科學硏究誌 Vol.25 No.2
This article explores the use of qEEG, began in the 1970s and early 80s as an attempt to extract from brain electrical activity more than what could be ready appreciate by simple, unaided visual inspection of EEG. EEG was able to examine 12 healthy young persons with eye dosed and aged 25-39. We gets 4 sample datasets; each dataset consists of 21 columns corresponding to the 21 channels, the sampling rate is 128 Hz, total time is 2 seconds (i.e. 258 points per channels). And result of qEEG is suggested.
박석윤,정기영,박래현,이낙영,이석훈,이주호,김주한,김홍기,김종우,조한석,정현용,김재문,한상익,전양환,이민선 충남대학교 기초과학연구소 1999 忠南科學硏究誌 Vol.26 No.2
With the correct equipment, microvolt EEG signals can be recorded from the scalp. Their potential use for diagnosis of physiological and psychiatric diseases and for increasing our understanding of cognitive processes is being realized by current research in many fields. Our work focuses on the research for good EEG signal representations and on careful analysis classification results using statistical EEG analysis(SEEG).