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종 분포 모형을 이용한 구상나무림의 지속 및 쇠퇴에 관한 연구 - 전라남도 광양시 백운산을 중심으로 -
조선희 ( Seon Hee Cho ),박종영 ( Jong Young Park ),박정호 ( Jeong Ho Park ),이양근 ( Yang Geun Lee ),문이만 ( Lee Man Mun ),강상호 ( Sang Ho Kang ),김광현 ( Gwang Hyun Kim ),윤종국 ( Jong Guk Yun ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3
The present study investigated the habitats of Korean fir trees (Abies koreana E. H. Wilson) on Mt. Baekwun (Baekwun-san), determined the current distribution, quantified the contribution of biological and nonbiological environmental factors affecting the distribution, derived actual and potential habitats, presented a plan for the establishment of protected areas, applied RCP 8.5 climate change scenario to analyze the effects of climate change on the future distribution of Korean fir trees, and predicted future potential habitats. According to the results of the study, 3,325 Korean fir trees (DBH >= 2.5 cm) inhabited Mt. Baekwun, and their distribution area was approximately 150 ha. Populations of Korean fir trees were confirmed to exist at an altitude of 900 m above sea level and were distributed up to 1,200 m. Based on potential distribution, areas appropriate for habitation by Korean fir trees were analyzed to be 450 ha, three times the current distribution area, with a focus on Sang Peak (Sang-bong), Eokbul Peak (Eokbul-bong), Ddari Peak (Ddari-bong), and Dosol Peak (Dosol-bong). The forest stands near Sang Peak, the main peak, were evaluated as those with the most appropriate potential for the habitation of Korean fir trees, and populations of the trees tended to prefer the northern slope rather than the southern slope. When climate change scenario RCP 8.5 was applied and future potential distribution was analyzed, the habitats were expected to decrease in area to 20 ha by 2050, with a focus on Sang Peak, and areas appropriate for habitation were predicted not to exist by 2080. Judging from such results, as global warming accelerates, the habitats of Korean fir trees are clearly expected to move from lowlands to highlands.
Yang, Jae Jeong,Cho, Lisa Y.,Lim, Yun Jeong,Ko, Kwang-Pil,Lee, Kun-Sei,Kim, Hyeongsu,Yim, Sung Vin,Chang, Soung Hoon,Park, Sue K. Mary Ann Liebert 2010 Journal of women's health Vol.19 No.2
<P>The aim of this study was to investigate the role of the estrogen receptor 1 (ESR1) genetic polymorphisms for early menopause that was classified as premature ovarian failure (POF) and early menopause (EM) and to examine whether the associations of ESR1 genetic variants are different for POF and EM.</P>
Sang Min Kyu,Park Jie eun,Song Dae Kwon,Jeong Jun Yang,Hwang Hee Ju,Kim Hyun woo,Kim Tae Yun,Park So Young,Kang Se Won,Patnaik Bharat Bhusan,Cha Sung‐Jae,Han Yeon Soo,Lee Hee Il,Lee Yong Seok 한국곤충학회 2022 Entomological Research Vol.52 No.6
Ticks are vectors that cause disease by transmitting bacteria, viruses, and protozoa to humans or animals. The Asian longhorned tick Haemaphysalis longicornis, a vector of medical and veterinary importance, is widely distributed in the Korean peninsula and can transmit various pathogens including Rickettsia spp., Borrelia spp., Francisella spp., Coxiella spp., and severe fever with thrombocytopenia syndrome virus (SFTS virus). Despite the abundance and importance, studies on the microbiome of H. longicornis in Korea are limiting. Here we first report the microbiome diversity of H. longicornis in terms of region, stage, and sex. H. longicornis used in this study were collected from 16 different regions. The V3-V4 region was amplified and sequenced by MiSeq platform. The microbial diversity analysis was performed using Qiime2. A total of 1,754,418 non-chimeric reads were obtained from a total of 46 samples, and an average of 126 operational taxonomic units (OTUs) and a total of 1,398 OTUs were identified. Our results were used for H. longicornis microbial community database construction for each region that enables to identify singularities in each region.
Gallbladder paraganglioma with hemorrhage: A case report and literature review
Sang Hwa Song,Chol Kyoon Cho,Eun Kyu Park,Hee Joon Kim,Young Hoe Hur,Yang Seok Koh,Yun Ho Lee 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.4
Gallbladder paraganglioma (GP) is a rare tumor, with only 12 cases reported in the literature to date. Due to its rarity, clinical information of GP is insufficient. We present a case of GP in a 48-year-old female along with a literature review of all GP cases described to date. A 48-year-old female presented with intermittent right upper abdominal pain. Preoperative imaging revealed a hematoma in the gallbladder lumen without any definite etiology. Laparoscopic cholecystectomy was performed. Gross examination of the gallbladder revealed multiple small stones and a large hematoma as well as a 1.6-cm-sized polypoid mass at the gallbladder fundus. Microscopic study of the polypoid mass showed a zellballen appearance. Immunohistochemical analysis revealed that the mass was positive for synaptophysin, CD56, and chromogranin, suggesting GP. GP is difficult to diagnose because of non-specific clinical findings. Almost all GP cases are diagnosed based on histologic findings after cholecystectomy. Simple cholecystectomy was performed as a treatment in all reported cases of GP, including our case. There was no postoperative tumor recurrence or metastasis after surgery.
Sung, Nak Yoon,Kim, Seung Cheol,Kim, Yun Hwan,Kim, Gihyeon,Lee, Yunmi,Sung, Gi-Ho,Kim, Ji Hye,Yang, Woo Seok,Kim, Mi Seon,Baek, Kwang-Soo,Kim, Jong-Hoon,Cho, Jae Youl The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.4
It has been found that 4-isopropyl-2,6-bis(1-phenylethyl)phenol (KTH-13), a novel compound isolated from Cordyceps bassiana, is able to suppress tumor cell proliferation by inducing apoptosis. To mass-produce this compound, we established a total synthesis method. Using those conditions, we further synthesized various analogs with structural similarity to KTH-13. In this study, we aimed to test their anti-cancer activity by measuring anti-proliferative and pro-apoptotic activities. Of 8 compounds tested, 4-methyl-2,6-bis(1-phenylethyl)phenol (KTH-13-Me) exhibited the strongest anti-proliferative activity toward MDA-MB 231 cells. KTH-13-Me also similarly suppressed the survival of various cancer cell lines, including C6 glioma, HCT-15, and LoVo cells. Treatment of KTH-13-Me induced several apoptotic signs in C6 glioma cells, such as morphological changes, induction of apoptotic bodies, and nuclear fragmentation and chromatin condensation. Concordantly, early-apoptotic cells were also identified by staining with FITC-Annexin V/PI. Moreover, KTH-13-Me highly enhanced the activation of caspase-3 and caspase-9, and decreased the protein level of Bcl-2. In addition, the phosphorylation levels of Src and STAT3 were diminished in KTH-13-Me-treated C6 cells. Therefore, these results suggest that KTH-13-Me can be developed as a novel anti-cancer drug capable of blocking proliferation, inducing apoptosis, and blocking cell survival signaling in cancer cells.
Yang, Wookyeom,Park, In-Ja,Yun, Hee,Im, Dong-Uk,Ock, Sangmi,Kim, Jaetaek,Seo, Seon-Mi,Shin, Ha-Yeon,Viollet, Benoit,Kang, Insug,Choe, Wonchae,Kim, Sung-Soo,Ha, Joohun American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.8
<P>Doxorubicin is one of the most widely used anti-cancer drugs, but its clinical application is compromised by severe adverse effects in different organs including cardiotoxicity. In the present study we explored mechanisms of doxorubicin-induced cytotoxicity by revealing a novel role for the AMP-activated protein kinase α2 (AMPKα2) in mouse embryonic fibroblasts (MEFs). Doxorubicin robustly induced the expression of AMPKα2 in MEFs but slightly reduced AMPKα1 expression. Our data support the previous notion that AMPKα1 harbors survival properties under doxorubicin treatment. In contrast, analyses of <I>Ampk</I>α<I>2</I><SUP>−/−</SUP> MEFs, gene knockdown of AMPKα2 by shRNA, and inhibition of AMPKα2 activity with an AMPK inhibitor indicated that AMPKα2 functions as a pro-apoptotic molecule under doxorubicin treatment. Doxorubicin induced AMPKα2 at the transcription level via E2F1, a transcription factor that regulates apoptosis in response to DNA damage. E2F1 directly transactivated the <I>Ampk</I>α<I>2</I> gene promoter. In turn, AMPKα2 significantly contributed to stabilization and activation of E2F1 by doxorubicin, forming a positive signal amplification loop. AMPKα2 directly interacted with and phosphorylated E2F1. This signal loop was also detected in H9c2, C2C12, and ECV (human epithelial cells) cells as well as mouse liver under doxorubicin treatment. Resveratrol, which has been suggested to attenuate doxorubicin-induced cytotoxicity, significantly blocked induction of AMPKα2 and E2F1 by doxorubicin, leading to protection of these cells. This signal loop appears to be non-carcinoma-specific because AMPKα2 was not induced by doxorubicin in five different tested cancer cell lines. These results suggest that AMPKα2 may serve as a novel target for alleviating the cytotoxicity of doxorubicin.</P>