Overall damage identification of flag-shaped hysteresis systems under seismic excitation

Cong Zhou,J. Geoffrey Chase,Geoffrey W. Rodgers,Hamish Tomlinson,Chao Xu 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.16 No.1

This research investigates the structural health monitoring of nonlinear structures after a major seismic event. It considers the identification of flag-shaped or pinched hysteresis behavior in response to structures as a more general case of a normal hysteresis curve without pinching. The method is based on the overall least squares methods and the log likelihood ratio test. In particular, the structural response is divided into different loading and unloading sub-half cycles. The overall least squares analysis is first implemented to obtain the minimum residual mean square estimates of structural parameters for each sub-half cycle with the number of segments assumed. The log likelihood ratio test is used to assess the likelihood of these nonlinear segments being true representations in the presence of noise and model error. The resulting regression coefficients for identified segmented regression models are finally used to obtain stiffness, yielding deformation and energy dissipation parameters. The performance of the method is illustrated using a single degree of freedom system and a suite of 20 earthquake records. RMS noise of 5%, 10%, 15% and 20% is added to the response data to assess the robustness of the identification routine. The proposed method is computationally efficient and accurate in identifying the damage parameters within 10% average of the known values even with 20% added noise. The method requires no user input and could thus be automated and performed in real-time for each sub-half cycle, with results available effectively immediately after an event as well as during an event, if required.

Evaluation of mandibular lingula and foramen location using 3-dimensional mandible models reconstructed by cone-beam computed tomography

Zhou, Cong,Jeon, Tae-Hyun,Jun, Sang-Ho,Kwon, Jong-Jin Korean Association of Maxillofacial Plastic and Re 2017 Maxillofacial Plastic Reconstructive Surgery Vol.39 No.-

Background: The positions of the mandibular lingula and foramen have been set as indexes for inferior alveolar nerve (IAN) block and ramus osteotomies in orthognathic surgery. This study aimed to evaluate the anatomical structures of mandibular ramus, especially the mandibular lingula and foramen, by analyzing the cone-beam computed tomography (CBCT) data of young adults. Methods: We evaluated 121 sides of hemi-mandibular CBCT model of 106 patients (51 male and 55 female patients; 18 to 36 years old). All the measurements were performed using the 2- and 3-dimensional rulers of $OnDemand3D^{(R)}$ software. Results: Statistical analysis of the data revealed that there was no significant difference in the mandibular angle between the genders. The mandibular lingula was found to be located at the center of ramus in males, but a little posterior in relation to the center in females. The mandibular lingula was rarely located below the occlusal plane; however, the position of the mandibular foramen was more variable (84.3% below, 12.4% above, and 3.3% at the level of the occlusal plane). Conclusions: The results of this study provide a valuable guideline for IAN block anesthesia and orthognathic surgery. CBCT can be considered effective and accurate in evaluating the fine structures of the mandible.

Construction of a Protein-Protein Interaction Network for Chronic Myelocytic Leukemia and Pathway Prediction of Molecular Complexes

Zhou, Chao,Teng, Wen-Jing,Yang, Jing,Hu, Zhen-Bo,Wang, Cong-Cong,Qin, Bao-Ning,Lv, Qing-Liang,Liu, Ze-Wang,Sun, Chang-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known. Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network. Materials and Methods: Genes involved in chronic myelocytic leukemia were selected from OMIM database. Literature mining was performed by Agilent Literature Search plugin and a protein-protein interaction network of chronic myelocytic leukemia was established by Cytoscape. The molecular complexes in the network were detected by Clusterviz plugin and pathway enrichment of molecular complexes were performed by DAVID online. Results and Discussion: There are seventy-nine chronic myelocytic leukemia genes in the Mendelian Inheritance In Man Database. The protein-protein interaction network of chronic myelocytic leukemia contained 638 nodes, 1830 edges and perhaps 5 molecular complexes. Among them, complex 1 is involved in pathways that are related to cytokine secretion, cytokine-receptor binding, cytokine receptor signaling, while complex 3 is related to biological behavior of tumors which can provide the bioinformatic foundation for further understanding the mechanisms of chronic myelocytic leukemia.

HOCl Oxidation-modified CT26 Cell Vaccine Inhibits Colon Tumor Growth in a Mouse Model

Zhou, Rui,Huang, Wen-Jun,Ma, Cong,Zhou, Yan,Yao, Yu-Qin,Wang, Yu-Xi,Gou, Lan-Tu,Yi, Chen,Yang, Jin-Liang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Despite progress in elucidating mechanisms associated with colorectal cancer and improvement of treatment methods, it remains a frequent cause of death worldwide. New and more effective therapies are therefore urgently needed. Recent studies have shown that immunogenicity of whole ovarian tumor cells and subsequent T cell response were potentiated by oxidation modification with hypochlorous acid (HOCl) in vitro and ex vivo. These results prompted us to investigate the protective antitumor response with an HOCl treated CT26 colorectal cancer cell vaccine in an in vivo mouse model. Administration of HOCl modified vaccine triggered robust antitumor immunity to autologous tumor cells in mice and prolonged survival period significantly. In addition, increased necrosis and apoptosis were found in tumor tissue from the oxidation group. Interestingly, ELISPOT assays showed that specific T cell responses were not elicited in response to the immunizing cellular antigen, in contrast to raising sera antibody titer and antibody binding activity shown by ELISA assay and flow cytometry. Further evaluation of the mechanisms underlying HOCl modified vaccine mediated humoral immunity highlighted the role of antibody-dependent cell-mediated cytotoxicity. These results combined with previous studies suggest that HOCl oxidation modified whole cell vaccine has wide applicability as a cancer vaccine because it can target both T cell- and B cell-specific responses. It may thus represent a promising approach for the immunotherapy of colorectal cancer.

Effect of anti-skin disorders of ginsenosides- A Systematic Review

Lele Cong,Jinli Ma,Yundong Zhang,Yifa Zhou,Xianling Cong,Miao Hao 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.5

Ginsenosides are bioactive components of Panax ginseng with many functions such as anti-aging, antioxidation,anti-inflammatory, anti-fatigue, and anti-tumor. Ginsenosides are categorized into dammarane,oleanene, and ocotillol type tricyclic triterpenoids based on the aglycon structure. Based on thesugar moiety linked to C-3, C-20, and C-6, C-20, dammarane type was divided into protopanaxadiol (PPD)and protopanaxatriol (PPT). The effects of ginsenosides on skin disorders are noteworthy. They play antiagingroles by enhancing immune function, resisting melanin formation, inhibiting oxidation, andelevating the concentration of collagen and hyaluronic acid. Thus, ginsenosides have previously beenwidely used to resist skin diseases and aging. This review details the role of ginsenosides in the anti-skinaging process from mechanisms and experimental research.

DNA Vaccines Encoding Toxoplasma gondii Cathepsin C1 Induce Protection against Toxoplasmosis in Mice

Yali Han,Aihua Zhou,Gang Lu,Guanghui Zhao,Wenchao Sha,Lin Wang,Jingjing Guo,Jian Zhou,Huaiyu Zhou,Hua Cong,Shenyi He 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.5

Research Progress on the Livin Gene and Osteosarcomas

Li, Cheng-Jun,Cong, Yu,Liu, Xiao-Zhou,Zhou, Xing,Shi, Xin,Wu, Su-Jia,Zhou, Guang-Xin,Lu, Meng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Osteosarcoma is a common malignant tumor of bone, but mechanisms underlying its development are still unclear. At present, it is believed that the inhibition of normal apoptotic mechanisms is one of the reasons for the development of tumors, so specific stimulation of tumor cell apoptosis can be considered as an important therapeutic method. Livin, as a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family, has specifically high expression in tumor tissues and can inhibit tumor cell apoptosis through multiple ways, which can become a new target for malignant tumor treatment (including osteosarcoma) and might of great significance in the clinical diagnosis of tumors and the screening of anti-tumor agents and carcinoma treatment.

Investigation of Grinding Characteristic using Nanofluid Minimum Quantity Lubrication

Cong Mao,Xiaojun Tang,Hongfu Zou,Xiangming Huang,Zhixiong Zhou 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.

Conventional grinding fluid is widely used in grinding process, which results in high consumption and impacting the environment. The promising alternative to conventional dry and fluid coolant application is minimum quantity lubrication (MQL). It is known that the cooling and lubrication performance of the grinding fluid is the key technical area for the success application of MQL grinding process. In this study, Water based Al2O3 nanofluid was applied to grinding process with MQL approach for its excellent convection heat transfer and thermal conductivity properties. The grinding characteristics of hardened AISI 52100 steel were investigated and compared with those of wet, dry and pure water MQL grinding. Experimental results show that water based Al2O3 nanofluid MQL grinding can significantly reduce the grinding temperature, decrease the grinding forces, improve the ground surface morphology and reduce the surface roughness in comparison to pure water MQL grinding. Furthermore, the cooling and lubricating mechanism for nanofluid MQL grinding was discussed in detail.

Comparison of immunoadjuvant activities of four bursal peptides combined with H9N2 avian influenza virus vaccine

Cong Zhang,Jiangfei Zhou,Zhixin Liu,Yongqing Liu,Kairui Cai,Tengfei Shen,Cheng-Shui Liao,Chen Wang 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.6

The bursa of Fabricius (BF) is a central humoral immune organ unique to birds. Four bursal peptides (BP-I, BP-II, BP-III, and BP-IV) have been isolated and identified from the BF. In this study, the immunoadjuvant activities of BPs I to IV were examined in mice immunized with H9N2 avian influenza virus (AIV) vaccine. The results suggested that BP-I effectively enhanced cell-mediated immune responses, increased the secretion of Th1 (interferon gamma)- and Th2 (interleukin-4)-type cytokines, and induced an improved cytotoxic T-lymphocyte (CTL) response to the H9N2 virus. BP-II mainly elevated specific antibody production, especially neutralizing antibodies, and increased Th1- and Th2-type cytokine secretion. BP-III had no significant effect on antibody production or cell-mediated immune responses compared to those in the control group. A strong immune response at both the humoral and cellular levels was induced by BP-IV. Furthermore, a virus challenge experiment followed by H&E staining revealed that BP-I and BP-II promoted removal of the virus and conferred protection in mouse lungs. BP-IV significantly reduced viral titers and histopathological changes and contributed to protection against H9N2 AIV challenge in mouse lungs. This study further elucidated the immunoadjuvant activities of BPs I to IV, providing a novel insight into immunoadjuvants for use in vaccine design.

Running-in performance of 7075 aluminum alloy strengthened by burnishing technology

Cong Ding,Shiqing Feng,Zhizhao Qiao,Zhenyu Zhou,Zhongyu Piao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.5

A 2D ultrasonic burnishing technology was employed to strengthen 7075 aluminum alloy. The running-in experiments for original and burnished samples were implemented, and the running-in performance was explored qualitatively and quantitatively. The results show that the worn surface of an original sample exhibited the peelings, scratches, and abrasive particles, yet the wear form of a burnished sample was relatively single, mainly with scratches. The quantitative parameter “maximum distance between phase points d max ” was calculated. During the friction and wear process, the d max of friction coefficient signal displayed the variation of first decreasing and then stabilizing, which was consistent with the running-in and steadystate stages of the friction system. Compared with the original sample, the burnished sample had a less d max , which indicated that the phase trajectory had a more convergence, and the friction system had a better stability. This study can guide surface strengthening and running-in performance analysis.