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( Sang Yoon Ko ),( Hyung Eun Lee ),( Se Jin Park ),( Se Jin Jeon ),( Bo Seong Kim ),( Qing Tao Gao ),( Dae Sik Jang ),( Jong Hoon Ryu ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.2
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms, therapeutic strategies for AD are limited. Alternatively, the identification of traditional herbal medicines or their active compounds has received much attention. The aims of the present study were to characterize the ameliorating effects of spinosin, a C-glucosylflavone isolated from Zizyphus jujuba var. spinosa, on memory impairment or the pathological changes induced through amyloid-b1-42 oligomer (AbO) in mice. Memory impairment was induced by intracerebroventricular injection of AbO (50 μM) and spinosin (5, 10, and 20 mg/kg) was administered for 7 days. In the behavioral tasks, the subchronic administration of spinosin (20 mg/kg, p.o.) significantly ameliorated AbO-induced cognitive impairment in the passive avoidance task or the Y-maze task. To identify the effects of spinosin on the pathological changes induced through AbO, immunohistochemistry and Western blot analyses were performed. Spinosin treatment also reduced the number of activated microglia and astrocytes observed after AbO injection. In addition, spinosin rescued the AbO-induced decrease in choline acetyltransferase expression levels. These results suggest that spinosin ameliorated memory impairment induced through AbO, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of spinosin. Therefore, spinosin might be a useful agent against the amyloid b protein-induced cognitive dysfunction observed in AD patients.
A New Report of Anthurid Isopod (Crustacea, Isopoda, Anthuridae) from Korea
Sung Hoon Kim,Seong Myeong Yoon 한국동물분류학회 2018 Animal Systematics, Evolution and Diversity Vol.34 No.3
In this study, Caenanthura engimatica (Kensley and Reid, 1984) is newly reported from Korea along with detailed description and illustrations. This species can be characterized by the following features: cephalon has a rostrum extending as long as anterolateral lobes; pereonites 4-6 have shallow middorsal pits; the mandible palp has 2 articles; article 1 of the mandible palp is twice longer than article 2; and the maxillipedal palp has 1-3 fused and 4-5 fused articles. This is the first report of C. engimatica beyond Arabian Gulf, the type locality, and Indian Ocean. Additionally, we proposed a revised key to known species of the genus Caenathura Kensley, 1978.
Anti-tumor Activity of Novel Indirubin Derivatives in Rat Tumor Model
Sang Gun Ahn,Soo A Kim,Hyun Woo Kim,Young Ho Woo,Jung Hoon Yoon 대한구강악안면병리학회 2005 대한구강악안면병리학회지 Vol.29 No.5
lndil‘ ubin is the active ingredient of Danggui Longhui Wan‘ a mixture of herbal medici l1e t hat is used to treat chronic myelocytic leukemia in tradi t ional Chinese medicine‘ He re, we show that new indirubin deri vatives 5' -ni tro-indirubinoxime, 5' -f1 uoro-indiru binoxime and 5’ -tri rnethylacetamino-i nd i 1'1.1 bi noxi me‘ have potent a n ti- proliferative activity on various human cancer cells and oncogenic RK3E-ras rat kidney cells with lC50 con centration ranging from 1-25 μ M, When the RK3E-ras cells were treated with indirubin derivatives for 24 h, the activity of caspase-3 and caspasc-7 was induccd followed by apoptosis , 011 the other hand, the activity of SAPK/JNK was inhi bited over the same period , lndirubin deri vatives a lso s howed strong ant i-tumor activity in rat s이 id and oral tumor models The inhibition of tlUl10r g:rowth was observed in animals beaJ‘ing RK3E-ras-induced turnor given subcutaneous dose of 100 mg/kg every other day for 10 days, Histologically, μeatment of indirubin derivatives caused significant inhibition of tumor formation associated wi th increased apoptosis and decreased proliferation of tumor cell s , These findings provide the potential value of indirubin derivatives as a novel candi date fOl 없l tJ -cancer agents ,
Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition
( Yoon Hee Chung ),( Keon Woong Oh ),( Sung Tae Kim ),( Eon Sub Park ),( Hyun Dong Je ),( Hyuk-jun Yoon ),( Uy Dong Sohn ),( Ji Hoon Jeong ),( Hyen-oh La ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2
The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Hypothermia significantly inhibited fluoride-, thromboxane A<sub>2-</sub>, phenylephrine-, and phorbol ester-induced vascular contractions regardless of endothelial nitric oxide synthesis, suggesting that another pathway had a direct effect on vascular smooth muscle. Hypothermia significantly inhibited the fluorideinduced increase in pMYPT1 level and phorbol ester-induced increase in pERK1/2 level, suggesting inhibition of Rho-kinase and MEK activity and subsequent phosphorylation of MYPT1 and ERK1/2. These results suggest that the relaxing effect of moderate hypothermia on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rho-kinase and MEK activities.
Clinical study of 11 cases with acanthosis nigricans
( Hoon Choi ),( Yoon Soo Kim ),( Yea Son Lee ),( Chan Ho Na ),( Min Sung Kim ),( Bong Seok Shin ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Acanthosis nigricans is characterized by symmetrical hyperpigmentations and papillomatosis. It has been known to occur in the neck, axilla, groin, and antecubital area, and be associated with obesity, insulin resistance, and endocrine disorders. Objectives: To investigate the associated diseases, medications and clinical features of patients with acanthosis nigricans Methods: The clinical study included patients with complete medical records who visited our clinic and who were clinically and histopathologically diagnosed as acanthosis nigricans. We analyzed the family history, age, locations, body mass index, associated diseases, and medications based on medical records. Results: A total of 11 patients who met the mentioned criteria were included in the study. Among 11 patients, there was no family history, and mean age of patients was 16.1 years(7-25). All patients had skin lesions in the neck, followed by axilla(91%), and inguinal area(45%). The mean BMI was 31.0 and obesity was present in 82% of patients. The obesity was the most common comorbid disease, with diabetes (9%), fatty liver (9%), Cushing’s syndrome (9%). And there were two patients being treated with growth hormone. And other patients had no significant drug use. Conclusion: Recently, growth hormone has been used for various purposes, and it may be associated with acanthosis nigricans as in this study. The suggest that periodic examinations should be paid to patients who received growth hormone treatment.