남성 근로자의 건강관련 행태와 건강수준과의 관련성

함정오,김화성,이성수,우극현,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

This study was conducted to evaluate the health related behaviors associated with blood pressure, results of liver function and renal function, and anemia indices. Study subjects were 499 male workers who visited to General Health Screening Center of A hospital located in Chonan. Data were collected from March to December 1996. By the questionnaire, the informations of health related behaviors such as, age, smoking and drinking habits, food intake habit, sleeping time, stress were obtained. Height, weight and blood pressure were measured by a trained nurse. The level of total Cholesterol, HDL Cholesterol, triglyceride, fasting blood sugar, glutamate oxaloacetate transaminase(GOT), glutamate pyruvate transaminase (GPT), r-glutamyl transferase(rGTP), blood urea nitrogen(BUN), serum creatinine(Cr), hemoglobin(Hb), hematocrit(Hct), hepatitis B surface antigen were selected as biometric test variables. Statistical analysis, such as t-test, Chi square-test, stepwise multiple regression, multiple logistic regression were performed using SAS package program. There were significant differences in age, systolic blood pressure, total cholesterol, GOT, GGT, BUN, Hb, and Hct between drinkers and non-drinkers, and significant differences in age, body mass index(BMI), systolic blood pressure, diastolic blood pressure, rGTP, BUN, and Hb between smokers and non-smokers . Triglyceride, age, BMI, and HDL cholesterol were found to be positivc independent predictors of blood pressure, but drinking habit(mild drinking group vs. non-drinking group) and pack-year of smoking were negative predictors of blood pressure. Logistic analysis of systolic hypertensive related condition indicated that triglyceride(OR=1.003, 95% CI; 1.000-1.006), total cholesterol(OR=1.008, 95% CI; 1.000-1.016), and pack-years of smoking (OR=0.972, 95% CI; 0.952-0.994) were significantly contribution to dependent variable, Logistic analysis of diastolic hypertensive related condition revealed that age3(≥50 years vs. <40 years) (OR=4.702 (95% CI; 1.919-11.521), age2(40-49 years vs. <40 years) (OR=4.702 (955 CI; 1.919-11.521), triglyceride (OR=1.005, 95% CI; 1.002-1.008), pack-years of smoking(OR=0.972, 95% CI; 0.951-0.993), and meal regularity (yes vs. no) (OR=0.618, 95% CI; 0.383-0.991) were significantly contribution to dependent variable. Triglyceride, total cholesterol, fasting blood sugar, and animal food intake(yea vs. no) were found to be positive independent predictors to BMI, but HDL and stress(yes vs. no) were negative predictors. Logistic analysis of abnormal BMI condition indicated that total cholesterol(OR= 1.013, 95% CI; 1.007-1.020) and HDL cholesterol (OR=0.943, 95% CI; 0.916-0.972) were significantly contribution to dependent variable. BMI, HBs Ag, and the frequency of drinking were found to be positive independent predictors to GOT, but meal regularity(yes vs. no) were negative predictors. Logistic analysis of abnormal GOT condition indicated that HBs Ag(yes vs. no)(OR-6.666, 95% CI; 1.724-25.779), BMI(OR=1.199, 95% CI;1.015-1.416), and meal regularity(yes vs. no)(OR=0.248, 95% CI; 0.096-0.639) were significantly contribution to dependent variable. BMI, and HBs Ag were found to be positive independent predictors to GPT, but meal regularity(yes vs. no) were negative predictors. Logistic analysis of abnormal GPT condition showed that only BMI (OR=1.301, 95% CI; 1.301(1.176-1.440) was significantly contribution to dependent variable. BMI and the frequency of drinking were found to be positive independent predictors to rGTP, but meal regularity(yes vs. no) were negative predictors. Logistic analysis of abnormal rGTP conditionindicated that BMI(OR=1.340, 95% CI; 1.197-1.499), Alc5(abovc 5 times/week vs. non-drinking) (OR=21.733, 95% CI; 3.671-128.684), Alc4(3-4 times/week vs. non-drinking) (OR=4.533, 95% CI; 1.463-14.049), Alc3(1-2 times/week vs. non-drinking) (OR=3.918, 95% CI; 1.406-10.916), and meal regularity(yes vs. no) (OR=0.405, 95% CI; 0.221-0.740) were significantly contribution to dependent variable. BMI and age were found to be positive independent predictors to BUN, but stress(yes vs. no) and pack-year of smoking were negative predictors. Logistic analysis of abnormal BUN condition indicated that only age3(≥50 years vs. <40 years) (OR=4.808 (95% CI; 1.307-17.676) was significantly contribution to dependent variable. BMI was found to be positive independent predictors to Hb and Hct, respectively, but regular exercise(yes vs. no) was negative predictors to Hb and Hct, respectively. With above results, it was found that age, BMI, level of serum triglyceride, and level of serum total cholesterol were significantly associated with hypertension and that BMI was significantly associated with abnormal results of liver function tests and especially the frequency of drinking was associated with abnormal rGTP. Also the workers with meal regularity habits, compared to those with meal irregularity habits, were lower prevalence of hypertension and abnormal liver function tests, therefore the meal regularity habits seem to be reflected good health related behaviors.

작업환경측정이 작업환경개선에 미치는 효과

함정오,안규동,황규윤,이병국,이성수,정두신 가톨릭대학산업의학센타 산업의학연구소 1992 韓國의 産業醫學 Vol.31 No.3

To investigate the effect of environmental measurement on the improvement of working condition in small and medium sized industries and to evaluate the usefulness of this measurement which is covered by Occupational Safety and Health Act for the protection of workers from hazardous working condition, authors selected 107 small and medium sized manufacturing industries mainly from Chunan area and partly from lead using industries which were in special contract of agent specific occupational health service with Institute of Industrial Medicine, Soonchunhyang University. Environmental measurements were provided twice in interval of 6 months to study industries. At the end of second measurement questionnaires were collected to check the usefulness of this measurement for the workers and industries itself. The results obtained were as follows: 1. Out of 107 manufacturing industries, the most frequently measured index of harmful agent in environmental measurement was noise, and the next indices were dust, organic solvents and special chemicals in descending order. While the excess rates of measurement over Permissible Exposure Level(PEL) in the first measurement were 19.3% in noise, 22.8% in dust, 14.3% I organic solvents and 20.3% in special chemicals measurement, those in second measurement were 26.0% in noise, 14.7% in dust, 10.0% in organic solvents and 29.5% in special chemicals measurement, respectively. 2. The supply rate of protective equipment and the labeling condition of health and safety poster in the later period of study were improved than early period. 3. Most persons in charge of health and safety management(97.2%) had engaged in other administrative works and only 2.8% of study industries had independent occupational safety and health personnels who engaged only in health and safety of workers. 4. The purpose of environmental measurement answered by the eligible of persons each industries was to report at the regional office of labor affair. Only 7 out of 107 industries answered that their measurements were for the real improvement of working condition and 3 industries for the fulfilment of requirement of trade union. 5. While 86.0% in industries (92/107) felt the report of environmental measurement was helpful to set up protective equipment program to prevent workers from harmful condition, 66.4% in industries answered that it was useful for the establishment of health education program. The measurement of environmental conditions were also useful for the installation of ventilatory system of workplace, for the isolation of work process and for the improvement of work process. But 8.4% in industries answered that it was not useful at all.

연작업자들에서의 δ -aminolevulinic acid dehydratase 유전형질의 다형성이 신기능에 미치는 영향

안익수,황보영,김용배,리갑수,이성수,장봉기,함정오,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

δ-aminolevulinic acid hehydratase (ALAD) is a polymorphic enzyme that has two alleles, ALAD1 (ALAD1-1 as phenotype) and ALAD2 (ALAD1-2 or ALAD2-2 as phenotype). ALAD genotype has been reported to modify the toxicokinetics of lead. To investigate the influence of ALAD genotype polymorphism on renal function in lead workers, author studied 1022 male lead workers and 149 non lead workers in the same industries. For the cross-sectional renal function indices, blood urea nitrogen (BUN), serum creatinine, uric acid and total protein were selected. Blood lead and blood zinc protoporphyrin were also measured as indices of lead exposure. Information on weight, age, job duration, smoking & drinking history were collected. Following results are as follows: 1. Whereas the mean (standard deviation) of blood lead and blood ZPP of lead workers were 27.2±12.5 ㎍/㎗ and 57.7±37.8 ㎍/㎗, those of non-lead workers in the same premises were 14.9±6.5 ㎍/㎗ and 44.6± 15.8 ㎍/㎗ respectively. The difference of mean blood lead and blood ZPP between two groups were statistically significant. 2. Whereas the prevalence of the variant allele, ALAD2 in 1022 lead workers was 10.2 %, the prevalence of that in 149 non-lead workers was 7.4 %. But there was no difference of prevalence between two groups. 3. The mean±standard deviation of blood lead of subjects with ALAD1 was 25.5± 12.7 ㎍/㎗ and was slightly lower than that of subjects with ALAD2 (26.5±10.9 ㎍/㎗), and the mean±standard deviation of blood ZPP of subjects with ALAD1 was slightly higher than that of subjects with ALAD2 (56.7±37.3 ㎍/㎗ vs 48.9±18.6 ㎍/㎗). But the differences of blood lead and blood ZPP between two genotypes were not statistically significant. 4. There were no differences of cross-sectional renal function indices (BUN, serum creatinine, uric acid and total protein) either by lead workers and non-lead workers or two genotypes. 5. In multiple regression analysis of ALAD genotype on BUN after controlling for possible confounders (sex, weight, job duration, smoking and drinking status), the mean of BUN in ALAD2 subjects was 0.629 ㎎/㎗ lower than ALAD1 subjects with a weak statistical significance (p=0.07). But in logistic analysis of ALAD genotype on median value of BUN revcaled that subjects of ALAD2 genotype were 32% less likely to have median value or more of BUN than subjects of ALAD1 with odd ratio of 0.618 (95% confidence interval 0.411-0.920). 6. In multiple regression analysis of ALAD genotype on serum creatinine after controlling for possible confounders (sex, weight, job duration, smoking and drinking status), the mean of serum creatinine in ALAD2 subjects was 0.0271 ㎎/㎗ lower than ALAD1 subjects with statistical significance (p=0.02). On the other hand, in logistic analysis of ALAD genotype on median value of serum creatinine revealed that subjects of ALAD2 genotype were 30% less likely to have median value or more of scrum creatinine than subjects of ALAD1 with odd ratio of 0.700 (95% confidence interval 0.442-1.080). With the above results, it was found that the variant allcle, ALAD2 appeared to modify the association of lead and renal function and ALAD2 genotype may be supportive for the protective effect of lead.

영덕 달산 지역 화산층서와 용암의 공급지

황상구,함희수,김지영,정해오 안동대학교 기초과학연구소 1999 基礎科學 硏究論文集 Vol.10 No.1

We traced the flow direction of Ipbong Andesite and dacite in Dalsan area, Yeongdeok. Elongate vesicles and lathlike plagioclase phenocysts are aligned in the outcrops or under microscope. The lineations from their alignment are excellently indicating the flow direction of lavas. The flow directions, which were measured from the lineations in the Ipbong Andesite, are NNW-SSE in the eastern part and NNE-SSW in the southwestern part. The flow lineations show a fanlike movement pattern from the mid-northern part that the diorite is distributed. The diorite area is prabably a potential source area of the andesite

직업적인 납 노출이 없는 일부 중년 한국인의 골중납량 및 혈중납량

김남수,최성우,김진호,함정오,박해윤,안규동,이병국 大韓産業醫學會 2007 대한직업환경의학회지 Vol.19 No.4

목적: 우리나라에서 납에 직업적으로 노출되지 않은 일부 중년 성인들의 골중납량과 혈중납량의 수준과 상호관련성을 알아보기 위하여 40세 이상 남자 86명 여자 51명 총 137명을 대상으로 본 연구를 시도하였다. 방법: 연구변수로 골중납량인 경골납량,혈중납량을 택하였다. 경골납량은 K-shell XRF를 이용하여 각 대상 자들을 30분간 측정하였고,혈중납량은 원자흡광광도계법으로 분석하였다. 결과: 총대상자 137명의 경골납량의 평균±표준편차는 3.49±4.99 μg/g이었으며, 남자와 여자는 각각 3.90± 4.88 μg/g 및 2.80±5.14 μg/g이었으나 양군 평균의 통계적 차이는 없었다. 한편 총대상자 137명의 혈중납량의 평균±표준편차는 3.70±1.35 μg/dl이었으며,남자와 여자는 각각 3.93±1.25 μg/dl 및 3.30±1.42 μg/dl이었으나 양군 평균의 통계적 차이는 없었다. 음주,흡연 및 BMI를 통제한 후 혈중납량을 종속변수로 한 중 회귀분석에서 연령은 양의 영향을 주는 변수로 나타났다. 여자대상자만을 대상으로 한 중 회귀분석에서 교란변수를 통제한 후 연령은 경골납량에 경계수준의 양의영향을 나타내었다. 결론: 40세 이상의 우리나라 중년성인의 경골납량의 평균±표준편차는 3.49±4.99 μg/g이었으며,혈중납량의 평균±표준편차는 3.70±1.35 μg/dl이었다 혈중납량은 연령과 성과 유의한 양의 관련성이 있었으나,골중납량은 여자에서만 연령과 경계수준의 유의한 관련을 나타냈다. Objectives: In order to investigate the level and the association between bone lead and blood lead levels of non-occupationally, lead-exposed Koreans, the authors studied the lead biomarkers of 137 middle aged Koreans (86 males and 51 females) older than whose age were above 40 years. Methods: The tibia lead level was selected as the bone lead indicator of cortical bone, and the blood lead level was also measured. The tibia lead level was measured by K-shell XRF with 30-minute measurement of each subjects. The blood lead level was analyzed by AAS method. Results: The mean (SD) of the tibia lead level of the 137 study subjects was 3.49 (4.99) ,㎍/g, and tended to be higher. The mean (SD) of tibia lead level in male subjects (was 3.90 (4.88) ㎍/g) and larger than in that of female subjects (2.80 (5.14) ㎍/g), but without no statistical significance was observed. The mean (SD) of blood lead level of all total subjects was 3.70 (1.35) ,㎍/dl, and tended to be higher. The mean (SD) of blood lead level in male subjects (was 3.93 (1.25) ㎍/dl) and larger than in that of female subjects (3.30 (1.42) ㎍/dl), but without no statistical significance was observed. In multiple regression analysis of blood lead levels after adjusting for covariates, age was a significant independent variable. A weak association of age with tibia lead in female subjects was also observed in multiple regression analysis. Conclusion: The mean (SD) of tibia and blood lead levels of middle aged Koreans whose ages were over 40 years old were 3.49 (4.99) ㎍/g and 3.70 (1.35) ㎍/dl, respectively. Age and sex were positive predictors of blood lead level in multiple regression analysis after controlling for the covariates. However, in multiple regression analysis whereas age was weakly association with tibia lead level only in female subjects in multiple regression analysis.

일부 종합검진 수검자에 비만도 및 혈중 지질이 혈압에 미치는 영향

임대식,함정오'김화성'이성수 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

This study was conducted to evaluate blood pressure associated with body mass index and blood lipids. Study subjects were 3,076 persons (1,623 males and 1,453 females) who visited to General Health Screening Center located in Chonan. Data were collected from 2001 to 2003. Height, weight and blood pressure were measured by a trained nurse. The level of total cholesterol, HDL cholesterol, triglyceride, and fasting blood sugar were selected as biometric test variables. Statistical analysis, such as t-test, simple correlation, and stepwise multiple regression were performed using SAS package program. The mean (standar deviation) of age, BMI, systolic blood pressure, diastolic blood pressure, fasting blood sugar, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol in study subjects were 48.4 ±11.8 years, 23,7 ± 3.2 kg/m^(2), 124.6 ± 16.3 mmHg, 80.9 ± 10.7 mmHg, 97.6 ± 24.9 mg/㎗, 154.4 ± 105.6 mg/㎗, 203.2 ± 39.2 mg/㎗, 51.0 ± 12.8 mg/㎗, and 121.8 ± 35.6 mg/㎗, respectively. In multiple regression analysis of BMI and blood lipids on systolic blood pressure after controlling for confounders (age, sex, and fasting blood sugar), BMI, HDL cholesterol, and triglyceride were found to be significant positive independent predictors of systolic blood pressure. In multiple regression analysis of BMI and blood lipids on systolic blood pressure after controlling for confounders (age, sex, and fasting blood sugar), BMI, triglyceride, HDL cholesterol, and LDL cholesterol were found to be significant positive independent predictors fo systolic blood pressure. With above results, it was found that BMI and blood lipids were significantly associated with blood pressure.

졸참나무 수피의 추출성분

김진규,이상극,함연호,배영수 江原大學校 森林科學硏究所 2002 Journal of Forest Science Vol.18 No.-

졸참나무 수피를 채취하여 아세톤:물(7:3, v/v) 혼합용액으로 추출하고 유기용매를 제거한 후 hexane, CH₂Cl₂, EtOAc 및 수용성으로 분획하여 등결건조하였다. 그 중에서 EtOAc용성 분획물을 MeOH 수용액 및 EtOH-hexane 혼합용액을 사용하여 Sephadex LH-20 칼럼크로마토그래피를 수행하여 (+)-catechin, ellagic acid, taxifolin, taxifolin-3-O-β-D-glucopyranoside를 단리하였다. 단리된 화합물의 구조는 ¹H, ^(13)C-NMR spectrum으로 구조를 구명하였다. The bark of Quercus serrata Thunb were collected, extracted with acetone-H~O(7: 3, v/v), fractionated with hexane, methylene chloride and ethylacetate, and freeze dried to give some dark brown powder. The ethylacetate soluble mixture was chromatographed on a Sephadex LH-20 column using a series of aqueous methanol and ethanol-hexane mixture as eluents. The isolated compounds from &. serrata were (1- 1-catechin, ellagic acid taxifolin and taxifoiin-3-O-ll-D-glucop~anos~de. The structures of isolated compounds were characterized by ¹H, ^(13) C-NMR spectroscopy.

일부 종합검진 수검자에서 비만도 및 혈중 지질이 혈압에 미치는 영향

임대식,함정오,김화성,이성수 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

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대구시 하수도 설계를 위한 기본 조사연구

조병하,이상렵,이순탁,함능수,나인엽,오창언,김자홍 경북대학교 1971 生産技術 Vol.5 No.-

This study is a "reconnaissance" of "preliminary" grade survery with the objectives of compiling and analyzing drainage systems, river pollution, hydraulic and hydrologic characteristics of sewage, and conservation of public water supplies for design of sewer systems in Taegu. In addition, it contains basis information for design of new sanitary sewage and drainage systems for Taegu. The results are shown as follows;1) Before attempting to design a sewage system, it was necessary to set up reliable standards for estinating sewage amounts. 2) The results of analysis and examination of Taegu's drainage systems. 3) The investigation of "sewage quality and river pollution in Taegu. 4) In order to maintain the B.O.D. value of the Kumho River below 8 ppm, a sewage treatment plant will be necessary. The basic information necessary in planning a treatment plant is given. This study is a summary of reseach that was conducted jointly by Kyung-Pook National Univ ersity's Insttute of Industrial Sciences and Young-Nam Universty's Institute of Industrial Sciences and Young-Nam University's Department of Civil Engineering. The study was begun on Novemver 4,1969 and completed on November 3,1970. By an agreement between the United States Agency for International Development and the Ministry of Science and Technology of the Republic of Korea, the work was financial out of the MO ST/USAID Trust Fnnd.

새로운 연노출의 효과지표로서의 혈장 δ-aminolevulinic acid 측정의 유용성

이금원,황보영,김용배,리갑수,이성수,장봉기,함정오,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

To evaluate the usefulness of the measurement of plasma δ - aminolevulinic acid (ALAP) as a new effect indicator of lead exposure, the association of ALAP with blood lead, DMSA chelatable lead and bone lead with a special emphasis of genetic interaction of ALAD polymorphism was studied with 419 lead exposed workers and 85 non-lead exposed workers. Lead workers were recruited from storage battery industries, secondary smelting industries and other lead using industries and non-lead workers selected from electronic refrigerator manufacturing industry. Blood lead, DMSA chelatable lead and bone lead were chosen for parameters of lead exposure. Plasma and urinary ALA were selected for the effect parameter of lead intoxication. Information for age, smoking, drinking habit and body mass index were also obtained. Job duration for lead workers was also collected. The overall prevalence of the variant allele, ALAD type 1-2 or 2-2(ALAD2) in lead exposed workers was 10.0% (42 out of 419 lead workers) which was not differed from control workers (9.4% : 8 out of 85). The means blood lead and DMSA chelatable lead of lead workers with ALAD 1(ALAD type 1-1) were lower than those of lead workers with ALAD2, but the differences were not statistically significant. On the other hand, the mean of tibia lead of lead workers with ALADI was higher than that of lead workers with ALAD2, but the difference was not statistically significant. DMSA chelatable lead showed highest correlation with log transformed plasma ALA(LALAP)(r=0.682) and blood lead and tibia lead had r=0.650, r=0,402 correlation coefficient with LALAP respectively On the other hand. log transformed urinary ALA(LALAU) had lower correlation coefficient with all three parameters of lead exposure than LALAP. The equation of robustic simple linear regression of blood lead on LALAP was LALAP=2.0439+0.0165PbB in ALADI lead workers and LALAP=2.031+0.0121PbB in ALAD2 lead workers. ALAD genotype in the multiple regression analysis of blood lead with LALAP after adjusting for possible confounders(sex, ago, BMI, smoking and drinking status and job duration) showed significant main effect on LALAP resulting lower LALAP in ALAD2 lead workers than ALADI lead workers. On the other hand, effect modification of ALAD genotype was observed in the multiple regression analysis of tibia lead with LALAP after adjusting for possible confounders, but there was no significant effect of ALAD genotype in the multiple regression analysis of DMSA chelatable lead with LALAP after covariate adjustment. With above results, plasma ALA was found to be a useful effect parameter of lead exposure compared with urinary ALA. It was also observed that ALAD polymorphism made significant effect on the association of blood and tibia lead with ALAP. Thc lower plasma ALA in ALAD2 lead workers suggested supportive effect of ALAD2 in lead exposure.