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Antiapoptotic Effect of Paricalcitol in Gentamicin-induced Kidney Injury
Sang Heon Suh,Ko Eun Lee,Jeong Woo Park,In Jin Kim,Ok Kim,Chang Seong Kim,Joon Seok Choi,Eun Hui Bae,Seong Kwon Ma,Jong Un Lee,Soo Wan Kim 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.5
While the anti-apoptotic effect of paricalcitol has been demonstrated in various animal models, it is not yet clear whether paricalcitol attenuates the apoptosis in gentamicin (GM)-induced kidney injury. We investigated the effect of paricalcitol on apoptotic pathways in rat kidneys damaged by GM. Rats were randomly divided into three groups: 1) Control group (n=8), where only vehicle was delivered, 2) GM group (n=10), where rats were treated with GM (150 mg/kg/day) for 7 days, 3) PARI group (n=10), where rats were co-treated with paricalcitol (0.2 Ռg/kg/day) and GM for 7 days. Paricalcitol attenuated renal dysfunction by GM administration in biochemical profiles. In terminal deoxynu-cleotidyl transferase dUTP nick end labeling staining, increased apoptosis was observed in GM group, which was reversed by paricalcitol co-treatment. Immunoblotting using protein samples from rat cortex/outer stripe of outer medulla showed increased Bax/Bcl-2 ratio and cleaved form of caspase-3 in GM group, both of which were reversed by paricalcitol. The phosphorylated Jun-N-terminal kinase (JNK) expression was increase in GM, which was counteracted by paricalcitol. The protein expression of p-Akt and nitro-tyrosine was also enhanced in GM-treated rats compared with control rats, which was reversed by paricalcitol co-treatment. Paricalcitol protects GM-induced renal injury by antiapoptotic mechanisms, including inhibition of intrinsic apoptosis pathway and JNK.
( Jin-hwa Son ),( Sung-min Park ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hoon-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Cellulitis is the common infectious disease occurred on the skin and soft tissue, and is associated with frequent recurrence. Lymphedema is one of risk factors of recurrent cellulitis, and common causes of it are malignancy and malignancy-associated treatment. Bulky lymphadenopathy by cancer invasion and direct tumor compression of regional lymphatic vessels can play a role in lymphedema. A 57-year-old woman presented with erythematous indurated patches on right lower quadrant of abdomen, right thigh and lower leg. Histopathologic examinations revealed perivascular inflammation with neutrophil infiltration. In addition, total WBC count was 14,460/ul, ESR and CRP were 14mm/hr and 17.56mg/dl respectively. She was diagnosed as cellulitis and improved with antibiotics treatment. But, for 9 months these clinical findings were repeated and imaging studies were performed. On imaging test of lower extremity, no specific findings were found except for lymphedema. After 1 year, subcutaneous mass on left supraclavicular region was found incidentally, and a biopsy revealed a metastatic carcinoma. Finally, cervical cancer was identified as the origin of metastatic carcinoma and its regional lymphatic invasion was considered as the cause of recurrent cellulitis with lymphedema. Herein, we report a rare case in which recurrent cellulitis related to lymphedema was significant cutaneous sign of regional lymphatic invasion of occult internal malignancy.
Inexplicable but real phenomenon: rapidly regressed
( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Gun Wook Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Kaposi’s sarcoma (KS) is a type of spindle cell malignancy that arises from the vascular endothelium, usually presenting as violaceous papules and plaques. KS development is invariably linked with human herpesvirus (HHV)-8 infection. Almost spontaneous regressions of KS have been previously described in the iatrogenic type. Herein, we present a classic KS in immunocompetent patient showing rapid regression after biopsy. A 78-year-old male presented with relatively well-defined erythematous patches on forehead, Rt. upper eyelid and chin, and violaceous papule on nose. His medical and family histories were noncontributory. The patient denied history of recent overseas travel, homosexual or unnatural sexual practices, and serum anti-HIV antibody was negative. A histopathologic examination from the nose revealed typical findings of KS and tumor cells showed positive staining for CD31, CD34, and factor VIII-related antigen. Polymerase chain reaction in a biopsy specimen was positive for HHV-8. Without specific treatment, the lesion rapidly regressed within 2 weeks. It is generally accepted that immune status plays an important role for KS. As viral wart disappear after biopsy occasionally, it is possible that the biopsy may have then exposed antigens and induced an immunologic reaction, which led to the rapid regression of KS.
Mycoplasma pneumoniae -induced rash and mucositis
( Sung Min Park ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Mycoplasma pneumoniae (M. pneumoniae)is one of the most common causes of respiratory tract infections in pediatric and adult populations worldwide. In dermatologic disorder, M. pneumoniae infection is known to be associated with erythema multiforme (EM) and Stevens-Johnson syndrome (SJS) in children and young adults. Recently, several cases with M. pneumoniae-associated mucositis with lacks typical target lesions have been reported. The term of Mycoplasma-induced rash and mucositis (MIRM) was suggested to revise from M. pneumoniae-associated mucocutaneous disease including EM and SJS because of distinct morphology, mild disease course, and potentially important clinical implications regarding treatment.Herein, we report a patient with MIRM. A 5-year-old boywas referred to the department of dermatology forerythematous maculopapuleson the face, trunk, and extremities. Physical examination revealed swollen eyelids with conjunctival injection, swollen lips, and erythematous erosive patch on the penile tip and perianal area.Histopathologic finding showed subepidermal blister with epidermal necrosis, and perivascular lymphohistiocytic infiltrations.Chest radiograph demonstrated localized infiltration in the right upper lobe, and M. pneumoniaeIgM antibodies was positive. Hewas treated with antibiotics, intravenous immunoglobulins, and showed rapid recovery within 2 weeks without any sequelae. Keyword: Mycoplasma pneumoniae, Mucositis, Rash, Stevens-Johnsons syndrome, Erythema multiforme
[P440] Acral acanthosis nigricans associated with diabetes.
( Jin-hwa Son ),( Sung-min Park ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Acanthosis nigricans (AN) is a disorder characterized by skin hyperpigmentation and velvety thickening, especially on back, neck, axillae, inframammary areas and groins. It is categorized into eight types; benign, malignant, associated with obesity, syndromic, unilateral, drug induced, mixed and acral. In acral AN, the lesions are localized to the knee, ankle, phalangeal joints and tarsophalangeal joints. Since this type essentially occurs in healthy patients, evaluation for underlying disorders is usually unnecessary. However, there were many reports about the associations of acral AN with lymphoma, gastric adenocarcinoma and etc.. A 33-year-old man presented with velvety hyperpigmented patches on knuckles of both hands for 1 month. On examination, there was diffuse hyperpigmentation over both axillae and groins for about 1 year. Although he had diabetes since age of 13, he was not on treatment. Level of blood sugars were 363 mg/dl and HbA1c was 12.7%. Histopathologic examinations revealed epidermal hyperkeratosis and acanthosis. The diagnosis was confirmed to acral AN associated with diabetes. In the present case, acral AN may also be accompanied with underlying disease and necessitate a evaluation for a possible diagnosis of underlying disorder.
The use of ingenol mebutate gel as adjuvant therapy for large or multiple Bowen disease
( Sang Jin Cheon ),( Hyun Ju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Bowen disease (BD) is squamous cell carcinoma in situ, which may progress to invasive carcinoma if not adequately managed. In single and small BD, many therapeutic options are available including excision, curettage, cryotherapy, and topical agents such as 5-fluorouracil and imiquimod. But in the case with large or multiple lesions, therapeutic choice is restrictive. Herein, we experienced two cases of large or multiple BD successfully managed with ingenol mebutate gel. A 81-year-old woman was diagnosed as BD for large lesion on the right calf measuring 7 x 10 cm. We applied ingenol mebutate gel 0.05% on the affected area once daily for 2 consecutive days. 1 month after treatment, crust fell out and only focal small lesion was remained. After additional cryotherapy was done twice and clinically resolved large BD during follow-up 6 months.. A 54-years-old woman was diagnosed as BD for multiple hyperkeratotic plaques on the both palms. We applied ingenol mebutate gel 0.05% once daily for 2 consecutive days. After 3 months, only a few lesions were remained. Following three times additional cryotherapy, the lesions were improved enough to be controlled cryotherapy. Through our experience, we suggest ingenol mebutate gel could be effective adjuvant therapy option for large or multiple BD.