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Genome-wide association study of recalcitrant atopic dermatitis in Korean children
Kim, K.W.,Myers, R.A.,Lee, J.H.,Igartua, C.,Lee, K.E.,Kim, Y.H.,Kim, E.J.,Yoon, D.,Lee, J.S.,Hirota, T.,Tamari, M.,Takahashi, A.,Kubo, M.,Choi, J.M.,Kim, K.E.,Nicolae, D.L.,Ober, C.,Sohn, M.H. Mosby 2015 The Journal of allergy and clinical immunology Vol.136 No.3
Background: Atopic dermatitis (AD) is a heterogeneous chronic inflammatory skin disease. Most AD during infancy resolves during childhood, but moderate-to-severe AD with allergic sensitization is more likely to persist into adulthood and more often occurs with other allergic diseases. Objective: We sought to find susceptibility loci by performing the first genome-wide association study (GWAS) of AD in Korean children with recalcitrant AD, which was defined as moderate-to-severe AD with allergic sensitization. Methods: Our study included 246 children with recalcitrant AD and 551 adult control subjects with a negative history of both allergic disease and allergic sensitization. DNA from these subjects was genotyped; sets of common single nucleotide polymorphisms (SNPs) were imputed and used in the GWAS after quality control checks. Results: SNPs at a region on 13q21.31 were associated with recalcitrant AD at a genome-wide threshold of significance (P < 2.0 x 10<SUP>-8</SUP>). These associated SNPs are more than 1 Mb from the closest gene, protocadherin (PCDH)9. SNPs at 4 additional loci had P values of less than 1 x 10<SUP>-6</SUP>, including SNPs at or near the neuroblastoma amplified sequence (NBAS; 2p24.3), thymus-expressed molecule involved in selection (THEMIS; 6q22.33), GATA3 (10p14), and S-phase cyclin A-associated protein in the ER (SCAPER; 15q24.3) genes. Further analysis of total serum IgE levels suggested 13q21.31 might be primarily an IgE locus, and analyses of published data demonstrated that SNPs at the 15q24.3 region are expression quantitative trait loci for 2 nearby genes, ISL2 and proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1), in immune cells. Conclusion: Our GWAS of recalcitrant AD identified new susceptibility regions containing genes involved in epithelial cell function and immune dysregulation, 2 key features of AD, and potentially extend our understanding of their role in pathogenesis.
Hysteresis and fast timescales in transport relations of toroidal plasmas
Itoh, K.,Itoh, S.-I.,Ida, K.,Inagaki, S.,Kamada, Y.,Kamiya, K.,Dong, J.Q.,Hidalgo, C.,Evans, T.,Ko, W.H.,Park, H.,Tokuzawa, T.,Kubo, S.,Kobayashi, T.,Kosuga, Y.,Sasaki, M.,Yun, G.S.,Song, S.D.,Kasuya, International Atomic Energy Agency 2017 Nuclear fusion Vol.57 No.10
<P>This article assesses current understanding of hysteresis in transport relations, and its impact on the field. The rapid changes of fluxes compared to slow changes of plasma parameters are overviewed for both core and edge plasmas. The modulation ECH experiment is explained, in which the heating power cycles on-and-off periodically, revealing hysteresis and fast changes in the gradient–flux relation. The key finding is that hystereses were observed simultaneously in both the the gradient–flux and gradient–fluctuation relations. Hysteresis with rapid timescale exists in the channels of energy, electron and impurity densities, and plausibly in momentum. Advanced methods of data analysis are explained. Transport hysteresis can be studied by observing the higher harmonics of temperature perturbation <img ALIGN='MIDDLE' ALT='$\delta T_{\rm m}$ ' SRC='http://ej.iop.org/images/0029-5515/57/10/102021/nfaa796aieqn001.gif'/> in heating modulation experiments. The hysteresis introduces the term <img ALIGN='MIDDLE' ALT='$\delta T_{\rm m}$ ' SRC='http://ej.iop.org/images/0029-5515/57/10/102021/nfaa796aieqn002.gif'/>, which depends on the harmonic number <I>m</I> in an algebraic manner (not exponential decay). Next, the causes of hysteresis and its fast timescale are discussed. The nonlocal-in-space coupling works here, but does not suffice. One mechanism for ‘the heating heats turbulence’ is that the external source <I>S</I> in phase space for heating has its fluctuation in turbulent plasma. This coupling can induce the direct input of heating power into fluctuations. The height of the jump in transport hysteresis is smaller for heavier hydrogen isotopes, and could be one of the origins of isotope effects on confinement. Finally, the impacts of transport hysteresis on the control system are assessed. Control systems must be designed so as to protect the system from sudden plasma loss.</P>
Studies on electron Bernstein wave heating in CHS and LHD at NIFS
Y. Yoshimura,H. Igami,S. Ferrando-Margalet,K. Nagasaki,S. Kubo,T. Shimozuma,M. Isobe,C. Suzuki,A. Shimizu,T. Akiyama,C. Takahashi,K. Nagaoka,S. Nishimura,T. Minami,K. Matsuoka,S. Okamura,T. Mutoh 한국진공학회 2007 한국진공학회 학술발표회초록집 Vol.16 No.2
Extension of the operational regime of the LHD towards a deuterium experiment
Takeiri, Y.,Morisaki, T.,Osakabe, M.,Yokoyama, M.,Sakakibara, S.,Takahashi, H.,Nakamura, Y.,Oishi, T.,Motojima, G.,Murakami, S.,Ito, K.,Ejiri, A.,Imagawa, S.,Inagaki, S.,Isobe, M.,Kubo, S.,Masamune, S IOP 2017 Nuclear fusion. Fusion nucléaire. &n.Illiga Vol.57 No.10
<P>As the finalization of a hydrogen experiment towards the deuterium phase, the exploration of the best performance of hydrogen plasma was intensively performed in the large helical device. High ion and electron temperatures, <I>T</I> <SUB>i</SUB> and <I>T</I> <SUB>e</SUB>, of more than 6 keV were simultaneously achieved by superimposing high-power electron cyclotron resonance heating onneutral beam injection (NBI) heated plasma. Although flattening of the ion temperature profile in the core region was observed during the discharges, one could avoid degradation by increasing the electron density. Another key parameter to present plasma performance is an averaged beta value <img ALIGN='MIDDLE' ALT='$\left\langle \beta \right\rangle $ ' SRC='http://ej.iop.org/images/0029-5515/57/10/102023/nfaa7fc2ieqn001.gif'/>. The high <img ALIGN='MIDDLE' ALT='$\left\langle \beta \right\rangle $ ' SRC='http://ej.iop.org/images/0029-5515/57/10/102023/nfaa7fc2ieqn002.gif'/> regime around 4% was extended to an order of magnitude lower than the earlier collisional regime. Impurity behaviour in hydrogen discharges with NBI heating was also classified with a wide range of edge plasma parameters. The existence of a no impurity accumulation regime, where the high performance plasma is maintained with high power heating >10 MW, was identified. Wide parameter scan experiments suggest that the toroidal rotation and the turbulence are the candidates for expelling impurities from the core region.</P>
Characteristics of second harmonic ECCD on CHS
yasuo Yoshimura,H. Matsushita,H. Igami,K. Nagasaki,K. Matsuoka,K. Ohkubo,K. Nagaoka,M. Isobe,S. Kobayashi,S. Okamura,S. Kubo,S. Nishimura,T. Minami,T. Akiyama,T. Notake,T. Shimozuma,A. Shimizu,C. Suzu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
Second harmonic electron cyclotron current drive (ECCD) has been investigated on CHS (Compact Helical System) by using a 2-D steerable EC-beam injection system. The direction of the plasma current, which is the sum of bootstrap current and EC-driven current, is clearly reversed by a reversal of the EC-beam injection direction. The direction of driven current is consistent with expectation in the case of low-field side injection of EC wave. So far, a driven current up to 6 kA has been obtained when bootstrap current is less than 2 kA. It is confirmed that right-hand polarization and low density are effective for ECCD.