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Radiation Safety and Education in the Applicants of the Final Test for the Expert of Pain Medicine
( Pyong Eun Park ),( Jung Min Park ),( Joo Eun Kang ),( Jae Hun Cho ),( Suk Ju Cho ),( Jae Hun Kim ),( Woo Seog Sim ),( Yong Chul Kim ) 대한통증학회 2012 The Korean Journal of Pain Vol.25 No.1
Background: The C-arm fluoroscope is known as the most important equipment in pain interventions. This study was conducted to investigate the completion rate of education on radiation safety, the knowledge of radiation exposure, the use of radiation protection, and so on. Methods: Unsigned questionnaires were collected from the 27 pain physicians who applied for the final test to become an expert in pain medicine in 2011. The survey was composed of 12 questions about the position of the hospital, the kind of hospital, the use of C-arm fluoroscopy, radiation safety education, knowledge of annual permissible radiation dose, use of radiation protection, and efforts to reduce radiation exposure. Results: In this study, although most respondents (93%) had used C-arm fluoroscopy, only 33% of the physicians completed radiation safety education. Even though nine (33%) had received education on radiation safety, none of the physicians knew the annual permissible radiation dose. In comparing the radiation safety education group and the no-education group, the rate of wearing radiation-protective glasses or goggles and the use of radiation badges or dosimeters were significantly higher in the education group. However, in the use of other protective equipment, knowledge of radiation safety, and efforts to reduce radiation exposure, there were no statistical differences between the two groups. Conclusions: The respondents knew very little about radiation safety and had low interest in their radiation exposure. To make the use of fluoroscopy safer, additional education, as well as attention to and knowledge of practices of radiation safety are required for pain physicians. (Korean J Pain 2012; 25: 16-21)
Radiation Safety and Education in the Applicants of the Final Test for the Expert of Pain Medicine
Park, Pyong-Eun,Park, Jung-Min,Kang, Joo-Eun,Cho, Jae-Hun,Cho, Suk-Ju,Kim, Jae-Hun,Sim, Woo-Seog,Kim, Yong-Chul The Korean Pain Society 2012 The Korean Journal of Pain Vol.25 No.1
Background: The C-arm fluoroscope is known as the most important equipment in pain interventions. This study was conducted to investigate the completion rate of education on radiation safety, the knowledge of radiation exposure, the use of radiation protection, and so on. Methods: Unsigned questionnaires were collected from the 27 pain physicians who applied for the final test to become an expert in pain medicine in 2011. The survey was composed of 12 questions about the position of the hospital, the kind of hospital, the use of C-arm fluoroscopy, radiation safety education, knowledge of annual permissible radiation dose, use of radiation protection, and efforts to reduce radiation exposure. Results: In this study, although most respondents (93%) had used C-arm fluoroscopy, only 33% of the physicians completed radiation safety education. Even though nine (33%) had received education on radiation safety, none of the physicians knew the annual permissible radiation dose. In comparing the radiation safety education group and the no-education group, the rate of wearing radiation-protective glasses or goggles and the use of radiation badges or dosimeters were significantly higher in the education group. However, in the use of other protective equipment, knowledge of radiation safety, and efforts to reduce radiation exposure, there were no statistical differences between the two groups. Conclusions: The respondents knew very little about radiation safety and had low interest in their radiation exposure. To make the use of fluoroscopy safer, additional education, as well as attention to and knowledge of practices of radiation safety are required for pain physicians.
두개부 혈관 조영검사 시 기하학적 특성에 따른 선량 감소 방안
박찬우 ( Chan Woo Park ),조평곤 ( Pyong Kon Cho ) 한국방사선학회 2019 한국방사선학회 논문지 Vol.13 No.3
본 연구의 목적은 디지털 혈관 조영 촬영장치를 이용한 검사 시 X선관, 환자 테이블, 검출기 또는 환자등의 기하학적 특성에 따라 실무자가 수시로 변화시켜 적용할 수 있는 매개변수에 대해 알아보고 이에 따른 환자 및 의료진의 방사선 피폭선량을 감소시키는 방안에 대해 알아보고자 하였다. 기하학적 특성들에 따라 각각 fluoroscopy mode와 Digital subtraction angiography로 촬영하고 유효 선량으로 환산한 값을 비교하였다. 연구결과 FPS mode에 따른 선량은 FPS mode를 낮게 설정할수록 선량이 30-40%까지 감소하였다. X 선관 각도에 따른 선량은 AP View에서 가장 높게 측정되었고 머리 방향으로 각도가 들어갈수록 선량이 낮게 측정되었다. FOV가 확대될수록 선량이 1.2-1.6배 증가하였고 X선관과 테이블의 거리가 가까워질수록 약10% 증가하였다. X선관과 평판형 검출기의 거리가 100 mm 멀어질수록 선량이 20-30% 증가하였다. 결론 적으로 혈관 조영검사 시 다양한 기하학적 특성들은 실무자가 수시로 변화시켜 적용할 수 있는 매개변수 이며 다양한 상황에서 적합한 기하학적 특성들을 고려하여 적용함으로써 적절한 선량 감소 효과를 기대할 수 있다. This study aims to find geometric parameters that the radiologist can change from time to time to reduce dose in angiography examinations. Depending on the geometric characteristics, the values calculated by effective dose were compared, while filming in fluoroscopy mode and Digital subtraction angiography, respectively. The study found that the lower the dose was in FPS mode, the lower the dose was reduced to 30-40%. Doses according to the X-ray angle were measured highest in AP View and lower as the angle went in the head direction. The greater the FOV, the higher the dose was 1.2-1.6 times, and the closer the distance between the X-ray tube and the table, the greater the dose was about 10%. Source-image intensifier distance(SID) get longer to 100 mm, dose of each fluoroscopy and Digital subtraction angiography increase up to 25-30%. In conclusion, various geometric characteristics in angiography examinations are parameters that can be applied by radiographers as frequently as possible, and appropriate geometric properties can be considered and applied in various situations, resulting in appropriate dose reduction.
Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-α Activation
Lee, Eun-Jung,Han, Jeong Eun,Woo, Moon-Sook,Shin, Jin A.,Park, Eun-Mi,Kang, Jihee Lee,Moon, Pyong Gon,Baek, Moon-Chang,Son, Woo-Sung,Ko, Young Tag,Choi, Ji Woong,Kim, Hee-Sun The American Association of Immunologists, Inc. 2014 JOURNAL OF IMMUNOLOGY Vol.193 No.5
<P>Matrix metalloproteinases (MMPs) play important roles in normal brain development and synaptic plasticity, although aberrant expression of MMPs leads to brain damage, including blood–brain barrier disruption, inflammation, demyelination, and neuronal cell death. In this article, we report that MMP-8 is upregulated in LPS-stimulated BV2 microglial cells and primary cultured microglia, and treatment of MMP-8 inhibitor (M8I) or MMP-8 short hairpin RNA suppresses proinflammatory molecules, particularly TNF-α secretion. Subsequent experiments showed that MMP-8 exhibits TNF-α–converting enzyme (TACE) activity by cleaving the prodomain of TNF-α (A<SUP>74</SUP>/Q<SUP>75</SUP>, A<SUP>76</SUP>/V<SUP>77</SUP> residues) and, furthermore, that M8I inhibits TACE activity more efficiently than TAPI-0, a general TACE inhibitor. Biochemical analysis of the underlying anti-inflammatory mechanisms of M8I revealed that it inhibits MAPK phosphorylation, NF-κB/AP-1 activity, and reactive oxygen species production. Further support for the proinflammatory role of microglial MMP-8 was obtained from an in vivo animal model of neuroinflammatory disorder. MMP-8 is upregulated in septic conditions, particularly in microglia. Administration of M8I or MMP-8 short hairpin RNA significantly inhibits microglial activation and expression/secretion of TNF-α in brain tissue, serum, and cerebrospinal fluid of LPS-induced septic mice. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-α activity, which may explain neuroinflammation in septic mouse brain.</P>
Microbial Subversion of Heparan Sulfate Proteoglycans
Ye Chen,Martin Götte,Jian Liu,Pyong Woo Park 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.5
The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry. The ability to interact with heparan sulfate proteoglycans is widespread among viruses, bacteria, and parasites. Certain pathogens also use heparan sulfate proteoglycans to evade host defense mechanisms. These findings suggest that heparan sulfate proteoglycans are critical in microbial pathogenesis, and that heparan sulfate proteoglycan-pathogen interactions are potential targets for novel prophylactic and therapeutic approaches.
설계인자 변화에 따른 소형 전기집진장치의 최적효율 예측
서정민 ( Jeong Min Suh ),이병인 ( Pyong In Yi ),정문섭 ( Moon Sub Jung ),박정호 ( Jeong Ho Park ),임우택 ( Woo Taik Lim ),박출재 ( Chool Jae Park ),최금찬 ( Kum Chan Choi ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.9
The result of a small electrostatic precipitator which is in order to decrease indoor air pollution for optimal efficiency was shown as follows. Although the closer distance between the discharge electrode and dust collecting electrode shows the better throughput efficiency by forming strong electrostatic Field, it does not have profound impact in case of optimal dust collecting area. G.P(gas passage) which is the distance from dust collecting electrode to dust collecting electrode is a crucial factor to decide dust collecting efficiency. The narrower distance of G.P shows the better throughput efficiency whereas it decreases when the distance is too narrow since sparks ensue by increasing the capacity of electrostatic charging system 5 mm regards as optimal efficiency in this experiment. Although the higher voltage shows the higher dust collecting efficiency overall, the experiment was not able to keep performing since the sparks which decrease dust collecting efficiency ensue over 40 kV. The efficient and safe voltage state is considered 3.6 kV in this experiment. The most crucial factor for dust collecting efficiency of an electrostatic precipitator which is in order to decrease indoor air pollution is applied voltage. In addition, optimal raw gas flow rate(2.4 m/sec) is more important factor than the excessive increase of dust collecting area.