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Taiji Sakai,Kanako Wake,Soichi Watanabe,Osamu Hashimoto 한국전자파학회JEES 2010 Journal of Electromagnetic Engineering and Science Vol.10 No.4
This study proposes a temperature compensation method of the complex permittivities of biological tissues and organs. The method is based on the temperature dependence of the Debye model of water, which has been thoroughly investigated. This method was applied to measured data at room temperature for whole blood, kidney cortex, bile, liver, and heart muscle. It is shown that our method can compensate for the Cole-Cole model using measured data at 20 ℃, given the Cole-Cole model based on measured data at 35 ℃, with a root-mean-squared deviation of 3~11 % and 2~6 % for the real and imaginary parts of the complex permittivities, respectively, among the measured tissues.
Myosin X and Cytoskeletal Reorganization
Ikebe, Mitsuo,Sato, Osamu,Sakai, Tsuyoshi Korean Society of Microscopy 2018 Applied microscopy Vol.48 No.2
Myosin X is one of myosin superfamily members having unique cellular functions on cytoskeletal reorganization. One of the most important cellular functions of myosin X is to facilitate the formation of membrane protrusions. Since membrane protrusions are important factors for diverse cellular motile processes including cell migration, cell invasion, path-finding of the cells, intercellular communications and so on, it has been thought that myosin X plays an important role in various processes that involve cytoskeletal reorganization including cancer progression and development of neuronal diseases. Recent studies have revealed that the unique cellular function of myosin X is closely correlated with its unique structural characteristics and motor properties. Moreover, it is found that the molecular and cellular activities of myosin X are controlled by its specific binding partner. Since recent studies have revealed the presence of various specific binding partners of myosin X, it is anticipated that the structural, biochemical and cell biological understanding of the binding partner dependent regulation of myosin X function can uncover the role of myosin X in diverse cell biological processes and diseases.
Magnetism of SrM3P4O14 (M2+ = 3d Ions) Investigated Using Neutron-scattering Measurements
Masashi Hase,Andreas D¨onni,Osamu Sakai,Kiyoshi Ozawa,Hideaki Kitazawa,Vladimir Yu. Pomjakushin,Lukas Keller,Tao Yang,Rihong Cong,Jianhua Lin 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
The substances SrM3P4O14 (M = Mn, Fe, Co or Ni) have the same crystal structure. However,the magnetism of SrMn3P4O14 differs qualitatively from that of the other substances. We determinedthe magnetic structures of SrM3P4O14 (M = Mn or Co) by using neutron powder diffractionmeasurements. The spin system in SrMn3P4O14 can be regarded as a trimerized spin chain, whichis consistent with the spin system inferred from the crystal structure and the appearance of the 1/3quantum magnetization plateau. The spin system in SrCo3P4O14 is not a trimerized spin chain.
Phospholipid-dependent regulation of the motor activity of myosin X
Umeki, Nobuhisa,Jung, Hyun Suk,Sakai, Tsuyoshi,Sato, Osamu,Ikebe, Reiko,Ikebe, Mitsuo Nature Publishing Group, a division of Macmillan P 2011 Nature structural & molecular biology Vol.18 No.7
Myosin X is involved in the reorganization of the actin cytoskeleton and protrusion of filopodia. Here we studied the molecular mechanism by which bovine myosin X is regulated. The globular tail domain inhibited the motor activity of myosin X in a Ca<SUP>2+</SUP>-independent manner. Structural analysis revealed that myosin X is monomeric and that the band 4.1-ezrin-radixin-moesin (FERM) and pleckstrin homology (PH) domains bind to the head intramolecularly, forming an inhibited conformation. Binding of phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P<SUB>3</SUB>) to the PH domain reversed the tail-induced inhibition and induced the formation of myosin X dimers. Consistently, disruption of the binding of PtdIns(3,4,5)P<SUB>3</SUB> attenuated the translocation of myosin X to filopodial tips in cells. We propose the following mechanism: first, the tail inhibits the motor activity of myosin X by intramolecular head-tail interactions to form the folded conformation; second, phospholipid binding reverses the inhibition and disrupts the folded conformation, which induces dimer formation, thereby activating the mechanical and cargo transporter activity of myosin X.
Itoh Yasunobu,Kitagawa Ryo,Numazawa Shinichi,Yamakawa Kota,Yamada Osamu,Akasu Isao,Sakai Jun,Otomo Tomoko,Yoshida Hirotaka,Mori Kentaro,Watanabe Sadayoshi,Watanabe Kazuo 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.3
In C1–C2 posterior fixation, the C1 lateral mass and C2 pedicle/translaminar screw insertion under spine navigation have been used frequently. To avoid the risk of neurovascular damage in atlantoaxial stabilization, we assessed the safety and effectiveness of a preoperative computed tomography (CT) image-based navigation system with intraoperative independent C1 and C2 vertebral registration. It is ideal when a reference frame can be linked directly to the C1 posterior arch for C1-direct-captured navigation, but there is a mechanical challenge. A new spine clamp-tracker system was implemented recently, which allows reliable C1- and C2- direct-captured navigation in nine patients with traumatic C2 fractures. In this way, there was no misalignment of C1–C2 screws. C1 lateral mass screws were used except for one case, and translaminar screws were primarily used as an anchor for C2. The C1 lateral mass screw locations, which are 19 mm laterally from the C1 posterior arch’s center, are taken to be constant. However, there is one unusual circumstance in which using a C1 laminar hook instead of a C1 lateral mass screw appears to be a beneficial substitute. The increase of surgical accuracy for posterior C1–C2 screw fixation without cost constraints is significantly facilitated by intraoperative C1- and C2-direct-captured navigation with preoperative computed CT images.
Tsuneaki Takao,Seiji Okada,Yuichiro Morishita,Takeshi Maeda,Kensuke Kubota,Ryosuke Ideta,Eiji Mori,Itaru Yugue,Osamu Kawano,Hiroaki Sakai,Takayoshi Ueta,Keiichiro Shiba 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.3
Study Design: Retrospective case series. Purpose: To clarify the influence of cervical spinal canal stenosis (CSCS) on neurological functional recovery after traumatic cervical spinal cord injury (CSCI) without major fracture or dislocation Overview of Literature: The biomechanical etiology of traumatic CSCI remains under discussion and its relationship with CSCS is one of the most controversial issues in the clinical management of traumatic CSCI. Methods: To obtain a relatively uniform background, patients non-surgically treated for an acute C3–4 level CSCI without major fracture or dislocation were selected. We analyzed 58 subjects with traumatic CSCI using T2-weighted mid-sagittal magnetic resonance imaging. The sagittal diameter of the cerebrospinal fluid (CSF) column, degree of canal stenosis, and neurologic outcomes in motor function, including improvement rate, were assessed. Results: There were no significant relationships between sagittal diameter of the CSF column at the C3–4 segment and their American Spinal Injury Association motor scores at both admission and discharge. Moreover, no significant relationships were observed between the sagittal diameter of the CSF column at the C3-4 segment and their neurological recovery during the following period. Conclusions: No relationships between pre-existing CSCS and neurological outcomes were evident after traumatic CSCI. These results suggest that decompression surgery might not be recommended for traumatic CSCI without major fracture or dislocation despite pre-existing CSCS.