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Increased Expression of Histone Deacetylase 2 is Found in Human Hepatocellular Carcinoma
Noh, Ji-Heon,Eun, Jung-Woo,Ryu, So-Yeon,Jeong, Kwang-Wha,Kim, Jung-Kyu,Lee, Sug-Hyung,Park, Won-Sang,Yoo, Nam-Jin,Lee, Jung-Young,Nam, Suk-Woo The Korean Society of Toxicogenomics and Toxicopro 2006 Molecular & cellular toxicology Vol.2 No.3
Accumulated evidences have established that aberrant regulation of histone deacetylases (HDACs) is one of major causes for development of human malignancies. Mammalian HDACs can be divided into three subclasses consisting of 11 homologous of HDACs and 7 of sirtuins, but little is known about HDAC2 causes for carcinogenesis in solid tumors. Here, in order to investigate the roles of HDAC2 in carcinogenesis of liver cancer progression, we analyzed the expression of HDAC2 in 62 human hepatocellular carcinomas by utilizing Immunohistochemistry. Moderate to strong expression of HDAC2 was found in 54 (87%) out of total 62 tumors. The majority of positive tumors were detected in nucleous, but normal hepatocytes did not express of HDAC2 or showed weak positive staining. Interestingly, we were also noted that HDAC2 expression was appeared to be associated with aggressiveness of the tumors by the fact that HDAC2 expression was observed with significances in high grade tumors (Edmonson grade II, III). Taken together, we found the aberrant expression of HDAC2 in hepatocellular carcinomas, and this suggests that HDAC2 may play an important role in the development of liver cancer.
Noh, Ho-Sung,Son, Ji-Won,Lee, Heon,Kim, Hae-Ryoung,Lee, Jong-Ho,Lee, Hae-Weon The Korean Ceramic Society 2010 한국세라믹학회지 Vol.47 No.1
The feasibility of using the thin film technology in utilizing lanthanum strontium manganite (LSM) for a solid oxide fuel cell (SOFC) cathode in a low-temperature regime is investigated in this study. Thin film LSM cathodes were fabricated using pulsed laser deposition (PLD) on anode-supported SOFCs with yttria-stabilized zirconia (YSZ) electrolytes. Although cells with a 1 ${\mu}m$-thick LSM cathode showed poor low-temperature cell performance compared to that of a cell with a bulk-processed cathode due to the lack of a triple-phase boundary length, the cell with 200 nm-thick gadolinia-doped ceria (GDC) inserted between the LSM and YSZ showed enhanced performance and more stable operation characteristics in a comparison of a cell without a GDC layer. We postulate that the GDC layer likely improved the cathode adhesion, therefore contributing to the improvement of the cell performance instead of serving as an interfacial reaction buffer.
Noh, Ji Yun,Choi, Won Suk,Song, Joon Young,Lee, Han Sol,Lim, Sooyeon,Lee, Jacob,Seo, Yu Bin,Lee, Jin-Soo,Wie, Seong-Heon,Jeong, Hye Won,Heo, Jung Yeon,Kim, Young Keun,Park, Kyung Hwa,Kim, Shin Woo,Lee Elsevier 2018 Vaccine Vol.36 No.35
<P><B>Abstract</B></P> <P>We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007–2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007–2008 season to 2013–2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages.</P> <P>A total of 571 influenza B virus sequences were analyzed. During the 2009–2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007–2008, 2011–2012, and 2013–2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain.</P> <P>During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.</P> <P><B>Highlights</B></P> <P> <UL> <LI> During the 2007–2014 seasons, influenza B epidemics were substantial in 4 seasons. </LI> <LI> The lineages of influenza B viruses in South Korea were investigated. </LI> <LI> Rate of lineage mismatch of vaccine and circulating influenza B viruses was 41.7%. </LI> <LI> QIV may improve the vaccine effectiveness, especially in the high-risk groups. </LI> </UL> </P>
Electrochemical properties of Si film electrodes deposited on electrochemically etched Cu substrate
Noh, Jung-Pil,Kim, Ji-Heon,Kim, Bo-Min,Lee, Jung-Goo,Cho, Kwon-Koo,Cho, Gyu-Bong Royal Swedish Academy of Sciences 2010 Physica scripta Vol.2010 No.t139
<P>In order to investigate the electrochemical properties of Si electrodes deposited on a roughened current collector (substrate), the electrochemical etching method was applied to a Cu current collector. The surface roughness of a Cu current collector could be controlled with an electrochemical etching time and the roughest surface was obtained at 20 min etched Cu foil. After the etching, a thin Cu<SUB>2</SUB>O film was formed on the surface due to high reactivity with air. Amorphous Si films were deposited on flat and rough substrates and their morphologies were considerably affected by those of substrates. A Si electrode with a rough current collector exhibited remarkably improved cycle performance and maintained a discharge capacity over 1200 mA h g<SUP>−1</SUP> even after the 50th cycle. The formation of large cracked Si tiles was caused by the improved adhesion between Si film and Cu substrate.</P>
Noh, Je-Heon,Lee, Sun-Ho,Kim, Hyun-Joong,Jeong, Wu-Jin,Kim, Min-Young,Kim, Sun-A,Roh, Ji-Ae,Bae, Young-Chun,Kim, Bo-Hyun Korean AcupunctureMoxibustion Medicine Society 2018 대한침구의학회지 Vol.35 No.2
Background: Length of hospitalization for patients with lower back pain sustained in road traffic accidents was assessed clinically. Methods: In total, 170 patients with lower back pain injury sustained in road traffic accidents, were included in the study. They were divided into 2 groups: Group A with a shorter hospitalization period (1-7 days) and Group B with a longer hospitalization period (8-14 days). Each group was treated daily with traditional Korean medicine including: acupuncture, herbal acupuncture, herbal decoction medicine, and chuna treatment. To compare the treatment effects between the 2 groups, health-related quality of life, Oswestry disability index, and numeric rating scale were used. Statistical analysis between the 2 groups was assessed using Chi-square test, independent t test, and paired t test. Results: After hospitalization, Group A and Group B both showed a significant increase in their health-related quality of life scores and significant decreases in Oswestry disability index and numeric rating scale scores. In addition, Group B, with a longer hospitalization period than Group A, showed a significant improvement over Group A in its health-related quality of life and numeric rating scale scores. Conclusion: This study suggests that control of pain caused by lower back injury sustained in a road traffic accident, may be more effectively achieved in patients receiving 8-14 days of hospitalization and traditional Korean medicine treatment, compared to those receiving < 7 days of hospitalization treatment. In the future, more systematic and large-scale studies are needed to ascertain the effects of other variables.
Ji Han Kim,Ha Young Noh,Gyeom Heon Kim,Go Eun Hong,Soo Ki Kim,Chi Ho Lee 한국축산식품학회 2015 한국축산식품학회지 Vol.35 No.3
The effects of dietary supplementation of processed sulfur in pigs according to the level provided during the fattening phase were examined. The pigs were divided into three groups: control (CON), non-sulfur fed pigs; T1, 0.1% processed sulfur fed pigs; T2, 0.3% processed sulfur fed pigs. Physicochemical and sensory properties, as well as meat quality and oxidative stability of the Longissimus dorsi muscle were investigated. The feeding of processed sulfur did not affect moisture and protein contents (p>0.05). However, the crude fat content of T2 was significantly decreased compared to CON (p<0.05), while the pH value of T2 was significantly higher than those of both CON and T1 (p<0.05). Cooking loss and expressible drip of T2 were also significantly lower than that of CON (p<0.05). The redness of meat from T1 was significantly higher than both CON and T2 (p<0.01). During storage, lipid oxidation of the meat from sulfur fed pigs (T1 and T2) was inhibited compared to CON. Examination of omega-3 polyunsaturated fatty acids revealed T2 to have significantly higher content than CON (p<0.05). In the sensory test, the juiciness and overall acceptability of T2 recorded higher scores than CON. This study demonstrated that meat from 0.3% processed sulfur fed pigs had improved nutrition and quality, with extended shelf-life.
Sclerosing Adenosis Diagnosed by Needle Biopsy
Heon Jin Jung(정헌진),Won Shik Han(한원식),Hyeong-Gon Moon(문형곤),Soo Kyung Ahn(안수경),Ji-Sun Kim(김지선),Dong-Yong Noh(노동영),Jung-Min Chang(장정민),Nariya Cho(조나리야),Woo Kyung Moon(문우경),In-Ae Park(박인애),Hee-Chul Shin(신 대한종양외과학회 2012 Korean Journal of Clinical Oncology Vol.8 No.2
목적 : 본 연구는 침생검을 통해 진단 받은 경화성 선증에 대해 추가적인 수술 없이 경과 관찰했을 때의 잠재적 안정성을 알아보고자 하였다. 방법 : 1996년 1월부터 2010년 5월까지 침생검을 통해 경화성 선증으로 진단된 143명의 환자의 145개 병변을 대상으로 (core-needle biopsies 118례, vacuum-assisted biopsies 27례) 의무기록 검토를 토대로 한 후향적 고찰이다. 결과 : 환자들의 BI-RADS(The American College of Radiology Breast Imaging Reporting and Data System) 분류는 다음과 같다: C3(n=8), C4a(n=123), C4b(n=11), C4c(n=e), C5(n=1). 그 중 14명은 조직검사를 재시행하였고 BI-RADS 분류 C5이면서 영상의학적 소견과 병리학적 소견의 불일치를 보인 1명의 환자가 침윤성 유방암으로 진단되어 수술을 시행하였다. 나머지 환자들은 정기적인 초음파 검사 및 유방촬영술을 통해 경과 관찰하였고, 평균 추적관찰 기간 40개월 동안 144개의 병변의 최종 BI-RADS 분류는 다음과 같다: C1(n=5), C2(n=107), C3(n=32), 경과 관찰기간 동안 142명의 환자에서 악성 유방질환이 발견된 환자는 없었다. 결론 : 침생검을 통해 경화성 선증으로 진단된 환자에 있어서 추가적인 수술 없이 정기적인 검진을 통하여 경과 관찰하는 것은 잠재적 안전성을 가지고 있다. 하지만 조직검사와 영상검사 결과의 불일치 소견을 보이는 경우 수술적 생검을 통한 최종 진단이 필요하다. Background : The aim of this study was to assess the potential safety of follow up for patients diagnosed with sclerosing adenosis through needle biopsies without additional surgery. Patients and Methods : From January 1996 to May 2010, 145 lesions in 143 sclerosing adenosis patients who underwent core-needle biopsies (n=118), vacuum-assisted biopsies (n=27) in our institution were followed. Results : The American College of Radiology Breast Imaging Reporting and Data System (BI-BADS) classification in these patients was as follows : C3(n=8), C4a(n=123), C4b(n=11), C4c(n=e) and C5(n=1). After sclerosing adenosis was diagnosed by needle biopsy, 14 patients underwent re-biopsy. Only 1 patient who had BIRAD C5 sonographic features was diagnosed with invasive ductal carcinoma and surrounding ductal carcinoma in situ. The remaining 142 patients received regular medical exam with ultrasonography and/or mammography. 144 lesions’ BI-RADS category were C1(n=5), C2(n=107) and C3(n=32). With the median follow-up period of 40 months, none of the patients developed breast malignancy. Conclusions : Our study suggest that patients with sclerosing adenosis diagnosed by needle biopsies can be safely followed without additional surgery. However, in case of discordance with images and biopsy result, surgical excision for definite diagnosis is recommended.