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NATARAJAN VELMURUGAN,Mi Sook Choi,한상섭,이양수 한국미생물학회 2009 The journal of microbiology Vol.47 No.4
The antifungal activity of bacterial strains Bacillus subtilis EF 617317 and B. licheniformis EF 617325 was demonstrated against sapstaining fungal cultures Ophiostoma flexuosum, O. tetropii, O. polonicum, and O. ips in both in vitro and in vivo conditions. The crude active supernatant fractions of 7 days old B. subtilis and B. licheniformis cultures inhibited the growth of sapstaining fungi in laboratory experiments. Thermostability and pH stability of crude supernatants were determined by series of experiments. FT-IR analysis was performed to confirm the surface structural groups of lipoproteins present in the crude active supernatant. Partial purification of lipopeptides present in the crude supernatant was done by using Cellulose anion exchange chromatography and followed by Sephadex gel filtration chromatography. Partially purified compounds significantly inhibited the sapstaining fungal growth by in vitro analysis. The lipopeptides responsible for antifungal activity were identified by electrospray ionization mass spectrometry after partial purification by ion exchange and gel filtration chromatography. Four major ion peaks were identified as m/z 1023, 1038, 1060, and 1081 in B. licheniformis and 3 major ion peaks were identified as m/z 1036, 1058, and 1090 in B. subtilis. In conclusion, the partially purified lipopeptides may belong to surfactin and iturin family. In vivo analysis for antifungal activity of lipopeptides on wood was conducted in laboratory. In addition, the potential of extracts for fungal inhibition on surface and internal part of wood samples were analyzed by scanning electron microscopy.
Natarajan Sudhakar,Thangarajan Rajkumar,Kamalalayam Raghavan Rajalekshmy,Nirmala Karunakaran Nancy 대한혈액학회 2017 Blood Research Vol.52 No.1
Background: This study characterized clonal IG heavy V-D-J (IGH) gene rearrangements in South Indian patients with precursor B-cell acute lymphoblastic leukemia (precursor B-ALL) and identi-fied age-related predominance in VDJ rearrangements. Methods: IGH rearrangements were studied in 50 precursor B-ALL cases (common ALL=37, pre-B ALL=10, pro-B ALL=3) by polymerase chain reaction (PCR) heteroduplex analysis. Twenty randomly selected clonal IGH rearrangement sequences were analyzed using the IMGT/V-QUEST tool. Results: Clonal IGH rearrangements were detected in 41 (82%) precursor B-ALL cases. Among the IGHV1-IGHV7 subgroups, IGHV3 was used in 25 (50%) cases. Among the IGHD1-IGHD7 genes, IGHD2 and IGHD3 were used in 8 (40%) and 5 (25%) clones, respectively. Among the IGHJ1-IGHJ6 genes, IGHJ6 and IGHJ4 were used in 9 (45%) and 6 (30%) clones, respectively. In 6 out of 20 (30%) IGH rearranged sequences, CDR3 was in frame whereas 14 (70%) had rearranged sequences and CDR3 was out of frame. A so-matic mutation in Vmut/Dmut/Jmut was detected in 14 of 20 IGH sequences. On average, Vmut/Dmut/Jmut were detected in 0.1 nt, 1.1 nt, and 0.2 nt, respectively. Conclusion: The IGHV3 gene was frequently used whereas lower frequencies of IGHV5 and IGHV6 and a higher frequency of IGHV4 were detected in children compared with young adults. The IGHD2 and IGHD3 genes were over-represented, and the IGHJ6 gene was predom-inantly used in precursor-B-ALL. However, the IGH gene rearrangements in pre-cursor-B-ALL did not show any significant age-associated genotype pattern attributed to our population.
Ocular promoting activity of grape polyphenols—A review
Natarajan, Sithranga Boopathy,Hwang, Jin-Woo,Kim, Yon-Suk,Kim, Eun-Kyung,Park, Pyo-Jam Elsevier 2017 Environmental toxicology and pharmacology Vol.50 No.-
<P><B>Abstract</B></P> <P>The eye is a sensitive organ with complex optical system involves in the perception of light. Although it has several protective mechanisms by itself, various physiological and metabolic disorders are detrimental to the proper functioning of the visual system. Grape juice has long been used worldwide for its potent medicinal values including ocular promotion. Bioactivities of grape products are highly attributed to the presence of health promoting phytochemicals in them. Some phytochemicals present in the grape juice have been involved in the maintenance of intra-ocular pressure, regulation of glucose metabolisms and suppression of pro-inflammatory cytokines in the system. Particularly, the grape derived phytochemicals involve in minimizing various eye defects such as macular degradation, uvea, cataract formation, red eye, diabetic retinopathy and so on. However, only limited number of studies has been conducted so far focusing the ocular promoting activity of grape polyphenols. In this review, we discuss the role of grape polyphenols in ocular promotion relating their anti-oxidant, anti-microbial, anti-aging, anti-hypertensive and anti-inflammatory properties.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Natarajan Senthilkumar,최영선,박소현,강학수,박대원 한국공업화학회 2011 Journal of Industrial and Engineering Chemistry Vol.17 No.4
We have investigated the effect of strong p-type organic semiconductor F_4-TCNQ-doped CuPc hole transport layer on the performance of p-i-n hetero-junction photovoltaic device from ITO/PEDOT:PSS/CuPc:F_4-TCNQ (5 wt%)/CuPc:C60 (blending ratio 1:1)/C60/BCP/LiF/Al, fabricated via vacuum deposition process and have evaluated the J–V characteristics such as short circuit current (Jsc), open circuit voltage (Voc), fill factor (FF) and energy conversion efficiency (he) of the device. By doping of F_4-TCNQ into CuPc hole transport layer, absorption intensities in absorption spectra were increased, which supports that uniform dispersion of organic molecules in the hole transport layer with lowered value of surface roughness can be obtained. Eventually, current injection was enhanced through the layer, which comparatively improves the performance of the photovoltaic cell with energy conversion efficiency of 0.50% in this study.
Natarajan Prabhakaran,Chandrababu Prathyusha,Karmegam Patchai Murugan,Madasamy Jothieswari,Somasundaram Swarnalatha 한국탄소학회 2023 Carbon Letters Vol.33 No.4
Volatile organic compounds (VOCs) are a paramount factor in air pollution of the environment. VOCs are vastly present in the wastewater discharged by the pharmaceutical industries. As it is evaporative in nature, it enters the environment spontaneously and causes air pollution, global warming, acid rain and climate change. VOCs must be treated before discharging or any other aerobic methods using an efficient catalyst. As the catalytic oxidation in the liquid phase is facile compared to the gas phase, this study investigated on catalytic liquid-phase oxidation of VOCs in model and real pharmaceutical wastewater. The model compounds of toluene-, ethylbenzene- and chlorobenzene-contaminated waters were treated separately along with the VOCs present in real pharmaceutical wastewater using a tungsten-based carbon catalyst. The tungsten was impregnated on the low-cost activated carbon matrix as it has good selectivity and catalytic property toward VOCs for facile catalytic operations. The metal catalysts were characterised by Fourier transform infrared spectroscopy, X-ray diffraction studies, and scanning electron microscopy with elemental and mapping analysis. The treatability was monitored by total organic carbon, ultra-violet spectroscopy and high-pressure liquid chromatography analysis. The tungsten-impregnated activated carbon matrix (WACM) has a catalytic efficiency toward toluene by 85.45 ± 1.78%, ethylbenzene by 93.9 ± 1.16%, chlorobenzene by 85.9 ± 2.26% and pharmaceutical VOCs by 85.05 ± 1.73% in 20 treatment cycles. The results showed that WACM worked efficiently in VOCs treatment, preventing the environment from air pollution. Furthermore, liquid-phase oxidation could easily be implementable on an industrial scale.
Natarajan, A.,Narayanan, Suthanthiravanitha The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.2
Flashover of power transmission line insulators due to contamination is a major threat to the reliable operation of power system. This paper deals with the analysis of leakage current characteristics of polymeric insulator using S-Transform technique in order to develop a better diagnostic tool to identify the surface condition of outdoor polymeric insulators. In this work, experiments were carried out on 11 kV silicone rubber insulator under AC voltage at different pollution levels. Moving average technique was adopted to find the trend followed by LC peak at different relative humidity conditions. S-Transform was used to find the relationship between energy and frequency content of the leakage current signal with respect to increase in pollution level over a period of time. From the S-Transform time-frequency contour analysis, point of transition to severe arcing due to increase in pollution and its thershold limit were evaluated. Reported results show that the surface condition of insulators could be easily identified from the S-Transform time-frequency analysis of leakage current signals.
HYDROGEN STORAGE ON NANOFULLERENE CAGES
NATARAJAN SATHIYAMOORTHY VENKATARAMANAN,HIROSHI MIZUSEKI,YOSHIYUKI KAWAZOE 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2009 NANO Vol.4 No.5
In this paper, we discuss and compare various nanocage materials proposed theoretically as storage medium for hydrogen. Doping of transition elements leads to clustering which reduces the gravimetric density of hydrogen, while doping of alkali and alkali-earth metals on the nanocage materials, such as carborides, boronitride, and boron cages, were stabilized by the charger transfer from the dopant to the nanocage. Further, the alkali or alkali-earth elements exist with a charge, which are found to be responsible for the higher uptake of hydrogen, through a dipole–dipole and change-induced dipole interaction. The binding energies of hydrogen on these systems were found to be in the range of 0.1 eV to 0.2 eV, which are ideal for the practical applications in a reversible system.