http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge
SHIN, NA-RAE,SHIN, IN-SIK,JEON, CHAN-MI,HONG, JU-MI,KWON, OK-KYOUNG,KIM, HUI-SEONG,OH, SEI-RYANG,HAHN, KYU-WOUNG,AHN, KYUNG-SEOP SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.3
<P>Zingiber mioga (Thunb.) Roscoe (ZM) is a traditional medicine, used to treat inflammatory diseases. The present study aimed to evaluate the inhibitory effects of ZM on the inflammatory response in lipopolysaccharide (LPS)?stimulated RAW264.7 murine macrophage cells and in a mouse model of ovalbumin (OVA)?induced allergic asthma. Mice received OVA sensitization on day 0 and 14, and were challenged with OVA between days 21 and 23. ZM was administered to the mice at a dose of 30 mg/kg, 1 h prior to OVA challenge. In LPS?stimulated RAW264.7 cells, ZM significantly decreased nitric oxide (NO) and tumor necrosis factor (TNF)?α production in a concentration?dependent manner, and mRNA expression of inducible NO synthase (iNOS), TNF?α and matrix metalloproteinase (MMP)?9 was reduced. In addition, treatment with ZM decreased the inflammatory cell count in bronchoalveolar lavage fluid from the mice, and reduced the expression of interleukin (IL)?4, IL?5, IL?13, eotaxin and immunoglobulin E. ZM also reduced airway hyperresponsiveness in OVA?challenged mice, and attenuated the infiltration of inflammatory cells and mucus production in the airways, with a decrease in the expression of iNOS and MMP?9 in lung tissue. In conclusion, the results of the present study indicate that ZM effectively inhibits inflammatory responses. Therefore, it may be that ZM has potential as a therapeutic agent for use in inflammatory diseases.</P>
Shin, Na-Rae,Kwon, Hyung-Jun,Ko, Je-Won,Kim, Joong-Sun,Lee, In-Chul,Kim, Jong-Choon,Kim, Sung-Hwan,Shin, In-Sik Elsevier 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.68 No.-
<P><B>Abstract</B></P> <P>S-Allyl cysteine (SAC) is an active component in garlic and has various pharmacological effects, such as anti-inflammatory, anti-oxidant, and anti-cancer activities. In this study, we explored the suppressive effects of SAC on allergic airway inflammation induced in an ovalbumin (OVA)-induced asthma mouse model. To induce asthma, BALB/c mice were sensitized to OVA on days 0 and 14 by intraperitoneal injection and exposed to OVA from days 21 to 23 using a nebulizer. SAC was administered to mice by oral gavage at a dose of 10 or 20 mg/kg from days 18 to 23. SAC significantly reduced airway hyperresponsiveness, inflammatory cell counts, and Th2 type cytokines in bronchoalveolar lavage fluid induced by OVA exposure, which was accompanied by reduced serum OVA-specific immunoglobulin E. In histological analysis of the lung tissue, administration of SAC reduced inflammatory cell accumulation into lung tissue and mucus production in airway goblet cells induced by OVA exposure. Additionally, SAC significantly decreased MUC5AC expression and nuclear factor-κB phosphorylation induced by OVA exposure. In summary, SAC effectively suppressed allergic airway inflammation and mucus production in OVA-challenged asthmatic mice. Therefore, SAC shows potential for use in treating allergic asthma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SAC is a compound present in garlic extract used as a traditional medicine. </LI> <LI> SAC decreased AHR in OVA-induced asthma model. </LI> <LI> SAC attenuated the production of Th2 cytokines in OVA-induced asthma model. </LI> <LI> SAC reduced the expression of NF-κB and MUC5AC in OVA-induced asthma model. </LI> <LI> SAC may be a potent therapeutic agent in allergic asthma. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>