Callus distraction method를 이용한 하악골 신장술 : 계단골절단술식의 적용

김명진,윤필영,신동준,김수경,김종원,김규식 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Since callus distraction technique was applied clinically for the correction of dentofacial deformity to the patients with hemifacial dysplasia by McCarthy in 1992, many surgeons have tried to apply this method to the maxillofacial region. But this technique has some drawbacks. One of the disadvantages of this technique is extensive scar formation in the facial area, which is a sequelae of extraoral approach for supraperiosteal dissection of the periosteum overlying the mandible. Recently, we have made an effort to perform this technique through intraoral approaches to prevent scar formation on the submandibular area and modified the design of the osteotomy, that is step osteotomy technique, to increase the raw bone surface on both osteotomized segments. The rationale for the application of this step osteotomy technique is to increase the amount of regeneracted bone and the length of distraction, to avoid damage of inferior alveolar neurovascular bundle, and to increase initial stability of the splitted segments. Step osteotomy procedure can be done with fine micro-osteotomy saw through subperiosteal tunneling. Extraoral pins should be inserted before making the osteotomy. Since 1974 we have applied this technique at 8 sites In 5 patients with mandibular deficiencies: 2 cases of hemifacial microsomia, 1 case of developmental facial asymmetry and 2 cases of mandibular bony defect. Mandibular elongation have been achieved from 12 to 20mm in length. 1 out of 8 site, we experienced non-union in the case of mandibular body defect. Some skeletal relapse and growth retardation phenomenon have been observed in some cases with the longest follow-up of 48 months.

선천 섬유화 증후군 1예

김동섭,신정철,고명규,최준규,장세진 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.1

The congential fibrosis syndorme is rare congenital disorder which is characterized by blepharoptosis, varying degrees of limitation of eye movement, especially in vertical gaze, and abnormal head position. These clinical findings result from the fibrous replacement of normal contractile extraocular muscle tissue. The authors report one sporadic case of congential fibrosis syndrome. The 14 year-old-girl showed bilateral ptosis, fixed ocular misalignment in downward gaze, limited ductions and versions, and characteristic chin up position. The surgical management attempted to achieve functional readjustment of the ocular alignment and lid position and to correct cosmetically unacceptable abnormal head position. Result of histopathologic examination obtained at surgery shows replacement of the extraocular muscles, conjuctiva and Tenon's capsule by collagen and dense fibrous tissue. The surgical outcome is considered satisfactory when compared with preoperative status although the limitation of vertical eye movement remains unchanged after surgery.

배양된 망막색소 상피세포의 탐식기능

고명규,최준규,김동섭 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.2

This study was performed to observe the phagocytosis of latex bead in cultured human retinal pigment epithelium (RPE). RPE cells were isolated from retina of enucleated human eye and 5 to 7㎛ diameter latex beads were added to culture media of human RPE cells at 50th day of culture. Phagocytic processes were observed serially by phase-contrast microscopy and ight microscopy up to 58 days. After a latent period of about 16hours, latex particles were rapidly phagocytized by cultured human RPE cells. These result may indicate that PRE cells can be cultured up to 58 days without subculture and phamocytic property of RPE remains an that time.

임프란트 식립을 위한 하치조신경 전위술 후 신경손상 및 회복에 대한 임상연구

김명진(Myung Jin Kim),김태영(Tae Young Kim),황경균(Kyeng Gyun Hwang),정필훈(Pill Hoon Choung),김수경(Soo Kyung Kim),김종원(Jong Won Kim),김규식(Kyoo Sik Kim) 대한구강악안면외과학회 1996 대한구강악안면외과학회지 Vol.22 No.1

In case of severe alveolar bony resorption in the edentulous mandible, implant placement posterior to the mental foramen is a problematic procedure. Inferior alveolar nerve transpositioning is often required for implant installation on premolar and molar area for the purpose of more functional prosthodontic rehabilitation. Installation of longer implant fixtures can be performed by this method avoiding the damage of inferior alveolar nerve. We checked Orthopantomograph or MPR(multiplanar reformatted) CT in order to evaluate the anatomical relationship of residual ridge and inferior alveolar nerve accurately and experienced mild to moderate nerve damages on 11 sites, in 7 patients who were received transpositioning of inferior alveolar nerve from 1992 to january, 1995, and had performed serial follow-up study about the recovery of neurosensory function periodically. We can extended the application of implant surgery and get several results as follows about sensory nerve recovery. 1. In all of the cases, the decrease of sensory function were observed postoperatively. 2. Tinel s sign appeared in 8 cases at 1-2 months postoperatively and continued for 2-3 months and disappeared at 6 months postoperatively, and the type of sensory dysfunction was changed as anesthesia, dysesthesia, paresthesia in order and to the normal sensation in 63.6% at 1 year postoperatively. 3. The pain sensation in skin surface was recovered in 68.2% at 6 months, in 81.8% at 12 months postoperatively and the tactile sensation was recovered in 40.1% at 6 months in 77.3% at 12 months postoperatively. 4. Two-point discriminations were checked as normal range in 54.5% of the operation sites at 6 months, 81.8% at 12 months postoperatively, and the area of sensory dysfunction on skin surface diminished by degrees with time. 5. The nerve damage appeared in all the cases postoperatively and the sensory recovery times were different depend on to the amount of nerve damage during the operation. The degree of the recovery of sensory function increased with time, but the permanent slight depression of sensory function remained in a few cases. Therefore patients should be informed enough about that preoperatively.

상악동저 점막 거상술을 이용한 인공치아 임프란트 동시 식립술 후 예후에 관한 임상적 연구

김명진(Myung Jin Kim),김태영(Tae Young Kim),황경균(Kyung Gyun Hwang),유상진(Sang Jin Yu),명훈(Hoon Myoung),김수경(Soo Kyung Kim),김종원(Jong Won Kim),김규식(Kyoo Sik Kim) 대한구강악안면외과학회 2000 대한구강악안면외과학회지 Vol.26 No.6

In cases of severe alveolar bony resorption in the edentulous posterior maxillae, implant placement is limited anatomically due to maxillary sinus. If the ridge is atrophic, the various bone grafting methods are required for the ridge augmentation. But the result of the onlay grafting procedure is not always promising. On the posterior maxilla, maxillary sinus mucosa lifting and bone grafting into the sinus floor, subantral augmentation(SA) technique are recommended. Various SA procedures have been developed for implant installation. We perfer to simultaneous block bone graft and implant installation through the residual alveolar ridge into the grafted block bone to fix the grafted bone and to gain the primary stability of the installed fixture. When a sagittal skeletal discrepancy in present due to the severe alveolar bony resorption of the maxilla, the advancement of the maxilla by Le Fort I osteotomy simultaneously with installation of implant fixtures combined with sinus lifting and interpositional bone graft procedure can be indicated. We applied various SA techniques for implant installtion to the 46 edentulous posterior maxillae, and total 154 implants were installed at our department from 1992 to 1999. Various SA techniques were classified in detail and the indications of each techniques were discussed. The changes of residual bony height following SA procedure were studied. The results were as follows. 1. The SA procedure combined with bone graft and simultaneous fixture installation were performed in 41 cases, 126 fixtures were installed and 5 fixtures were removed out of them. Le Fort I osteotomy procedure combined with sinus lifting and interpositional bone graft simultaneous with fixture installation were performed in 5 cases. Total 28 fixtures were installed and 2 fixtures were removed so far. 2. Autogenous block bone graft into sinus floor were performed in 35 cases, autogenous particulated marrow cancellous bone(PMCB) graft in 9 cases, and demineralized human bone powder in 2 cases. The donor site for bone graft were anterior iliac bone in 39 cases, posterior iliac bone in 3 cases and mandibular symphysis in 1 case and mandibular ramus in 1 case. 3. In 9 cases with which SA procedure had been performed with the block bone graft, the change of pre- and postoperative residual bony height were measured using MPR(multiplanar reformatted)-CT. The mean residual bony height was 8.0mm preoperatively, 20.2mm at 6 months following up operation and we gained average 12.2mm alveolar bony height. So, we can recommend this one-stage subantral augmentation and fixture installation technique as a time conserving, safe and useful method for compromised posterior edentulous maxilla.

Efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenia patients with moderate thrombocytopenia.

Kim, Hawk,Lee, Won-Sik,Lee, Kyoo-Hyung,Bae, Sung Hwa,Kim, Min Kyoung,Joo, Young-Don,Zang, Dae Young,Jo, Jae-Cheol,Lee, Sang Min,Lee, Je-Hwan,Lee, Jung-Hee,Kim, Dae-Young,Ryoo, Hun-Mo,Hyun, Myung Soo,K Springer International 2015 Annals of hematology Vol.94 No.5

<P>The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication as the first line treatment for persistent or chronic ITP patients with moderate thrombocytopenia. Patients with persistent or chronic ITP showing moderate thrombocytopenia (30??10(9)/L??platelet count??70??10(9)/L) and positive C(13)-urea breath test (UBT) were selected. Medication consisted of lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg orally twice daily for a week. Complete response (CR) rate at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 50.0, 50.0, 26.9, and 65.4%, respectively. Overall response rate (ORR) at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 57.7, 65.4, 30.8, and 69.2%, respectively. Median maximal platelet count during the first 3 months was 110??10(9)/L (range, 40-274). Median time to CR was 8 weeks (95% CI?=?5.429-10.571). Median time to ORR was 4 weeks (95% CI?=?1.228-6.772). Only per-protocol population was a response predictor for ORR at 3 months (70.0%, p?=?0.054) and maximal ORR (80.0%, p?=?0.051), but not for CR at 3 months (60.0%, p?=?0.160). Therefore, eradication of H. pylori is an effective and durable first line treatment for persistent or chronic ITP with moderate thrombocytopenia with high ORR and rapid onset in this study.</P>

Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition

Kim, Jeong-Keun,Kim, Mijin,Cho, Ssang-Goo,Kim, Myung-Kyoo,Kim, Suhng Wook,Lim, Young-Hee Springer-Verlag 2010 Journal of industrial microbiology & biotechnology Vol.37 No.6

The Muscle Fatigue Analysis Associated with Using Various Stretchers

Myung Kug Moon,Day Sung Kim,Kyoo Sang Kim,Yeon Ju Oh,Chol Hong Kim 한국산업경영시스템학회 2013 한국산업경영시스템학회 학술대회 Vol.2013 No.춘계

The purpose of this study was to provide a practical guide to the use of various stretchers that rescue workers use by analyzing muscle fatigue degree associated with lifting a patient. The experiment was conducted with working male and female rescue crews. Having mixed groups of gender complete tasks such as lifting, moving, and unloading a patient using four different types of stretcher, we recorded each muscle fatigue degree in the shoulder and lower back regions of each subject. The data showed, in terms of muscle activity, differences within each group of genders and its combinations were significant in certain muscle groups depending on the types of stretcher used and body sizes of each subject, and, when it comes to Elerctor Spenae, the female subjects used more muscular strength than the males did. In regards to the muscle fatigue degree, there was no significant difference found within each group of the genders, body sizes, and their combinations. However, in the case of applying different models of stretcher, there were significantly differences in the fatigue degree.

N‐Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation

Kim, Bora,Kim, Jin Eun,Lee, Su Min,Lee, Soung‐,Hoon,Lee, Jin Won,Kim, Myung Kyoo,Lee, Kye Jong,Kim, Hyuk,Lee, Joo Dong,Choi, Kang‐,Yell Blackwell Publishing Ltd 2011 Experimental dermatology Vol.20 No.11

<P><B>Abstract: </B> We synthesized a novel derivative of a well‐known skin‐lightening compound niacinamide, N‐nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.</P>

Synthesis of Dimeric Cinnamoylamide Derivatives and Evaluation of Their Depigmenting Activities

Kim, Myung Kyoo,Youk, Hyun Soo,Yoo, Jae Jin,Ahn, Soo Mi,Rho, Ho Sik,Ha, Ji Hoon,Hwang, Jun Pil,Park, Soo Nam Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10