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Effects of elastic medium on buckling of microtubules due to bending and torsion
Taj, Muhammad,Hussain, Muzamal,Afsar, Muhammad A.,Safeer, Muhammad,Ahmad, Manzoor,Naeem, Muhammad N.,Badshah, Noor,Khan, Arshad,Tounsi, Abdelouahed Techno-Press 2020 Advances in concrete construction Vol.9 No.5
Microtubules buckle under bending and torsion and this property has been studied for free microtubules before using orthotropic elastic shell model. But as microtubules are embedded in other elastic filaments and it is experimentally showed that these elastic filaments affect the critical buckling moment and critical buckling torque of the microtubules. To prove that, we developed orthotropic Winkler like model and demonstrated that the critical buckling moment and critical buckling torque of the microtubules are orders of higher magnitude than those found for free microtubules. Our results show that Critical buckling moment is about 6.04 nNnm for which the corresponding curvature is about θ = 1.33 rad /㎛ for embedded MTs, and critical buckling torque is 0.9 nNnm for the angle of 1.33 rad/㎛. Our results well proved the experimental findings.
Abdullah Muhammad,Alharbi Fatemah Farraj,Khosa Rabia Yasmin,Alburaih Huda A.,Manzoor Sumaira,Abid Abdul Ghafoor,Ali Haitham Elhosiny,Waheed Muhammad Suleman,Ansari Muhammad Numair,Farid Hafiz Muhammad 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.6
Manganese ferrite offers several advantages when employed as an electrocatalytic material for supercapacitors, including outstanding cycle stability and energy capacity. When compared to identical-metal sulfides, specific capacitance (Csp) of MnFe2O4 remains inadequate. So, using the hydrothermal synthesis technique, partial sulfur doping of MnFe2O4 was achieved to investigate the synergetic effect of oxides and sulfides. Various spectroscopic and microscopic studies demonstrate that adding sulfur atoms into MnFe2O4 increases the lattice parameters, which improves electrochemical performance. At a current density around 2 A g−1, then calculating MnFe2O4 with partial sulfur doping has a Csp of 1,201.60 F g−1, that is greater than 784.0 F g−1 of pure MnFe2O4. Maximum energy density (Ed) of 93.62 Wh kg−1 was produced with a power density (Pd) of 749 W kg−1. The current study depicts that partial sulfur doping can enhance the electrochemical behavior of MnFe2O4. As a result, the present work shows more effective in field of energy storage by enhancing their poor electrochemical performance.
Buckling behavior of intermediate filaments based on Euler Bernoulli and Timoshenko beam theories
Muhammad Taj,Muzamal Hussain,Mohamed A. Khadimallah,Muhammad Safeer,S.R. Mahmoud,Zafer Iqbal,Mohamed R. Ali,Aqib Majeed,Abdelouahed Tounsi,Manzoor Ahmad Techno-Press 2023 Advances in concrete construction Vol.15 No.3
Cytoskeleton components play key role in maintaining cell structure and in giving shape to the cell. These components include microtubules, microfilaments and intermediate filaments. Among these filaments intermediate filaments are the most rigid and bear large compressive force. Actually, these filaments are surrounded by other filaments like microtubules and microfilaments. This network of filaments makes a layer as a surface on intermediate filaments that have great impact on buckling behavior of intermediate filaments. In the present article, buckling behavior of intermediate filaments is studied by taking into account the effects of surface by using Euler Bernoulli and Timoshenko beam theories. It is found that effects of surface greatly affect the critical buckling force of intermediate filaments. Further, it is observed that the critical buckling force is inversely proportional to the length of filament. Such types of observations are helpful for further analysis of nanofibrous in their actual environments within the cell.
Muhammad U Manzoor,Abdullah A. Alrashed,Ibrahim A. Almulhim,Sultan Alqahtani,Fahmi Al Senani 대한뇌혈관외과학회 2023 Journal of Cerebrovascular and Endovascular Neuros Vol.25 No.4
84 years old gentle man with past medical history of hypertension and diabetes presented with sudden onset right sided weakness and aphasia for two hours. Initial neurological assessment revealed National Institute of Health Stroke Scale (NIHSS) 17. Computed tomography (CT) scan demonstrated minimal early ischemic changes along left insular cortex with occlusion of left middle cerebral artery (MCA). Based on clinical and imaging findings, decision was made to perform mechanical thrombectomy procedure. Initially, right common femoral artery approach was utilized. However, due to unfavorable type-III bovine arch, left internal carotid artery could not be engaged via this approach. Subsequently, access was switched to right radial artery. Angiogram revealed small caliber radial artery, with larger caliber ulnar artery. Attempt was made to advance the guide catheter through the radial artery, however significant vasospasm was encountered. Subsequently, ulnar artery was accessed and successful thrombolysis in cerebral infarction (TICI) III left MCA reperfusion was achieved with a single pass of mechanical thrombectomy via this approach. Post procedure neurological examination demonstrated significant clinical improvement. Doppler ultrasound 48 hours after the procedure demonstrated patent flow in radial and ulnar arteries with no evidence of dissection.
Muhammad Taj,Muhammad Safeer,Muzamal Hussain,Muhammad N. Naeem,Manzoor Ahmad,Kamran Abbas,Abdul Q. Khan,Abdelouahed Tounsi 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.3
Cytoskeleton components in living cell bear large compressive force and are responsible in maintaining the cell shape. Actually these filaments are surrounded by viscoelastic media within the cell. This surrounding, viscoelastic media affects the buckling behavior of these filaments when external force is applied on these filaments by exerting continuous pressure in opposite directions to the incipient buckling of the filaments. In this article a mechanical model is applied to account the effects of this media on the buckling behavior of intermediate filaments network of cytoskeleton. The model immeasurably associates; filament’s bending rigidity, adjacent system elasticity, and cytosol viscosity with buckling wavelength, buckling growth rate and buckling amplitude of the filaments.
Muhammad Ismail,Shazia Jabeen,Tahira Akber,Ijaz Talib,Fayyaz Hussain,Anwar Manzoor Rana,Muhammad Hussain,Khalid Mahmood,Ejaz Ahmed,Dinghua Bao 한국물리학회 2018 Current Applied Physics Vol.18 No.8
Effect of oxygen annealing on bipolar resistive switching (BRS) properties of TiN/ZnO/CeO2-x/Pt devices was investigated. Bilayer ZnO/CeO2-x thin films were fabricated by rf-magnetron sputtering. It was observed that the improvement in cycle-to-cycle endurance degradation and uniformity of the bilayer ZnO/CeO2-x thin film is optimum at 400 °C annealing temperature due to decrease in oxygen vacancies during annealing, as confirmed by x-ray photoelectron spectroscopy. The BRS could be caused by the formation of interfacial TiON layer, which is most likely to be accountable for creating an adequate quantity of oxygen vacancies necessary for the formation and rupture of conductive filaments. Smaller Gibbs free energy of the formation of interfacial TiON (−611 kJmol−1) layer as compared to bilayer film ZnO (−650 kJmol−1) and CeO2 (−1024 kJmol−1) results in an easier re-oxidation of the filaments through the oxygen exchange with TiN top electrode. The analysis of current– voltage characteristics shows that the charge transport mechanism is Schottky emission. Moreover, the temperature dependence of high resistance state (HRS) and low resistance state (LRS) revealed the physical origin of the RS mechanism, which entails the oxygen vacancies for the formation and rupture of conducting paths.
Muhammad Hayat,Nadeem Raza,Umair Jamal,Suryyia Manzoor,Naseem Abbas,Muhammad Imran Khan,Jechan Lee,Richard J. C. Brown,김기현 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
As a key member of benzoylurea insecticides, lufenuron exhibits a strong potential for bioaccumulationin ecosystems. Here, we report the synthesis of a molecularly imprinted polymer (MIP) and its applicationfor selective extraction of lufenuron from agricultural runoff samples. The morphology and thermalstability of the prepared MIP was characterized by SEM and TGA, respectively. The experimental conditionsfor lufenuron detection were optimized through batch binding assay and response surface methodology(RSM). The MIP showcased a two-fold enhancement in binding capacity of lufenuron (74 mg g1)relative to non-imprinted polymer (36 mg g1), when measured through batch binding assay. Using aRSM based on central composite design, the qe value was predicted as 73.6 mg g1 under optimal experimentalconditions (e.g., pH 8). Furthermore, the percentage recovery of lufenuron was estimated as98.8 ± 1.8% (n = 9). The adsorption kinetics of the MIP followed the pseudo-first-order model with v2value of 0.004 (correlation coefficient of 0.99). The limit of detection for lufenuron using MIP-basedmethod was 3 106 mg mL1. There was no significant decrease in the performance of MIP against lufenuronover five successive cycles.
Initial experience with Scepter Mini dual lumen balloon for embolization of cerebrovascular diseases
Muhammad U Manzoor,Ibrahim A. Almulhim,Abdullah A. Alrashed,Shorog Althubait,Abdulrahman Y. Alturki,Sultan M. Al-Qahtani 대한뇌혈관외과학회 2023 Journal of Cerebrovascular and Endovascular Neuros Vol.25 No.2
Objective: Endovascular treatment of cerebrovascular diseases is often challenging due to small caliber, tortuous distal vessels. Several devices and techniques have evolved to overcome these challenges. Recently, a low profile dual lumen microballoon catheter, specifically designed for distal navigation is employed for neurovascular procedures. Due to its recent advent, scarce data is available on clinical utility and safety of Scepter Mini. The aim of this case series is to report our initial experience with Scepter Mini in the management of various cerebrovascular diseases.Methods: All interventional neurovascular cases performed using Scepter Mini between January 2020 till April 2021 were included. Data regarding patient demographics, procedural details and complications was retrospectively collected from patient’s electronic medical record and procedure reports.Results: Total twelve embolization procedures were performed in eleven patients, including six brain arteriovenous malformation, two dural arteriovenous fistula, one vein of Galen malformation and three hyper-vascular glomus tumor embolizations. All procedures were successfully performed with adequate penetration of the embolic agent. Complete embolization was performed in six procedures, while intended partial embolization was performed in the rest of procedures. Scepter Mini was solely used in ten procedures, however in the other two embolization procedures it was used as an additional conjunct tool to complete the intended embolization. No balloon related complication was observed in any procedure.Conclusions: Scepter Mini dual lumen microballoon catheter is safe and feasible for delivery of liquid embolic agents for cerebrovascular embolization procedures.
Non-local orthotropic elastic shell model for vibration analysis of protein microtubules
Muhammad Taj,Afnan Majeed,Muzamal Hussain,Muhammad N. Naeem,Muhammad Safeer,Manzoor Ahmad,Hidayat Ullah Khan,Abdelouahed Tounsi 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.3
Vibrational analysis in microtubules is examined based on the nonlocal theory of elasticity. The complete analytical formulas for wave velocity are obtained and the results reveal that the small scale effects can reduce the frequency, especially for large longitudinal wave-vector and large circumferential wave number. It is seen that the small scale effects are more significant for smaller wave length. The methods and results may also support the design and application of nano devices such as micro sound generator etc. The effects of small scale parameters can increase vibrational frequencies of the protein microtubules and cannot be overlooked in the analysis of vibrating phenomena. The results for different modes with nonlocal effect are checked.
Muhammad Ahmed BILAL,Hadi Hassan KHAN,Muhammad IRFAN,S.M. Nabeel Ul HAQ,Manzoor ALI,Ali KAKAR,Wahab AHMED,Abdul RAUF 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.1
This paper attempts to study the impact of Financial Literacy on Youth Entrepreneurial Intent in Pakistan. A closed-ended self-administered structured questionnaire covering financial literacy, computer knowledge, financial attitude, and financial knowledge with Entrepreneurial Intent was collected from young entrepreneurs. The research tried to investigate the education level with computer skill to inspect the effect of financial literateness on young generation Entrepreneurial Intent in the context of Pakistan. The research model was tested using PLS-SEM and authenticating a measurement model through the advanced methodology and their association with Entrepreneurial Intent. Results revealed that financial literacy and its two parts (financial attitude and financial knowledge) have a positive impact on Entrepreneurial Intent. The size of the joint impact of financial literacy and its components on Entrepreneurial Intent was assessed to be adequate. Entrepreneurial Intent is essential for creating new firms to maintain economic development. Furthermore, it is determined in this research that if youth has better financial knowledge and financial attitude, the probability of Entrepreneurial Intent increases. This suggests that if the youth in Pakistan desire to attain a higher limit of Entrepreneurial Intent, they must implement financial literacy models for enhancing and promoting their current Entrepreneurial Intent.