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- 저자 : Minmin Chen (검색결과 4 건)
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Minmin Jiang,Ying Zhao,Jing Wang,Long Hua,Yan Chen,Yingshui Yao,Yuelong Jin 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.1
Objective This cross-sectional study explores the serial multiple mediation of the correlation between internet addiction and depression by social support and sleep quality of college students during the COVID-19 epidemic. Methods We enrolled 2,688 students from a certain university in Wuhu, China. Questionnaire measures of internet addiction, social support, sleep quality, depression and background characteristics were obtained. Results The prevalence of depression, among 2,688 college students (median age [IQR]=20.49 [20.0, 21.0] years) was 30.6%. 32.4% of the students had the tendency of internet addiction, among which the proportion of mild, moderate and severe were 29.8%, 2.5% and 0.1%, respectively. In our normal internet users and internet addiction group, the incidence of depression was 22.6% and 47.2%, respectively. The findings indicated that internet addiction was directly related to college students’ depression and indirectly predicted students’ depression via the mediator of social support and sleep quality. The mediation effect of social support and sleep quality on the pathway from internet addiction to depression was 41.97% (direct effect: standardized estimate=0.177; total indirect effect: standardized estimate= 0.128). The proposed model fit the data well. Conclusion Social support and sleep quality may continuously mediate the link between internet addiction and depression. Therefore, the stronger the degree of internet addiction, the lower the individual’s sense of social support and the worse the quality of sleep, which will ultimately the higher the degree of depression. We recommend strengthening monitoring of internet use during the COVID-19 epidemic, increasing social support and improving sleep quality, so as to reduce the risk of depression for college students.
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Shen Xuefang,Chen Xiangyuan,Wang Jing,Liu Jing,Wang Zhiyao,Hua Qing,Wu Qichao,Su Yanguang,He Huanzhong,Hu Yuqin,Meng Zhipeng,Xiong Wanxia,Zhu Minmin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 participate in high glucose-mediated endothelial inflammation. In this study, we hypothesize that SET8 regulates PTEN expression, thus contributing to high glucose-mediated vascular endothelial inflammation. Our data indicated that plasma soluble intercellular adhesion molecule-1 (sICAM-1) and endothelial selectin (e-selectin) were increased in patients with diabetes and diabetic rats. PTEN expression was augmented in the peripheral blood mononuclear cells of patients with diabetes and in the aortic tissues of diabetic rats. Our in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells (HUVECs). Moreover, high glucose led to endothelial inflammation via upregulation of PTEN. Furthermore, high glucose inhibited SET8 expression and histone H4 lysine 20 methylation (H4K20me1), a downstream target of SET8. SET8 overexpression reversed the effects of high-glucose treatment. shSET8-mediated endothelial inflammation was counteracted by siPTEN. Furthermore, SET8 was found to interact with FOXO1. siFOXO1 attenuated high glucose-mediated endothelial inflammation. FOXO1 overexpression-mediated endothelial inflammation was counteracted by siPTEN. H4K20me1 and FOXO1 were enriched in the PTEN promoter region. shSET8 increased PTEN promoter activity and augmented the positive effect of FOXO1 overexpression on PTEN promoter activity. Our in vivo study indicated that SET8 was downregulated and FOXO1 was upregulated in the peripheral blood mononuclear cells of patients with diabetes and the aortic tissues of diabetic rats. In conclusion, SET8 interacted with FOXO1 to modulate PTEN expression in vascular endothelial cells, thus contributing to hyperglycemia-mediated endothelial inflammation.
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Effective of high salt diet (HSD) on letrozole-induced polycystic ovarian syndrome (PCOS) mice
Suying Liang,Xiaoying Tang,Minmin Chen,Huiwen Liu,Wanying Li,Zixian Wang,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To investigate the effect of high salt diet (HSD, 8% NaCl) on the letrozole induced PCOS mice. At the total of experimental periods (35 days), all female C57BL/6J mice were randomly divided into normal groups, PCOS group (ingested letrozole daily for 21 days) and HSD+PCOS group. The body weight (BW) and histologic changes were evaluated. The serum levels of testosterone (T), LH, E2, FSH, INS, TG, TC, LDL, HDL were determined by ELISA kits. Compared with normal groups, the BW, T, LH, INS, TG, TC LDL-C in PCOS rats were significantly increased, and the levels of E2, FSH and HDL-C were significantly decreased. In addition, compared with the PCOS group, the BW, T, LH, INS, TG, TC LDL-C in HSD+PCOS rats were significantly increased, and the levels of E2, FSH and HDL-C were significantly decreased. Our results showed that HSD exacerbates metabolic disorders and hormonal imbalances in PCOS mice.
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Xiaodong Yu,Weicheng Gao,Yanan Feng,Guangqiang Shi,Shihao Li,Minmin Chen,Ruiming Zhang,Junfeng Wang,Wentao Jia,Jianhua Jiao,Ruichun Dai 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.6
Hydrostatic bearing has the advantages of wide speed range, large bearing capacity, high precision and stability. Hydrostatic-hydrodynamic hybrid bearing can make up for the lack of stiffness of hydrostatic bearing and prevent tribological failure under the condition of high speed and heavy load. Therefore, hydrostatic bearing and hydrostatic-hydrodynamic hybrid bearing have become important bearing parts of high-end computer numerical control (CNC) machine equipment. The research on hydrostatic and hydrostatic-hydrodynamic open a new way for precision improvement of high-end CNC machine equipment. This paper reviews research progress of hydrostatic linear guideway, hydrostatic rest and ram, hydrostatic thrust bearing, hydrostatic-hydrodynamic thrust bearing and hydrostatic-hydrodynamic spindle of high-end CNC machine equipment, and discusses the influence of structure and working parameters on lubrication performance, accuracy and stability of bearing parts. Finally, the future research direction in hydrostatic bearing and hydrostatic-hydrodynamic hybrid bearing are suggested. This review provides a theoretical basis for design and development of high-end CNC machine equipment in the future.
KCI
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