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Choi, Minji,Starbuck, Richmond,Lee, Seulbi,Hwang, Sungjoo,Lee, SangHyun,Park, Moonseo,Lee, Hyun-Soo Elsevier 2018 AUTOMATION IN CONSTRUCTION - Vol.93 No.-
<P><B>Abstract</B></P> <P>Disaster-related simulations can be helpful for conducting various analysis on damage evaluations and response operations in damaged facilities. However, no single simulation can solve all the functional needs for complex disaster situations due to diverse disasters, damage types, and response efforts. To address these issues, the authors have developed a distributed simulation platform for a comprehensive analysis of facility damage and response operations, which can be flexibly applied to diverse disaster situations. The High Level Architecture is adopted to synchronize different federates such as simulation models and incoming data streams within an interoperable simulation environment. The developed simulation platform includes five different disaster-related federates such as the Fire Dynamics Simulator, USGS earthquake data feeds, OpenSees structure response simulation, evacuation simulation, and restoration simulation. The accuracy of interactions among different federates was confirmed with the case simulations of a facility fire evacuation and an earthquake restoration situation. The developed platform provides a flexible and interoperable distributed simulation environment for comprehensive disaster response management of unexpected disaster situations while promoting reusability and future extendibility of existing and newly-added disaster-related simulations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A distributed simulation platform for facility damage/response analysis is developed. </LI> <LI> The platform provides interoperability among different disaster-related simulators. </LI> <LI> Simulators' interaction accuracy is confirmed using fire and earthquake situations. </LI> <LI> The interacted simulation is flexible enough to analyze various disaster situations. </LI> <LI> The platform can be extended for more comprehensive disaster-response management. </LI> </UL> </P>
Immunogenic cell death in cancer immunotherapy
( Minji Choi ),( Jisoo Shin ),( Chae-eun Lee ),( Joo-yoon Chung ),( Minji Kim ),( Xiuwen Yan ),( Wen-hao Yang ),( Jong-ho Cha ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.5
Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment, with notable therapeutic effects on certain cancer types. Despite their significant potential, clinical studies over the past decade have revealed that cancer immunotherapy has low response rates in the majority of solid tumors. One of the key causes for poor responses is known to be the relatively low immunogenicity of solid tumors. Because most solid tumors are immune desert ‘cold tumors’ with antitumor immunity blocked from the onset of innate immunity, combination therapies that combine validated T-based therapies with approaches that can increase tumor-immunogenicity are being considered as relevant therapeutic options. This review paper focuses on immunogenic cell death (ICD) as a way of enhancing immunogenicity in tumor tissues. We will thoroughly review how ICDs such as necroptosis, pyroptosis, and ferroptosis can improve anti-tumor immunity and outline clinical trials targeting ICD. Finally, we will discuss the potential of ICD inducers as an adjuvant for cancer immunotherapy. [BMB Reports 2023; 56(5): 275-286]
Choi, Minji,Min, Yoo Hong,Pyo, Jaehyuk,Lee, Chang-Woo,Jang, Chang-Young,Kim, Ja-Eun Wiley (Blackwell Publishing) 2017 British journal of pharmacology Vol.174 No.12
<P>Conclusion and ImplicationsTC Mps1 12 results in the accumulation of chromosomal instabilities and mitotic catastrophe in HCC cells. Overall, these data demonstrate that the inhibition of Mps1 kinase using TC Mps1 12 is a promising therapeutic approach for liver cancer.</P>
( Minji Kim ),( Sir Yeon Hong ),( Yejin Kim ),( Yun Sun Choi ),( Ilyeo Jang ),( Ji Hee Sung ),( Suk Joo Choi ),( Soo Young Oh ),( Cheong Rae Roh ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: We compared the maternal and neonatal outcomes between elective labor induction versus spontaneous labor or rupture of membranes in women with non-complicated singleton pregnancies who tried labor after 39 weeks of gestation. Methods: This was a retrospective cohort study of 342 women with singleton pregnancy who tried labor after 39 weeks of gestation in a single institution between 2018 and 2021. Pregnant women who delivered before 39 weeks of gestation, who delivered by elective cesarean section, or with multiple gestation or complicated pregnancy were excluded. Subjects were categorized into two groups: pregnant women who underwent elective labor induction (induction group) and pregnant women who had spontaneous labor or rupture of membranes (spontaneous group). Pregnancy outcomes and neonatal outcomes were reviewed. Subgroup analyses were done in nulliparous and multiparous women. Results: Maternal characteristics were similar in the two groups. Cesarean section rate was significantly higher in the induction group than the spontaneous group (27.0% vs. 14.6%, P=0.005). However, the indications for cesarean delivery were significantly different between the two groups: induction failure (35.4% vs. 0%), failure to progress (64.6% vs. 79.2%), and fetal distress (0% vs. 20.8%) in the induction group and spontaneous group (P<0.001), respectively. Postoperative complications were comparable between the two groups, but postoperative hemoglobin drop more than 10% was significantly more common in the induction group. Neonatal outcomes were similar between the two groups. In nulliparous women, cesarean section rate was significantly higher in the induction group (37.0% vs. 20.2%, P=0.004). Conclusion: Elective labor induction in non-complicated singleton women at 39 weeks of gestation was associated with a higher cesarean section rate than spontaneous labor or rupture of membranes. And this was mostly due to a higher rate of cesarean delivery for induction failure in nulliparous women.
Genomic Analysis of Monkeypox Virus During the 2023 Epidemic in Korea
Choi Chi-Hwan,Lee Minji,Lee Sang Eun,Kim Jin-Won,Shin Hwachul,Choi Myung-Min,Yi Hwajung,Kim Min-Kyung,Jeon Jaehyun,Park Jun-Sun,Kim Yeonjae,Lim So Yun,Chin BumSik,Chung Yoon-Seok 대한의학회 2024 Journal of Korean medical science Vol.39 No.18
We aimed to characterize the genomes of monkeypox virus isolates from the Far East, providing insights into viral transmission and evolution. Genomic analysis was conducted on 8 isolates obtained from patients with monkeypox virus disease in the Republic of Korea between May 2022 and early 2023. These isolates were classified into Clade IIb. Distinct lineages, including B.1.1, A.2.1, and B.1.3, were observed in 2022 and 2023 isolates, with only the B.1.3 lineage detected in six isolates of 2023. These genetic features were specific to Far East isolates (the Republic of Korea, Japan, and Taiwan), distinguishing them from the diverse lineages found in the Americas, Europe, Africa, and Oceania. In early 2023, the prevalence of the B.1.3 lineage of monkeypox virus identified in six patients with no overseas travel history is considered as an indicator of the potential initiation of local transmission in the Republic of Korea.
Choi, Minji,Mukherjee, Sulagna,Kang, Nam Hyeon,Barkat, Jameel Lone,Parray, Hilal Ahmad,Yun, Jong Won Wiley Blackwell (John WileySons) 2018 IUBMB life Vol.70 No.6
<P>Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L-rhamnose induced browning by elevating expression levels of beige-specific marker genes, including Cd137, Cited1, Tbx1, Prdm16, Tmem26, and Ucp1, in 3T3-L1 adipocytes. Moreover, L-rhamnose markedly elevated expression levels of proteins involved in thermogenesis both in 3T3-L1 white and HIB1B brown adipocytes. L-rhamnose treatment in 3T3-L1 adipocytes also significantly elevated protein levels of p-HSL, p-AMPK, ACOX, and CPT1 as well as reduced levels of ACC, FAS, C/EBP, and PPAR, suggesting its possible role in enhancement of lipolysis and lipid catabolism as well as reduced adipogenesis and lipogenesis, respectively. The quick technique of efficient molecular docking provided insight into the strong binding of L-rhamnose to the fat-digesting glycine residue of (3)-adrenergic receptor (AR), indicating strong involvement of L-rhamnose in fat metabolism. Further examination of the molecular mechanism of L-rhamnose revealed that it induced browning of 3T3-L1 adipocytes via coordination of multiple signaling pathways through (3)-AR, SIRT1, PKA, and p-38. To the best of our knowledge, this is the first study to demonstrate that L-rhamnose plays multiple modulatory roles in the induction of white fat browning, activation of brown adipocytes, as well as promotion of lipid metabolism, thereby demonstrating its therapeutic potential for treatment of obesity. (c) 2018 IUBMB Life, 70(6):563-573, 2018</P>
Optimal route selection model for fire evacuations based on hazard prediction data
Choi, Minji,Chi, Seokho Elsevier Science B.V., Amsterdam. 2019 SIMULATION MODELLING PRACTICE AND THEORY Vol.94 No.-
<P><B>Abstract</B></P> <P>Providing accurate information on available evacuation routes is critical during the time-sensitive emergency situation of a building fire, particularly when it occurs in a large-scale facility with a complex layout. Timely access to safe and efficient egress paths helps minimize exposure to hazardous fire effluents such as toxic smoke during evacuation. The following study develops a computational model which uses hazard prediction data to identify optimal evacuation routes, the safest and shortest paths to the nearest exit, during the event of a building fire. It uses the Fire Dynamics Simulator to provide prediction data on smoke propagation inside a structure and the A* algorithm to search for the fastest escape path. The algorithm is modified to consider whether the ensuing nodes in the route are in a normal or hazardous state. The test simulations demonstrate that the model is both accurate and effective in guiding evacuees to a place of safety while minimizing direct exposure to smoke. These results enable a more informed approach to safety management during indoor fires and reduce the likelihood of evacuees impeding the evacuation process by entering a dangerous area unprepared.</P>