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HYPER 빔창주위의 열유동 해석에 의한 안전성 평가에 관한 연구
송민근,최진호,주은선,송태영 경상대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.16 No.-
A spent fuel problem has prevented the nuclear power from claiming to be a completely clean energy source. The nuclear transmutation technology to incinerate the long lived radioactive nuclides and produce energy during the incineration process is believed to be one or the best solutions. HYPER(Hybrid Power Extraction Reactor)is the accelerator driven transmutation system which is being developed by KAERI(Korea Atomic Energy Research Institute). Some major feature of HYPER have been developed and employed. On-power fueling concepts are employed to keep system power constant with minimum variation of accelerator power. A hollow cylinder-type metal fuel is designed for the on-line refueling concept. Lead-bismuth(Pb-Bi) is adopted as a coolant and Spallation target material. One of the issues related to the HYPER target system is the thermal and mechanical loads imposed on the Pb-Bi and the beam window. FLUENT is used for thermal-hydraulic calculation, and finally stress calculation is performed by ANSYS. A beam condition such as current is varied. The initial velocity of Pb-Bi is also varied.
A Study of the Content Validity of Reading Comprehension Tests in NMET II
Zhen-Jie Liu,Ming-Hao Jin 대한언어학회 2018 언어학 Vol.26 No.4
Liu, Zhen-Jie & Jin, Ming-Hao. (2018). A study of the content validity of reading comprehension tests in NMET II. The Linguistic Association of Korea Journal, 26(4), 103-124. Based on Bachman and Palmer’s (1996) framework of task characteristics, this paper aims to compare the reading comprehension tests of the 2013-2017 National Matriculation English Test II (NMET II) with the requirements of the New Curriculum Standards and Testing Syllabus, in particular, concerning the content validity of the tests in terms of the characteristics of input and expected responses. The implications of this study are discussed for test designers, teachers, and students. The results show that reading comprehension tests from 2013 to 2017 basically meet the requirements of the New Curriculum Standard and Testing Syllabus and have a high content validity. In terms of the characteristics of input, the length, reading speed, and readability of comprehension passages are appropriate for students; however, the distribution of topics and genres in each year is uneven. In terms of the characteristics of expected responses, the wordings of questions and the design of question items are reasonable. However, the response type is mainly restricted to selected response questions (multiple-choice), and the measure of reading skills coverage is unbalanced.
권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.
성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.
Jin, Jian-Ming,Lee, Seunghoon,Lee, Jungkwan,Baek, Seung-Ryul,Kim, Jin-Cheol,Yun, Sung-Hwan,Park, Sook-Young,Kang, Seogchan,Lee, Yin-Won Blackwell Publishing Ltd 2010 Molecular microbiology Vol.76 No.2
<P>Summary</P><P>Apicidin is a cyclic tetrapeptide produced by certain isolates of <I>Fusarium semitectum</I> and has been shown to inhibit Apicomplexan histone deacetylase. An apicidin-producing strain (KCTC16676) of the filamentous fungus was mutated using an <I>Agrobacterium tumefaciens</I>-mediated transformation, resulting in 24 apicidin-deficient mutants. Three of the mutants had a T-DNA insertion in a gene that encodes a non-ribosomal peptide synthetase (NRPS). Results of sequence, expression, and gene deletion analyses defined an apicidin biosynthetic gene cluster, and the NRPS gene was named as apicidin synthetase gene 1 (<I>APS1</I>). A 63 kb region surrounding <I>APS1</I> was sequenced and analysis revealed the presence of 19 genes. All of the genes including <I>APS1</I> were individually deleted to determine their roles in apicidin biosynthesis. Chemical analyses of the mutant strains showed that eight genes are required for apicidin production and were used to propose an apicidin biosynthetic pathway. The apicidin analogues apicidin E, apicidin D<SUB>2</SUB> and apicidin B were identified from chemical analysis of the mutants. The cluster gene <I>APS2</I>, a putative transcription factor, was shown to regulate expression of the genes in the cluster and overexpression of <I>APS2</I> increased apicidin production. This study establishes the apicidin biosynthetic pathway and provides new opportunities to improve the production of apicidin and produce new analogues.</P>
Jin, Ming Li,Kim, Young Woong,Jin, Hong Lan,Kang, Hoin,Lee, Eun Kyung,Stallcup, Michael R.,Jeong, Kwang Won Alan R. Liss, Inc 2018 International journal of cancer Vol.143 No.11
<P>The histone H3 lysine 4‐specific methyltransferase SETD1A is associated with transcription activation and is considered a key epigenetic regulator that modulates the cell cycle and metastasis in triple‐negative breast cancer cells. However, the clinical role of SETD1A in estrogen receptor (ER)‐positive breast cancer cells remains unclear. Here, we examined whether SETD1A is a potential target for ERα‐positive breast cancer therapy. SETD1A expression was upregulated in breast tumor tissue compared to that in normal breast tissue. Moreover, ER‐target genes regulated by SETD1A were particularly enriched in cell cycle and cancer pathways. SETD1A is involved in histone H3K4 methylation, subsequent recruitment of ERα, and the establishment of accessible chromatin structure at the enhancer region of ERα target genes. In addition to ERα target genes, other cell survival genes were also downregulated by SETD1A depletion in MCF‐7 cells, leading to significant decrease in cell proliferation and migration, and spontaneous induction of apoptosis. We also found that <I>miR‐1915‐3p</I> functioned as a novel regulator of SETD1A expression in breast cells. Importantly, the growth of tamoxifen‐resistant MCF‐7 cells was effectively repressed by SETD1A knockdown. These results indicate that SETD1A may serve as a molecular target and prognostic indicator in ERα‐positive breast cancer.</P>
Ming Hao Jin,Eunhye Shin,Saera Jin,Hongil Jo,Kang Min Ok,Jongin Hong,Byung-Hyuk Jun,James R. Durrant 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.5
Cubic BaTiO3 (C-BT) and tetragonal BaTiO3 (T1-BT) nanoparticles were prepared by a solvothermal method with controlling the Ba/Ti precursor ratio. Triethanolamine was additionally employed in the synthesis to obtain ferroelectric BaTiO3 with improved particle size distribution and tetragonality (T2-BT). The prepared nanoparticles were thoroughly characterized by scanning electron microscopy, transmission electron microscopy, Brunauer-Emmett-Teller analysis, X-ray diffraction, X-ray photoelectron spectroscopy, ultraviolet-visible spectroscopy, photoluminescence, and second-harmonic generation. Importantly, the BaTiO3 nanoparticles were introduced into the scattering layer of dye-sensitized solar cells and T2-BT showed better power conversion eciency than C-BT and T1-BT.