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Inhibition of Skin Irritant Reaction by (-)-Epigallocatechin-3-gallate
Jin, Ming,Cho, Hyang-Hoon,Chung, Myung-Sub,Amatya, PN,Acharya, S,Kim, Kee-Hune,Ha, Hyun-Chul,Jeon, Young-Jin 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2
Background and Objectives: (-)-Epigallocatechin-3-gallate (EGCG), one of the major constituents of green tea, is known to possess the chemopreventive effects against chemical- and UV-induced skin damage. The aim of this study was to examine the in vivo effects of EGCG on skin irritant reaction. Materials and Methods: To analyze the effects of EGCG on skin irritant reaction, the ear punch disc (8 ㎜ diameter) weights were determined after 4 hr of treatment to assess the extent of edema. Total RNA was isolated and analyzed the expression of interleukin- 1β (IL-1β) mRNA by reverse transcriptase-polymerase chain reaction. Results: In the ear skin of BALB/c mouse, Pretreatment with EGCG reduced edema and water accumulation caused by 1-chloro-2,4-dinitrobenzene (DNCB), a well known skin allergen. DNCB-induced mRNA expression of proinflammatory cytokine, IL-1β, was inhibited by pretreatment of EGCG. Conclusion: Collectively, these results suggest that EGCG reduces the DNCB-induced skin irritant reaction, and the inhibition of IL-1β mRNA expression can be one of the possible mechanisms.