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White Roland,Croft Michael,Bird Stephen,Sampson Matthew 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.12
The expanding scope of interventional musculoskeletal procedures has resulted in increased pressure on general radiologists. The confidence of general radiologists in performing ultrasound-guided musculoskeletal procedures varies with their clinical exposure. This didactic review provides a methodologically and clinically oriented approach to enhancing user understanding and confidence in performing ultrasound-guided musculoskeletal procedures. The body of the text is accompanied by figures depicting the procedural approach, injection site, and labeled ultrasonography images. This paper aims to provide a teaching and bedside aid for education on and the execution of musculoskeletal procedures to ensure the provision of quality health care.
Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.
Roe, Matthew T,Armstrong, Paul W,Fox, Keith A A,White, Harvey D,Prabhakaran, Dorairaj,Goodman, Shaun G,Cornel, Jan H,Bhatt, Deepak L,Clemmensen, Peter,Martinez, Felipe,Ardissino, Diego,Nicolau, Jose C Massachusetts Medical Society 2012 The New England journal of medicine Vol.367 No.14
<P>The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated.</P>
Bioremediation Options for Nuclear Sites a Review of an Emerging Technology
Callum Robinson,Matthew White-Pettigrew,Samuel Shaw,Katherine Morris,James Graham,Jonathan R. Lloyd 한국방사성폐기물학회 2022 방사성폐기물학회지 Vol.20 No.3
60+ Years of nuclear power generation has led to a significant legacy of radioactively contaminated land at a number of nuclear licenced “mega sites” around the world. The safe management and remediation of these sites is key to ensuring there environmental stewardship in the long term. Bioremediation utilizes a variety of microbially mediated processes such as, enzymatically driven metal reduction or biominerialisation, to sequester radioactive contaminants from the subsurface limiting their migration through the geosphere. Additionally, some of these process can provide environmentally stable sinks for radioactive contaminants, through formation of highly insoluble mineral phases such as calcium phosphates and carbonates, which can incorporate a range of radionuclides into their structure. Bioremediation options have been considered and deployed in preference to conventional remediation techniques at a number of nuclear “mega” sites. Here, we review the applications of bioremediation technologies at three key nuclear licenced sites; Rifle and Hanford, USA and Sellafield, UK, in the remediation of radioactively contaminated land.
SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication
Kim, Eui Tae,White, Tommy E.,Brandariz-Nú,ñ,ez, Alberto,Diaz-Griffero, Felipe,Weitzman, Matthew D. American Society for Microbiology 2013 Journal of virology Vol.87 No.23
<P>Macrophages play important roles in host immune defense against virus infection. During infection by herpes simplex virus 1 (HSV-1), macrophages acquire enhanced antiviral potential. Restriction of HSV-1 replication and progeny production is important to prevent viral spread, but the cellular mechanisms that inhibit the DNA virus in macrophages are unknown. SAMHD1 was recently identified as a retrovirus restriction factor highly expressed in macrophages. The SAMHD1 protein is expressed in both undifferentiated monocytes and differentiated macrophages, but retroviral restriction is limited to differentiated cells by modulation of SAMHD1 phosphorylation. It is proposed to block reverse transcription of retroviral RNA into DNA by depleting cellular deoxynucleotide triphosphates (dNTPs). Viruses with DNA genomes do not employ reverse transcription during infection, but replication of their viral genomes is also dependent on intracellular dNTP concentrations. Here, we demonstrate that SAMHD1 restricts replication of the HSV-1 DNA genome in differentiated macrophage cell lines. Depleting SAMHD1 in THP-1 cells enhanced HSV-1 replication, while ectopic overexpression of SAMHD1 in U937 cells repressed HSV-1 replication. SAMHD1 did not impact viral gene expression from incoming HSV-1 viral genomes. HSV-1 restriction involved the dNTP triphosphohydrolase activity of SAMHD1 and was partially overcome by addition of exogenous deoxynucleosides. Unlike retroviruses, restriction of HSV-1 was not affected by SAMHD1 phosphorylation status. Our results suggest that SAMHD1 functions broadly to inhibit replication of DNA viruses in nondividing macrophages.</P>
Eun Young Lee,Maria Luisa G. Tejada,Insun Song,Seung Soo Chun,Susanne Gier,Laurent Riquier,Lloyd T. White,Bernhard Schnetger,Hans-Jurgen Brumsack,Matthew M. Jones,Mathieu Martinez 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10
This study investigates the linkages between physical properties, primary lithology, and alteration processes of a volcanic sequence at Site U1513 on the Naturaliste Plateau, offshore southwest Australia. The volcanic eruption and emplacement occurred in subaerial to shallow water setting on the rifted continental margin during the Early Cretaceous. The volcanic sequence consists of alternating basalt flows and volcaniclastic deposits, intruded by multiple dolerite dikes. We compile a variety of petrophysical data and correlate these with lithologic, mineralogical, and geochemical analyses (e.g., XRD, XRF), acquired during and after the International Ocean Discovery Program (IODP) Expedition 369. Variable alteration intensities from fresh-slight to strong are evaluated using Chemical Index of Alteration, alteration mineralogy, and textural changes. Intervals of fresh-slightly altered dikes exhibit low porosity (~13%) and high values of bulk density (~2.7 g/cm³), P-wave velocity (~4900 m/s) and thermal conductivity (~1.7 W/(m·K)). The increase of alteration intensity corresponds to decreases in bulk density to ~2 g/cm³, P-wave velocity to ~2000 m/s, thermal conductivity to ~1.2 W/(m·K) and an increase in porosity up to 50%. Natural Gamma Ray and magnetic susceptibility vary downhole with rock composition and at lithologic boundaries. The distinct physical variations exhibit a good correlation with primary lithologic characteristics as well as secondary mineralogical and textural changes attributed to alteration processes by subaerial exposure, seawater interaction and hydrothermal activities. Synthesis models of petrophysical variation with alteration intensity are provided for future studies. Although limitations and uncertainties are introduced due to differences in primary lithology, alteration type, and petrophysical methodology, there is a reasonable applicability of our results to rapidly characterize the alteration intensity and volcanic stratigraphy in volcanic sequences. Our results can be used to develop strategies better for exploration, drilling, and geophysical research of volcanic terrains.