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Effect of pH on Types of Acidogenic Fermentation of Fruit and Vegetable Wastes
Mingxia Zheng,Mingyue Zheng,Yuanyuan Wu,Hailing Ma,Kaijun Wang 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.2
The effect of pH (4.0, 5.0, and 6.0) on acidification and fermentation of fruit and vegetable wastes was investigated using batch and semi-continuous experiments under mesophilic condition. Results showed that fermentation types change with pH variation. The pH of acidification system containing fruit and vegetable wastes could automatically decrease to 3.0 ~ 4.0. At this pH range, a stable ethanol production was observed, at which ethanol-type fermentation was obtained. Based on the results, the fermentation types were classified into ethanol-type, mixed acid-type, propionic acid-type, and butyric acid-type fermentations, which occurred at pH 4.0 ~ 4.5, 4.5 ~ 5.0, 5.0 ~ 5.5, and 5.5 ~ 6.5, respectively.
Piao, Zhonglie,Ma, Teng,Li, Jiawen,Wiedmann, Maximilian T.,Huang, Shenghai,Yu, Mingyue,Kirk Shung, K.,Zhou, Qifa,Kim, Chang-Seok,Chen, Zhongping American Institute of Physics 2015 Applied Physics Letters Vol.107 No.8
<P>Intravascular photoacoustic imaging at 1.7 mu m spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection. (C) 2015 AIP Publishing LLC.</P>
Li Juanfei,Wu Lei,Ma Mingyu,Song Ruifeng,Dong Chunhui,Wei Junfang,Li Jinsheng,Wang Xiaoqiang,Li Mingya 한국물리학회 2023 Current Applied Physics Vol.46 No.-
La0.7Sr0.3MnO3 (LSMO)/LaNiO3 (LNO) thin films were deposited successively on Si single crystal by the sol-gel method. The bipolar resistive switching (RS) behavior was studied in Al/LSMO/LNO devices. Obvious current hysteresis was observed, the set (reset) voltage and resistance ratio were modulated by the annealing temperature of LSMO thin films. At the annealing temperature of 750 ◦C, good endurance and retention performance were obtained in the memory device. According to the fitting results of I–V curves, based on Schottky emission model, the conduction mechanisms of Al/LSMO/LNO devices were discussed. Our results may give a valuable insight on developing perovskite-type rare earth manganese oxide.
Quantitative Stability Analysis of an Unmanned Tethered Quadrotor
Dong Liang,Li Ding,Mingyue Lu,Rui Ma,Jie Cao 한국항공우주학회 2023 International Journal of Aeronautical and Space Sc Vol.24 No.3
Tethered quadrotors, unmanned aerial quadrotors connected to a fixed point via tether cables, have been widely applied in numerous aerial tasks. However, their structural parameters and external disturbances give rise to dynamic stability issues, resulting in uncontrolled autonomous flight, shaking, and vibrating. Thus, this article investigates the quantitative stability of a tethered quadrotor using the Lyapunov exponent approach. First, a mathematical model of the tethered quadrotor is developed, and its dynamic stability is quantified to verify the rationality of the designed physical prototype and enhance the aerial system’s stability. Both simulation and experimental results show that the dynamic stability during the landing phase is better than that during takeoff. Finally, optimizing the structural parameters enhances the dynamic stability, which is sensitive to cable length, wind gusts, and yaw angle.
Effects of dissolving microneedle fabrication parameters on the activity of encapsulated lysozyme
Fakhraei Lahiji, Shayan,Jang, Yoojung,Ma, Yonghao,Dangol, Manita,Yang, Huisuk,Jang, Mingyu,Jung, Hyungil Elsevier 2018 European journal of pharmaceutical sciences Vol.117 No.-
<P><B>Abstract</B></P> <P>Dissolving microneedle (DMN) is referred to a microscale needle that encapsulates drug(s) within a biodegradable polymer matrix and delivers it into the skin in a minimally invasive manner. Although vast majority of studies have emphasized DMN as an efficient drug delivery system, the activity of DMN-encapsulated proteins or antigens can be significantly affected due to a series of thermal, physical and chemical stress factors during DMN fabrication process and storage period. The objective of this study is to evaluate the effects of DMN fabrication parameters including polymer type, polymer concentration, fabrication and storage temperature, and drying conditions on the activity of the encapsulated therapeutic proteins by employing lysozyme (LYS) as a model protein. Our results indicate that a combination of low temperature fabrication, mild drying condition, specific polymer concentration, and addition of protein stabilizer can maintain the activity of encapsulated LYS up to 99.8 ± 3.8%. Overall, findings of this study highlight the importance of optimizing DMN fabrication parameters and paves way for the commercialization of an efficient delivery system for therapeutics.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Suyong,Dangol, Manita,Kang, Geonwoo,Lahiji, Shayan F.,Yang, Huisuk,Jang, Mingyu,Ma, Yonghao,Li, Chengguo,Lee, Sang Gon,Kim, Chang Hyun,Choi, Young Wook,Kim, So Jeong,Ryu, Ja Hyun,Baek, Ji Hwoon,K American Chemical Society 2017 Molecular Pharmaceutics Vol.14 No.6
<P>Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated in a biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the encapsulated drugs into the body. However, because of limited loading capacity of drugs within microsized structures, only a small dosage can be delivered, which is often insufficient for patients. We propose a novel DMN application that combines topical and DMN application simultaneously to improve skin permeation efficiency. Drugs in pretreated topical formulation and encapsulated drugs in DMN patch are delivered into the skin through microchannels created by DMN application, thus greatly increasing the delivered dose. We used 4-n-butylresorcinol to treat human hyper pigmentation and found that sequential application of serum formulation and DMNs was successful. In skin distribution experiments using Alexa Fluor 488 and 568 dyes as model drugs, we confirmed that the pretreated serum formulation was delivered into the skin through microchannels created by the DMNs. In vitro skin permeation and retention experiments confirmed that this novel combined application delivered more 4-n-butylresorcinol into the skin than traditional DMN-only and serum-only applications. Moreover, this combined application showed a higher efficacy in reducing patients' melanin index and hyperpigmented regions compared with the serum-only application. As combined application of DMNs on serum-treated skin can overcome both dose limitations and safety concerns, this novel approach can advance developments in transdermal drug delivery.</P>
Dangol, Manita,Kim, Suyong,Li, Cheng Guo,Fakhraei Lahiji, Shayan,Jang, Mingyu,Ma, Yonghao,Huh, Inyoung,Jung, Hyungil Elsevier 2017 Journal of controlled release Vol.265 No.-
<P><B>Abstract</B></P> <P>Natural products such as caffeine have been found to be effective in reducing body weight through lipolysis. Here, we report the successful loading of caffeine onto dissolving microneedle following inhibition of its crystal growth by hyaluronic acid (HA), the matrix material of the dissolving microneedle (DMN). Further, the anti-obesity activity of caffeine was evaluated in high-fat diet-induced obese C57BL/6J mice. After 6weeks of caffeine loaded dissolving microneedle patch (CMP) administration, lipolysis improved significantly as shown by leptin and adiponectin activity, which resulted in considerable weight loss of about 12.8±0.75% in high-fat diet-induced obese mice. Comparison of the levels of triglyceride, total cholesterol, high-density lipoprotein (HDL)-cholesterol, and low-density lipoprotein (LDL)-cholesterol after CMP administration with the initial levels in obese mice indicated significant anti-obesity activity of CMP. These findings suggested that a novel CMP with an increased amount of caffeine loaded onto DMN has therapeutic activity against obesity.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
MIRIS observation of near-infrared diffuse Galactic light
Onishi, Yosuke,Sano, Kei,Matsuura, Shuji,Jeong, Woong-Seob,Pyo, Jeonghyun,Kim, Il-Jong,Seo, Hyun Jong,Han, Wonyong,Lee, DaeHee,Moon, Bongkon,Park, Wonkee,Park, Younsik,Kim, MinGyu,Matsumoto, Toshio,Ma Astronomical Society of Japan 2018 Publications of the Astronomical Society of Japan Vol.70 No.4