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- 저자 : Ma Chunping (검색결과 4 건)
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Chunping Li,Shiwei Wang,Cuifang Zhang,Junjie Ding,Bin Ma,Rabigul Yasin,Zezheng Xue 한국원예학회 2020 원예과학기술지 Vol.38 No.3
Nitrogen is a critical determinant of forest growth and productivity, and root respiration rate and nonstructural carbohydrates are important parameters for evaluating the effects of supplied nutrients. Here, we assessed the effects of nitrogen on walnut seedlings (Juglans regia Linn.) that grew consistently for a year under favorable conditions. Seedlings were potted in seven concentrations of N availability, 0, 1, 2, 4, 8, 12, and 16 mmol·L1, and the specific root respiration rate and nonstructural carbohydrate content of the root system were determined via the offbody root system and the ketone color ratio methods, respectively. Nitrogen concentration was positively correlated with specific root respiration, and root diameter was the main factor related to specific root respiration and nonstructural carbohydrate content of walnut seedlings. Under the same nitrogen concentrations, the soluble total sugar and starch content of roots increased with increasing root diameter, while the specific root respiration increased with decreasing root diameter. Compared to the 0 mmol·L1 nitrogen concentration, the content of nonstructural carbohydrates in the root system and the specific root respiration were higher when nitrogen concentration was N16. Our comprehensive analysis showed that a nitrogen concentration of N16 improved the respiration rate of the seedling root system, significantly increased the content of nonstructural carbohydrates in the seedling root system, and effectively promoted the growth and development of the seedling root system of walnut seedlings.
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Chunping Yu,Yi Zhang,Ning Wang,Wensu Wei,Ke Cao,Qun Zhang,Peiying Ma,Dan Xie,Pei Wu,Biao Liu,Jiahao Liu,Wei Xiang,Xing Hu,Xuewen Liu,Jianfei Xie,Jin Tang,Zhi Long,Long Wang,Hongliang Zeng,Jianye Liu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1
Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-adherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.
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Knockdown of dorsal/relish increases larvae susceptibility to microbes in Spodoptera litura
Yangyang Cai,Zimo Guo,Chunping Ma,Jianya Su 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1
The tobacco cutworm, Spodoptera litura has developed high levels of resistance to frequently-used insecticides, and failures of chemical control has frequently been reported in China. Moreover, the control efficiency of biological control agents was not satisfactory by farmers, and thus the development of novel or combined techniques for such pest control becomes an imperative requirement. In this study the potential application of innate immune-related genes in insect control was investigated. Sldorsal and Slrelish were identified from S. litura. Sldorsals were mainly expressed in epidermal and fatbody of larvae, and Slrelish highly expressed in fatbody and haemolymph of larvae. Their expression characteristic suggests potential roles in defense against fungi or bacteria. The expression of Sldorsal was up-regulated by the challenge of entomogenous fungi Isaria javanica and Beauveria bassiana, however, the expression of Slrelish could only be induced by Escherichia coli challenge. Injection of Sldorsal or Slrelish dsRNA down-regulated the expression level of the corresponding gene and broke specific signaling transduction pathway of innate immunity in S. litura. Knockdown of Sldorsal by RNAi significantly increased the mortality of S. litura larvae caused by I. javanica and B. bassiana, and Slrelish RNAi highly increased the mortality caused by E. coli. Sldorsal and Slrelish are essential genes for innate immunity, their knockdown by RNAi increases S. litura susceptibility to insect pathogens, therefore enhances the mortalities caused by I. javanica, B. bassiana and E. coli respectively.
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MiR-601 inhibited small cell lung cancer progression by modulating SIRT1
Ding Hao,Gong Chenhu,Zhang Zhihong,Xu Hui,Ma Chunping 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background Dysfunction of microRNAs (miRNAs) contribute to small cell lung cancer (SCLC) progression. Accumulating evidence indicated miR-601, acted as a tumor suppressor gene, has shown an altered expression pattern in multiple cancers. However, little was known about in terms of the function of miR-601 during SCLC progression. Objective Our project intended to illustrate the functions of miR-601 during the development and metastasis of SCLC. Results We found a decreased expression of miR-601 in SCLC tumor tissues and cell lines. Moreover, functional studies suggested that miR-601 overexpression resulted in a reduced cell growth and induced apoptosis of SCLC cells. Notably, sirtuin 1 (SIRT1) was identifi ed as a putative target of miR-601. MiR-601 suppressed SIRT1 expression via interacting with the 3′-untranslated region (UTR) of SIRT1 in SCLC cells. Also, SIRT1 expression was negatively associated with that of miR-601 in SCLC tissues. The restoration of SIRT1 alleviated the inhibitory eff ect of miR-601 on SCLC progression. Conclusion Our data documented the tumor-suppressive function of miR-601 in SCLC via targeting SIRT1, suggesting miR-601 as a new potential therapeutic approach for SCLC treatment.
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