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Spricigo, J.F.W.,Morais, K.S.,Yang, B.S.,Dode, M.A.N. Academic Press 2012 Cryobiology Vol.65 No.3
The present study aimed to evaluate the effect of methyl-β-cyclodextrin (MβCD) as a cholesterol loader to change oocyte plasma membrane and increase its tolerance toward cryopreservation. The first and second experiments were conducted to investigate if MβCD could improve nuclear and cytoplasmic maturation after oocyte exposure to cold stress for 10 or 30min, respectively. No differences (P>0.05) in either experiment in the metaphase II (MII) rate of oocytes exposed to MβCD and cold stress; but these oocytes presented lower maturation rates than control groups. In the second experiment, a lower percentage of oocytes showed degenerated chromatin (P<0.05) after exposure to 2mg/mL of MβCD compared to the group exposed to 0mg/mL. However, no differences among treatments were observed in cytoplasmic maturation. Groups exposed to cold stress demonstrated a lower (P<0.05) capacity for embryonic development compared to the control groups. In the third experiment immature oocytes were exposed to MβCD and then, vitrified (cryotop). After warming, we observed that the ability to reach MII and chromatin degeneration were altered (P<0.05) by MβCD. The blastocysts rate (P<0.05) on D7 was higher in the 2mg/mLMβCD group, but an identical finding was not observed on D8 (P>0.05). Chromatin degeneration was higher in the vitrification groups. We conclude that MβCD improved nuclear maturation by reducing oocyte degeneration after cold stress or vitrification; however, more studies are required to clarify the usefulness of MβCD use in oocyte cryopreservation.
Computer-aided tumor diagnosis using shear wave breast elastography
Moon, W.K.,Huang, Y.S.,Lee, Y.W.,Chang, S.C.,Lo, C.M.,Yang, M.C.,Bae, M.S.,Lee, S.H.,Chang, J.M.,Huang, C.S.,Lin, Y.T.,Chang, R.F. Butterworth Scientific Ltd., etc.] 2017 Ultrasonics Vol.78 No.-
<P>The shear wave elastography (SWE) uses the acoustic radiation force to measure the stiffness of tissues and is less operator dependent in data acquisition compared to strain elastography. However, the reproducibility of the result is still interpreter dependent. The purpose of this study is to develop a computer-aided diagnosis (CAD) method to differentiate benign from malignant breast tumors using SWE images. After applying the level set method to automatically segment the tumor contour and hue-saturation value color transformation, SWE features including average tissue elasticity, sectional stiffness ratio, and normalized minimum distance for grouped stiffer pixels are calculated. Finally, the performance of CAD based on SWE features are compared with those based on B-mode ultrasound (morphologic and textural) features, and a combination of both feature sets to differentiate benign from malignant tumors. In this study, we use 109 biopsy-proved breast tumors composed of 57 benign and 52 malignant cases. The experimental results show that the sensitivity, specificity, accuracy and the area under the receiver operating characteristic ROC curve (Az value) of CAD are 86.5%, 93.0%, 89.9%, and 0.905 for SWE features whereas they are 86.5%, 80.7%, 83.5% and 0.893 for B-mode features and 90.4%, 94.7%, 92.3% and 0.961 for the combined features. The Az value of combined feature set is significantly higher compared to the B-mode and SWE feature sets (p = 0.0296 and p = 0.0204, respectively). Our results suggest that the CAD based on SWE features has the potential to improve the performance of classifying breast tumors with US. (C) 2017 Elsevier B.V. All rights reserved.</P>
Magnetoelectric complex-oxide heterostructures
Ramesh, R.,Zavaliche, F.,Chu, Y. H.,Martin, L. W.,Yang, S. Y.,Cruz, M. P.,Barry, M.,Lee, K.,Yang, P.,Zhan, Q. Taylor and Francis 2007 Philosophical magazine letters Vol.87 No.3
<P> A short review of recent progress in the field of multiferroic thin films and heterostructures is given. We focus on the bismuth iron oxide system due to its desirable properties, namely high ferroelectric Curie temperature and antiferromagnetic Neel temperature. Epitaxial growth of this model system in various crystallographic orientations has conclusively demonstrated the large ferroelectric polarization in this system. Piezoforce microscopy reveal a complex domain structure, especially on (100) SrTiO3 substrates. Electrical switching experiments show the co-existence of 71°, 109° and 180° domain switching mechanisms in such films. Preliminary work has shown promise for electrically controllable exchange bias in ferromagnet-multiferroic heterostructures.</P>
Yang, Y.,He, S.,Wang, Q.,Li, F.,Kwak, M.J.,Chen, S.,O'Connell, D.,Zhang, T.,Pirooz, S.,Jeon, Y.,Chimge, N.O.,Frenkel, B.,Choi, Y.,Aldrovandi, Grace M.,Oh, B.H.,Yuan, Z.,Liang, C. Cell Press 2016 Molecular cell Vol.62 No.4
<P>UV-induced DNA damage, a major risk factor for skin cancers, is primarily repaired by nucleotide excision repair (NER). UV radiation resistance-associated gene (UVRAG) is a tumor suppressor involved in autophagy. It was initially isolated as a cDNA partially complementing UV sensitivity in xeroderma pigmentosum (XP), but this was not explored further. Here we show that UVRAG plays an integral role in UV-induced DNA damage repair. It localizes to photolesions and associates with DDB1 to promote the assembly and activity of the DDB2-DDB1-Cul4A-Roc1 (CRL4(DDB2)) ubiquitin ligase complex, leading to efficient XPC recruitment and global genomic NER. UVRAG depletion decreased substrate handover to XPC and conferred UV-damage hypersensitivity. We confirmed the importance of UVRAG for UV-damage tolerance using a Drosophila model. Furthermore, increased UV-signature mutations in melanoma correlate with reduced expression of UVRAG. Our results identify UVRAG as a regulator of CRL4(DDB2)-mediated NER and suggest that its expression levels may influence melanoma predisposition.</P>
Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line
Yusufi, F.N.K.,Lakshmanan, M.,Ho, Y.S.,Loo, B.L.W.,Ariyaratne, P.,Yang, Y.,Ng, S.K.,Tan, T.R.M.,Yeo, H.C.,Lim, H.L.,Ng, S.W.,Hiu, A.P.,Chow, C.P.,Wan, C.,Chen, S.,Teo, G.,Song, G.,Chin, J.X.,Ruan, X. Cell Press 2017 Cell systems Vol.4 No.5
Effective development of host cells for therapeutic protein production is hampered by the poor characterization of cellular transfection. Here, we employed a multi-omics-based systems biotechnology approach to elucidate the genotypic and phenotypic differences between a wild-type and recombinant antibody-producing Chinese hamster ovary (CHO) cell line. At the genomic level, we observed extensive rearrangements in specific targeted loci linked to transgene integration sites. Transcriptional re-wiring of DNA damage repair and cellular metabolism in the antibody producer, via changes in gene copy numbers, was also detected. Subsequent integration of transcriptomic data with a genome-scale metabolic model showed a substantial increase in energy metabolism in the antibody producer. Metabolomics, lipidomics, and glycomics analyses revealed an elevation in long-chain lipid species, potentially associated with protein transport and secretion requirements, and a surprising stability of N-glycosylation profiles between both cell lines. Overall, the proposed knowledge-based systems biotechnology framework can further accelerate mammalian cell-line engineering in a targeted manner.
STEREOSELECTIVITY IN ^4π_s^+4π_s PHOTOCYCLOADDITION OF 1,3-CYCLOHEXADIENE TO ARENES
Yang, Nien-chu C.,Kim, Sung Sik,Gan, Hong,Masnovi, John M.Yang, Nien-chu C.,Rafalko, P. White,Ezell, Edward F.,Lenz, George R. 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.2
The stereoselectivity in photocycloaddition of 1,3-cyclohexadiene to unsymmetrical arenes may be controlled by the secondary orbital interactions between LUMOs of the arene and the diene.
Li, L.L.,Hou, Z.P.,Yin, Y.L.,Liu, Y.H.,Hou, D.X.,Zhang, B.,Wu, G.Y.,Kim, S.W.,Fan, M.Z.,Yang, C.B.,Kong, X.F.,Tang, Z.R.,Peng, H.Z.,Deng, D.,Deng, Z.Y.,Xie, M.Y.,Xiong, H.,Kang, P.,Wang, S.X. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.5
This study was conducted to determine the effects of exogenous zinc-metallothionein (Zn-MT) on anti-oxidative function and pork quality. After feeding a corn-soybean meal-based diet for two weeks, 48 pigs ($Duroc{\times}Landrace{\times}Chinese\;Black Pig$) were assigned randomly to four groups. Pigs in Group 1 were maintained under non-stress conditions, whereas pigs in Groups 2, 3 and 4 were aggressively handled for 25 min to produce stress. Pigs in Groups 1, 2, 3, and 4 received intramuscular administration of saline (control group; CON), 0 (negative control group; NCON), 0.8 (low dose group; LOW), and 1.6 (high dose group; HIGH) mg rabbit liver Zn-MT per kg body weight, respectively. Pigs were slaughtered at 3 and 6 h post-injection. Zn-MT treatment increased (p<0.05) the activities of superoxide dismutase (SOD) and glutathione-peroxidase (GSH-PX) while decreasing the concentration of malondialdehyde (MDA) in liver. These responses were greater (p<0.05) at 6 h than at 3 h post Zn-MT injection. Zn-MT treatment increased (p<0.05) hepatic SOD mRNA levels in a time and dose-dependent manner and decreased (p<0.05) serum glutamate-pyruvate transaminase and lactate dehydrogenase activities (indicators of tissue integrity). Zn-MT administration decreased (p<0.05) lactate concentration and increased (p<0.05) pH and water-holding capacity in the longissimus thorasis meat. Collectively, our results indicate that intramuscular administration of Zn-MT to pre-slaughter stressed pigs improved tissue anti-oxidative ability and meat quality.
Magnetic resonance in bilayers of ferrite and functionally graded piezoelectric
Bichurin, M.I.,Petrov, R.V.,Petrov, V.M.,Saplev, A.F.,Tatarenko, A.S.,Kovalenko, D.V.,Melnichuk, D.G.,Yang, Su-Chul Elsevier 2017 Materials research bulletin Vol.96 No.3
<P><B>Abstract</B></P> <P>The particular purpose of this paper is theoretical modeling of magnetoelectric interactions at the ferromagnetic resonance in a layered structure of a ferrite and a piezoelectric with through-thickness graded polarization. We show that using the functionally graded piezoelectric with through-thickness variation of polarization can lead to an electric field induced broadening of ferromagnetic resonance line. As an example, we consider the laminate based on the yttrium iron garnet layer which is placed between two lead zirconate titanate layers with different poling direction. The maximal ferromagnetic resonance line broadening of 9.3Oe is obtained for the yttrium iron garnet to lead zirconate titanate layer thickness ratio of 1.7 at 9.3GHz for E equal to 10kV/cm.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ferromagnetic resonance in a ferrite-piezoelectric laminate is studied. </LI> <LI> An electric field induced FMR line broadening results from bending the sample. </LI> <LI> Ferrite layer between the two piezoelectric layers shows a large line broadening. </LI> </UL> </P>