http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lingappa Mallesha,Kikkeri N. Mohana,Bantal Veeresh,Ravi Alvala,Alvala Mallika 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.1
A series of new 2-methyl-3-(2-piperazin-1-yl-ethyl)-pyrido[1,2-a]pyrimidin-4-one derivatives 6a-j were synthesized by a nucleophilic substitution reaction of 2-methyl-3-(2-piperazin-1-ylethyl)-pyrido[1,2-a]pyrimidin-4-one with various sulfonyl chlorides. The compounds were characterized by different spectral studies. All the compounds were evaluated for their antiproliferative effect using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method against four human cancer cell lines (K562, Colo-205, MDA-MB 231, IMR-32) for the time period of 24 h. Among the series, compounds 6d, 6e and 6i showed good activity on all cell lines except K562, whereas the other compounds in the series exhibited moderate activity. Compound 6d could be a potential anticancer agent and therefore deserves further research.
( Sivakumar Lingappa ),( Muthugounder Subramanian Shivakumar ),( Thamilarasan Manivasagam ),( Somasundaram Thirugnanasambandan Somasundaram ),( Palaniappan Seedevi ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.6
Epalrestat (EPS) is a brain penetrant aldose reductase inhibitor, an approved drug currently used for the treatment of diabetic neuropathy. At near-plasma concentration, EPS induces glutathione biosynthesis, which in turn reduces oxidative stress in the neuronal cells. In this study, we found that EPS reduces neurodegeneration by inhibiting reactive oxygen species (ROS)-induced oxidative injury, mitochondrial membrane damage, apoptosis and tauopathy. EPS treatment up to 50 μM did not show any toxic effect on SH-SY5Y cell line (neuroblastoma cells). However, we observed toxic effect at a concentration of 100 μM and above. At 50 μM concentration, EPS showed better antioxidant activity against H<sub>2</sub>O<sub>2</sub> (100 μM)-induced cytotoxicity, ROS formation and mitochondrial membrane damage in retinoic acid-differentiated SH-SY5Y cell line. Furthermore, our study revealed that 50 μM of EPS concentration reduced the glycogen synthase kinase-3 β (GSK3-β) expression and total tau protein level in H<sub>2</sub>O<sub>2</sub> (100 μM)-treated cells. Findings from this study confirms the therapeutic efficacy of EPS on regulating Alzheimer's disease (AD) by regulating GSK3- β and total tau proteins phosphorylation, which helped to restore the cellular viability. This process could also reduce toxic fibrillary tangle formation and disease progression of AD. Therefore, it is our view that an optimal concentration of EPS therapy could decrease AD pathology by reducing tau phosphorylation through regulating the expression level of GSK3-β.
Identification of Preventable Risk Factors for Developmental Delay in Children: A Pilot Study
Tejanjani Vathada,Lokesh Lingappa 대한소아신경학회 2023 대한소아신경학회지 Vol.31 No.2
Purpose: Developmental delay (DD) is reported to be frequent in developing countries, such as India. Hence, this study was carried out to evaluate preventable risk factors that can predispose children to DD, through observations of pediatric neurology outpatients. Methods: This was a prospective, observational, and descriptive cross-sectional single-center hospital-based study for a period of 30 days, split into two separate time periods due to the impact of the coronavirus disease 2019 pandemic. Children who newly presented to the pediatric neurology outpatient department were considered. There were a total of 151 boys and girls, from 6 months to 14 years of age. Detailed demographic information on prenatal, natal and postnatal risk factors relevant to the neurological diagnosis was collected. Antenatal education for mothers about breastfeeding and newborn care, place of delivery, the availability of round-the-clock pediatric care during the delivery, gestational age, maternal fever, encephalitis, seizures, meningitis, blood pressure, gestational diabetes mellitus, infections, history of consanguinity, and genetic disorders were all considered. The data were analyzed with odds ratios and multivariable logistic regression. Results: Forty-three of the 151 enrolled children had DD. Significant associations were found between consanguinity and DD (adjusted odds ratio [AOR], 6.50; 95% confidence interval [CI], 1.96 to 21.51; P<0.002) and between prematurity and DD (AOR, 2.34; 95% CI, 1.07 to 5.13; P<0.033). Conclusion: This study shows that consanguineous marriages and prematurity predisposed children to DD when prenatal, natal, and postnatal risk factors were comprehensively considered.
Rekha, Dasari,Kumar, Jengiti. Dilip,Jayaraj, Bellum,Lingappa, Y.,Chiranjeevi, Pattium Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.3
A micro organism Agrobacterium tumifacient as an immobilized cell on a solid support was presented as a new biosorbent in a simple and sensitive spectrophotometry determination of Ni(II) in various samples using 4-hydroxy benzaldehyde-4-bromophenyl hydrazone as a color developing agent (λmax 497 nm) at pH 4.0 ± 0.2. Beer's law was obeyed over the range of 0.01-0.1 μg L-1. The molar absorptivity and Sandell's sensitivity were 1.285 × 105 L mol-1cm-1 and 0.007245 μg cm-2 respectively. Under these conditions, the preconcentration factor obtained was 82, and the detection limit achieved was 0.05 μg L-1. The detailed study of various interfering ions made the method more sensitive and selective. The recovery of Ni(II) from various samples range from 97.75 to 99.35%. The present method was successfully applied for the determination of Ni(II) in spiked, natural water and alloy samples. The proposed method was compared with reported methods in terms of Student's ‘t'-test and Variance ratio ‘f'-test which indicates that there is no significant difference between proposed and literature method at 95% confidence level.
Al-doped ZnS layers synthesized by solution growth method
K. Nagamani,N. Revathi,P. Prathap,Y. Lingappa,K.T. Ramakrishna Reddy 한국물리학회 2012 Current Applied Physics Vol.12 No.2
ZnS is one of the potential candidates as a window/buffer layer for solar photovoltaic applications. Aldoped ZnS nanocrystalline films were grown by a simple and economic process, chemical solution growth method. The layers were prepared for different Al-dopant concentrations that vary in the range, 0e10 at. %. The effect of Al-doping on the composition, structure, optical, electrical and photoluminescence properties of the synthesized layers was determined using appropriate techniques. The elemental composition of a typical sample with 6 at. % ‘Al’ in ZnS was Zn ¼ 44.9 at. %, S ¼ 49.8 at. % and Al ¼ 5.3 at. %. The films were nanocrystalline in nature and showed (111) plane of ZnS as the preferred orientation for all the doping concentrations. The layers with 6 at. % of Al showed a crystallite size of w9 nm. The FTIR studies confirmed the presence of ZnS in the layers. The layers showed an average transmittance of w75% in the visible region. The change of photoluminescence behaviour with dopant concentration was also studied. The electrical resistivity was considerably decreased from 107 Ucm to 103 Ucm with Al-doping. The detailed analysis of results will be presented and discussed.
Dasari Rekha,Jengiti. Dilip Kumar,Bellum Jayaraj,Y. Lingappa,Pattium Chiranjeevi* 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.3
A micro organism Agrobacterium tumifacient as an immobilized cell on a solid support was presented as a new biosorbent in a simple and sensitive spectrophotometry determination of Ni(II) in various samples using 4-hydroxy benzaldehyde-4-bromophenyl hydrazone as a color developing agent (lmax 497 nm) at pH 4.0 0.2. Beers law was obeyed over the range of 0.01-0.1 g L-1. The molar absorptivity and Sandells sensitivity were 1.285 105 L mol-1cm-1 and 0.007245 g cm-2 respectively. Under these conditions, the preconcentration factor obtained was 82, and the detection limit achieved was 0.05 g L-1. The detailed study of various interfering ions made the method more sensitive and selective. The recovery of Ni(II) from various samples range from 97.75 to 99.35%. The present method was successfully applied for the determination of Ni(II) in spiked, natural water and alloy samples. The proposed method was compared with reported methods in terms of Students t-test and Variance ratio f-test which indicates that there is no significant difference between proposed and literature method at 95% confidence level.
Historical and More Common Nongenetic Movement Disorders From Asia
Norlinah Mohamed Ibrahim,Priya Jagota,Pramod Kumar Pal,Roongroj Bhidayasiri,Shen-Yang LIM,Yoshikazu Ugawa,Zakiyah Aldaajani,Beomseok Jeon,Shinsuke Fujioka,Jee-Young Lee,Prashanth Lingappa Kukkle,Huifa 대한파킨슨병및이상운동질환학회 2023 Journal Of Movement Disorders Vol.16 No.3
Nongenetic movement disorders are common throughout the world. The movement disorders encountered may vary depending on the prevalence of certain disorders across various geographical regions. In this paper, we review historical and more common nongenetic movement disorders in Asia. The underlying causes of these movement disorders are diverse and include, among others, nutritional deficiencies, toxic and metabolic causes, and cultural Latah syndrome, contributed by geographical, economic, and cultural differences across Asia. The industrial revolution in Japan and Korea has led to diseases related to environmental toxin poisoning, such as Minamata disease and β-fluoroethyl acetate-associated cerebellar degeneration, respectively, while religious dietary restriction in the Indian subcontinent has led to infantile tremor syndrome related to vitamin B12 deficiency. In this review, we identify the salient features and key contributing factors in the development of these disorders.