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Lian Yu Guo,Xing Fu Cai,Jung Joon Lee,강삼식,신은명,Hong Yu Zhou,Ji Won Jung,김영식 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
Demethoxycurcumin and bisdemethoxycurcumin are the main active ingredients isolated from Curcumae Longae Radix. Recent studies demonstrated that both compounds exhibit antioxidative and anti-inflammatory effects as well as effects on cancer cell lines. In this study, we compared the activities of demethoxycurcumin and bisdemethoxycurcumin, and both compounds were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cycloxygenase-2 (COX-2) and nuclear factor-kappaB (NF-κB) activity in a RAW 264.7 macrophage cell line. The evaluation:results suggested that the anti-inflammatory properties of demethoxycurcumin and bisdemethoxycurcumin were attributed to the inhibition of iNOS and COX-2 expression, as initiated by the inhibition of NF- κB activity. Additionally, both of them significantly inhibited carrageenan-induced paw edema in mice. Taken together, all of the results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxycurcumin, indicating that the methoxy group had enhanced demethoxycurcumin’s anti-inflammation effects.
Lian-min Cao,Yong Cai,Guotai Xu,Jiulong Cui 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.6
By use of the concept of impedance, this paper establishes a random energy harvester output model of double-ended fi xed beam piezoelectric energy harvester under random White Gaussian noise excitation, which is based on the discussion of the output characteristics infl uenced by changing vibration beam shape and piezoelectric sheet length under random excitation, while improving piezoelectric structure of double-ended fi xed beam piezoelectric energy harvester. It also deduces the output voltage, current and power of energy harvester with Fokker–Planck equation, which are verifi ed by Monte Carlo simulation and experimental testing. It can be found that improving vibration beam shape can reduce resonant frequency and increase average output power of the system. The optimal value of piezoelectric sheet length can be diff erent corresponding to diff erent structures, which proves that double-ended fi xed beam piezoelectric energy harvester under random White Gaussian noise excitation can achieve maximum output with optimal piezoelectric sheet length. In addition, in order to further improve the output performance of piezoelectric energy harvester under random excitation, it is necessary to increase the acceleration spectral density under random excitation and set an optimal value of the piezoelectric loading resistance, which is more suitable for energy harvester applied under random low-frequency environment.
Lian Shen,Yan Han,C.S. Cai,Guochao Dong,Jianren Zhang,Peng Hu 한국풍공학회 2017 Wind and Structures, An International Journal (WAS Vol.24 No.1
Wind environment in urban residential areas is an important index to consider when evaluating the living environment. However, due to the complexity of the flow field in residential areas, it is difficult to specify the correct inflow boundary conditions in the large eddy simulation (LES). In this paper, the weighted amplitude wave superposition (WAWS) is adopted to simulate the fluctuating velocity data, which satisfies the desired target wind field. The fluctuating velocity data are given to the inlet boundary of the LES by developing an UDF script, which is implemented into the FLUENT. Then, two numerical models - the empty numerical wind tunnel model and the numerical wind tunnel model with spires and roughness elements are established based on the wind tunnel experiment to verify the present method. Finally, the turbulence generation approach presented in this paper is used to carry out a numerical simulation on the wind environment in an urban residential area in Lisbon. The computational results are compared with the wind tunnel experimental data, showing that the numerical results in the LES have a good agreement with the experimental results, and the simulated flow field with the inlet fluctuations can generate a reasonable turbulent wind field. It also shows that strong wind velocities and turbulent kinetic energy occur at the passageways, which may affect the comfort of people in the residential neighborhood, and the small wind velocities and vortexes appear at the leeward corners of buildings, which may affect the spreading of the pollutants.
Guo, Lian Yu,Cai, Xing Fu,Lee, Jung-Joon,Kang, Sam-Sik,Shin, Eun-Myoung,Zhou, Hong-Yu,Jung, Ji-Won,Kim, Yeong-Shik 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
Demethoxycurcumin and bisdemethoxycurcumin are the main active ingredients isolated from Curcumae Longae Radix. Recent studies demonstrated that both compounds exhibit antioxidative and anti-inflammatory effects as well as effects on cancer cell lines. In this study, we compared the activities of demethoxycurcumin and bisdemethoxycurcumin, and both compounds were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cycloxygenase-2 (COX-2) and nuclear factor-kappaB $(NF-{\kappa}B)$ activity in a RAW 264.7 macrophage cell line. The evaluation:results suggested that the anti-inflammatory properties of demethoxycurcumin and bisdemethoxycurcumin were attributed to the inhibition of iNOS and COX-2 expression, as initiated by the inhibition of $NF-{\kappa}B$ activity. Additionally, both of them significantly inhibited carrageenan-induced paw edema in mice. Taken together, all of the results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxycurcumin, indicating that the methoxy group had enhanced demethoxycurcumin's anti-inflammation effects.