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Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer
오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.
Significance of Inflammatory Markers in Diabetic Patients with Stable Coronary Artery Disease
( Hyo Jin Lee ),( Sung Ho Her ),( Yun Sun Im ),( Kang Yeon Won ),( Sun Hong Yoo ),( Dong Bin Kim ),( Dong Il Shin ),( Pum Joon Kim ),( Ki Bae Seung ),( Jae Hyung Kim ),( Keon Yeop Kim ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3
Background/Aims: Patients with diabetes are prone to coronary artery disease (CAD); however, the majority of diabetic patients show normal coronary arteries. We examined differences in the clinical aspects of diabetic patients with insignificant and with significant stenosis of the coronary artery. Methods: A total of 418 consecutive diabetic patients with stable angina who had undergone coronary angiography from January 2004 to March 2007 were included in this study. Patients were subdivided into control and CAD groups and then clinical characteristics and CAD-associated factors were evaluated. Results: A total of 92 (22%) patients were assigned to the control group and 326 (78%) patients were assigned to the CAD group. Using univariate regression analysis, we found that patients with CAD were significantly older (control vs. CAD; 59±21 vs. 64.7±33.7, years, p<0.001), had a longer duration of diabetes (8.2±21.8 vs. 10.2±29.8, years, p=0.027), higher titers of high sensitivity C-reactive protein (hsCRP; 0.3±6.79 vs. 0.9±12.6, mg/dL, p=0.015), and increased hemoglobin A1c (HbA1c) levels (7.1±3.8 vs. 7.5±4.8, %, p=0.007) compared to control patients. Multivariate regression analysis showed that only differences in age, hsCRP, and HbA1c were statistically significant. When patients were subdivided into groups based on hsCRP levels (208 patients in the low group [49.8%], 210 patients in the high group [50.2%]), we found that patients with higher hsCRP levels showed more frequent multivessel disease. Conclusions: In diabetic patients, age, hsCRP, and HbA1c were associated with stable CAD. Among these factors, hsCRP levels were significantly correlated with multivessel involvement in diabetic CAD. Therefore, high hsCRP levels may be a strong predictor for atherosclerotic progression of the coronary arteries in diabetic patients, suggesting that regular screening tests should be performed. (Korean J Intern Med 2009;24:212-219)
( Hyo Jung Lee ),( In Sung Yeo ),( Taer Ka Kwon ) 한국조직공학·재생의학회 2013 조직공학과 재생의학 Vol.10 No.5
Implant geometry and surface properties are important factors for successful osseointegration. The purpose of this study was to compare hydrophilic and hydrophobic implants with different geometries via the continuous measurement of removal torque (RT) and calculation of angular momentum for each implant. Five New Zealand white rabbits were used in the study. Each rabbit received 2 implants. A chemically modified hydrophilic implant with buttress thread was inserted into one tibia, and an anodically oxidized hydrophobic implant with V-shape threads was inserted into the other. After 1 week of healing, RT values were measured continuously in real-time. Using the time-torque curve resulting from the measurements, the maximum values were determined and angular momentums were calculated. The chemically modified hydrophilic implant exhibited significantly higher peak RT and mean torque values before the peak torque (MTBP) than the anodically oxidized hydrophobic implant (p < 0.05). The chemically modified hydrophilic implants exhibited superior early bone response compared to the anodically oxidized implants.
Hyo-Sang Choi,Na-Young Lee,Young-Hee Han,Tae-Hyun Sung,Byoung-Sung Han IEEE 2008 IEEE transactions on applied superconductivity Vol.18 No.2
<P>We have proposed a flux-coupling type superconducting fault current limiter (SFCL) using coils and analyzed its operating characteristics. The SFCL consisted of the primary and secondary coils, which were wound in series each other through an iron core. The superconducting unit, which was based on YBCO thin film, was connected with secondary coil in parallel. Meanwhile, the primary coil and secondary coil with serially connected superconducting unit were connected in parallel in a flux-lock type SFCL, which didn't permit the same inductances between the primary and secondary coils. The short-circuit currents were effectively limited by adjusting the numbers of winding turns of each secondary coil and the winding directions of the coils without a certain limitation in a flux-coupling type SFCL. The flux generated from a coil in normal operation is cancelled out by the direction of windings in the SFCL and the zero resistance behavior of the superconducting unit. In order to compare the influence by turn numbers between coils, the turn number of the secondary coil was varied from 21 to 84 while the turn number of the primary coil was 42 and 63. We confirmed that the flux-coupling type SFCL was significantly efficient in reducing the initial line current after fault initiation. The voltage generated in the superconducting unit was also lowered by reducing power burden of the YBCO thin film in the flux-coupling type SFCL. We considered that this was caused by mutual linkage of the flux between two coils. The current limiting behavior of the flux-coupling type SFCL was more effective for fault current limiting operation.</P>