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Risperidone이 백서의 억제된 자발적 교대행동에 미치는 영향
이기철,이정호,김진규,정홍경,천강훈,류정환,최영민,전성일 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2
Objectives : Recently, some case reports have shown that risperidone is effective to refractory obsessive-compulsive disorder. Possible explanations for efficacy of risperidone in refractory obsessive-compulsive disorder maybe due to that it is both serolonin and dopamine receptor antagonist. On the basis of serotonin-dopamine interaction hypothesis, a biological etiology of obsessive-compulsive disorder, the effect of risperidone was evaluated to the suppressed spontaneous alternation behaviour of animal model of obsessive-compulsive disorder in rats. Methods : The apparatus for spontaneous alternation behaviour was a black plexiglas T-maze with distinctive black and white goal boxes. Black gullotine doors separated the start box and the goal boxes from the main body of the T-maze Small cups were placed in the corners of both goal boxes(all arms measured 50×10cm) 24 hours prior to experiment, rats(Spraque-Dawley) were food-deprived. The food-deprived rats were put into T-maze, in which both goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for checked. After baseline of the number of choices of spontaneous alternation behaviour was stabilized, the pontaneous alternation disrupted by nonselective 5-HT agonist, 5-MeODMT (1.25mg/kg/IP). The experimental animals were stratified into 5 groups, fluoxetine(10mg/kg/IP), risperidone(0.1mg/Kg/IP), haloperidol(0.1㎎/Kg/IP), fluoxetine(10mg/Kg) with haloperidol(0.1 mg/Kg), and saline(0.5cc/IP) control group. Each drugs were injected for 21 days as a chronic treatment. The protective effects were evaluated on the nest day of discontinuation of the each drugs among 5 groups. Results : 1) After 21 days of the drug treatment, the risperidone group and the fluoxetine group showed significant difference from the haloperidol group and the saline control group on the protection of the 5-MeODMT induced suppression of spontaneous alternation behaviour. 2) The fluoxetine group and fluoxetine with haloperidol group showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. The risperidone group also showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour, but the protective effect of risperidone was superior to fluoxetine. Conclusion : These findings suggest that both risperidone and fluoxetine have a favorable effect in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. We think that risperidone can be possible alternatives to SSRIs in the treatment of refractory obsessive-compulsive disorder in clinical situation.
이덕희,문종국,배강우,이용환,김진하,박강원 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.3
This study was conducted to evaluate the blood lead levels in 141 pregnant women who were not occupationally exposed to lead and their umbilical cord, and to identify some differences in blood lead levels by living area. The subjects were all delivered at St. Benedict Hospital in Pusan and the blood lead levels were measured by graphite furance atomic absorption spectrophotometer. The summarized results were as follows. 1. The geometric mean lead levels in maternal and cord blood were 8.0±1.8μg/dl, 5.0±0.6μg/dl respectively. 2. Lead levels in maternal(8.7±1.7μg/dl) and cord blood(5.4μ±0.7μg/dl) of industrial area(n=24) were higher than residential area(n=124) which were 7.9±1.7μg/dl and 5.0±0.6μg/dl respectively(p<0.05). 3. Maternal blood lead concentration was significantly correlated to cord blood lead concentration(r=0.6090, p<0.001), but other variables(maternal age, paternal smoking, birth weight, etc) were not correlated.
2009 Historical Consideration of Hanji Used as Art Materials
Lee, Ji-Young,Kim, Chul-Hwan,Lee, Young-Rok,Baek, Gyeong-Gil,Lee, Hee-Jin,Gwak, Hye-Jung,Kim, Sung-Ho,Gang, Ha-Ryun Korea Furniture Society 2009 한국가구학회지 Vol.20 No.3
Traditional Korean paper called Hanji using bast fibers from mulberry tree is made through complicated handmade works. This made Hanji very strong and exceedingly durable. Therefore it is said to last a thousand years. Such incomparable features of Hanji come from the unique sheet forming method called ouibalttugi using a bamboo screen. Excellent physical properties of Hanji reflect the wide variety of use, all central to everyday life. Despite its Excellency, the papermaking practice of traditional handmade paper, Hanji, from Korea is little known outside its country. This might be due to public apathy on Hanji in modern times. Without future apprentices dedicated to the craft, the Korean tradition able to make its soul is in danger of extinction in its homeland. Therefore more concern and more affection on Hanji is required immediately. It must be kept in mind that Hanji is our cultural heritage in pride over time.
Role of protein kinase C delta in X-ray-induced apoptosis of keratinocyte
Lee, Young-Sook,Sohn, Kyung-Cheol,Kim, Ki-Hwan,Cho, Moon-June,Hur, Gang Min,Yoon, Tae-Jin,Kim, Sung Kyu,Lee, Kyungmoon,Lee, Jeung-Hoon,Kim, Chang Deok Blackwell Publishing Ltd 2009 Experimental dermatology Vol.18 No.1
<P>Abstract: </P><P>In this study, we investigated the process of X-ray-induced apoptosis of skin keratinocyte, and the functional role of protein kinase C delta (PKC&dgr;) and downstream signalling cascade. High-dose X-ray irradiation (10 Gy) led to the apoptosis of HaCaT keratinocyte, accompanied by PKC&dgr; cleavage. Treatment with PKC&dgr; inhibitor and adenoviral transduction of dominant-negative PKC&dgr; clearly inhibited the X-ray-induced apoptosis of keratinocyte. In addition, X-ray induced the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and inhibition by ERK1/2 inhibitor abrogated the X-ray-induced apoptosis. Interestingly, overexpression of dominant-negative PKC&dgr; markedly blocked the X-ray-induced phosphorylation of ERK1/2, suggesting that ERK1/2 is the functional downstream effector of PKC&dgr;. Next, we investigated the difference between UVB and X-ray response. UVB induced the apoptosis of keratinocyte in a PKC&dgr;-dependent manner, similar to X-ray response. However, UVB irradiation induced the phosphorylation of c-jun N-terminal kinases (JNK) and inhibition of JNK significantly protected the UVB-induced apoptosis. These results demonstrate that PKC&dgr; is a key regulator in X-ray-induced apoptosis of keratinocyte and suggest that there is subtle difference in downstream signalling cascade between UVB and X-ray response of keratinocyte.</P>
Prevalence and antimicrobial susceptibility of Salmonella isolated from Korean slaughter pigs
Lee, Woo-Won,Jung, Byeong-Yeal,Kim, Hong-Tae,Chung, Kyung-Tae,Lee, Gang-Rok,Kim, Keum-Hyang,Lee, Dong-Soo,Kim, Yong-Hwan The Korean Society of Veterinary Service 2003 韓國家畜衛生學會誌 Vol.26 No.4
During the period of December 2000 to November 2001, a total of 419(10.9%) Salmonella was isolated from 3,850 slaughtered pig samples(2,732 lymph nodes and 1,118 caecal contents) in Korea. Three hundred and seventy(13.5%) and 49(4.4%) Salmonella were isolated from lymph nodes and caecal contents, respectively. In the isolation ratio of Salmonella spp originated from each class of season, summer(15.7%), autumn(11.5%), spring(10.0%) and winter(8.3%), in order. As the result of serotyping, B group(67.5%) were the most common, in order of C$_1$(14.6%), D$_1$(6.0%), C$_2$(4.1%) and E$_1$(3.3%). 32 serovars were found, the major serotypes were as follows; S typhimurium(21.7%), S schwarzengrund(16.0%), S derby(15.8%), S typhimurium variant copenhagen(9.8%), S enteritidis (6.0%) and S mbandaka(6.0%). All of the isolates were susceptible to norfloxacin and ofloxacin. The isolates were resistant in order of doxycycline(69.2%), tetracycline(68.7%), penicliin(54.9%) and streptomycin(52.5%).
EWT 태양전지 제작을 위한 레이저 미세 관통홀 가공 기술
이홍구(Lee,Hong-Gu),서세영(Seo,Se-Young),현덕환(Hyun,Deoc-hwan),이용화(Lee,Yong-wha),김강일(Kim,Gang-il),정우원(Jung,Woo-won),이아름(Lee,Ah-Reum),조재억(Cho,Jaee-ock) 한국태양에너지학회 2011 한국태양에너지학회 논문집 Vol.31 No.4
Laser drilling or vias is the one of key technologies in developing Emitter-Wrap Through(EWT) solar cell which is particularly attractive due to the use of industrial processing and common solar grade p-type silicon materials. While alternative economically feasible drilling process is not available to date, the processing time and laser induced damage should be as small as possible in this process. This paper provides an overview on various factors that should be considered in using the laser via drilling technology for developing highly efficient and industrially applicable EWT solar cells.
Prevalence and antimicrobial susceptibility of Salmonella isolated from Korean slaughter pigs
( Woo Won Lee ),( Byeong Yeal Jung ),( Hong Tae Kim ),( Kyung Tae Chung ),( Gang Rok Lee ),( Keum Hyang Kim ),( Dong Soo Lee ),( Yong Hwan Kim ) 한국가축위생학회 2003 韓國家畜衛生學會誌 Vol.26 No.4
During the period of December 2000 to November 2001, a total of 419(10.9%) Salmonella was isolated from 3,850 slaughtered pig samples(2,732 lymph nodes and 1,118 caecal contents) in Korea. Three hundred and seventy(13.5%) and 49(4.4%) Salmonella were isolated from lymph nodes and caecal contents, respectively. In the isolation ratio of Salmonella spp originated from each class of season, summer(15.7%), autumn(11.5%), spring(10.0%) and winter(8.3%), in order. As the result of serotyping, B group(67.5%) were the most common, in order of C1(14.6%), D1(6.0%), C2(4.1%) and E1(3.3%). 32 serovars were found, the major serotypes were as follows; S typhimurium(21.7%), S schwarzengrund(16.0%), S derby(15.8%), S typhimurium variant copenhagen(9.8%), S enteritidis(6.0%) and S mbandaka(6.0%). All of the isolates were susceptible to norfioxacin and ofloxacin. The isolates were resistant in order of doxycycline(69.2%), tetracycline(68.7%), penicliin(54.9%) and streptomycin(52.5%).