Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis

Kang, EH,Moon, KC,Lee, EY,Lee, YJ,Lee, EB,Ahn, C,Song, YW SAGE Publications 2009 Lupus Vol.18 No.1

<P>The aim of the study is to characterize the expression pattern of galectin-3 (Gal-3) in renal tissues of patients with systemic lupus erythematosus (SLE) nephritis and to determine whether tissue and serum Gal-3 are associated with SLE nephritis. Gal-3 expressions were examined with immunohistochemistry in renal biopsy specimens of 88 patients with SLE nephritis and in five normal specimens. Activity and chronicity indexes and glomerular Gal-3 expressions were analysed in each specimen. Serum Gal-3 levels were measured using enzyme-linked immunosorbent assays in 20 patients with SLE, including 11 with nephritis, and in 50 healthy controls. Glomerular Gal-3 expression was observed in 81.8% (72/88) of patients with SLE nephritis but not in 5 controls. Gal-3 staining was attributed mainly to its cellular expression rather than its deposition, and Gal-3 expression levels were correlated with histologic activity indexes, anti-dsDNA titers, and complement 3 and 4 levels. Serum Gal-3 levels were higher in patients with SLE, particularly in those with nephritis, than in healthy controls, and correlated with anti-dsDNA titers. In conclusion, glomerular Gal-3 expression in renal tissue and serum Gal-3 levels were elevated in patients with SLE nephritis versus healthy controls; moreover, they reflected disease activity. These findings suggest that Gal-3 might contribute to the inflammatory process in SLE.</P>

Costs of illness and quality of life in patients with systemic lupus erythematosus in South Korea

Cho, JH,Chang, SH,Shin, NH,Choi, BY,Oh, HJ,Yoon, MJ,Lee, EY,Lee, EB,Lee, TJ,Song, YW SAGE Publications 2014 Lupus Vol.23 No.9

<P><B>Objective</B></P><P>To assess the costs of illness, health-related quality of life (HRQOL) and their associated factors in patients with systemic lupus erythematosus (SLE) in South Korea.</P><P><B>Method</B></P><P>Two hundred and one patients with SLE were enrolled at the Rheumatology clinic of Seoul National University Hospital. Direct, indirect and total costs and HRQOL were measured using hospital electronic data and face-to-face interview. Socio-demographic and clinical factors associated with cost of illness and HRQOL were analyzed using multiple regression and multivariate logistic regression.</P><P><B>Results</B></P><P>The average total cost of illness was estimated to be KRW 9.82 million (US $ 8993) per year, of which 41.6% was accounted for by direct costs and 58.4% by indirect costs. In multivariate regression, patients with renal involvement and those with depression incurred an average increment in annual total costs of 37.6% (<I>p</I> = 0.050) and 49.1% (<I>p</I> = 0.024), respectively, and an average increment in annual direct costs of 26.4% (<I>p</I> = 0.050) and 43.3% (<I>p</I> = 0.002), respectively, compared with patients without renal involvement and depression, respectively. In addition, disease damage was positively associated with an average increment in annual total and direct costs (55.3%, <I>p</I> = 0.006; 33.3%, <I>p</I> = 0.013, respectively), and the occurrence of indirect costs (OR 2.21, 1.09–4.88). There was no significant difference in HRQOL between patients with and without renal involvement (0.655 vs. 0.693, <I>p</I> = 0.203)</P><P><B>Conclusion</B></P><P>Renal involvement, depression, and disease damage were major factors associated with higher total and medical costs for patients with SLE in South Korea. Effective treatment of renal disorders and depression may reduce the high economic burden of SLE.</P>

Novel <i>ITGB6</i> mutation in autosomal recessive amelogenesis imperfecta

Seymen, F,Lee, K-E,Koruyucu, M,Gencay, K,Bayram, M,Tuna, EB,Lee, ZH,Kim, J-W Stockton Press 2015 Oral diseases Vol.21 No.4

<P><B>Objective</B></P><P>Hereditary defects in tooth enamel formation, amelogenesis imperfecta (AI), can be non-syndromic or syndromic phenotype. Integrins are signaling proteins that mediate cell–cell and cell–extracellular matrix communication, and their involvement in tooth development is well known. The purposes of this study were to identify genetic cause of an AI family and molecular pathogenesis underlying defective enamel formation.</P><P><B>Materials and Methods</B></P><P>We recruited a Turkish family with isolated AI and performed mutational analyses to clarify the underlying molecular genetic etiology.</P><P><B>Results</B></P><P>Autozygosity mapping and exome sequencing identified a novel homozygous <I>ITGB6</I> transversion mutation in exon 4 (c.517G>C, p.Gly173Arg). The glycine at this position in the middle of the <I>β</I>I-domain is conserved among a wide range of vertebrate orthologs and human paralogs. Clinically, the enamel was generally thin and pitted with pigmentation. Thicker enamel was noted at the cervical area of the molars.</P><P><B>Conclusions</B></P><P>In this study, we identified a novel homozygous <I>ITGB6</I> mutation causing isolated AI, and this advances the understanding of normal and pathologic enamel development.</P>

직장암의 수술 전 병기 판정의 정확도 : 경직장 초음파 검사와 전산화 단층 촬영과의 비교 연구

천승희,이석환,김광호,박응범 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.5

Effects of Alloying Element Mn on the Microstructure and Physical Properties of Ti-Mn Alloys

Kim JW,Kim MK,Cho JH,Lee EB,Lim JB,Song HJ,Park YJ 대한치과재료학회 2011 대한치과기재학회 학술대회 Vol.2011 No.5

자궁외임신시 혈청 beta-HCG , Progesterone 및 SP1에 관한 연구

조성진,박찬용,박창서,이명아,노은배,한지현 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.12

자궁외임신의 진단을 위한 혈중 SP1의 진단적 의의를 평가하기 위해 정상임신 49예와 자궁외임신 24예를 대상으로 임신 제 5주에서 제 11주의 SP1, -HCG, progesterone치를 이중항체 방사면역측정법으로 측정하여 비교연구 함으로써 다음과 같은 결과를 얻었다. 1. 정상임신군의 연령분포는 20세에서 44세까지로 평균 32.3세이었고, 자궁외 임신군에서는 20세에서 30세까지로 평균 27.6세이었다. 2. 혈중 -HCG측정치(평균치±2표준편차)는 정상임신에서는 임신 제 5주에서 28,741±19,080mIU/ml이었고, 임신이 진행됨에 따라 점차 증가하여 제 10주에 159,185±54,884mIU/ml이었으나, 제 11주에서는 114,068±83,072mIU/ml로 감소하는 양상을 보였다. 그러나 자궁외임신에 있어 혈청 -HCG측정치는 무월경 제 5주에 5,354±3,204mIU/ml, 제 9주에 11,124±7,450mIU/ml로 정상임신에 비해 낮은 수치를 보였다. 3. 혈청 progesterone측정치는 정상임신에 있어 임신 제 5주에 47.96±38.62ng/ml, 임신 제 8주에 48.59±29.12ng/ml로 별다른 증가 양상은 없었고, 제 9주부터는 증가하여 제 11주에 102.76±31.60이었다. 자궁외임신시 혈청 progesterone치는 무월경 제 5주에 22.99±10.52ng/ml, 제 9주에 16.96±1.94ng/ml로 정상임신군보다 낮은 수치를 보였다. 4. SP1도 임신 제 5주에는 0.4±0.24mg/l이었고, 점차 증가하여 제 10주는 8.7±4.80mg/l이었다. 그러나 자궁외임신에 있어서 무월경 제 5주에는 0.033±0.012mh/l, 제 9주에는 0.692±0.210mg/l로 재태기간에 따라 증가하나 정상범위 미만이었다. 5. 혈청 -HCG, progesterone 및 SP1의 예측치는 각각 73.1%, 80.0%, 80.8%이었고, 예민도는 79.2%, 83.3%, 87.5%였으며, 정확도는 85.7%, 89.8%, 89.8%이었다. The ectopic pregnancy has recently become one of the most important issues in obstetrics. The development of diagnostic method, such as, untrasonogram, serial serum beta-HCG measurement has made a great contribution to the treatment of ectopic pregnancies. In order to investigate the various hormonal factors of ectopic pregnancy and contribute to prevention of infertility thereafter, retrospective studies were made on serum beta-HCG, progesterone, and SPI values of 24 cases of ectopic pregnancy, which was diagnosed by biopsy of surgical specimen. The results were obtained as follows. 1. The age in normal pregnancy were ranged from 20 to 44 years and mean age was 32.3 years, but the age in ectopic pregnancy were ranged from 20 to 40 years and mean age was 27.6years. 2. Serum beta-HCG values(mean ±2SD) in normal pregnancy were 24,741±19,080mIU/ml, 159,185±54,884mIU/ml at 5th and 10th weeks of gestational age. But in ectopic pregnancy, 5,354±3,204mIU/ml, 11,124±7,450mIU/ml at 5th and 9th weeks of gestational age. 3. Serum progesterone values in normal pregnancy were 47.96±38.62ng/ml, 97.83±12.62ng/ml at 5th and 10th weeks of gestational age. But in ectopic pregnancy, 22.99±10.52ng/ml and 16.96±1.94ng/ml at 5th and 9th weeks of gestational age. 4. Serum SP1 values in normal pregnancy were 0.4±0.24mg/1,8.7±4.80mg/1 at 5th and 10th weeks of gestational age. But in ectopic pregnancy, 0.033±0.012mg/1, 0.692±0.210mg/1 at 5th and 9th weeks of gestational age. 5. Predictive value, sensitivity, and specificity of serum beta-HCG in ectopic pregnancy were 73.1%, 79.2% and 85.7%. 6. Predictive value, sensitivity, and specificity of progesterone in ectopic pregnancy were 80.0%, 83.3% and 89.8%, respectively. 7. Predictiv value, sensitivity, and specificity of serum SPI were 80.0%, 87.5% and 89.8%, respectively.

Noble gas studies of lunar meteorites MIL 090034, MIL 090036, and MIL 090070

Jisun Park,Keisuke Nagao,Jisu Choi,Jong Min Baek,Changkun Park,Jong Ik Lee,Mi Jung Lee,Laurence E. Nyquist,Gregory F. Herzog,Brent D. Turrin,Akira Yamaguchi,Michael K. Weisberg,Naoki Shirai,Mitsuru Eb 대한지질학회 2018 대한지질학회 학술대회 Vol.2018 No.10