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Lee, Hong Jae,Kim, Sung Eun,Kwon, Il Keun,Park, Chiyoung,Kim, Chulhee,Yang, Jaemoon,Lee, Sang Cheon Royal Society of Chemistry 2010 Chemical communications Vol.46 No.3
<P>Polymer micelles with bioabsorbable mineralized calcium phosphate nanoshells have been synthesized and demonstrated to be robust nanocarriers for efficient intracellular drug delivery.</P> <P>Graphic Abstract</P><P>Formation of CaP nanoshells greatly enhanced the robustness of polymer micelles, and the dissolution of CaP nanoshells in lysosomal environments facilitated the release of entrapped anticancer drugs. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b913732g'> </P>
Lee, Chulhee,Kim, Kyudong,Lee, Hyuk-Jae Elsevier 2018 Displays Vol.55 No.-
<P><B>Abstract</B></P> <P>This paper presents a novel algorithm to classify complex-rendered text images by examining the color levels of the adjacent sub-pixels. The proposed algorithm is different from the previous approaches in that it uses the combined characteristics of RGB sub-channels, whereas the previous approaches use independent characteristics of RGB sub-channels. Experimental results demonstrate that the proposed algorithm improves the classification accuracy over the previous best algorithm by 15.9% for complex-rendered texts. Furthermore, the compression method optimized for text sub-images significantly reduces the computational complexity without degradation in compression efficiency.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This paper presents a novel algorithm to classify complex-rendered text images. </LI> <LI> The proposed algorithm uses the combined characteristics of RGB sub-channels. </LI> <LI> The classification accuracy is improved by 15.9% for complex-rendered texts. </LI> <LI> The computational complexity is reduced without compression efficiency degradation. </LI> </UL> </P>
Lee, Jeonghun,Kim, Hyunmi,Han, Songyi,Hong, Eunjung,Lee, Keun-Hyeung,Kim, Chulhee American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.37
<P>The use of peptides as gatekeepers for payloads of mesoporous silica nanoparticles would allow triggering the release of guests by various biological stimuli. We investigated the effect of peptide conformation on their gatekeeping capability by employing two model peptides with a turn or a random structure. The conformation-dependent gatekeeping properties provided an opportunity to utilize the conformational conversion of peptides as a valuable motif for stimuli-responsive gatekeepers. Based on that investigation, we demonstrated that Fmoc-CGGC-SS-Si, which exhibited a zero-release property without any stimuli due to a turn-like conformation induced by the intramolecular disulfide bond, can be triggered to release guests by converting its conformation to a random structure, induced by reduction of the disulfide bond upon addition of glutathione. We further demonstrated that the conformational conversion of Fmoc-CGGC by Zn(II) ion can also be utilized as a triggering motif.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-37/ja507767h/production/images/medium/ja-2014-07767h_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja507767h'>ACS Electronic Supporting Info</A></P>
Lee, Keun Woo,Maeng, Jin-Soo,Choi, Jeong Yi,Lee, Yu Ran,Hwang, Chae Young,Park, Sung Sup,Park, Hyun Kyu,Chung, Bong Hyun,Lee, Seung-Goo,Kim, Yeon-Soo,Jeon, Hyesung,Eom, Soo Hyun,Kang, ChulHee,Kim, Do American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.3
Chulhee Lee,Chae Eun Rhee,Hyuk-Jae Lee Institute of Electrical and Electronics Engineers 2017 IEEE transactions on circuits and systems for vide Vol.27 No.10
<P>Scale-invariant feature transform (SIFT) is one of the most widely used local features for computer vision in mobile devices. A mobile graphic processing unit (GPU) is often used to run computer-vision applications using SIFT features, but the performance in such a case is not powerful enough to generate SIFT features in real time. This paper proposes an efficient scheme to optimize the SIFT algorithm for a mobile GPU. It analyzes the conventional scale-space construction step in the SIFT generation, finding that reducing the size of the Gaussian filter and the scale-space image leads to a significant speedup with only a slight degradation of the quality of the features. Based on this observation, the SIFT algorithm is modified and implemented for real-time execution. Additional optimization techniques are employed for a further speedup by efficiently utilizing both the CPU and the GPU in a mobile processor. The proposed SIFT generation scheme achieves a processing speed of 28.30 frames/s for an image with a resolution of 1280 x 720 running on a Galaxy S5 LTE-A device, thereby gaining a speedup by the factors of 114.78 and 4.53 over CPU-and GPU-only implementations, respectively.</P>
Lee, Jeonghun,Kim, Hyunjung,Kim, Seahee,Lee, Hyemi,Kim, Jin,Kim, Namkug,Park, Heon Joo,Choi, Eun Kyoung,Lee, Jin Seong,Kim, Chulhee The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.28
<P>We report on the dual function of a silica–iron oxide hybrid nanoparticle combined with a stimulus responsive gatekeeper on the surface. Multifunctional hybrid nanoparticles (Fe@Si–DOX–CD–PEG) composed of an Fe<SUB>3</SUB>O<SUB>4</SUB> core, a mesoporous silica shell, and GSH-responsive CD gatekeepers are an excellent platform for anticancer drug delivery and MR imaging. In particular, the CD gatekeepers on the surface of the hybrid nanoparticle play a key role in accommodating anticancer drug molecules in the pore of the silica shell without premature release until CD gatekeepers are cleaved by GSH. We confirmed, from an <I>in vitro</I> study with the A549 cell line, that DOX was released from the internalized carriers due to GSH-mediated cleavage of the CD gatekeeper. Consequently, apoptotic and clonogenic death occurred in the cells treated with Fe@Si–DOX–CD–PEG. The accumulation of Fe@Si–DOX–CD–PEG in the tumors was detected by <I>in vivo</I> MR imaging. The growth of the tumor <I>in vivo</I> was effectively suppressed by the intravenously injected Fe@Si–DOX–CD–PEG. In addition, the results of the <I>in vivo</I> MR imaging reflected the <I>in vivo</I> inhibition of the cancer growth by Fe@Si–DOX–CD–PEG.</P> <P>Graphic Abstract</P><P>Multimodal hybrid nanoparticles composed of a Fe<SUB>3</SUB>O<SUB>4</SUB> core, a mesoporous silica shell, and GSH-responsive CD gatekeepers are an excellent theranostic platform for MR imaging and anticancer drug delivery not only <I>in vitro</I> but also <I>in vivo</I>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm32137h'> </P>
Changing Industrial Structure and Economic Activity of Older Males in Korea: 1980-2000
Chulhee Lee 서울대학교 경제연구소 2004 Seoul journal of economics Vol.17 No.2
This article examines how long-term changes in the industrial structure in Korea affected the economic activity of older males. The structural shift in industry between 1980 and 2000 greatly lowered the average labor market survival rate, a measure of employment stability, for male workers aged 55 and older. In particular, the relative decline of the agricultural sector fully explains the observed impact of the sectoral shift on the employment of the elderly. The labor force participation rate of older men would have been much higher if the percentage of the labor force employed in agriculture had remained unchanged since 1980. It is estimated that the shrinkage of agriculture explains 84% of the actual decline in the labor force participation rate of men aged 55 to 69 between 1985 and 2000. These results suggest that changing industrial structure, especially the decline in agriculture, could produce a further decline in the labor market activity of older men in the near future. It also points out the limitations of the recent government labor-market policies to boost the employment of older workers, because it is highly difficult, and sometimes undesirable, to alter the course of long-term structural economic changes that diminish the economic activity of the elderly.