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- 저자 : Kranthi, Sandhya (검색결과 10 건)
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Kranthi Kumar Deveerasetty,Yimin Zhou 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
The paper proposes two different controllers for tracking control of a quadrotor. An Euler-Lagrange formulation is used to drive the dynamic mathematical model of a quadrotor. To illustrate the advantages of the proposed controllers and for simplicity, all the aerodynamics, Coriolis, drags and gyroscopic effect are abandoned. A PID controller with derivative filter is proposed for the position tracking of the quadrotor here. The advantage of the proposed PID controller include easiness of implementation, effectuate higher stability and less dependent on the system model. The integral sliding-mode controller is proposed to obtain the desired attitude angles for the quadrotor tracking and its advantage is unaffected by the system model errors. The designed controllers can stabilize the roll, pitch, and yaw angles and make the quadrotor to move (x; y; z) positions to their desired values. The Lyapunovs theorem is useful to obtain the quadrotor controllers and also ensure the system track to attain and maintain on the sliding surfaces. The validation of results has been tested in MATLAB simulation and exhibits adequate performance.
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Grapefruit Juice Modulates Bone Quality in Rats
Farzad Deyhim,Kranthi Mandadi,Bahram Faraji,Bhimanagouda S. Patil 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
Hypogonadism and oxidative stress increase the risk for developing osteoporosis. The objective of this researchwas to evaluate the efficacy of drinking grapefruit juice on bone quality in orchidectomized (ORX) and non-ORX rats. Fifty-six 90-day-old male Sprague-Dawley rats were equally divided into four groupsnon-ORX rats (sham), sham. grapefruitjuice, ORX, and ORX. grapefruit juiceand treated for 60 days. Thereafter, all rats were sacrificed to determine the plasmaantioxidant status, insulin-like growth factor I (IGF-I), and indices of bone turnover, bone quality, and calcium and magne-sium concentrations in the bone, urine, and feces. Orchidectomy decreased (P. .05) antioxidant status, bone quality, andbone mineral contents and increased (P. .05) indices of bone turnover, urinary deoxypridinoline, calcium, and magnesium,and fecal calcium excretions. In contrast to the ORX group, ORX rats that drank grapefruit juice had an increase (P. .05)in antioxidant status, bone density, and bone mineral contents, delayed femoral fracture, and slowed down (P. .05) boneturnover rate and tended to have a decrease (P. .08) in urinary deoxypridinoline. In sham-treated animals, drinking grape-fruit juice increased (P. .05) bone density and tended to increase the femoral strength. The concentration of IGF-I in theplasma was not affected across treatments. In conclusion, drinking grapefruit juice positively affected bone quality by en-hancing bone mineral deposition in ORX rats and by improving bone density in non-ORX rats via an undefined mechanism.
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Detection of High-Risk Human Papillomaviruses in the Prevention of Cervical Cancer in India
Baskaran, Krishnan,Kumar, P Kranthi,Karunanithi, Santha,Sethupathy, Subramanian,Thamaraiselvi, B,Swaruparani, S Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Human papillomaviruses (HPVs) are small, non-enveloped, double-stranded DNA viruses that infect epithelial tissues. Specific genotypes of human papillomavirus are the single most common etiological agents of cervical intraepithelial lesions and cervical cancer. Cervical cancer usually arises at squamous metaplastic epithelium of transformation zone (TZ) of the cervix featuring infection with one or more oncogenic or high-risk HPV (HR-HPV) types. A hospital-based study in a rural set up was carried out to understand the association of HR-HPV with squamous intraepithelial lesions (SILs) and cervical cancer. In the present study, HR-HPV was detected in 65.7% of low-grade squamous intraepithelial lesions (LSILs), 84.6% of high-grade squamous intraepithelial lesions (HSILs) and 94% of cervical cancer as compared to 10.7% of controls. The association of HPV infection with SIL and cervical cancer was analyzed with Chi square test (p<0.001). The significant association found confirmed that detection of HR-HPV is a suitable candidate for early identification of cervical precancerous lesions and in the prevention of cervical cancer in India.
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van Rosendael, Alexander R.,Maliakal, Gabriel,Kolli, Kranthi K.,Beecy, Ashley,Al’Aref, Subhi J.,Dwivedi, Aeshita,Singh, Gurpreet,Panday, Mohit,Kumar, Amit,Ma, Xiaoyue,Achenbach, Stephan,Al-Mallah, Mou Elsevier 2018 Journal of cardiovascular computed tomography Vol.12 No.3
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores.</P> <P><B>Methods</B></P> <P>From the multi-center CONFIRM registry, patients were included with complete CCTA risk score information and ≥3 year follow-up for myocardial infarction and death (primary endpoint). Patients with prior coronary artery disease were excluded. Conventional CCTA risk scores (conventional CCTA approach, segment involvement score, duke prognostic index, segment stenosis score, and the Leaman risk score) and a score created using ML were compared for the area under the receiver operating characteristic curve (AUC). Only 16 segment based coronary stenosis (0%, 1–24%, 25–49%, 50–69%, 70–99% and 100%) and composition (calcified, mixed and non-calcified plaque) were provided to the ML model. A boosted ensemble algorithm (extreme gradient boosting; XGBoost) was used and the entire data was randomly split into a training set (80%) and testing set (20%). First, tuned hyperparameters were used to generate a trained model from the training data set (80% of data). Second, the performance of this trained model was independently tested on the unseen test set (20% of data).</P> <P><B>Results</B></P> <P>In total, 8844 patients (mean age 58.0 ± 11.5 years, 57.7% male) were included. During a mean follow-up time of 4.6 ± 1.5 years, 609 events occurred (6.9%). No CAD was observed in 48.7% (3.5% event), non-obstructive CAD in 31.8% (6.8% event), and obstructive CAD in 19.5% (15.6% event). Discrimination of events as expressed by AUC was significantly better for the ML based approach (0.771) vs the other scores (ranging from 0.685 to 0.701), P < 0.001. Net reclassification improvement analysis showed that the improved risk stratification was the result of down-classification of risk among patients that did not experience events (non-events).</P> <P><B>Conclusion</B></P> <P>A risk score created by a ML based algorithm, that utilizes standard 16 coronary segment stenosis and composition information derived from detailed CCTA reading, has greater prognostic accuracy than current CCTA integrated risk scores. These findings indicate that a ML based algorithm can improve the integration of CCTA derived plaque information to improve risk stratification.</P>
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Arup Kumar Mukherjee,Prasun Kumar Mukherjee,Sandhya Kranthi 한국식물병리학회 2016 Plant Pathology Journal Vol.32 No.6
The cotton leafroll dwarf virus (CLRDV) is one of themost devastating pathogens of cotton. This malady,known as cotton blue disease, is widespread in SouthAmerica where it causes huge crop losses. Recentlythe disease has been reported from India. We noticedoccurrence of cotton blue disease and chickpea stuntdisease in adjoining cotton and chickpea fields and gotinterested in knowing if these two viral diseases havesome association. By genetic studies, we have shownhere that CLRDV is very close to chickpea stunt diseaseassociated virus (CpSDaV). We were successfulin transmitting the CLRDV from cotton to chickpea. Our studies indicate that CpSDaV and CLRDV in Indiaare possibly two different strains of the same virus. These findings would be helpful in managing theseserious diseases by altering the cropping patterns.
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Mukherjee, Arup Kumar,Mukherjee, Prasun Kumar,Kranthi, Sandhya The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.6
The cotton leafroll dwarf virus (CLRDV) is one of the most devastating pathogens of cotton. This malady, known as cotton blue disease, is widespread in South America where it causes huge crop losses. Recently the disease has been reported from India. We noticed occurrence of cotton blue disease and chickpea stunt disease in adjoining cotton and chickpea fields and got interested in knowing if these two viral diseases have some association. By genetic studies, we have shown here that CLRDV is very close to chickpea stunt disease associated virus (CpSDaV). We were successful in transmitting the CLRDV from cotton to chickpea. Our studies indicate that CpSDaV and CLRDV in India are possibly two different strains of the same virus. These findings would be helpful in managing these serious diseases by altering the cropping patterns.
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Farzad Deyhim,Cheri Gonzales,Claudia Garcia,Arnulfo Villarreal,Kristi Garcia,Ryan Rios,Kranthi Mandadi,Bhimanagouda S. Patil 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.3
Vitamin E is known to improve antioxidant status and to prevent lipoprotein oxidation. However, the effectof vitamin E on other cardiovascular risk factors, including C-reactive protein (CRP) and lipid profile status, in orchiectomizedrats is unknown. In the present study, 32 1-year-old male rats were randomized into two groups: a sham-control group (n .8) and an orchiectomized group (n . 24). The orchiectomized group was divided into three groups of eight and assigned toone of the following treatments: orchiectomy (ORX), ORX . vitamin E mixture (65.6 mg/kg) diet, or ORX . vitamin Emixture (656 mg/kg) diet. For 120 days all four groups consumed a basal AIN-93M diet, while the vitamin E groups ate di-ets containing an additional vitamin E mixture. Four months after the study began, all the rats were killed, the blood was col-lected, and the plasma was assayed for antioxidant status, CRP, lipid profile, and indices of peroxidation. ORX decreased(P. .05) the plasma antioxidant status, superoxide dismutase (SOD) activity, and CRP level and increased (P. .05) theplasma malondialdeyde, nitrite, and lipid profile compared with that of the sham-control group. In contrast to the ORX group,supplementation with vitamin E mixture increased (P. .05) plasma antioxidant status and dose-dependently increased (P..05) SOD activity, while the vitamin E decreased (P. .05) plasma malondialdeyde and nitrite. The vitamin E mixture hadno effect on CRP or on lipid profiles when compared to the orchiectomized rats. In conclusion, vitamin E appears to reduceoxidative stress without modulating lipid profile or inflammatory response.
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Choi Jae-Han,Oh Eun-Seok,Min Hansol,Chae Won Byoung,Mandadi Kranthi Kiran,Oh Man-Ho 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: Brassinosteroids (BRs), a group of plant growth hormones, control biomass accumulation and biotic and abiotic stress tolerance, and therefore are highly relevant to agriculture. BRs bind to the BR receptor protein, brassinosteroid insensitive 1 (BRI1), which is classified as a serine/threonine (Ser/Thr) protein kinase. Recently, we reported that BRI1 acts as a dual-specificity kinase both in vitro and in vivo by undergoing autophosphorylation at tyrosine (Tyr) residues. Objective: In this study, we characterized the increased leaf growth and early flowering phenotypes of transgenic lines expressing the mutated recombinant protein, BRI1(Y831F)-Flag, compared with those expressing BRI1-Flag. BRI1(Y831F)-Flag transgenic plants showed a reduction in hypocotyl and petiole length compared with BRI1-Flag seedlings. Transcriptome analysis revealed differential expression of flowering time-associated genes (AP1, AP2, AG, FLC, and SMZ) between BRI1(Y831F)-Flag and BRI1-Flag transgenic seedlings. We also performed site-directed mutagenesis of the BRI1 gene, and investigated the effect of methionine (Met) substitution in the extracellular domain (ECD) of BRI1 on plant growth and BR sensitivity by evaluating hypocotyl elongation and root growth inhibition. Methods: The pBIB-Hyg+-pBR-BRI1-Flag construct(Li et al. 2002) was used as the template for SDM with QuickChange XL Site Directed Mutagenesis Kit (Stratagene, La Jolla, CA, USA) to make the SDM mutants. After PCR with SDM kit, add 1 μl of Dpn1 to PCR reaction. Incubate at 37 °C for 2 h to digest parental DNA and then transformed into XL10-gold competent cells. Transcriptome analysis was carried out at the University of Illinois (Urbana-Champaign, Illinois, USA). RNA was prepared and hybridized to the Affymetrix GeneChip Arabidopsis ATH1 Genome Array using the Gene Chip Express Kit (Ambion, Austin, TX, USA). Results: Tyrosine 831 autophosphorylation of BRI1 regulates Arabidopsis flowering time, and mutation of methionine residues in the extracellular domain of BRI1 affects hypocotyl and root length. BRI1(M656Q)-Flag, BRI1(M657Q)-Flag, and BRI1(M661Q)-Flag seedlings were insensitive to the BL treatment and showed no inhibition of root elongation. However, BRI1(M665Q)-Flag and BRI1(M671Q)-Flag seedlings were sensitive to the BL treatment, and exhibited root elongation inhibition. the early flowering phenotype of BRI1(Y831F)-Flag transgenic plants is consistent with the expression levels of key flowering-related genes, including those promoting flowering (AP1, AP2, and AG) and repressing flowering (FLC and SMZ).
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Farzad Deyhim,Bhimanagouda S. Patil,Arnulfo Villarreal,Erica Lopez,Kristi Garcia,Ryan Rios,Claudia Garcia,Cheri Gonzales,Kranthi Mandadi 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Oxidative stress and hypogonadism are linked to the increased incidence of cardiovascular disease in males.The objective of this research was to delineate whether drinking cranberry juice for 4 months affects antioxidant capacity andlipid profile in orchidectomized rats. Thirty-two 1-year-old male rats were randomized to two groups: a sham-control group(n . 8) and an orchidectomized group (n . 24). The orchidectomized group was divided into three groups of eight and as-cranberry juice. At 120 days after initiation of the study, all rats were killed, blood was collected, and plasma was harvestedfor total antioxidant status, malondialdehyde, nitrate. nitrite, and superoxide dismutase (SOD) activity in liver, and concen-trations of cholesterol and triglyceride in liver and in plasma. Orchidectomy depressed (P. .05) plasma antioxidant capac-ity and SOD activity, elevated (P. .05) nitrate. nitrite and malondialdehyde in plasma, and increased (P. .05) triglycerideand cholesterol values in liver and in plasma. Cranberry juice increased (P. .05) plasma antioxidant capacity and SOD ac-P. .05) nitrate. nitrite and malondialdehyde concentrations. Drinking cranberry juice did not affect cho-lesterol concentrations in liver and in plasma. Triglyceride concentration in plasma of orchidectomized rats that were drink-ing cranberry juice increased (P. .05), but its concentration in liver decreased (P. .05) to the level of shams. The protectiveeffect of cranberry juice from oxidative damage may be mediated by a decrease in nitrate. nitrite and dose-dependent de-crease in peroxidation.
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