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      • Noise Reduction and Signal Enhancement in IVR Images by ICA Shrinkage Filters and Multiscale Filters

        Kiyotaka Matsuo,Xianhua Han,Koichi Shibata,Yukio Mishina,Yoshihiro Mukuta,Yen-Wei Chen 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7

        Interventional Radiology (IVR) is an important technique to visualize and diagnosis the vascular disease. In real medical application, a weak x-ray radiation source is used for imaging in order to reduce the radiation dose, resulting in a low contrast noisy image. It is important to develop a method to smooth out the noise while enhance the vascular structure. In this paper, we propose to combine an ICA Shrinkage filter with a multiscale filter for enhancement of IVR images. The ICA shrinkage filter is used for noise reduction and the multiscale filter is used for enhancement of vascular structure. Experimental results show that the quality of the image can be dramatically improved without any blurring in edge by the proposed method. Simultaneous noise reduction and vessel enhancement have been achieved.

      • KCI등재

        Magnetic Properties of the Frustrated Magnet Cu5(PO4)3(OH)4 on a Peculiar Spin Network Composed of Pentagons and Triangles

        Hikomitsu Kikuchi,Nguyen Thi Tinh Y,Yutaka Fujii,Akira Matsuo,Koichi Kindo 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12

        Orthorombic Cu5(PO4)3(OH)4 (pseudomalachite) is a layered compound. Each Cu-O layer in thiscompound is separated by PO4 tetrahedra. The spin network in the bc-plane of a pseudomlachite iscomposed of triangles and pentagons, which will induce the spin frustration effect. This network maybe a new type of geometrically frustrated spin lattice. Magnetic susceptibility, specific heat, highfield magnetization measurements are used to study the magnetic properties of Cu5(PO4)3(OH)4 innatural mineral samples. Magnetic ordering is observed at around 4.2 K. The spin entropy changeat the transition temperature is about one-fifth times smaller than that expected for a usual longrangeorder. A 1/5 magnetization plateau is observed in the high-field magnetization curve. Theplateau is explained based on a simple model in which the spin network is assumed to be composedof chain, dimer and monomer units.

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        The Association of Fever with Total Mechanical Ventilation Time in Critically Ill Patients

        박동원,Moritoki Egi,Masaji Nishimura,장유진,서기영,임채만,김재열,Keiichi Tada,Koichi Matsuo,Shinhiro Takeda,Ryosuke Tsuruta,Takeshi Yokoyama,김선옥,고윤석 대한의학회 2016 Journal of Korean medical science Vol.31 No.12

        This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study. We included mechanically ventilated patients for more than 24 hours from 10 Korean and 15 Japanese intensive care units (ICU), and recorded maximal body temperature under the support of mechanical ventilation (MAXMV). To assess the independent association of MAXMV with TVT, we used propensity-matched analysis in a total of 769 survived patients with medical or surgical admission, separately. Together with multiple linear regression analysis to evaluate the association between the severity of fever and TVT, the effect of MAXMV on ventilator-free days was also observed by quantile regression analysis in all subjects including non-survivors. After propensity score matching, a MAXMV ≥ 37.5°C was significantly associated with longer mean TVT by 5.4 days in medical admission, and by 1.2 days in surgical admission, compared to those with MAXMV of 36.5°C to 37.4°C. In multivariate linear regression analysis, patients with three categories of fever (MAXMV of 37.5°C to 38.4°C, 38.5°C to 39.4°C, and ≥ 39.5°C) sustained a significantly longer duration of TVT than those with normal range of MAXMV in both categories of ICU admission. A significant association between MAXMV and mechanical ventilator-free days was also observed in all enrolled subjects. Fever may be a detrimental factor to prolong TVT in mechanically ventilated patients. These findings suggest that fever in mechanically ventilated patients might be associated with worse mechanical ventilation outcome.

      • The mechanism of osteoclast differentiation induced by IL-1.

        Kim, Jung Ha,Jin, Hye Mi,Kim, Kabsun,Song, Insun,Youn, Bang Ung,Matsuo, Koichi,Kim, Nacksung Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.3

        <P>IL-1 is a potent cytokine that can induce bone erosion in inflammatory sites such as rheumatoid joint regions via activation of osteoclasts. Not only is IL-1 capable of activating osteoclasts, but it is also a key cytokine involved in the differentiation, multinucleation, and survival of osteoclasts. Herein, we show that IL-1 has the potential to drive osteoclast differentiation via a receptor activator of NF-kappaB ligand (RANKL)/RANK-independent mechanism. Although IL-1 has a synergistic effect on RANKL-induced osteoclast formation, IL-1 alone cannot induce osteoclast differentiation from osteoclast precursors (bone marrow-derived macrophages (BMMs)) due to a lack of IL-1 signaling potential in these cells. However, we demonstrate that overexpression of the IL-1RI receptor in BMMs or induction of IL-1RI by c-Fos overexpression enables IL-1 alone to induce the formation of authentic osteoclasts by a RANKL/RANK-independent mechanism. The expression of IL-1RI is up-regulated by RANKL via c-Fos and NFATc1. Furthermore, the addition of IL-1 to IL-1RI overexpressing BMMs (IL-1/IL-1RI) strongly activates NF-kappaB, JNK, p38, and ERK which is a hallmark gene activation profile of osteoclastogenesis. Interestingly, IL-1/IL-1RI does not induce expression of c-Fos or NFATc1 during osteoclast differentiation, although basal levels of c-Fos and NFATc1 seem to be required. Rather, IL-1/IL-1RI strongly activates MITF, which subsequently induces osteoclast-specific genes such as osteoclast-associated receptor and tartrate-resistant acid phosphatase. Together, these results reveal that IL-1 has the potential to induce osteoclast differentiation via activation of microphthalmia transcription factor under specific microenvironmental conditions.</P>

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