전국체육대회 시민 참여 활성화 방안

김응식,안재오,김옥주 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-

The Possibility holding the National Games in this area is arithmetically adout inthervals of fifteen-year. All the areas which hold National Games reconstruct the sports infrastructure, using this opportunity, do up the existing facilities nawly and cultivate men of ability who can manage the National Games. Also the city government double-checks the accomodations and reeducates the related workers to strengthen a defect. And all the citizens participate in the National Games systematically and non-systematically. The National Games is an open space with wide latitude that promotes huge cultura exchange among parents of students, staffs, tourists, teams of each city and overseas teams. Making the 88th Gwangju National Games in 2007 of an opportunity, Gwangju also should show widely the mettle as the city for the citizens, the city of culture, the first Gwangju and the first citizens.

병적 담낭 상피세포내 점액질의 조직화학적 관찰

이희래,김순희,조정실,김옥경 梨花女子大學校 醫科大學 醫科學硏究所 1978 EMJ (Ewha medical journal) Vol.1 No.1

The present study was performed to evaluate the histochemical properties of epithelial mucins in diseased gallbladders. 18 gallbladder specimens were selected in which metaplastic goblet cells had been observed. Of the specimens 9 were gallstone and 9 cholecystitis. For microscopic examination, tissues were sectioned at a thickness 5μm, and were stained with following histochemical techniques: Alcian blue at pH 1.0 or 2.5^13) and periodic acid Schiff's reaction (PAS).^12) Observed results were as follows: 1) In ordinary gallbladder the epithelial cells showed a predominance of sulphated mucosubstance. 2) In many case of cholelithiasis a typical goblet-typed epithelial cells were found in the top of folds. In large goblet cell area the relative proportion of sulphated acid mucin decreased and correspondingly non-sulphated acid mucin increased. 3) In the case of cholecystitis the intracellular mucin of high columnar epithelium predominated in the deep area of folds. 4) The neutral mucin predominated in the surface epithelium of gallbladder under pathological condition.

말하기·읽기 능력 향상을 위한 효율적인 읽기 자료 개발

유정숙,Busbee, E.,김은실,이정숙,황규삼,노옥자 전주대학교 교육문제연구소 2000 敎育論叢 Vol.15 No.-

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the <i>SLCO1B1</i> or <i>CYP2C9</i> genetic polymorphism affect these drug interactions?

Kim, Choon Ok,Oh, Eun Sil,Kim, Hohyun,Park, Min Soo Dove Medical Press 2017 Drug design, development and therapy Vol.11 No.-

<P>To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed to evaluate the pharmacokinetic (PK) interactions between these two drugs in healthy males and to explore the effect of <I>SLCO1B1</I> and <I>CYP2C9</I> polymorphisms on their interactions in two randomized, open-label crossover studies. Glimepiride was studied in part 1 and rosuvastatin in part 2. Twenty-four participants were randomly assigned to each part. All subjects (n=24) completed part 1, and 22 subjects completed part 2. A total of 38 subjects among the participants of the PK interaction studies were enrolled in the genotype study to analyze their <I>SLCO1B1</I> and <I>CYP2C9</I> polymorphisms retrospectively (n=22 in part 1, n=16 in part 2). Comparison of the PK and safety of each drug alone with those of the drugs in combination showed that both glimepiride and rosuvastatin did not interact with each other and had tolerable safety profiles in all subjects. However, with regard to glimepiride PK, the <I>SLCO1B1 521TC</I> group had a significantly higher maximum plasma concentration (C<SUB>max,ss</SUB>) and area under the plasma concentration–time curve during the dose interval at steady state (AUC<SUB>τ,ss</SUB>) for glimepiride in combination with rosuvastatin than those for glimepiride alone. However, other significant effects of the <I>SLCO1B1</I> or <I>CYP2C9</I> polymorphism on the interaction between the two drugs were not observed. In conclusion, there were no significant PK interactions between the two drugs; however, the exposure to glimepiride could be affected by rosuvastatin in the presence of the <I>SLCO1B1</I> polymorphism.</P>

Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells

Kim, Min Joo,Choi, Ok Kyong,Chae, Kyung Sil,Kim, Min Kyeong,Kim, Jung Hee,Komatsu, Masaaki,Tanaka, Keiji,Lee, Hakmo,Chung, Sung Soo,Kwak, Soo Heon,Cho, Young Min,Park, Kyong Soo,Jung, Hye Seung Korean Endocrine Society 2015 Endocrinology and metabolism Vol.30 No.1

<P><B>Background</B></P><P>Damaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells. Here, we investigated mitochondrial function and the expression of mitochondrial complexes in autophagy-related 7 (<I>Atg7</I>)-deficient β-cells.</P><P><B>Methods</B></P><P>To evaluate the effect of autophagy deficiency on mitochondrial function in pancreatic β-cells, we isolated islets from <I>Atg7</I><SUP>F/F</SUP>:RIP-<I>Cre</I>+ mice and wild-type littermates. Oxygen consumption rate and intracellular adenosine 5'-triphosphate (ATP) content were measured. The expression of mitochondrial complex genes in <I>Atg7</I>-deficient islets and in β-TC6 cells transfected with si<I>Atg7</I> was measured by quantitative real-time polymerase chain reaction.</P><P><B>Results</B></P><P>Baseline oxygen consumption rate of <I>Atg7</I>-deficient islets was significantly lower than that of control islets (<I>P</I><0.05). Intracellular ATP content of <I>Atg7</I>-deficient islets during glucose stimulation was also significantly lower than that of control islets (<I>P</I><0.05). By Oxygraph-2k analysis, mitochondrial respiration in <I>Atg7</I>-deficient islets was significantly decreased overall, although state 3 respiration and responses to antimycin A were unaffected. The mRNA levels of mitochondrial complexes I, II, III, and V in <I>Atg7</I>-deficient islets were significantly lower than in control islets (<I>P</I><0.05). Down-regulation of <I>Atg7</I> in β-TC6 cells also reduced the expression of complexes I and II, with marginal significance (<I>P</I><0.1).</P><P><B>Conclusion</B></P><P>Impairment of autophagy in pancreatic β-cells suppressed the expression of some mitochondrial respiratory complexes, and may contribute to mitochondrial dysfunction. Among the complexes, I and II seem to be most vulnerable to autophagy deficiency.</P>

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

Kim, Choon Ok,Oh, Eun Sil,Choi, Chungam,Kim, Yeonjoo,Lee, Sera,Kim, Semi,Park, Min Soo Dove Medical Press 2016 Drug design, development and therapy Vol.10 No.-

<P>CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. We investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult subjects. A randomized, double-blinded, placebo-controlled, single ascending dose study was performed. Eight healthy subjects were enrolled in each CKD-519 dose group (25, 50, 100, 200, or 400 mg) and randomized to CKD-519 (n=6) or matching placebo (n=2). CKD-519 reached the maximum plasma concentration (C<SUB>max</SUB>) at 5–6 h post-dose, and had a long terminal half-life ranging between 40–70 h. The area under the plasma concentration–time curve (AUC) and C<SUB>max</SUB> increased with the dose, however, C<SUB>max</SUB> and AUC normalized by dose decreased with each incremental dose. CETP activity decreased with dose, and the maximum decrease (63%–83%) was observed at 6–8 h post-dose. A sigmoid E<SUB>max</SUB> model best described the relationship between CKD-519 plasma concentrations and CETP activity with an EC<SUB>50</SUB> of 17.3 ng/mL. Overall, 11 adverse events (AEs) were observed. All AEs were mild or moderate in intensity, and resolved without any complications. There were no clinically significant effects on blood pressure. In conclusion, single doses of CKD-519 up to 400 mg were well tolerated and showed potent inhibition of CETP activity.</P>

Performance review of the National Blood Safety Improvement Project in Korea (2004-2009)

Kim, Sinyoung,Kim, Hyun Ok,Kim, Moon Jung,Lee, Sang Won,Shin, Young Hack,Choi, Young Sil,Lee, Dong Han Korean Society of Hematology; Korean Society of Bl 2013 Blood Research Vol.48 No.2

<P><B>Background</B></P><P>In 2004, the Korean government and blood transfusion community deliberated on the issue of a national blood system reform and agreed to implement a 5-year project (2004-2009) to further improve safety measures. Our study delineates the basis of the current national blood program and analyzes the performance of this 5-year project initiated by the Korean government.</P><P><B>Methods</B></P><P>A performance review of the 5-year project was conducted from May 2009 to February 2010 using various approaches. Numerous data and documentation were collected from the Korean Red Cross and the Korean Centers for Disease Control and Prevention and reviewed by experts. Approximately 20 interviews with representatives of stakeholder groups were conducted to gather information, opinions, and perceptions. We conducted a nationwide field survey on a total of 144 blood donor centers.</P><P><B>Results</B></P><P>Among the 5 major categories of the 5-year project, blood donor recruitment, laboratory testing, and product manufacturing were improved in terms of quality performance. Specifically, government's financial support ensured that the infrastructure of blood donor centers and blood laboratory centers improved. The pivotal role of the government contributed to improvements in the national blood program and enhanced national surveillance for blood safety.</P><P><B>Conclusion</B></P><P>Korea has made a tremendous effort with positive outcomes to provide safety measures for blood products for transfusion in its citizens. In all areas of blood management, from blood donations to transfusions, continuous developments in monitoring safety standards and practices are paramount.</P>

CASE REPORTS : Massive Hemoptysis due to Endotracheal Hemangioma: A Case Report and Literature Review

( Yeon Sil Yu ),( Su Hyeon Lee ),( Jin Young An ),( Jeong Min Lee ),( Ji Hoon Kim ),( Young Kyung Lee ),( Eun Ah Jung ),( Sook Hee Song ),( Hye Ok Kim ),( Su Hyun Kim ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.2

Tracheal hemangioma is a rare benign vascular tumor in adults. We reported a case of massive hemoptysis caused by a cavernous hemangioma in a 75-year-old man. This is the first report, to our knowledge, of a tracheal cavernous hemangioma that presented with massive hemoptysis. The lesion was removed with a CO2 laser under rigid laryngoscopy. Endovascular tumors, such as tracheobronchial hemangiomas, should be considered a diagnostic option in cases of massive hemoptysis without a significant underlying lung lesion.

Effect of Radiofrequency Induced Local Hyperthermia on Normal Canine Liver

Chang Ok Suh(서창옥) , John J.K.Loh(노준규) , Jin Sil Seong(성진실) , Sun Rock Moon(문성록) Hyung Sik Lee(이형식) , Hyun Soo Shin(신현수) , Sung Sil Chu(추성실) , Gwi Eon Kim(김귀언) , Chan Il Park(박찬일) ,Eun Kyung Han(한은경) 대한방사선종양학회 1991 Radiation Oncology Journal Vol.9 No.1

간조직에 온열치효를 시행시 출현하는 조직병리학적 소견 및 혈액의 생화학적 소견을 관찰하고자 13마리의 정상 간에 8MHz 라디오파를 이용한 온열치료를 시행하였다. 42.5±0.5°C로 30분간 온열치료를 받은 군 (제1군, n=5), 45±0.5°C로 30분간 온열치료를 받은 군 (제2군, n=5) 및 온열치료를 받지않은 대조군(n=3)으로 나누어 분석하였을때, 혈액의 SGOT의 SGPT는 온열치료를 시행한 두군 공히 증가된 소견을 보였고 제 1군에서는 간세포의 부종소견의 특이한 조직병리학적소견이 관찰되지않아 가역성 변화로 생각되었지만 제2군에서는 간 세포의 심한 괴사소견이 관찰되어 있는 불가역성의 가조직 손상으로 생각되었다. 이상의 결론으로 유추할 때 임상에서 행하여지는 간암의 온열치료시에 정상 가조직의 손상을 가능한 방지하기위하여는 정확한 종괴의 구역에 치료온도의 주의깊은 관찰이 요구된다. In order to assess the effects of radiofrequency-induced local hyperthermia on the normal liver, histopathologic findings and biochemical changes after localized hyperthermia in canine liver were studied. Hyperthemia was externally adminsitered using the Thermotron RF-8 (Yamamoto Vinyter Co., Japan; Capacitive type heating machine) with parallel opposed electrodes. Thirteen dogs were used and allocated into one control group (N=3) and two treatment groups according to the treatment temperature. Group I (N=5) was heated with 42.5±0.5°C for 30 minutes, and Group Ⅱ (N=5) was heated with 45±0.5°C for 15-30 minutes. Samples of liver tissue were obtained through a needle biopsy immediately after hyperthermia and 7, 14, and 28 days after treatment. Blood samples were obtained before treatment and 1, 3, 5, 7, 14 and 28 days after treatment and examined for SGOT, SGPT and alkaline phosphatase. Although SGOT and SGPT were elevated after hyperthermia in both groups (three of five in each group), there was no liver cell necrosis or hyperthermia related mortality in Group Ⅰ. A hydropic swelling of hepatocytes was prominent histologic finding. Hyperthermia with 45°C for 30 minutes was fatal and showed extensive liver cell necrosis. In conclusion, liver damage dy heat of 42.5±0.5°C for 30 minutes is reversible, and liver damage by heat of 45±0.5°C for 30 minutes can be fatal or irreversible. However, these results cannot be applied directly to human trial. Therefore, in order to apply hyperthermic treatment on human liver tumor safely, close observation of temperature with proper thermometry is mandatory. Hyperthermic treatment should be confined to the tumor area while sparing a normal liver as much as possible.

한 사상과 간호

김문실(Kim, Moon-Sil),고효정(Koh, Hyo-Jung),김애경(Kim, Ae-Kyoung),이옥자(Lee, Ok-Ja) 한국간호과학회 1991 Journal of Korean Academy of Nursing Vol.21 No.3