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Kim, Hye-Ri,Kumar, Rajesh,Kim, Woori,Lee, Jae Hong,Suh, Myungkoo,Sharma, Amit,Kim, Chang Hoe,Kang, Chulhun,Seung Kim, Jong The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.44
<P>Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.</P>
Kwak, Woori,Kim, Jin-Nam,Kim, Daewon,Hong, Jin Su,Jeong, Jae Hark,Kim, Heebal,Cho, Seoae,Kim, Yoo Yong Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.11
Although growth rate is one of the main economic traits of concern in pig production, there is limited knowledge on its epigenetic regulation, such as DNA methylation. In this study, we conducted methyl-CpG binding domain protein-enriched genome sequencing (MBD-seq) to compare genome-wide DNA methylation profile of small intestine and liver tissue between fast- and slow-growing weaning piglets. The genome-wide methylation pattern between the two different growing groups showed similar proportion of CpG (regions of DNA where a cytosine nucleotide occurs next to a guanine nucleotide in the linear sequence) coverage, genomic regions, and gene regions. Differentially methylated regions and genes were also identified for downstream analysis. In canonical pathway analysis using differentially methylated genes, pathways (triacylglycerol pathway, some cell cycle related pathways, and insulin receptor signaling pathway) expected to be related to growth rate were enriched in the two organ tissues. Differentially methylated genes were also organized in gene networks related to the cellular development, growth, and carbohydrate metabolism. Even though further study is required, the result of this study may contribute to the understanding of epigenetic regulation in pig growth.
Efficacy test of CETP inhibitor candidates (DN2019) using CETP-apoB100 transgenic mice
Woori JO,Heejaung KIM,Hee Young LEE,Hyun Ho YUN,Mi Jeoung CHOE,Kyung-ku KANG,Min-soo Seo,Soong-Hyun Kim,Hee Jong Hwang,Eunhye Lee,Sungwoo Lee,Minsoo Song,Woo Suk KOH,Kil-Soo KIM 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.7