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Kim, Ho Shin,Hoang, Van-Hai,Hong, Mannkyu,Chul Kim, Kyung,Ann, Jihyae,Nguyen, Cong-Truong,Seo, Ji Hae,Choi, Hoon,Yong Kim, Jun,Kim, Kyu-Won,Sub Byun, Woong,Lee, Sangkook,Lee, Seungbeom,Suh, Young-Ger Elsevier 2019 Bioorganic & medicinal chemistry Vol.27 No.7
<P><B>Abstract</B></P> <P>On the basis of deguelin, a series of the B,C-ring truncated surrogates with <I>N</I>-substituted amide linkers were investigated as HSP90 inhibitors. The structure activity relationship of the template was studied by incorporating various substitutions on the nitrogen of the amide linker and examining their HIF-1α inhibition. Among them, compound <B>57</B> showed potent HIF-1α inhibition and cytotoxicity in triple-negative breast cancer lines in a dose-dependent manner. Compound <B>57</B> downregulated expression and phosphorylation of major client proteins of HSP90 including AKT, ERK and STAT3, indicating that its antitumor activity was derived from the inhibition of HSP90 function. The molecular modeling of <B>57</B> demonstrated that <B>57</B> bound well to the C-terminal ATP-binding pocket in the open conformation of the <I>h</I>HSP90 homodimer with hydrogen bonding and pi-cation interactions. Overall, compound <B>57</B> is a potential antitumor agent for triple-negative breast cancer as a HSP90 C-terminal inhibitor.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Jaeyoung,Choi, Seungbeom,Jo, Jeong-Wan,Park, Sung Kyu,Kim, Yong-Hoon Elsevier 2018 THIN SOLID FILMS - Vol.660 No.-
<P><B>Abstract</B></P> <P>Solution-processed oxide gate dielectrics play an important in thin-film transistors (TFTs), determining their operation voltage, device performance and power consumption. Up to now, various solution-processed oxide gate dielectrics such as aluminum oxide (Al<SUB>2</SUB>O<SUB>3</SUB>) have been surveyed, however, they generally exhibit relatively high leakage current, low dielectric constant, and hysteresis which are unfavorable for stable device operation. Here, we demonstrate solution-processed lanthanum (La)-doped Al<SUB>2</SUB>O<SUB>3</SUB> (LAO) gate dielectrics which exhibit low leakage current density, high dielectric constant, and relatively small frequency-dependent capacitance variation. In order to find the optimal doping concentration of lanthanum in Al<SUB>2</SUB>O<SUB>3</SUB> film, various electrical, morphological, and spectroscopic analyses were carried out. We found that the addition of lanthanum in Al<SUB>2</SUB>O<SUB>3</SUB> film effectively reduced the defective metal hydroxide bonding states within the film and significantly enhanced its dielectric characteristics. At an optimal doping concentration of lanthanum (20 at.%), gate dielectrics showing leakage current density, dielectric constant, and breakdown field of ~10<SUP>−8</SUP> A/cm<SUP>2</SUP> (at 2 MV/cm), 10.5, and >5 MV/cm were obtained. Using the LAO film as a gate dielectric, solution-processed indium-zinc-oxide TFTs having a field-effect mobility of 11.9 cm<SUP>2</SUP>/V-s, subthreshold slope of 0.38 V/dec, and on/off ratio of 10<SUP>4</SUP>–10<SUP>5</SUP> were demonstrated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Lanthanum-doped Al<SUB>2</SUB>O<SUB>3</SUB> gate dielectrics were fabricated by using a solution process. </LI> <LI> The lanthanum doping enhanced the dielectric properties of Al<SUB>2</SUB>O<SUB>3</SUB> films. </LI> <LI> Solution-processed indium-zinc-oxide thin-film transistors were demonstrated. </LI> </UL> </P>
Kim, Jaeyoung,Choi, Seungbeom,Kim, Minho,Ha, Tae-Jun,Kim, Yong-Hoon Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.16
<P><B>Abstract</B></P> <P>In this paper, we investigated the strontium doping effects on the electrical and physical characteristics of solution-processed aluminum oxide dielectric layer and its application to low-voltage-operated indium-gallium-zinc-oxide (IGZO) thin-film transistors (TFTs). With an optimized doping concentration of strontium (5at%) in aluminum oxide (Al<SUB>2</SUB>O<SUB>3</SUB>), an oxide gate dielectric layer having a dielectric constant of ~7 and low leakage current characteristics (~4 × 10<SUP>−7</SUP> A/cm<SUP>2</SUP> at 3MV/cm) could be achieved by a solution process, which are comparably better than those of pristine Al<SUB>2</SUB>O<SUB>3</SUB> film. The enhanced dielectric properties from strontium doping can be attributed to the change in the physical properties of Al<SUB>2</SUB>O<SUB>3</SUB> film incorporated with strontium, providing charge relaxation of defect states in Al<SUB>2</SUB>O<SUB>3</SUB> film. Also, since the strontium is highly reactive with oxygen, the strontium substitution through a doping leads to more strongly bound structure in an Al<SUB>2</SUB>O<SUB>3</SUB> film without considerable lattice distortion. Using the strontium-doped aluminum oxide film as a gate dielectric layer, having a thickness less than 10nm, solution-processed IGZO TFTs operating at ≤ 1V were demonstrated showing a field-effect mobility of 1.74 ± 1.10cm<SUP>2</SUP>/Vs and an on-current level of ~10<SUP>−5</SUP> A.</P>
Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium
Kim, You-Joung,Park, Sooyeon,Ha, Taejeong,Kim, Seungbeom,Lim, Soyeon,You, Han,Kim, Jin Woo Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.8
In vertebrate eyes, the retinal pigment epithelium (RPE) provides structural and functional homeostasis to the retina. The RPE takes up retinol (ROL) to be dehydrogenated and isomerized to 11-cis-retinaldehyde (11-cis-RAL), which is a functional photopigment in mammalian photoreceptors. As excessive ROL is toxic, the RPE must also establish mechanisms to protect against ROL toxicity. Here, we found that the levels of retinol dehydrogenases (RDHs) are commonly decreased in phosphatase tensin homolog (Pten)-deficient mouse RPE, which degenerates due to elevated ROL and that can be rescued by feeding a ROL-free diet. We also identified that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten-deficient mouse RPE. Together, our findings suggest that a homeostatic pathway comprising PTEN, FOXO, and RDH can protect the RPE from ROL toxicity.
Mathematical Modeling for Risk Averse Firm Facing Loss Averse Customer’s Stochastic Uncertainty
Kim, Seungbeom,Lee, Jinpyo,Park, Minjae Hindawi Limited 2017 Mathematical problems in engineering Vol.2017 No.-
<P>To optimize the firm’s profit during a finite planning horizon, a dynamic programming model is used to make joint pricing and inventory replenishment decision assuming that customers are loss averse and the firm is risk averse. We model the loss averse customer’s demand using the multinomial choice model. In this choice model, we consider the acquisition and transition utilities widely used by a mental accounting theory which also incorporate the reference price and actual price. Then, we show that there is an optimal inventory policy which is base-stock policy depending on the accumulated wealth in each period.</P>
서비스운영관리 이론을 미술관 경영에 접목하는 방안에 관한 고찰
김승범(Kim, Seungbeom),이보람(Lee, Bo Ram) 한국전시산업융합연구원 2016 한국과학예술융합학회 Vol.26 No.-
본 연구는 서비스 운영관리의 이론들을 문화예술경영 분야에 적용하기 위하여 문헌 조사와 적용 사례연구의 방법을 통하여 현재까지 이루어진 성과를 살펴보고, 이를 통하여 후속 연구의 방향 또한 제시한다는 목적을 가지고 수행되었다. 서비스 산업이 우리 산업에서 차지하는 비율은 나날이 커져가고 있으며, 이에 따라 서비스 산업 간 또는 내부의 경쟁도 점차 심해지고 있는 상황이다. 한편 문화 예술 기관도 이러한 추세를 실감하며, 그 경영에 있어서의 새로운 방향성을 정립하기 위하여 힘쓰고 있다. 서비스 운영 관리는 서비스 기업들이 과학적 경영 기법을 이용하여 비즈니스 프로세스를 디자인, 운영, 조정하는 방법을 제시함으로써, 서비스를 이용하는 고객들에게 효율적인 방법으로 최대한의 가치를 전달하는 것을 추구하고 있으며, 이는 문화 예술기관이 추구하는 운영의 방향성과 그 궤를 함께 한다 볼 수 있다. 이에, 본 논문에서는 주요 문화예술기관 중 하나인 미술관의 경영에 있어서 적용될 수 있는 서비스운영관리 분야의 이론들을 탐색하고 제안한다. 특히, 전략적 서비스 비전(Strategic Service Vision), 대기행렬이론(Queuing Theory), 서비스품질(SERVQUAL), 수익관리(Revenue Management), 자료포괄분석(Data Envelopment Analysis), 고객경험관리 등의 이론들이 접목된 기존 연구 동향, 사례를 제시하고 앞으로의 연구 방향을 제안한다. The aim of this research is to provide the ways of implementation of the theories in service operations management to the fields of art and cultural management and, furthermore, to suggest the directions of the future research, by exploring the current achievements through literature review and case study. The portion of the service industry keeps growing. This makes the competition among different types of service industries and inside the industry severe. By realizing this current trend, art and cultural organizations are also eager to find the new directions of their management. Service operations management provides service firms with the methods of design, operations and control of business processes. This enables the firms to offer the maximum value to their customers in an efficient way, and this is aligned with what the art and cultural organizations pursue. Among the organizations in art and culture, we focus on art museums. We find and suggest the theories in service operations management that can be applied to the management of the art museums. We provide current research and cases studies of implementing the methods and theories such as strategic service vision, queuing theory, revenue management, SERVQUAL, data envelopment analysis, and customer experience management. Finally, we suggest future research.