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복숭아씨살이좀벌 암컷 특이적 성분의 화학구조 동정과 야외 유인력 펑가
양창열,Kenji Mori,김준헌,김동환,강택준,김형환 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
우리나라와 중국에서 매실과 살구의 종자를 가해하는 복숭아씨살이좀벌(Eurytomoa maslovskii)을 비롯한 씨살이좀벌과(Eurytomidae)의 몇몇 종들은 암컷 성충이 수컷 성충을 유인하기 위하여 장거리 페로몬 유인제를 방출하는 것으로 알려져 있다. 유럽과 중동에 분포하는 Eurytomoa amygdali의 경우, Z6Z9-23:Hy와 Z6Z9-25:Hy를 성페로몬으로 이용한다고 알려져 있으나 이 2가지 성분들의 야외 유인성은 의심받고 있는 실정이며, 복숭아씨살이좀벌 수컷에 대한 유인력도 없는 것으로 밝혀졌다. 본 연구에서는 복숭아씨살이좀벌 암컷 특이적 성분을 동정하기 위하여 암컷의 흉부를 가위로 잘라 헥산에 담가 추출한 후 GC/MS로 분석하였다. 극성이 다른 칼럼에서 추출물 내의 성분들을 분리하여 분석한 결과 암컷 추출물에만 존재하는 4가지 탄화수소가 동정되었는데, 그 중 2가지는 단일메틸 분지된 불포화탄화수소였고, 나머지 2가지는 이중메틸 분지된 포화탄화수소였다. 2가지 단일메틸 분지된 불포화탄화수소를 합성하여 야외에서 유인력을 평가한 결과, 이 2가지 성분들은 단독 또는 혼합 처리되었을 때 복숭아씨살이좀벌 수컷을 유인하지 못하였다. 이러한 결과는 수컷 유인에 필수적인 다른 성분이 존재함을 암시하며, 추후 나머지 2가지 이중메틸 분지된 포화탄화수소를 합성하여 수컷에 대한 유인력을 평가할 예정이다.
Risk Factors for Renal Cell Carcinoma in a Japanese Population
Washio, Masakazu,Mori, Mitsuru,Mikami, Kazuya,Miki, Tsuneharu,Watanabe, Yoshiyuki,Nakao, Masahiro,Kubo, Tatsuhiko,Suzuki, Koji,Ozasa, Kotaro,Wakai, Kenji,Tamakoshi, Akiko Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
The incidence of renal cell carcinoma (RCC) is high in Western and Northern Europe and North America, and low in Asia. Although the incidence of RCC in Japan is lower than the rates in the other industrialized countries, there is no doubt that it is increasing. In this paper, we would like to introduce the summary of findings of JACC study, which evaluate the risk factors for RCC in a Japanese population. JACC study suggests nine risk factors (i.e., smoking, obesity, low physical activity, hypertension, diabetes mellitus, kidney diseases, beef, fondness for fatty food and black tea) and one preventive factor (i.e., starchy roots such as taro, sweet potato and potato) in a Japanese population. In Japan, however, drinking black tea may be a surrogate for westernized dietary habits while eating starchy roots may be a surrogate for traditional Japanese dietary habits. Further studies may be needed to evaluate risk factors for RCC because the number of cases is small in our studies.
Yuko Kato-Mori,Michiko Sato,Kenji Sera,Takenori Orihashi,Yuta Kanai,Katsuro Hagiwara 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6
Lactobacillus gasseri OLL 2716 promotes the elimination of Helicobacter pylori and is utilized in yogurts that are specifically labeled as health foods. On the other hand, milk whey fermented by Propionibacterium freudenreichii ET-3, which increases the numbers of Bifidobacterium, is effective for intestinal disorders. We previously demonstrated that oral administration of L. gasseri and P. freudenreichii fermentation metabolites (LP-FM) improved calf intestinal microflora and reduced the incidence of diarrhea. However, the detailed immunological mechanisms responsible for these effects remain to be fully understood. In this study, we investigated whether LP-FM stimulates the innate immune response and promotes the elimination of Listeria monocytogenes in mice. The C57BL/6 female mice that were treated with LP-FM or L. gasseri fermentation metabolites alone for 4 weeks had more peripheral white blood cells than the untreated control mice. In particular, LP-FM-treated mice had higher CD4- and CD8-positive T-cell counts. The levels of reactive oxygen and nitrogen species produced by peritoneal macrophages were also higher in LP-FM-treated mice. Furthermore, LP-FM-treated mice that were infected with L. monocytogenes exhibited significant enhancement of the elimination of Listeria from the spleen and the liver in comparison with untreated control mice infected with Listeria. The activation of innate immunity by LP-FM was increased by the combination of fermentation metabolites from P. freudenreichii. These results suggest that LP-FM, which contains metabolites from L. gasseri and P. freudenreichii, stimulates the function of the innate immune system, thereby significantly promoting the elimination of L. monocytogenes in mice.
Tan, Ce,Mori, Mitsuru,Adachi, Yasushi,Wakai, Kenji,Suzuki, Sadao,Suzuki, Koji,Hashimoto, Shuji,Watanabe, Yoshiyuki,Tamakoshi, Akiko Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10
Objective: Our aim was to estimate whether diabetes mellitus (DM) may be associated with an increased risk of colorectal cancer (CRC) mortality in Japan. Methods: The Japan Collaborative Cohort (JACC) Study is a nationwide prospective study, initiated in 1988, which involves 110,585 subjects (age range: from 40 to 79 years; 46,395 males and 64,190 females). Our present analysis population comprised 96,081 (40,510 men and 55,571 women) who provided details on DM history. The questionnaire also included age, sex, weight, height, family history of CRC, smoking, drinking and exercise habits, and education. Cox proportional-hazard regression was used to estimate the hazard ratio (HR). We used SPSS 21 software to analyze all data. Results: Among the participants with DM, we followed up for 71,174 person-years and 640. deaths from CRC were confirmed; and, among the non-diabetic participants, 785 CRC deaths were identified during 1,499,324 person-years. After adjusting for multivariate confounding factors, such as age, sex, body mass index (BMI), family history of colorectal cancer, smoking habit, drinking habit, physical activity (sports and walking) and education, DM was associated with an increased risk of CRC death (HR 1.4, 95% confidence interval [CI] 1.0-2.0). Diabetic women, but not diabetic men, experienced increased mortality from CRC (HR 1.7, 95% CI 1.0-3.0). Conclusion: The risk of CRC mortality is significantly increased in both sexes and women with diabetes, but no significant increase was seen for diabetic men among Japanese.
Washio, Masakazu,Mori, Mitsuru,Mikami, Kazuya,Miki, Tsuneharu,Watanabe, Yoshiyuki,Nakao, Masahiro,Kubo, Tatsuhiko,Suzuki, Koji,Ozasa, Kotaro,Wakai, Kenji,Tamakoshi, Akiko Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Cigarette smoking is the largest single recognized cause of human cancers. In Western countries, many epidemiologists have reported risk factors for kidney cancer including smoking. However, little is known about the Japanese population. Materials and Methods: We evaluated the association of smoking with the risk of kidney cancer death in the Japan Collaborative Cohort (JACC) Study. Participants included 46,395 males and 64,190 females. The Cox proportional hazards model was used to determine age-and-sex adjusted relative risks. Results: A total of 62 males and 26 females died from kidney cancer during the follow-up of 707,136 and 1,025,703 person-years, respectively. Heavy smokers (Brinkman index >1200), fondness of fatty foods, hypertension, diabetes mellitus (DM), and obesity were suggested to increase the risk of renal cell carcinoma while walking was suggested to decrease the risk. Even after controlling for age, sex, alcohol drinking and DM, heavy smoking significantly increased the risk. Conclusions: The present study suggests that six factors including smoking may increase and/or reduce the risk of kidney cancer in the Japanese population. Because of the small number of outcomes, however, we did not evaluate these factors after adjusting for all possible confounding factors. Further studies may be needed to confirm the findings in this study.