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Kaoru Okugawa,Hideaki Yahata,Tatsuhiro Ohgami,Masafumi Yasunaga,Kazuo Asanoma,Hiroaki Kobayashi,Kiyoko Kato 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3
Objective: To apply the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system to all patients who underwent trachelectomy in our previous study and to update the oncologic and obstetric results. Methods: We retrospectively reviewed the medical records of patients in whom abdominal trachelectomy was attempted between June 2005 and September 2021. The FIGO 2018 staging system for cervical cancer was applied to all patients. Results: Abdominal trachelectomy was attempted for 265 patients. Trachelectomy was converted to hysterectomy in 35 patients, and trachelectomy was completed successfully in 230 (conversion rate: 13%). Applying the FIGO 2018 staging system, 40% of the patients who underwent radical trachelectomy had stage IA tumors. Among 71 patients who had tumors measuring ≥2 cm, 8 patients were classified as stage IA1 and 14 as stage IA2. Overall recurrence and mortality rates were 2.2% and 1.3%, respectively. One hundred twelve patients attempted to conceive after trachelectomy; 69 pregnancies were achieved in 46 patients (pregnancy rate: 41%). Twenty-three pregnancies ended in first-trimester miscarriage, and 41 infants were delivered between gestational weeks 23 and 37; 16 were deliveries at term (39%) and 25 were premature deliveries (61%). Conclusion: This study suggested that patients judged to be ineligible for trachelectomy and patients receiving overtreatment will continue to appear using the current standard eligibility criteria. With the revisions to the FIGO 2018 staging system, the preoperative eligibility criteria for trachelectomy, which were based on the FIGO 2009 staging system and tumor size, should be changed.
Kaoru Okugawa,Hideaki Yahata,Kenzo Sonoda,Tatsuhiro Ohgami,Masafumi Yasunaga,Eisuke Kaneki,Kiyoko Kato 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4
Objective: For oncologic safety, vaginal radical trachelectomy is generally performed onlyin patients with cervical cancers smaller than 2 cm. However, because inclusion criteriafor abdominal trachelectomy are controversial, we evaluated the safety of abdominaltrachelectomy for cervical cancers ≥2 cm. Methods: We began performing abdominal trachelectomies at our institution in 2005,primarily for squamous cell carcinoma ≤3 cm or adenocarcinoma/adenosquamous carcinoma≤2 cm. If a positive sentinel lymph node or cervical margin was diagnosed intraoperativelyby frozen section, the trachelectomy was converted to a hysterectomy. Medical records ofthese patients were reviewed retrospectively. Patients who had undergone simple abdominaltrachelectomy were excluded from this study. Results: We attempted trachelectomy in 212 patients. Among the 135 patients with tumors<2 cm, trachelectomy was successful in 120, one of whom developed recurrence and noneof whom died of their disease. Among 77 patients with tumors ≥2 cm, trachelectomy wassuccessful in 62, 2 of whom developed recurrence and 1 of whom died of her disease. Theoverall relapse rate after trachelectomy was 1.6% (0.8% in <2 cm group and 3.2% in ≥2 cmgroup), and the mortality rate was 0.5% (0% in <2 cm group and 1.6% in ≥2 cm group). Recurrence-free survival (p=0.303) and overall survival (p=0.193) did not differ significantlybetween the <2 cm and ≥2 cm groups. Conclusions: Abdominal trachelectomy with intraoperative frozen sections of sentinel lymphnodes and cervical margins is oncologically safe, even in patients with tumors ≥2 cm.
( Saya Tsuda ),( Reiko Kunisaki ),( Jun Kato ),( Mayu Murakami ),( Masafumi Nishio ),( Tsuyoshi Ogashiwa ),( Takeichi Yoshida ),( Hideaki Kimura ),( Masayuki Kitano ) 대한장연구학회 2018 Intestinal Research Vol.16 No.4
Background/Aims: In clinical practice, colonoscopy has been regarded as the gold standard for the evaluation of disease severity as well as mucosal healing in ulcerative colitis (UC). Some activity indices incorporating patient symptoms as parameters have been shown to reflect the endoscopic activity of UC. The aim of this study was to examine whether self-reported symptoms with visual analog scales (VAS) can predict endoscopic activity. Methods: A cross-sectional study of 150 UC patients who underwent colonoscopy with submission of VAS scores of 4 symptoms: general condition, bloody stools, stool form, and abdominal pain (0: no symptoms, 10: the most severe symptoms). Each VAS score was compared with colonoscopic activity assessed with the Mayo endoscopic subscore (MES). Results: All VAS scores were significantly correlated with the endoscopic severity (Spearman correlation coefficients of general condition, bloody stools, stool form, and abdominal pain: 0.63, 0.64, 0.58, and 0.43, respectively). Mucosal healing defined as MES 0 alone was predicted by VAS score <1.5 on general condition or 0 on bloody stools with sensitivity of 0.84 and 0.76 and specificity of 0.66 and 0.76, respectively. Additionally, VAS score <2.5 on stool form predicted active lesions in distal colorectum alone with sensitivity of 0.67 and specificity of 0.66, suggesting that this item could predict the indication of topical therapy. Conclusions: Self-reported VAS scores on symptoms were correlated with endoscopic activity of UC. To clarify the relationship between VAS and mucosal healing, further validation studies are needed. (Intest Res 2018;16:579-587)
( Kyeong Ho Byun ),( Kazuki Hyodo ),( Kazuya Suwabe ),( Sylwester Kujach ),( Morimasa Kato ),( Hideaki Soya ) 한국운동영양학회 2014 Physical Activity and Nutrition (Phys Act Nutr) Vol.18 No.4
[Purpose] Functional near-infrared spectroscopy (fNIRS) provides functional imaging of cortical activations by measuring regional oxy- and deoxy-hemoglobin (Hb) changes in the forehead during a cognitive task. There are, however, potential problems regarding NIRS signal contamination by non-cortical hemodynamic (NCH) variables such as skin blood flow, middle cerebral artery blood flow, and heart rate (HR), which are further complicated during acute exercise. It is thus necessary to determine the appropriate post-exercise timing that allows for valid NIRS assessment during a task without any increase in NCH variables. Here, we monitored post-exercise changes in NCH parameters with different intensities of exercise. [Methods] Fourteen healthy young participants cycled 30, 50 and 70% of their peak oxygen uptake (Vo2peak) for 10 min per intensity, each on different days. Changes in skin blood flow velocity (SBFv), middle cerebral artery mean blood velocity (MCA Vmean) and HR were monitored before, during, and after the exercise. [Results] Post-exercise levels of both SBFv and HR in contrast to MCA Vmean remained high compared to basal levels and the times taken to return to baseline levels for both parameters were delayed (2-8 min after exercise), depending upon exercise intensity. [Conclusion] These results indicate that the delayed clearance of NCH variables of up to 8 min into the post-exercise phase may contaminate NIRS measurements, and could be a limitation of NIRS-based neuroimaging studies.
Duc, Nguyen Minh,Du, Yang,Thorsen, Thor S.,Lee, Su Youn,Zhang, Cheng,Kato, Hideaki,Kobilka, Brian K.,Chung, Ka Young Springer New York LLC 2015 Journal of the American Society for Mass Spectrome Vol.26 No.5
<P>G protein-coupled receptors (GPCRs) have important roles in physiology and pathology, and 40% of drugs currently on the market target GPCRs for the treatment of various diseases. Because of their therapeutic importance, the structural mechanism of GPCR signaling is of great interest in the field of drug discovery. Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a useful tool for analyzing ligand binding sites, the protein-protein interaction interface, and conformational changes of proteins. However, its application to GPCRs has been limited for various reasons, including the hydrophobic nature of GPCRs and the use of detergents in their preparation. In the present study, we tested the application of bicelles as a means of solubilizing GPCRs for HDX-MS studies. GPCRs (e.g., β<SUB>2</SUB>-adrenergic receptor [β<SUB>2</SUB>AR], μ-opioid receptor, and protease-activated receptor 1) solubilized in bicelles produced better sequence coverage (greater than 90%) than GPCRs solubilized in n-dodecyl-β-D-maltopyranoside (DDM), suggesting that bicelles are a more effective method of solubilization for HDX-MS studies. The HDX-MS profile of β<SUB>2</SUB>AR in bicelles showed that transmembrane domains (TMs) undergo lower deuterium uptake than intracellular or extracellular regions, which is consistent with the fact that the TMs are highly ordered and embedded in bicelles. The overall HDX-MS profiles of β<SUB>2</SUB>AR solubilized in bicelles and in DDM were similar except for intracellular loop 3. Interestingly, we detected EX1 kinetics, an important phenomenon in protein dynamics, at the C-terminus of TM6 in β<SUB>2</SUB>AR. In conclusion, we suggest the application of bicelles as a useful method for solubilizing GPCRs for conformational analysis by HDX-MS.</P> [FIG OMISSION]</BR>
THERMOELECTRIC PROPERTIES OF OXIDE CERAMICS
Tsuchida, Kiyoshi,Tanaka, Yasunori,Ifuku, Toshihiro,Nakao, Yoshihiro,Matsuda, Takanori,Nagashima, Satoko,Maeda, Hideaki,Kato, Akio 한국화학공학회 1996 Korean Journal of Chemical Engineering Vol.13 No.5
Thermoelectric properties of several oxides were investigated. Al₂O₃-, TiO₂- or ZrO₂-doped ZnO showed large power factor over the wide temperature range. Fe₂O₂ showed large power factor by doping of TiO₂. BaO-doped RuO₂, BaRuO₃ and CaRuO₃ showed large power factor at high temperature. Improvement of electrical conductivity by doping was effective to increase power factor in these oxide materials.