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Physical Inactivity, Sedentary Behavior and Chronic Diseases
Karimé González,Jorge Fuentes,José Luis Márquez 대한가정의학회 2017 Korean Journal of Family Medicine Vol.38 No.3
New research into physical activity suggests that it is no longer sufficient just to meet minimum levels recommend-ed by health guidelines in order to reduce cardiovascular risk. Both physical inactivity and sedentary behavior have their own health hazards and need to be addressed separately, in order to explore their different deleterious mech-anisms. The aim of this review was to define and to characterize both concepts, and their relationship with major non-communicable chronic diseases. A PubMed database search was undertaken, using the following key words: physical activity, physical inactivity, sedentarism, sedentary behavior, and non-communicable chronic disease. This literature review provides an updated view on physical inactivity and sedentary behavior, and reevaluates their prevalence and association with major non-communicable chronic disease.
Karim S. Karim,F. Taghibakhsh,G. Sanaie-Fard Sanaie-Fard,M. H. Izadi,T. Ottaviani 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I
On-pixel amplifiers in amorphous silicon (a-Si) technology can offer increased pixel signal-to-noise ratios (SNR) compared to traditional switch based imaging pixels. Experiments reveal a reduction in readout noise and indicate that a-Si pixel amplifiers can meet the stringent requirements for digital X-ray fluoroscopy. However, larger input voltages can introduce non-linearities thereby reducing the pixel dynamic range. In this research, we investigate amplified pixel architectures that exhibit large signal linearity and consequently higher dynamic range. Gain, linearity, noise, metastability and area estimations of the amplified pixels indicate their applicability in large-area medical Xray imaging applications that require switching between low-exposure, real-time fluoroscopy and high-exposure chest radiography modes at a region of interest.
Karim, Masud,Shim, Mi-Young,Kim, Jeong-Mok,Choe, Gyeong-Jae,Kim, Jung-Rim,Choi, Jung-Do,Yoon, Moon-Young Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.4
Acetohydroxyacid synthase (AHAS, EC 2.2.1.6 also referred to as acetolactate synthase) catalyzes the first common step in the metabolic pathway leading to biosynthesis of the branched-chain amino acids in plants and microorganisms. Due to its presence in plants, AHAS is a target for the herbicides (sulfonylurea and imidazolinone), which act as potent inhibitors of the enzyme. Recently, we have shown [J. Kim, D.G. Baek, Y.T. Kim, J.D. Choi, M.Y. Yoon, Biochem. J. (2004) 384, 59-68] that the residues in the “mobile loop” 567-582 on the C-termini are involved in the binding/stabilization of the active dimer and ThDP (thiamin diphosphate) binding. In this study, we have demonstrated the role of the W573 in the mobile loop of the C-termini of tobacco AHAS. The substitution of this W573 residue caused significant perturbations in the activation process and in the binding site of ThDP. Position W573 plays a structurally important role in the binding of FAD, maintaining the enzyme active site in the required geometry for catalysis to occur. In here we propose that the tryptophan at position 573 is important for the catalytic process.
Karim, Muhammad Tariq,Inam, Sumera,Ashraf, Tariq,Shah, Nadia,Adil, Syed Omair,Shafique, Kashif The Korean Society for Preventive Medicine 2018 Journal of Preventive Medicine and Public Health Vol.51 No.2
Objectives: Areca nut is widely consumed in many parts of the world, especially in South and Southeast Asia, where cardiovascular disease (CVD) is also a huge burden. Among the forms of CVD, acute coronary syndrome (ACS) is a major cause of mortality and morbidity. Research has shown areca nut chewing to be associated with diabetes, hypertension, oropharyngeal and esophageal cancers, and CVD, but little is known about mortality and re-hospitalization secondary to ACS among areca nut users and non-users. Methods: A prospective cohort was studied to quantify the effect of areca nut chewing on patients with newly diagnosed ACS by categorizing the study population into exposed and non-exposed groups according to baseline chewing status. Cox proportional hazards models were used to examine the associations of areca nut chewing with the risk of re-hospitalization and 30-day mortality secondary to ACS. Results: Of the 384 ACS patients, 49.5% (n=190) were areca users. During 1-month of follow-up, 20.3% (n=78) deaths and 25.1% (n=96) re-hospitalizations occurred. A higher risk of re-hospitalization was found (adjusted hazard ratio [aHR], 2.05; 95% confidence interval [CI], 1.29 to 3.27; p=0.002) in areca users than in non-users. Moreover, patients with severe disease were at a significantly higher risk of 30-day mortality (aHR, 2.77; 95% CI, 1.67 to 4.59; p<0.001) and re-hospitalization (aHR, 2.72; 95% CI, 1.73 to 4.26; p<0.001). Conclusions: The 30-day re-hospitalization rate among ACS patients was found to be significantly higher in areca users and individuals with severe disease. These findings suggest that screening for a history of areca nut chewing may help to identify patients at a high risk for re-hospitalization due to secondary events.
Analysis of Marginal Count Failure Data by using Covariates
Karim, Md.Rezaul,Suzuki, Kazuyuki The Korean Reliability Society 2003 International Journal of Reliability and Applicati Vol.4 No.2
Manufacturers collect and analyze field reliability data to enhance the quality and reliability of their products and to improve customer satisfaction. To reduce the data collecting and maintenance costs, the amount of data maintained for evaluating product quality and reliability should be minimized. With this in mind, some industrial companies assemble warranty databases by gathering data from different sources for a particular time period. This “marginal count failure data” does not provide (i) the number of failures by when the product entered service, (ii) the number of failures by product age, or (iii) information about the effects of the operating season or environment. This article describes a method for estimating age-based claim rates from marginal count failure data. It uses covariates to identify variations in claims relative to variables such as manufacturing characteristics, time of manufacture, operating season or environment. A Poisson model is presented, and the method is illustrated using warranty claims data for two electrical products.
Dynamic behavior of a seven century historical monument reinforced by shape memory alloy wires
Karim Hamdaoui,Zahira Benadla,Houssameddine Chitaoui,Mohammed Elamine Benallal 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.4
This work resumes a research that proposes the use of the technique based on the dissipation energy of the shape memory alloy (SMA) ties. It focuses principally on the assessment of the effectiveness of the use of these smart materials on displacements, accelerations and the stresses of the minaret of the great mosque of Ajloun in Jordan. The 3-D finite element model of the minaret is performed by the ANSYS software. First of all, the proposed model is calibrated and validated according to the experimental results gathered from ambient vibration testing results. Then, a nonlinear transient analysis is considered, when the El-Centro earthquake is used as the input signal. Different simulating cases concerning the location, number and type of SMA devices are proposed in order to see their influence on the seismic response of the minaret. Hence, the results confirm the effectiveness of the proposed SMA device.
Oral Contraceptives, Abortion and Breast Cancer Risk: a Case Control Study in Saudi Arabia
Karim, Syed Mustafa,Baeshen, Wijdan,Neamatullah, Syed Nehal,Bin, Bakr Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Several studies have examined the relationship between oral contraceptive pill (OCP) use, abortions and breast cancer, with mixed results. Hormonal changes associated with OCP use and abortion may increase risk of breast cancer over time, but there is a lack of studies studying this association in Saudi Arabian women. Materials and Methods: We thererfore conducted a case control study in 192 women (92 as cases and 100 as controls), aged 30 to 65, and collected information on variables including examples related to study objectives and those which may confound findings. The Chi square test was used to detect associations between various factors and risk of breast cancer. Results: We found no evidence of interaction between history of abortion or frequency of abortion and breast cancer risk (Chi square=0.422, p =0.420 and 1, p =0.169) respectively. Oral contraceptives did not confer risk for breast cancer overall (OR=0.276, 95%CI 0.092-0.829, p=0.524), while long term use of OCP was associated with increased risk of breast cancer (OR=0.297, 95%CI 0.158-0.557, p=0.001), with higher association for those who used 10 years or more of OCPs (OR=0.282, 95%CI 0.095-0.835, p=0.02). Age at first use of OCPs had no effect on breast cancer risk (p=0.452) or age at diagnosis (p=0.074). Conclusions: Prolonged use of OC (more than 10 years) may be associated with increased risk of breast cancer in Saudi women. Larger population based studies are needed to confirm this finding in this population.
Simultaneous Determination of Harman, Harmaline and Norharman by Synchronous Fluorescence
Karim Mohammad Mainul,Lee Sang-Hak Korean Society of Photoscience 2005 Journal of Photosciences Vol.12 No.3
The simultaneous determination of harman, harmaline and norharman has been described using synchronous fluorescence technique. The method has been based on their natural fluorescence. It is difficult to analyze and determine their contents by conventional fluorescence method because of their similar molecular structures. The synchronous spectrum, maintaining a constant wavelength difference of ${\Delta}{\lambda}=185nm$ between the excitation and emission monochromators, was selected as optimum to perform the determination. The method was also performed in aqueous medium at pH 4.0 and in presence of sodium dodecyl sulfate (SDS), $1{\times}10^{-5}M$. Under the optimum conditions, each analyte has the linear determination range of $1{\times}10^{-7}M-\;1{\times}10^{-4}M$.