Capsaicin Reversely Regulates Activities of JNK and ERK in H-ras-Transformed MCF10A Human Breast Epithelial Cells

HJ Kang,YJ Soh,MS Kim,YJ Surh,A Moon 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

Treatment of Anterior Glenoid Rim Fracture with Comminuted Fragment Using Arthroscopic Reduction and AO Headless Compression Screw Fixation

Kang HJ,Kim YJ,Koh IH,Kim SG,Cheon YM,Kim HS,Kim SJ 대한견주관절의학회 2011 대한견주관절학회 학술대회논문집 Vol.2011 No.3

Redox-sensitive Transcriptional Regulators from Streptomyces coelicolor

Kang, JG,Bae, JB,Hahn, JS,Hahn, MY,Oh, SY,Seok, YJ,Roe, JH 이화여자대학교 세포신호전달연구센터 2000 고사리 세포신호전달 심포지움 Vol. No.2

We are investigating the regulation and the role of several oxidative defense enzyme systems in the growth and differentiation of the antibiotic-producing, Gram-positive bacterium Streptomyces coelicolor A3(2). Genes for catalase A(catA; monofunctional, vegetative catalase}, catalase B(catB; monofunctional, stationary phase specific), catalase C(catC; catalase-peroxidase, late exponential phase-specific), Fe-containing SOD(sodF), and Ni-containing SOD(sodN) have been examined for their regulation and the role in the growth and differentiation of S coelicolor. Transcriptional regulators governing the regulation of these genes in. response to thiol-oxidation(RsrA/SigR), nickel(SodR1), hydrogen peroxide(CatR, OxyR), osmolarity(RsbA/SigB), or others(FurA) were found and partially characterized. SigR(Φ^(R)) is a sigma factor responsible for inducing the thioredoxin system in response to oxidative stress in S coelicolor. A redox-sensitive, Φ^(R)-specific anti-sigma factor, RsrA, was identified. It binds <DR and inhibits Φ^(R)-directed transcription in vitro only under reducing conditions. Exposure to H₂O₂ or to the thiol-specific oxidant diamide caused the dissociation of the Φ^(R)-RsrA complex, thereby allowing Φ^(R)-dependent transcription. This correlated with intramolecular disulfide bond formation in RsrA. Thioredoxin was able to reduce oxidized RsrA, suggesting that Φ^(R), RsrA and the thioredoxin system comprise a novel feedback homeostasis loop that senses and responds to changes in the intracellular thiol-disulfide redox balance. Another redox-sensitive regulator CatR was identified as a repressor for catA gene expression encoding catalase A. The catR gene was isolated as a genetic locus whose mutation caused overproduction of catalase A. The catR gene encodes a 138 amino acids protein(15319 Da) showing homology to Fur proteins of other bacteria. Derepression of transcription from catRp1, catRp2, and catA promoters was observed within 10 min of H₂O₂ treatment, suggesting H₂O₂-mediated modification of CatR activity. Detailed mechanisms for the redox-dependent modulation of these transcriptional regulators are under investigation.

Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis

Kang, EH,Moon, KC,Lee, EY,Lee, YJ,Lee, EB,Ahn, C,Song, YW SAGE Publications 2009 Lupus Vol.18 No.1

<P>The aim of the study is to characterize the expression pattern of galectin-3 (Gal-3) in renal tissues of patients with systemic lupus erythematosus (SLE) nephritis and to determine whether tissue and serum Gal-3 are associated with SLE nephritis. Gal-3 expressions were examined with immunohistochemistry in renal biopsy specimens of 88 patients with SLE nephritis and in five normal specimens. Activity and chronicity indexes and glomerular Gal-3 expressions were analysed in each specimen. Serum Gal-3 levels were measured using enzyme-linked immunosorbent assays in 20 patients with SLE, including 11 with nephritis, and in 50 healthy controls. Glomerular Gal-3 expression was observed in 81.8% (72/88) of patients with SLE nephritis but not in 5 controls. Gal-3 staining was attributed mainly to its cellular expression rather than its deposition, and Gal-3 expression levels were correlated with histologic activity indexes, anti-dsDNA titers, and complement 3 and 4 levels. Serum Gal-3 levels were higher in patients with SLE, particularly in those with nephritis, than in healthy controls, and correlated with anti-dsDNA titers. In conclusion, glomerular Gal-3 expression in renal tissue and serum Gal-3 levels were elevated in patients with SLE nephritis versus healthy controls; moreover, they reflected disease activity. These findings suggest that Gal-3 might contribute to the inflammatory process in SLE.</P>

뇌동정맥기형에 대한 감마나이프 방사선수술의 합병증

강관수,임영진,임 언,이봉암,김국기,김태성 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.32 No.6

거대자궁근종의 1례

이영주(YJ Lee),박찬영(CY Park),정경환(KH Chung),서병화(BH Shu),유훈(H Yoo),이동화(DH Rhee),강득용(DY Kang) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.6

41세의 미산부에서 거대자궁근종을 경험하였기에 문헌고찰과 아울러 보고하는 바이다. A case of great myoma in 41 year-old nulliparous woman was presented, and a briefly review on literature was noticed.

초기임신에 자궁파열을 합병한 유착태반 1예

신영진(YJ Shin),이상호(SH Lee),박종식(JS Park),강성원(SW Kang) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.3

한림의과대학 부속 강남성심병언 산부인과에서 2nd Trimester 초기에 자궁파열을 동반한 placenta percreta 1예를 치험하였기에 문헌고찰과 함께 보고하는 바이다. During 1st and_2nd trimester, uterine perforation caused by placenta percreta is rarely found and is not easy to diagnose during these trimesters. We Had experienced a case of placenta percreta developed uterine perforation. So wo presented it with a brief case gistory and brief review of the concerned literatures.

정상 및 비정상 초기임신을 대상으로한 도플러검사에 의한 자궁-태반 순환계의 혈류상태에 관한 연구

박금자,강경일,박영자 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.7

Flow velocimetry waveforms of the uterine artery and subtrophoblastic blood flow were analyzed at normal early pregnancy, missed abortion and blighted ovum, by using transvaginal color Doppler ultrasonography. Results show that a progressive fall in S/D ratio and RI with advancing in gestation. Among the three groups, the S/D ratio and RI of both uterine arteries were not a significant difference in all gestational age. Characteristic subtrophoblastic blood flows were obtained in 60.3%, 47.2% and 53.3% of normal pregnancy, missed abortion and blighted ovum, respectively. The S/D ratio and RI of subtrophoblastic blood flow were not a significant difference among the three groups. Although the number of cases studied is small and not prospective study, the further study about this will give us some understanding to the pathophysiology of early pregnancy failure.

경관임신 2예

강신명(SM Kang),조성원(SW Cho),김원자(WJ Kim),노영자(YJ Rho) 대한산부인과학회 1964 Obstetrics & Gynecology Science Vol.7 No.1

1. 여기에 보고한 2예중 하나는 해부학적분류에 가깝고 다른 하나는 병리 및 임상적분류에 속하는 경관임신들이었다. 2. 이 2예는 모두 술전에 진단이 붙지 못하고 예 1은 전행소파술을 받은 후의 완고한 출혈이었으므로 인공유산후경손상으로 인상되었고, 예 2는 절박유산, 그후 천연유산으로 인상되었다. 전자는 시험소파술후 질식자궁척출을 하였고 후자는 일차 소파 및 경내팩킹을 하였는데 모두 결과 양호하였다. 3. 예 1에 있어서 자궁척출술시 저자가 곤란을 당한 것은 출혈이 보통이상으로 많아서 술중 2,000cc의 수혈을 하였다. 경관임신 때는 정상체부임신때와 달라서 골반상과 특히 방광 및 직장부착부에 혈관증대, 확장 등의 생리적변화가 일어나 있어서 술시 박리곤란 내지 극심한 출혈이 나타난다고 착자는 생각되었다. 따라서 자궁척출시에도 시험소파때와 같이 다량의 혈액을 준비하고서 한다는 것은 역시 대단히 중요하며 이로써 모성사망율도 감소될 것이다. 내반이 확실히 퇴행되었을 때(천연유산등)는 출혈의 위험이 적을 것이라고 본다(예 3). : 자궁경관임신, 자궁경부임신, 자궁외임신.... 2 cases of Cervical pregnancy meeting the criteria of Paalman and McElin; One closed to anatomical proof, the other proved pathologically and suggested clinically have been reported. It was impossible to me to make correct diagnosis preoperatively on either cases. Cases I, who had previous curettage therapeutic abortion(8 weeks gestation) 5 days prior to the admission was treated as post D. & C. hemorrhage or cervical injury, in which performing repeated curettages and cervical packings followed by vaginal hysterectomy. Case II, with vaginal spotting of 7 days duration was treated as threatened abortion at 7 weeks gestation, later as missed abortion, in which carrying out single curettage and cervical packing successfully. The results of 2 cases were good despite of one encountered a stomy hemorrhage during the hysterectomy. I would like to emphasize and urge that even in performing the hystectomy for cervical pregnancy, large amount of blood should be prepaired and available just like performing for the trical of curettage before any treatment is initiated, because I have experienced unforgetable severe hemorrhage during the hysterectomy, requiring up to 2.000 c.c. of blood transfusions(case I); probably due to the physiologic changes in cervical pregncy unlike the corporeal pregnancy, causing unusual vascularization or varicoses over the pelvic floor or vesico & recto-cervical areas depend on the site of implantation. The placenta regression type such as terminated as missed abortion (case II), however will be less chance of bleeding.

초음파검사에 의한 한국인 태아의 임신주수별 대퇴골 길이의 정상치에 관한 연구

박금자,유국영,강경일,박영자,신숙진,정미정,이병관 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.2

1993년 1월부터 1995년 8월까지 박금자 산부인과에 내원하여 산전검사를 받고 분만한 산모증 3,178명을 대상으로 후향적 연구를 시행하였으며, 태아의 아두대횡경치와 대퇴골 길이의 주수별(7일 간격) 평균치와 표준편차 및 백분위를 구하였고 임신주수와 이들 성장지표 간의 회귀분석을 통하여 임신주수에 따른 아두대 횡경치와 대퇴골의 예측치를 회귀분석을 시행하여 구하였으며 대퇴골 길이가 분만력, 태아의 성별에 따라 유의한 차이가 있는지 검증하여 다음 결과를 얻었다. 1. 아두대횡경치로 주수를 예측하는 경우, 1차 회귀식은 BPD=-0.61207+0.26602(GW)였고 2차 희귀식은 BPD=-3.4358+0.49768(GW)-0.00434(GW)^2였으며, 각각의 결정계수는 0.973과 0.986 이었다. 2. 대퇴골 길이의 경우 1차식은 FL=-1.7555+0.24182(GW)였고 2차식은 FL=-3.8783+0.41598(GW)-0.00326(GW)^2였고 각각의 결정계수는 0.973과 0.982이었다. 3. 대퇴골 길이로 임신주수를 예측하는 희귀식은 GW=7.7243+0.4034(FL), R2=0.973과 GW=10.7113+0.2381(FL)+0.0019(GW)^2,R^2=0.980이었다. 4. 기존에 쓰이던 구미 태아를 대상으로한 초음파 대퇴골 기준치와 비교하였을 때, 본연구에 의한 임신주수별 대퇴골 길이는 다소 짧았으며, 한국인 태아를 대상으로한 대퇴골 기준치를 이용하는 것이 바람직할 것으로 사료되었다. 5. 성별과 분만력은 주수에 따른 대퇴골 길이와 상관관계가 없었다. Ultrasonography is popular method for evaluating fetuses well-being and the determination of their gestational age. Several studies revealed that gestational age is strongly correlated with the femur length rather than the biparietal diameter. The fetal biparietal diameter and femur length were measured by ultrasonography in 3,178 Korean pregnant women. We caculated the mean, standard deviation and percentiles for each gestational week, and performed a linear and quadratic regression analysis. 1. The linear quadratic regression equation of the biparietal diameter for gestational ages were BPD=-3.4358+0.49768(GW)-0.0434(GW)^2, (R^2=0.982, p$lt;0.05). 2. The linear quadratic regression equation for the femur length of the gestational ages were FL=10.7113+0.2381(FL)+0.0019(GW)^2(R^2=0.980, p$lt;0.05). 3. The linear quadratic regression equation for the gestational age of the femur length was GW=10.7113+02381(FL)+0.0019(GW)^2, (R^2=0.980, p$lt;0.05). The predicted biparietal diameter and femur length were calculated using regression equations and compared with the findings from studies on western women. 4. Korean women`s gestational age predicted by fetal femur length is delayed when compared to the western standard. Therefore it is reasonable to use a Korean standard for fetal femur length.