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Kwon, Yu-Jin,Chung, Tae-Ha,Lee, Hye Sun,Park, JuYoung,Chung, Ji-Youn,Lee, Byoung-Kwon,Lee, Ji-Won Elsevier 2019 Journal of clinical lipidology Vol.13 No.4
<P><B>Background</B></P> <P>Previous studies indicate that circadian preference is associated with various energy metabolism and metabolic disorders. However, little is known about the associations between a circadian rhythm and blood lipid levels, especially in humans.</P> <P><B>Objective</B></P> <P>The aim of the study was to investigate whether the circadian rhythm affects serum lipid levels in Korean adults.</P> <P><B>Methods</B></P> <P>We designed a cross-sectional study to evaluate the associations between circadian preference and blood lipid levels in Korean adults. A total of 1984 participants (range of age 19–81 years) were included in this study. Propensity scores were calculated using logistic regression with age, sex, and body mass index. A total of 435 subjects were evaluated by propensity score matching analysis, equally distributed into morningness, intermediate, and eveningness groups, each with 145 subjects. Circadian preference was evaluated by the Morningness-Eveningness Questionnaire.</P> <P><B>Results</B></P> <P>Participants with the evening preference had significantly higher levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and non–high-density lipoprotein cholesterol (non–HDL-C) when compared with those with morning or intermediate preference, after adjusting for confounding variables. Regarding other lipid parameters, both total cholesterol/HDL-C and low-density lipoprotein cholesterol/HDL-C in the evening preference are significantly higher than those of other circadian preferences. Evening preference was also significantly associated with a higher atherogenic index of plasma.</P> <P><B>Conclusion</B></P> <P>Our study demonstrates that there is a significant association between circadian preference and blood lipid levels. Our findings suggest that individuals with evening preference could have a greater risk of atherosclerotic cardiovascular diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Circadian rhythms regulate a variety of physiological functions in humans. </LI> <LI> This cross-sectional study was conducted using 1:1:1 propensity score matching. </LI> <LI> Evening preference potentially has a more atherogenic lipid profile. </LI> <LI> The circadian rhythm plays a key role in lipid metabolism. </LI> </UL> </P>
Kwon, Nahyun,Baek, Gain,Swamy, K.M.K.,Lee, Minji,Xu, Qingling,Kim, Youngmee,Kim, Sung-Jin,Yoon, Juyoung Applied Science Publishers 2019 Dyes and pigments Vol.171 No.-
<P><B>Abstract</B></P> <P>The results of the current study show that fluoride and cyanide recognition by two naphthoimidazolium derivatives can be applied to CO<SUB>2</SUB> sensing. Among various anions, only fluoride and cyanide promote changes in absorption and fluorescence wavelegnth maxima of the naphthoimidazolium derivative in CH<SUB>3</SUB>CN. The changes are attributed to (C–H)<SUP>+</SUP>--anion<SUP>-</SUP> ionic hydrogen bonding interactions between the conjugated imidazolium salts and these anions. Especially important is the observations that the fluorescence emission maxima of the naphthoimidazolium derivative at 465 nm undergo hysochromic shifts to 375 nm upon addition of fluoride and cyanide exclusively. The naphthoimidazolium derivatives undergo highly selective changes in their fluoerecence maximum from 465 nm to 375 nm upon addition of CN<SUP>−</SUP> even when 2% water is present in the CH<SUB>3</SUB>CN solution. Moreover, exposure of the solution of CN<SUP>−</SUP> activated naphthoimidazolium derivative to CO<SUB>2</SUB> promotes a red shift of emission maximum back to 465 nm. The results demonstrate that the naphthoimidazolium derivatives can be utilized for anion activated ratiometric sensing of CO<SUB>2</SUB>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The probe <B>1</B> and <B>2</B> display selective and ratiometric fluorescence changes upon addition of F<SUP>−</SUP> and CN<SUP>−</SUP>. </LI> <LI> Naphthoimidazoliums of <B>1</B> and <B>2</B> can play dual roles as fluorophores and ionic hydrogen bonding donors. </LI> <LI> Anion-activated ratiometric sensing of CO<SUB>2</SUB> is demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Juyoung Kim,Juhae Kim,Young Hye Kwon 대한지역사회영양학회 2016 Nutrition Research and Practice Vol.10 No.4
BACKGROUND/OBJECTIVES: Changes in nutritional status during gestation and lactation have detrimental effects on offspring metabolism. Several animal studies have shown that maternal high-fat diet (HFD) can predispose the offspring to development of obesity and metabolic diseases, however the mechanisms underlying these transgenerational effects are poorly understood. Therefore, we examined the effect of maternal HFD consumption on metabolic phenotype and hepatic expression of involved genes in dams to determine whether any of these parameters were associated with the metabolic outcomes in the offspring. MATERIALS/METHODS: Female C57BL/6 mice were fed a low-fat diet (LFD: 10% calories from fat) or a high-fat diet (HFD: 45% calories from fat) for three weeks before mating, and during pregnancy and lactation. Dams and their male offspring were studied at weaning. RESULTS: Dams fed an HFD had significantly higher body and adipose tissue weights and higher serum triglyceride and cholesterol levels than dams fed an LFD. Hepatic lipid levels and mRNA levels of genes involved in lipid metabolism, including LXRα, SREBP-2, FXR, LDLR, and ABCG8 were significantly changed by maternal HFD intake. Significantly lower total liver DNA and protein contents were observed in dams fed an HFD, implicating the disturbed liver adaptation in the pregnancy-related metabolic demand. HFD feeding also induced significant oxidative stress in serum and liver of dams. Offspring of dams fed an HFD had significantly higher serum cholesterol levels, which were negatively correlated with liver weights of dams and positively correlated with hepatic lipid peroxide levels in dams. CONCLUSIONS: Maternal HFD consumption induced metabolic dysfunction, including altered liver growth and oxidative stress in dams, which may contribute to the disturbed cholesterol homeostasis in the early life of male mice offspring.
PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis
( Juyoung Kim ),( Kyung Hee Jung ),( Jaeho Yoo ),( Jung Hee Park ),( Hong Hua Yan ),( Zhenghuan Fang ),( Joo Han Lim ),( Seong-ryul Kwon ),( Myung Ku Kim ),( Hyun-ju Park ),( Soon-sun Hong ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.2
Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory processes. However, limited studies have reported the involvement of PI3KC2γ in RA, and the underlying mechanism remains largely unknown. Therefore, we investigated the role of PI3KC2γ as a novel therapeutic target for RA and the effect of its selective inhibitor, PBT-6. In this study, we observed that PI3KC2γ was markedly increased in the synovial fluid and tissue as well as the PBMCs of patients with RA. PBT-6, a novel PI3KC2γ inhibitor, decreased the cell growth of TNFmediated synovial fibroblasts and LPS-mediated macrophages. Furthermore, PBT-6 inhibited the PI3KC2γ expression and PI3K/ AKT signaling pathway in both synovial fibroblasts and macrophages. In addition, PBT-6 suppressed macrophage migration via CCL2 and osteoclastogenesis. In CIA mice, it significantly inhibited the progression and development of RA by decreasing arthritis scores and paw swelling. Three-dimensional micro-computed tomography confirmed that PBT-6 enhanced the joint structures in CIA mice. Taken together, our findings suggest that PI3KC2γ is a therapeutic target for RA, and PBT-6 could be developed as a novel PI3KC2γ inhibitor to target inflammatory diseases including RA.
Kwon, Hyunah,Ham, Juyoung,Kim, Dong Yeong,Oh, Seung Jae,Lee, Subin,Oh, Sang Ho,Schubert, E. Fred,Lim, Kyung-Geun,Lee, Tae-Woo,Kim, Sungjun,Lee, Jong-Lam,Kim, Jong Kyu Wiley Blackwell (John Wiley Sons) 2014 ADVANCED ENERGY MATERIALS Vol.4 No.7
<P>A three-dimensional indium tin oxide (ITO) nanohelix (NH) array is presented as a multifunctional electrode for bulk heterojunction organic solar cells for simultaneously improving light absorption and charge transport from the active region to the anode. It is shown that the ITO NH array, which is easily fabricated using an oblique-angle-deposition technique, acts as an effective antireflection coating as well as a light-scattering layer, resulting in much enhanced light harvesting. Furthermore, the larger interfacial area between the electrode and the active layer, together with the enhanced carrier mobility through highly conductive ITO NH facilitate transport and collection of charge carriers. The optical and electrical improvements enabled by the ITO NH electrode result in a 10% increase in short-circuit current density and power-conversion efficiency of the solar cells.</P>
Comparative Analysis of Speech Recognition Open API Error Rate
Juyoung Kim,Dai Yeol Yun,Oh Seok Kwon,Seok-Jae Moon,Chi-gon Hwang 한국인터넷방송통신학회 2021 Journal of Advanced Smart Convergence Vol.10 No.2
Speech recognition technology refers to a technology in which a computer interprets the speech language spoken by a person and converts the contents into text data. This technology has recently been combined with artificial intelligence and has been used in various fields such as smartphones, set-top boxes, and smart TVs. Examples include Google Assistant, Google Home, Samsung's Bixby, Apple's Siri and SK's NUGU. Google and Daum Kakao offer free open APIs for speech recognition technologies. This paper selects three APIs that are free to use by ordinary users, and compares each recognition rate according to the three types. First, the recognition rate of "numbers" and secondly, the recognition rate of "Ga Na Da Hangul" are conducted, and finally, the experiment is conducted with the complete sentence that the author uses the most. All experiments use real voice as input through a computer microphone. Through the three experiments and results, we hope that the general public will be able to identify differences in recognition rates according to the applications currently available, helping to select APIs suitable for specific application purposes.
Comparative Analysis of Speech Recognition Open API Error Rate
Kim, Juyoung,Yun, Dai Yeol,Kwon, Oh Seok,Moon, Seok-Jae,Hwang, Chi-gon The Institute of Internet 2021 International journal of advanced smart convergenc Vol.10 No.2
Speech recognition technology refers to a technology in which a computer interprets the speech language spoken by a person and converts the contents into text data. This technology has recently been combined with artificial intelligence and has been used in various fields such as smartphones, set-top boxes, and smart TVs. Examples include Google Assistant, Google Home, Samsung's Bixby, Apple's Siri and SK's NUGU. Google and Daum Kakao offer free open APIs for speech recognition technologies. This paper selects three APIs that are free to use by ordinary users, and compares each recognition rate according to the three types. First, the recognition rate of "numbers" and secondly, the recognition rate of "Ga Na Da Hangul" are conducted, and finally, the experiment is conducted with the complete sentence that the author uses the most. All experiments use real voice as input through a computer microphone. Through the three experiments and results, we hope that the general public will be able to identify differences in recognition rates according to the applications currently available, helping to select APIs suitable for specific application purposes.