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Jung, Hee-Yeon,Cho, Sun-Young,Choi, Ji-Young,Cho, Jang-Hee,Park, Sun-Hee,Kim, Yong-Lim,Kim, Hyung-Kee,Huh, Seung,Won, Dong Il,Kim, Chan-Duck KOREAN ACADEMY OF MEDICAL SCIENCE 2019 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.34 No.12
<P><B>Background</B></P><P>Optimal tacrolimus (TAC) trough levels for different periods after kidney transplantation (KT) has not been definitely established. This study aimed to investigate transplant outcomes of low-level (LL) and standard-level (SL) TAC according to post-transplant period.</P><P><B>Methods</B></P><P>A total of 278 consecutive kidney transplant recipients (KTRs) receiving TAC-based immunosuppression were divided into LL and SL-TAC groups (4–7 and 7–12 ng/mL for 0–2 months, 3–6 and 6–10 ng/mL for 3–6 months, 2–5 and 5–8 ng/mL for 7–12 months, respectively) according to TAC trough level at each period. We compared estimated glomerular filtration rate (eGFR), biopsy-proven acute rejection (BPAR), de novo donor-specific antibody (dnDSA), calcineurin inhibitor (CNI) toxicity, opportunistic infection, and allograft survival.</P><P><B>Results</B></P><P>SL-TAC group showed significantly higher mean eGFR at 0–2 months than LL-TAC group (72.1 ± 20.3 vs. 64.2 ± 22.7 mL/min/1.73m<SUP>2</SUP>; <I>P</I> = 0.003). Incidence of BPAR at 7–12 months was significantly lower in SL-TAC group than in LL-TAC group (0.0% vs. 3.9%; <I>P</I> = 0.039). Patients with persistent SL-TAC lasting 12 months showed higher eGFR at 7–12 months than those with persistent LL-TAC (65.5 ± 13.0 vs. 57.9 ± 13.9 mL/min/1.73m<SUP>2</SUP>; <I>P</I> = 0.007). No significant differences in dnDSA, CNI toxicity, serious infections, or allograft survival were observed.</P><P><B>Conclusions</B></P><P>Maintenance of proper TAC trough level after 6 months could reduce BPAR without adverse drug toxicities in KTRs. Moreover, persistent SL-TAC during the first year after KT might have a beneficial effect on a trend for a lower incidence of dnDSA and better renal allograft function.</P>
Jung, Hee-Won,Kim, Jin Won,Kim, Ji-Yeon,Kim, Sun-Wook,Yang, Hyun Kyung,Lee, Joon Woo,Lee, Keun-Wook,Kim, Duck-Woo,Kang, Sung-Bum,Kim, Kwang-Il,Kim, Cheol-Ho,Kim, Jee Hyun Springer International ; Springer 2015 SUPPORTIVE CARE IN CANCER Vol.23 No.3
<P>The purpose of this study was to elucidate the effect of decreased muscle mass on the toxicity and survival of patients with colon cancer treated with adjuvant chemotherapy after surgery.</P>
Jung, Young Kul,Kim, Ji Hoon,Ahn, Sung-Min,Yang, Jae Won,Park, Sang Jin,Kim, Jong Woo,Yeon, Jong Eun,Kwon, Oh Sang,Kim, Yun Soo,Choi, Duck Joo,Kim, Ju Hyun,Byun, Kwan Soo by Lippincott WilliamsWilkins 2013 Journal of clinical gastroenterology Vol.47 No.7
BACKGROUND:: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population. METHODS:: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon-α and ribavirin. RESULTS:: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5%, the CT-genotype was 11.5%, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5%, the TG-genotype was 10.5%, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D&vprime;=1.0, &khgr; =0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2% (n=58) for 1b, 91.6% (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9% and that in CT-genotype was 40.0%. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR. CONCLUSIONS:: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B.
Experimental Study on Spray Etching Process In Micro Fabrication of Lead Frame
Jung, Ji-Won,Choi, Gyung-Min,Kim, Duck-Jool The Korean Society of Mechanical Engineers 2004 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.18 No.12
The objective of this study is to obtain detailed information for the micro fabrication of lead frames by applying spray technology to wet etching process. Wet etching experiments were performed with different etching parameters such as injection pressure, distance from nozzle tip to etched substrate, nozzle pitch and etchant temperature. The characteristics of single and twin spray were measured to investigate the correlation between the spray characteristics and the etching characteristics. Drop size and velocity were measured by Phase-Doppler Anemometer (PDA). Four liquids of different viscosity were used to reveal the effects of viscosity on the spray characteristics. The results indicated that the shorter the distance from nozzle tip and the nozzle pitch, the larger etching factor became. The average etching factor had good positive correlation with average axial velocity and impact force. It was found that the etching characteristics depended strongly on the spray characteristics.
A New Pea Cultivar, Cheongmi with Short Stem Height, Lodging Resistance and High Yield
Won Young Han,Sang Ouk Shin,Myoung Gun Choung,Chan Sik Jung,Doo Chull Shin,Sea Kwan Oh,Sung Taeg Kang,In Youl Baek,Duck Yong Suh,Soon Chul Kim,Dong Kwan Kim,Chang Ki Son 한국육종학회 2004 한국육종학회지 Vol.36 No.5
A new pea cultivar, Cheongmi was developed at the Yeongnam Agricultural Research Institute (YARI) in 2003. It was selected from a cross YP303 (Frescoloy / Upton) // YP113 (Sparkle/Early Bird) /3/ YP115 (Sparkle / Euiseongjaerae) in 1992. The preliminary,
( Jung-min Shin ),( Soo Jung Kim ),( Xue Mei Li ),( Jin Gwi Yoo ),( Dong-kyun Hong ),( Jin-hyup Lee ),( Chong Won Choi ),( Kyung-duck Park ),( Chang Deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ),( 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Alopecia areata (AA) is a chronic, relapsing hair-loss disorder that is considered to be a T-cell-mediated autoimmune disease. Several animal models for AA have been created to investigate the pathophysiology and screen for effective therapeutic targets. Objectives: As C3H/HeJ mice develop AA spontaneously in a low frequency, a novel animal model is needed to establish an AA-like condition faster and more conveniently. In this study, we present a novel non-invasive AA rodent model that avoids skin or lymph-node cell transfer. Methods: We simply injected C3H/HeJ mice subcutaneously with interferon-gamma (IFNγ) along with polyinosinic:polycytidylic acid (poly[I:C]), a synthetic dsRNA, to initiate innate immunity via inflammasome activation. Results: Approximately 80% of the IFNγ and poly(I:C) co-injected mice showed patchy AA lesions after 8 weeks. None of the mice displayed hair loss in the IFNγ or poly(I:C) solely injection group. Immunohistochemical staining of the AA lesions revealed increased infiltration of CD4+ and CD8+ cells infiltration around the hair follicles. IFNγ and poly(I:C) increased the expression of NLRP3, IL-1b, CXCL9, CXCL10, and CXCL11 in mouse skin. Conclusion: Taken together, these findings indicate a shorter and more convenient means of AA animal model induction and demonstrate that inflammasome-activated innate immunity is important in AA pathogenesis.
CASE REPORT : Mycobacterium abscessus Lung Disease in a Patient with Kartagener Syndrome
( Jung Hoon Kim ),( Won Jun Song ),( Ji Eun Jun ),( Duck Hyun Ryu ),( Ji Eun Lee ),( Ho Jung Jeong ),( Suk Hyeon Jeong ),( Hyung Koo Kang ),( Jung Soo Kim ),( Hyun Lee ),( Hae Ri Chon ),( Kyeong Man J 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3
Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, including nontuberculous mycobacteria (NTM). There has been no report of NTM lung disease combined with Kartagener syndrome in Korea. Here, we report an adult patient with Kartagener syndrome complicated with Mycobacterium abscessus lung disease. A 37-year-old female presented to our hospital with chronic cough and sputum. She was ultimately diagnosed with M. abscessus lung disease and Kartagener syndrome. M. abscessus was repeatedly isolated from sputum specimens collected from the patient, despite prolonged antibiotic treatment. The patient’s condition improved and negative sputum culture conversion was achieved after sequential bilateral pulmonary resection.
A case of congenital calcinosis cutis of the ear
( Jung-woo Ko ),( Jin-hyup Lee ),( Dong-kyun Hong ),( Kyung-duck Park ),( Chong Won Choi ),( Young Lee ),( Jeung-hoon Lee ),( Young-joon Seo ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Calcinosis cutis is the deposition of insoluble calcium salts in the skin. It could be divided into 4 categories according to the pathogenesis: dystrophic, metastatic, idiopathic, and iatrogenic. Congenital calcinosis cutis has been classified as a rare form of idiopathic calcification. A 35-month-old female visited our clinic with a whitish verrucous papule on the helix of her right ear since birth. Histopathological examination revealed dark basophilic-stained granular calcium deposits in the dermis. Serum calcium and phosphorus levels as well as renal function tests were normal. Her medical and family history were unremarkable. Congenital calcinosis cutis of the ear is rather rare and most of the reported cases occurred on the helix, the outermost part of the ear. Although the pathogenesis is not yet known, it is presumed to be caused by trauma during gestation. Herein, we report a case of congenital calcinosis cutis occurring on the ear.