지연유합과 불유합에서 저신호 강도 초음파의 유용성

윤여헌,김종오,고영도,유재두,정준모,오종건,방한천,최창호,신명철 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 저 신호 강도 초음파를 이용한 지연유합과 불유합의 치료에 대한 유용성을 알아보고자 하였다. 대상 및 방법 : 2001년 7월부터 2002년 5월까지 본원에 내원한 지연유합 7례와 불유합 8례를 대상으로 5개월간 저 신호 강도 초음파로 치료하여 5개월후 골유합 여부를 알아 보았다. 결 과 : 총 15례 중 대퇴골 간부 2례, 경골 간부 1례, 상완골 간부 1례, 요골 1례의 지연유합에서 골유합을 얻었고 대퇴골 간부 불유합 3례에서 유합을 얻었다. 지연주합은 71%의 유합율을, 불유합은 37.5%의 유합율을 보였다. 결 론 : 저 신호 강도 초음파는 골유합을 촉진 시킬 수 있으며 지연유합에서 시도해 볼 만 하나 불유합 치료를 위해서는 보다 많은 연구가 필요 하다. Purpose : To evaluation of usefulness of low-intensity ultrasound for nonunion and delayed union. Materials and Methods : For 5 months, we treated 7 delayed union and 8 nonunion using low-intensity ultrasound. After 5 months, in checked X-ray AP and Lateral view, when cortical bridge formation was done, we through union. Results : In 7 delayed union, 5 cases-2 femur, tibia, humerus, radius were healed. In 8 nonunion, 3 femur nonunion were healed. Union rate was 71% in delayed union 37.5% in nonunion. Conclusion : we thought that the low-intensity ultrasound has capacity of induction of union and was considered as the method of treatment for delayed union.

노령의 대퇴 전자간 골절 치료에서 압박고 나사못의 안정성 및 유용성

김종오,노권재,윤여헌,고영도,유재두,정준모,방한천,정재학 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 노령의 대퇴 전자간 골절에서 압박고 나사못의 안정성에 영향을 주는 인자들간의 상관 관계와 골절 양상에 따른 술후 고관절 기능을 평가 및 분석하였다. 대상 및 방법: 압박고 나사를 이용하여 수술적 치료를 시행한 231명의 환자 중 6개월 이상 추시가 가능하였던 60세 이상 84명의 환자들을 대상으로 했다. 방사선적 계측은 압박고 나사못의 활강 길이 및 내반각, 가압 나사 위치, 정복 상태, 원위 골편의 내측 전위를 측정하였으며 술후 기능은 Clawson의 기능 평가표로 하였고 골절 양상에 따라 방사선 계측과 기능 회복과의 상관 관계를 평가하였다. 결 과: 임상 결과는 불안정 골절에서 양호가 10례, 불량이 23례, 안정 골절에서는 양호 40례, 불량이 11례로 안정 골절에서 임상 결과가 좋았고(p<0.001), 압박고 나사 활강은 10 ㎜ 이상일 때 양호가 4례, 불량이 21례, 10 ㎜ 이하에서 양호가 46례, 불량이 13례로 10 ㎜ 이상 활강시에 술후 결과가 불량했다(p<0.001). 다르 방사선적 계측 요인은 결과에 의미있는 차이를 보이지 않았다. 또한, 불안정 골절 중에서 전위 양상 골절의 경우 10㎜ 이상 활강이 12례, 10㎜ 이하 활강이 8례, 분쇄 양상 골절의 경우는 10㎜ 이상이 11례, 10㎜ 이하가 2례로 분쇄 양상의 불안정 골절에서 10㎜ 이상 활강이 의미있게 많았다 (p<0.001). 결 론: 10㎜ 이상의 지연 나사 활강은 고관절 기능 회복 약화를 유발시킬 수 있으며 불안정 골절 분쇄 양상 골절은 이런 지연 나사의 활강이 과도하게 유발될 수 있으므로 불안정 분쇄 양상 골절에서 압박고 나사의 단독 사용은 재고해 보아야 할 것이다. Purpose: To evaluate the relationship between fracture stability and functional results, and analyze the correlation between stability factors and the outcome in intertrochanteric fracture of the elderly. Materials and Methods: Of the 231 patients, 84 patients with age above 60 were able to follow up for minimum 6 months. We measured the sliding length of the lag screw, varus degree, position of lag screw, reduction status and medialization of distal fragment radiologically. The functional outcome of the treatment was evaluated with the Clawson's result classification and we evaluated the correlation between the radiological results of measurement and the functional recovery depending on the Evans fracture classification. Results: There were good results in 40 cases out of 51 stable fractures, and in 10 cases out of 33 unstable fractures (p<0.001). In case of sliding of lag screw more than 10㎜, good results were obtained in 4 cases, and poor in 21. And in case of sliding less than 10㎜, good results were obtained in 46, and poor in 13. (p<0.001).But there was no relationship between other radiologic factors and clinical results. In unstable type, there were 12 cases with lag screw sliding more than 10㎜ and 10 cases with less than 10㎜. In comminuted type, there were 11 cases with lag screw sliding more than 10㎜ and 2 cases with less than 10㎜(p<0.001). Conclusion: The sliding of lag screw more than 10㎜ may result in poor outcome. As in comminuted unstable pattern, sliding of lag screw might be excessive, the use of compression hip screw alone is not good treatment option.

Isolation and characterization of the Citrobacter freundii phage EF1 from earthworm (Eisenia fetida)

Jun Heon Yeo,Jung Seok Lee,Se Pyeong Im,Jassy Mary Lazarte,Si Won Kim,Jae Wook Jung,Hong Jae Shin,Jung Yeol Bae,Ae Rin Lee,Jae sung Kim,Tae Sung Jung 대한수의학회 2016 대한수의학회 학술대회발표집 Vol.2016 No.-

The etiology and natural course of Dermatomyositis/polymyositis (DM/PM) patients with acute respiratory failure

( Sung Jun Chung ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Purpose: The etiology and natural course of Dermatomyositis/polymyositis (DM/PM) patients with acute respiratory failure have not been well studied. Methods: A total of 36 patients who were admitted to medical intensive care unit between January, 2002 to August, 2018 in Hanyang Medical center due to acute respiratory failure were retrospectively evaluated. Results: Of the 36 patients, 19 had acute exacerbation (AE) of DM/PM-associated interstitial lung disease and 17 had pneumonia. The overall in-hospital mortality was 44.4% (16/36) including 9 (52.6%) in patients with AE of DM/PM-associated ILD and 7 (41.2%) in patients with pneumonia. There was no significant difference in-hospital mortality between the two groups (P=0.492). Conclusion: The treatment outcomes in DM/PM patients who developed respiratory failure was relatively poor. There was no significant difference in-hospital mortality according to etiologies.

Coexisting Respiratory Comorbidities and Mortality Risk in Patients with Asthma: A National Cohort Study

( Yoomi Yeo ),( Ji-yong Moon ),( Hyun Lee ),( Jiin Ryu ),( Sung Jun Chung ),( Tai Sun Park ),( Dong Won Park ),( Sang-Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Asthma patients often have coexisting pulmonary comorbidities that are associated with severe presentation, poor quality of life, and more health care resource use. However, except for chronic obstructive pulmonary disease (COPD), the impact of coexisting pulmonary comorbidities on mortality in patients with asthma has not been comprehensively evaluated using nationally representative data. Methods Using a nationally representative sample database, we performed a retrospective cohort study of patients with asthma and age- and sex-matched cohort. We estimated hazard ratio (HR) and 95% confidence interval (CI) for mortality comparing the asthma cohort with the matched cohort. Results During a median of 8.9 follow-up duration, the overall mortality rate was higher in the asthma cohort than in the matched cohort (1,312/100,000 person-years vs. 1,174/100,000 person-years, p <0.001). The HR for mortality in the asthma cohort relative to the matched cohort asthma was 1.13 (95% confidence interval [CI], 1.07-1.19), which was especially higher in males (HR = 1.22, 95% CI = 1.13-1.31) and patients under 60 years (HR = 1.25, 95% CI = 1.10-1.42). Comorbid respiratory diseases further increased mortality of patients in the asthma cohort compared to those in the matched cohort (adjusted HR = 2.94, 95% CI = 2.75-3.14 for COPD; adjusted HR = 2.50, 95% CI = 2.07-3.02; adjusted HR = 7.30, 95% CI = 4.60-11.58 for lung cancer; and adjusted HR = 1.92, 95% CI = 1.75-2.09 for pneumonia). Conclusions Patients with asthma had a higher mortality rate compared to those without asthma, especially in males and those under 60 years. Coexisting pulmonary comorbidities, including COPD, bronchiectasis, lung cancer, and pneumonia, primarily explained the higher mortality in patients with asthma compared to those without asthma.

COVID-19 Vaccine Induced Systemic Inflammatory Response Syndrome

( Sang-heon Kim ),( Soo Jin Lee ),( Sung Jun Chung ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-Yong Moon ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

To protect people from coronavirus disease 2019 (COVID-19), various types of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered. Adverse reactions to COVID-19 vaccines include various local and systemic adverse reactions which may occur immediately or weeks later. Here we report a case of systemic inflammatory response syndrome induced by COVID-19 vaccine. A 65-year-old man with a history of hypertension presented with 5 days of fever. On admission, he was febrile to 38.3℃ with mild dyspnea when experiencing febrile sensation. Six days ago, he was vaccinated with the BNT162b2 mRNA COVID-19 vaccine. Fever with chill developed one day after vaccination and persisted. Chest radiography and a CT scan showed bilateral pleural effusion. Abdomen CT showed interstitial edematous pancreatitis at pancreas tail and perinephric infiltration. PET/CT revealed diffuse hypermetabolic infiltration or activity in mediastinal fat tissue, pericardial and peritoneal thickening. Laboratory Results documented leukocytosis, elevated levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and C-reactive protein. There was no evidence of possible infectious diseases or rheumatic diseases after a full examination and consultation with the specialists. With the administration of high-dose oral corticosteroids, fever and pleural effusion disappeared gradually. These findings suggest systemic inflammatory response syndrome induced by COVID-19 mRNA vaccine.

Pyridine-functionalized graphene/polyimide nanocomposites; mechanical, gas barrier, and catalytic effects

Lim, Jun,Yeo, Hyeonuk,Kim, Seo Gyun,Park, Ok-Kyung,Yu, Jaesang,Hwang, Jun Yeon,Goh, Munju,Ku, Bon-Cheol,Lee, Heon Sang,You, Nam-Ho Elsevier 2017 Composites Part B, Engineering Vol.114 No.-

<P><B>Abstract</B></P> <P>In this paper, we describe a functionalization route for synthesizing pyridine-functionalized reduced graphene oxide (Py-rGO) and the effect in the polymer matrix. In addition, polyimide (PI) nanocomposites with different loadings of Py-rGO are fabricated by in-situ polymerization. Py-rGO can perform as a filler component, which enhances the mechanical properties of the composites as well as promote polycondensation as a catalyst. As a result, the PIs containing Py-rGO are obtained with a high degree of imidization and the nanocomposite films show improved mechanical properties and oxygen barrier properties compared to pure PI. To be specific, the tensile strength and tensile modules of the nanocomposite with 0.5 wt% loading of Py-rGO are enhanced by about 406% (527 MPa) and 928% (59 GPa) in comparison to those of pure PI, respectively. Furthermore, the oxygen barrier properties of the composites are extremely improved.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Grafting of Polyimide onto Chemically-Functionalized Graphene Nanosheets for Mechanically-Strong Barrier Membranes

Lim, Jun,Yeo, Hyeonuk,Goh, Munju,Ku, Bon-Cheol,Kim, Seo Gyun,Lee, Heon Sang,Park, Byoungnam,You, Nam-Ho American Chemical Society 2015 Chemistry of materials Vol.27 No.6

<P>A series of polyimide (PI) nanocomposite films with different loadings of aminophenyl functionalized graphene nanosheets (AP-rGO) was fabricated by in situ polymerization. AP-rGO, a multifunctional carbon nanofiller that can induce covalent bonding between graphene nanosheets and the PI matrix, was obtained through the combination of chemical reduction and surface modification. In addition, phenyl functionalized graphene nanosheets (P-rGO) were prepared by phenylhydrazine for reference nanocomposite films. Because of homogeneous dispersion of AP-rGO and the strong interfacial interaction between AP-rGO and the PI matrix, the resulting nanocomposite films that contained AP-rGO exhibited reinforcement effects of mechanical properties and oxygen barrier properties that were even better than those of pure PI and the reference nanocomposite films. In comparison to the tensile strength and tensile modules of pure PI, the composite films that contained AP-rGO with 3 wt % loading were increased by about 106% (262 MPa) and 52% (9.4 GPa), respectively. Furthermore, the oxygen permeabilities of the composites with 5 wt % filler content were significantly decreased, i.e., they were more than 99% less than the oxygen permeability of pure PI.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2015/cmatex.2015.27.issue-6/cm5044254/production/images/medium/cm-2014-044254_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm5044254'>ACS Electronic Supporting Info</A></P>

Acute respiratory distress syndrome caused by gadolinium: a case report

( Sung Jun Chung ),( Ho Joo Yoon ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0

Acute respiratory distress syndrome (ARDS) is a serious parenchymal lung disease characterized by acute respiratory failure. While various factors can lead to the development of ARDS, many drugs are also suggested to cause ARDS. Gadolinium is a chemical agent, which is used as contrast agents for magnetic resonance imaging (MRI). Here we report a case of gadolinium induced ARDS in a young male adult. A 25-year-old male patient presented to the emergency department of a tertiary university hospital with acute onset dyspnea. On the day of dyspnea onset, he underwent a brain MRI for evaluation of his headache which lasted for three months. Previously, he was healthy and had not taken any medications. Twenty minutes after administration of gadobutrol, a gadolinium- based contrast agent during MRI, he felt short of breath. As dyspnea aggravated over hours, he visited the emergency department of a tertiary university hospital. On physical examination, the respiratory rate was thirty per minute and the breath sound was decreased over the chest. Chest radiographs and CT scan showed bilateral diffuse infiltration of both lungs without cardiomegaly or pleural effusion. Arterial partial pressure of oxygen (PaO₂) was decreased below 60/ mmHg and the ratio of PaO₂ over the fraction of inspired oxygen was 220 mmHg. He was admitted to the intensive care unit for the treatment of ARDS. As initial therapy, oxygen was administered with a highflow nasal cannula and systemic corticosteroids were given. Over a week of hospitalization and treatment, chest infiltration was recovered and acute respiratory failure was resolved.

Risk factors of reintubation in patients receiving post-extubation nasal high flow therapy

( Yoomi Yeo ),( Tai Sun Park ),( Min Ju Jo ),( Ji-yong Moon ),( Tae-hyung Kim ),( Sung Jun Chung ),( Hyun Lee ),( Dong Won Park ),( Sang Heon Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Use of nasal high-low therapy (NHF) after extubation was known to lower reintubation rate. However, there are still patients undergoing reintubation despite of post-extubation NHF therapy. Purpose: The purpose of this study was to evaluate the risk factors of reintubation in patients receiving post-extubation NHF therapy. Methods: From January 2018 to June 2019, patients who underwent mechanical ventilation and NHF after extubation at Hanyang University Guri Hospital were analyzed retrospectively. All patients received adequate sedation and planned extubation was performed after passing spontaneous awakening test and spontaneous breathing test (SBT). Reintubation was performed in cases of followings: hemodynamic instability, a deterioration of neurologic status, or signs of persisting or worsening respiratory failure. Results: Of 20 patients, 6 (30%) were underwent reintubation. Patients who received reintubation had lower BMI (20.1 ± 3.4 vs. 23.4 ± 2.6, p = 0.03) compared to those who did not. There were no significant differences in age, sex, comorbidities, APACHE II score at ICU admission and day of extubation, duration of SBT, and PaO2/FiO2 ratio just before extubation. The kinds of sedatives used during mechanical respiration, the use of neuromuscular blockers, and the use of steroids prior to extubation also did not differ. However, low BMI did not show statistical significance in predicting reintubation risk in multivariate analysis (OR = 0.655, p = 0.059). Conclusion: The frequency of reintubation may be high in patients with low BMI in patients receiving NHF therapy after extubation.