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Won, Kyung Jong,Jung, Seung Hyo,Jung, Soo Hyun,Lee, Kang Pa,Lee, Hwan Myung,Lee, Dong-Youb,Park, Eun-Seok,Kim, Junghwan,Kim, Bokyung Oxford University Press 2014 Cardiovascular research Vol.101 No.3
<P><B>Aims</B></P><P>DJ-1/park7, a multifunctional protein, may play essential roles in the vascular system. However, the function of DJ-1/park7 in vascular contractility has remained unclear. The present study was designed to investigate whether the DJ-1/park7 is involved in the regulation of vascular contractility and systolic blood pressure (SBP).</P><P><B>Methods and results</B></P><P>Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7<SUP>−/−</SUP>) mice than in wild-type (DJ-1/park7<SUP>+/+</SUP>) mice. Acetylcholine inhibited NE-evoked contraction in endothelium-intact vessels, and this was markedly impaired in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP>. Nitric oxide (NO) production (82.1 ± 2.8% of control) and endothelial NO synthase (eNOS) expression (61.7 ± 8.9%) were lower, but H<SUB>2</SUB>O<SUB>2</SUB> production (126.4 ± 8.6%) was higher, in endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice than in those from DJ-1/park7<SUP>+/+</SUP> controls; these effects were reversed by DJ-1/park7-overexpressing endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice. Histone deacetylase (HDAC)-1 recruitment and H3 histone acetylation at the eNOS promoter were elevated and diminished, respectively, in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls. Moreover, SBP was significantly elevated in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls, but this elevation was inhibited in mice treated with valproic acid, an inhibitor of Class I HDACs including HDAC-1.</P><P><B>Conclusion</B></P><P>These results demonstrate that DJ-1/park7 protein may be implicated in the regulation of vascular contractility and blood pressure, probably by the impairment of NO production through H<SUB>2</SUB>O<SUB>2</SUB>-mediated epigenetic inhibition of eNOS expression.</P>
Doping effects of multiferroic manganitesYMn0.9X0.1O3(X=Al, Ru, and Zn)
Park, Junghwan,Kang, Misun,Kim, Jiyeon,Lee, Seongsu,Jang, Kwang-Hyun,Pirogov, A.,Park, J.-G.,Lee, Changhee,Park, S.-H.,Kim, Hyoung Chan American Physical Society 2009 Physical review. B, Condensed matter and materials Vol.79 No.6
우리나라 금융과 경제성장 -금융의 비효율성과 과잉금융을 중심으로
박정수 ( Jungsoo Park ),박하일 ( Hail Park ),박영철 ( Yung Chul Park ),박정환 ( Junghwan Park ) 한국금융연구원 2018 韓國經濟의 分析 Vol.24 No.1
우리나라에서는 금융부문의 양적발전과 실물경제의 발전 간의 상관관계가 최근 떨어지고 있어 금융과 실물 간 괴리현상이 관찰되고 있다. 본 연구는 이러한 현상에 주목하여 금융과 실물 간 괴리현상의 원인들을 점검해 보고 우리나라 산업패널 자료를 기초로 산업수준에서 금융심화와 경제성장, 그리고 과잉금융의 가능성을 분석해 보았다. 그 결과 기업의 위험기피 현상, 내부자본 의존성의 심화, 금융부문의 구조적 취약성과 배분적 비효율성의 증가, 가계대출 의존성의 심화 등이 그 잠재적 원인으로 지목되었다. 금융과 성장 간의 실증분석에서는 대부분의 모형추정결과에서 금융심화의 편익이 극히 미약하거나 유의하지 않는 것으로 나타났다. 본 연구 결과에 따르면 우리나라 금융이 향후 양적으로 발전한다고 하더라도 초기 발전단계에서 관찰된 금융심화의 성장효과는 기대하기 어려울 것으로 예상할 수 있다. As correlation between financial development and real sector development is weakening in Korea recently, we are observing disparity between finance and growth. This paper reviews and evaluates potential factors causing this observed disparity. We further analyze the relationship between financial deepening and economic growth, and check for the possibility of excessive finance based on analyses using Korean industry-level panel data. We find that risk aversion tendency of firms, growing dependence on internal funds, structural weakness of the financial system, increasing allocative inefficency of finance, and growing dependence on household lending are the factors which may potentially explain this gap. The empirical results show that benefits from financial deepening are weak or insignificant. The findings in this study show that we cannot expect growth induced from further financial deepening in Korea.
An electrochemical hydrogen peroxide sensor for applications in nuclear industry
Park, Junghwan,Kim, Jong Woo,Kim, Hyunjin,Yoon, Wonhyuck Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.1
Hydrogen peroxide is a radiolysis product of water formed under gamma-irradiation; therefore, its reliable detection is crucial in the nuclear industry for spent fuel management and coolant chemistry. This study proposes an electrochemical sensor for hydrogen peroxide detection. Cysteamine (CYST), gold nanoparticles (GNPs), and horseradish peroxidase (HRP) were used in the modification of a gold electrode for fabricating Au/CYST/GNP/HRP sensor. Each modification step of the electrode was investigated through electrochemical and physical methods. The sensor exhibited strong sensitivity and stability for the detection and measurement of hydrogen peroxide with a linear range of 1-9 mM. In addition, the Michaelis-Menten kinetic equation was applied to predict the reaction curve, and a quantitative method to define the dynamic range is suggested. The sensor is highly sensitive to H<sub>2</sub>O<sub>2</sub> and can be applied as an electrochemical H<sub>2</sub>O<sub>2</sub>-sensor in the nuclear industry.
Park, Junghwan,Choi, Yong Suk,Kim, Junhyuck,Lee, Jeongmook,Kim, Tae Jun,Youn, Young-Sang,Lim, Sang Ho,Kim, Jong-Yun Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.4
Most thickness measurement techniques using X-ray radiation are unsuitable in field processes involving fast-moving organic films. Herein, we propose a Compton scattering X-ray radiation method, which probes the light elements in organic materials, and a new simple, non-destructive, and non-contact calibration-free real-time film thickness measurement technique by setting up a bench-top X-ray thickness measurement system simulating a field process dealing with thin flexible organic films. The use of X-ray fluorescence and Compton scattering X-ray radiation reflectance signals from films in close contact with a roller produced accurate thickness measurements. In a high-thickness range, the contribution of X-ray fluorescence is negligible, whereas that of Compton scattering is negligible in a low-thickness range. X-ray fluorescence and Compton scattering show good correlations with the organic film thickness (R<sup>2</sup> = 0.997 and 0.999 for X-ray fluorescence and Compton scattering, respectively, in the thickness range 0-0.5 mm). Although the sensitivity of X-ray fluorescence is approximately 4.6 times higher than that of Compton scattering, Compton scattering signals are useful for thick films (e.g., thicker than ca. 1-5 mm under our present experiment conditions). Thus, successful calibration-free thickness monitoring is possible for fast-moving films, as demonstrated in our experiments.