Expression Characteristics of Proteins of the Insulin-like Growth Factor Axis in Non-small Cell Lung Cancer Patients with Preexisting Type 2 Diabetes Mellitus

Ding, Jing,Tang, Jie,Chen, Xin,Men, Hai-Tao,Luo, Wu-Xia,Du, Yang,Ge, Jun,Li, Cong,Chen, Ye,Cheng, Ke,Qiu, Meng,Liu, Ji-Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Preexisting type 2 diabetes mellitus (T2DM) affects the prognosis and mortality of patients with some cancers. Insulin like growth factor (IGF) and insulin receptor (IR) signaling axes play important roles in both cancer and diabetes development. We aimed to explore the expression characteristics of proteins in IGF/IR axis in non-small cell lung cancer (NSCLC) cases with preexisting T2DM. Methods: Fifty-five NSCLC patients with preexisting T2DM were retrospectively included and matched by 55 NSCLC without diabetes at a 1:1 ratio. The expression of proteins in IGF/IR axis was detected by immunohistochemical staining. Clinicopathological data were collected to analyze their relationship with the protein expression. Results: Both IGF 1 receptor (IGF-1R) and insulin receptor substrate 2 (IRS-2) showed higher expression in the NSCLC with T2DM group, compared with those without T2DM. The high expression of IGF-1R and IRS-2 were found to be negatively associated with lymph node metastases and T staging in the T2DM group, respectively, and IRS-2 expression was also found more in the subgroup whose T2DM duration was more than 4 years. No difference was detected in the expression of IRS-1, IGF-1, IGF-2, IGFBP3, IR and mTOR between groups with or without T2DM. Conclusion: Our study found higher expression of IGF-1R and IRS-2 proteins in NSCLC patients with preexisting T2DM, and that there was an association with early stage NSCLC, which suggested that IGF signaling may play an important early event in development of NSCLC associated with diabetes.

The Influence of Changing PV Array Interconnections under a Non-uniform Irradiance

Ding, Kun,Feng, Li,Qin, Si-Yu,Mao, Jing,Zhang, Jing-Wei,Wang, Xiang,Peng, Tao,Zhai, Quan-Xin The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2

Usually, the output characteristics of a photovoltaic (PV) array are significantly affected by non-uniform irradiance which is caused by ambient obstacles, clouds, orientations, tilts, etc. Some local maximum power points (LMPP) in the current-voltage (I-V) curves of a PV array can result in power losses of the array. However, the output power at the global maximum power point (GMPP) is different in different interconnection schemes in a PV array. Therefore, based on the theoretical analysis and mathematical derivation of different topological structures of a PV array, this paper investigated the output characteristics of dual series PV arrays with different interconnections. The proposed mathematical models were also validated by experimental results. Finally, this paper also concluded that in terms of performance, the total cross tied (TCT) interconnection was not always the optimal structure, especially in a dual series PV array. When one of the PV modules was severely mismatched, the TCT worked worse than the series parallel (SP) structure. This research can provide guidance for switching the interconnection to gain the greatest energy yield in a changeable- structure PV system.

중국인들의 한류스타에 대한 동일시욕구 및 관광기념품 선택속성이 한류 스타 관련 관광기념품 만족도, 재구매 및 구전의도에 미치는 영향 연구

Ding, Jing-Yi,남윤재 한국관광학회 2020 관광학연구 Vol.44 No.1

The purpose of this study is to examine how the perception level of the selective attribute of tourism souvenirs related to Hallyu stars and fandom and the desire for homogeneity for them affect purchasing behavior, including repurchase and friendly word-of-mouth behavior. Results indicate that the quality and uniqueness of tourism souvenirs and the atmosphere, facilities, and accessibility of the stores had a positive effect on purchase satisfaction. However, the language, knowledge, and attitude of salespersons who sold of Hallyu star souvenirs did not have a statistically significant effect on purchase satisfaction. Also, the desire to identify with Hallyu star fandom had a positive effect on purchase satisfaction for Hallyu star souvenirs. Furthermore, all optional attributes of Hallyu star tourist souvenirs and the desire for identification of fandom had a direct effect on word-of-mouth behavior. This study is meaningful in that it deals with Hallyu star tourism souvenirs, which have not been thoroughly covered in the previous research. In addition, the fact that the desire to identify with the fandom of Hallyu stars was studied together with the causal relationship between purchase satisfaction and post-purchase behavior is more significant than previous studies, which have mainly focused on the selection attributes of tourism souvenirs. 본 연구는 한류스타의 이미지를 활용해 제작한 관광기념품의 선택속성과 한류 스타에 대한 팬덤으로 인한 동일시 욕구가 한류스타 관광기념품 구매의 전반적인 만족도와 구전의도에 어떠한 영향을 주는지에 대하여 분석하였다. 연구결과로는 한류스타의 관광기념품의 품질, 독특함 그리고 점포 분위기 및 접근성은 구매 만족에 긍정적인 영향을 미치는 것으로 나타났다. 그러나 한류스타 관광기념품을 판매하는 판매원의 언어, 지식, 태도는 구매만족에 통계적으로 유의한 영향을 미치지 않는 것으로 나타났다. 그리고 한류스타에 대한 동일시 욕구도 구매 만족도에 영향을 주고 있으며, 재구매 및 구전의도에 통계적으로 직접적이고 유의미한 영향을 주는 것으로 나타났다. 본 연구는 선행연구에서 많이 다루지 않은 한류스타 관광기념품을 소재로 다뤘다는 점에서 의의가 있으며, 관광기념품의 선택 속성에 주로 중심을 두었던 선행연구들에 비해 한류스타에 대한 팬덤의 동일시 욕구를 함께 연구하여 구매만족과 구매 후 소비행동과의 인과 관계를 규명하였다는 점에 연구의 의의가 있다.

Electrochemical removal of nitrogenous species for high salinity contained industrial wastewater effluent

Jing Ding,Guanshu Zhao,Qingliang Zhao,Fanyu Meng 대한환경공학회 2019 대한환경공학회 학술발표논문집 Vol.2019 No.-

결혼이주여성의 공적 지원서비스 초기 이용 유형과 관련 요인

딩징야(Jing-ya Ding),진미정(Meejung Chin) 가정과삶의질학회 2021 가정과삶의질연구 Vol.39 No.4

The Influence of Changing PV Array Interconnections under a Non-uniform Irradiance

Kun Ding,Li Feng,Si-Yu Qin,Jing Mao,Jing-Wei Zhang,Xiang Wang,Tao Peng,Quan-Xin Zhai 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2

Usually, the output characteristics of a photovoltaic (PV) array are significantly affected by non-uniform irradiance which is caused by ambient obstacles, clouds, orientations, tilts, etc. Some local maximum power points (LMPP) in the current-voltage (I-V) curves of a PV array can result in power losses of the array. However, the output power at the global maximum power point (GMPP) is different in different interconnection schemes in a PV array. Therefore, based on the theoretical analysis and mathematical derivation of different topological structures of a PV array, this paper investigated the output characteristics of dual series PV arrays with different interconnections. The proposed mathematical models were also validated by experimental results. Finally, this paper also concluded that in terms of performance, the total cross tied (TCT) interconnection was not always the optimal structure, especially in a dual series PV array. When one of the PV modules was severely mismatched, the TCT worked worse than the series parallel (SP) structure. This research can provide guidance for switching the interconnection to gain the greatest energy yield in a changeable- structure PV system.

A Computer Model for Simulating the Bicycle Rider's Behavior in a Virtual Riding System

( Wei-long Ding ),( Xiao Ding ),( Kai Chen ),( Zang-xin Wan ),( Yan Xu ),( Yuan-jing Feng ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.3

People are increasingly demanding to experience realistic behavior of virtual characters in computer games. In this article, we build a computer model for simulating a bicycle rider’s behavior in a virtual riding system. A method to calculate the speed of a bicycle rider is proposed to improve the reality in a virtual riding system. In this method, the property of physical energy is introduced, and the bicycle-riding speed is calculated in real time according to the relationship between the rider’s physical energy and bicycle-riding speed. Then based on the analysis of the behavior of a cyclist in a real competition, various behaviors of the virtual rider are designed and a behavior-tree for the virtual bicycle rider is constructed accordingly. On the basis of these, a virtual riding system is developed. The experiments results show that our system can simulate the behavior of a virtual bicycle rider, and thus encourage exercise on a stationary bicycle.

Clinical Study of Thalidomide Combined with Dexamethasone for the Treatment of Elderly Patients with Newly Diagnosed Multiple Myeloma

Chen, Hai-Fei,Li, Zheng-Yang,Tang, Jie-Qing,Shen, Hong-Shi,Cui, Qing-Ya,Ren, Yong-Ya,Qin, Long-Mei,Jin, Ling-Juan,Zhu, Jing-Jing,Wang, Jing,Ding, Jie,Wang, Ke-Yuan,Yu, Zi-Qiang,Wang, Zhao-Yue,Wu, Tian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: To investigate the relationship between the efficacy and safety of different doses of thalidomide (Thal) plus dexamethasone (Dex) as the initial therapy in elderly patients with newly diagnosed multiple myeloma (MM). Methods: Clinical data of 28 elderly patients with newly diagnosed MM who underwent the TD regimen as the initial therapy were analyzed retrospectively. The patients were divided into two groups according to the maximal sustained dose of Thal: lower dose (group A) and higher dose (group B). The overall response rate (ORR), progression free survival (PFS), overall survival (OS), and adverse events (AES) were compared between the two groups. Results: A total of 28 patients were followed up with a median of 18 months. The ORR was 60.1%. The median response time and PFS were 2.0 and 17.0 months, respectively. The mean sustained dose of Thal in group B was significantly higher than group A (292.9 mg v 180.4 mg, P=0.01). There was no significantly difference in ORR (57.1% v 64.3%, P=1.00) and PFS (9.63months v 17.66 months, P=0.73) between groups A and B. During the follow up, only five patients died (<40%) and, therefore, median OS values were not available. It is estimated, however, that the mean survival time in the two groups was 35.6 and 33.4 months (P>0.05), respectively. All of the patients tolerated the treatment well. The incidence of AES in patients with a grading above 3 in group B was significantly higher than in group A (P=0.033). Conclusions: The TD regimen results in a high response rate and manageable AES as the initial therapy in elderly patients with MM. TD should be considered as the front line regimen for the treatment of elderly patients with MM in areas with financial constraints. The clinical response can be achieved at a low dose Thal with minimal toxicity.

Adverse effect of DEHP exposure on the serum insulin level of Balb/c mice

Jing Wang,Jinquan Li,Kashif Rafiq Zahid,Kun Wang,Yan Qian,Ping Ma,Shumao Ding,Xu Yang,Xianliang Wang,Xianliang Wang,Xu Yang 대한독성 유전단백체 학회 2016 Molecular & cellular toxicology Vol.12 No.1

Di(2-ethylhexyl) phthalate (DEHP) is a common indoor pollutant in the world, which may cause lots of harmful effects in human including diabetes according to epidemiological studies. To explore the underlying role of DEHP in diabetes-like symptoms, Balb/c mice were chose to be the experimental animals in this paper. They were separated as eight groups as follows: (1) saline+normal diet (vehicle control), (2) 10 mg/kg.day DEHP+normal diet, (3) 50 mg/kg.day DEHP+normal diet, (4) 250 mg/kg.day DEHP+normal diet, (5) streptozotocin (STZ)+high fat diet (diabetes model), (6) 10 mg/kg.day DEHP+ STZ+high fat diet, (7) 50 mg/kg.day DEHP+STZ +high fat diet, (8) 250 mg/kg.day DEHP+STZ+high fat diet. The biomarkers of this experiment include four groups: (1) general indicates: body weight and drinking water, (2) blood biomarkers: serum insulin and fasting glucose, (3) pathological examination: pancreas section and kidney section, and (4) biomarkers of oxidative stress: reactive oxygen species (ROS) and malondialdehyde (MDA) in liver cells. Our study results demonstrate that: (1) at our treatment levels DEHP cannot directly induce diabetes, but reduce serum insulin level in DEHP-exposed non-STZ-treated animals, (2) pathological examination finds that these is a dose-dependent damage in the pancreas in DEHP- exposed STZ-treated groups, and (3) the oxidative mechanism may be involved in this pathological process.

Investigation of surface-piercing fixed structures with different shapes for Bragg reflection of water waves

Ding, Wei-Wei,Zou, Zao-Jian,Wu, Jing-Ping,Huang, Bai-Gang The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.2

Bragg reflection of water waves by three kinds of surface-piercing fixed structures with rectangular, cosinoidal and triangular shapes is studied. Boundary element method is used to analyze the wave scattering by these structures based on the linear wave theory. Results of reflection and transmission coefficients are validated by comparing with those available in literature. These structures with proper configurations are proved to be effective in attenuating waves by using Bragg reflection, and the triangular structures are found to be the best choices among the structures with same width and same area. Systematic calculations are then carried out for the triangular structures by varying the number, the draft, the width, the gap and the combination of width and gap of the structures to analyze their influences on the characteristics of Bragg reflection. The results are of reference values for design of the structures to attenuate waves based on the Bragg reflection.