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Ok, Chul-Ho,Kang, Dong-Hun,Lee, Kang-Min,Han, Jin-Woo,Kim, Byoung-Yong,Oh, Byeong-Yun,Kim, Young-Hwan,Hwang, Jeong-Yeon,Lee, Sang-Keuk,Han, Jeong-Min,Seo, Dae-Shik The Korean Institute of Electrical and Electronic 2007 Transactions on Electrical and Electronic Material Vol.8 No.6
The liquid crystal(LC) aligning capabilities of a nematic liquid crystal(NLC) on a homeotropic polyimide(PI) surface using a new ion-beam method were studied. Exposure ion-beam of $45^{\circ}$ incidence angle shows a good LC alignment of the NLC on the homeotropic PI surface. Also, on the homeotropic PI surface, the tilt angle of the NLC by exposure ion-beam of $45^{\circ}$ incidence angle had a tendency to decrease as increased ion-beam energy density. And, on the homeotropic PI surface, the alignment character of the NLC with respect to ion-beam energy was good at 1500 eV. And we achieved satisfactory result for EO character.
Jin, Hyun Mi,Kim, Jeong Myeong,Lee, Hyo Jung,Madsen, Eugene L.,Jeon, Che Ok American Chemical Society 2012 Environmental science & technology Vol.46 No.14
<P>Following the 2007 oil spill in South Korean tidal flats, we sought to identify microbial players influencing the environmental fate of released polycyclic aromatic hydrocarbons (PAHs). Two years of monitoring showed that PAH concentrations in sediments declined substantially. Enrichment cultures were established using seawater and modified minimal media containing naphthalene as sole carbon source. The enriched microbial community was characterized by 16S rRNA-based DGGE profiling; sequencing selected bands indicated <I>Alteromonas</I> (among others) were active. <I>Alteromonas</I> sp. SN2 was isolated and was able to degrade naphthalene, phenanthrene, anthracene, and pyrene in laboratory-incubated microcosm assays. PCR-based analysis of DNA extracted from the sediments revealed naphthalene dioxygenase (NDO) genes of only two bacterial groups: <I>Alteromonas</I> and <I>Cycloclasticus</I>, having gentisate and catechol metabolic pathways, respectively. However, reverse transcriptase PCR-based analysis of field-fixed mRNA revealed <I>in situ</I> expression of only the <I>Alteromonas</I>-associated NDO genes; in laboratory microcosms these NDO genes were markedly induced by naphthalene addition. Analysis by GC/MS showed that naphthalene in tidal-flat samples was metabolized predominantly via the gentisate pathway; this signature metabolite was detected (0.04 μM) in contaminated field sediment. A quantitative PCR-based two-year data set monitoring <I>Alteromonas</I>-specific 16S rRNA genes and NDO transcripts in sea-tidal flat field samples showed that the abundance of bacteria related to strain SN2 during the winter season was 20-fold higher than in the summer season. Based on the above data, we conclude that strain SN2 and its relatives are site natives--key players in PAH degradation and adapted to winter conditions in these contaminated sea-tidal-flat sediments.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2012/esthag.2012.46.issue-14/es3018545/production/images/medium/es-2012-018545_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/es3018545'>ACS Electronic Supporting Info</A></P>
Applicability and Safety of in Vitro Skin Expansion Using a Skin Bioreactor: A Clinical Trial
Jeong, Cheol,Chung, Ho Yun,Lim, Hyun Ju,Lee, Jeong Woo,Choi, Kang Young,Yang, Jung Dug,Cho, Byung Chae,Lim, Jeong Ok,Yoo, James J.,Lee, Sang Jin,Atala, Anthony J. Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6
Background Tissue expansion is an effective and valuable technique for the reconstruction of large skin lesions and scars. This study aimed to evaluate the applicability and safety of a newly designed skin expanding bioreactor system for maximizing the graft area and minimizing the donor site area. Methods A computer-controlled biaxial skin bioreactor system was used to expand skin in two directions while the culture media was changed daily. The aim was to achieve an expansion speed that enabled the skin to reach twice its original area in two weeks or less. Skin expansion and subsequent grafting were performed for 10 patients, and each patient was followed for 6 months postoperatively for clinical evaluation. Scar evaluation was performed through visual assessment and by using photos. Results The average skin expansion rate was $10.54%{\pm}6.25%$; take rate, $88.89%{\pm}11.39%$; and contraction rate, $4.2%{\pm}2.28%$ after 6 months. Evaluation of the donor and recipient sites by medical specialists resulted in an average score of 3.5 (out of a potential maximum of 5) at 3 months, and 3.9 at 6 months. The average score for patient satisfaction of the donor site was 6.2 (out of a potential maximum of 10), and an average score of 5.2 was noted for the recipient site. Histological examination performed before and after the skin expansion revealed an increase in porosity of the dermal layer. Conclusions This study confirmed the safety and applicability of the in vitro skin bioreactor, and further studies are needed to develop methods for increasing the skin expansion rate.
Jin, Hyun Mi,Jeong, Hye Im,Jeon, Che Ok International Union of Microbiological Societies 2015 International journal of systematic and evolutiona Vol.65 No.5
<P>A Gram-stain-negative heterotrophic bacterium, designated GSD6<SUP>T</SUP>, capable of growth on aliphatic hydrocarbons as a sole carbon and energy source, was isolated from sea-tidal flat sediment of the Yellow Sea, South Korea. Cells were facultatively aerobic, catalase- and oxidase-positive, motile rods with a single polar flagellum. Growth of strain GSD6<SUP>T</SUP> was observed at 4–37 °C (optimum 30 °C), at pH 5.5–9.0 (optimum pH 6.5–7.5) and in the presence of 1–9 % (w/v) NaCl (optimum 2 %). Strain GSD6<SUP>T</SUP> contained ubiquinone-8 (Q-8) as the sole isoprenoid quinone and summed feature 3 (comprising C<SUB>16 : 1</SUB>ω7<I>c</I> and/or iso-C<SUB>15 : 0</SUB> 2-OH), C<SUB>16 : 0</SUB>, C<SUB>18 : 1</SUB>ω7<I>c</I>, C<SUB>17 : 0</SUB> 10-methyl and C<SUB>17 : 1</SUB>ω8<I>c</I> as the major fatty acids. Phosphatidylethanolamine and phosphatidylglycerol were identified as the major polar lipids. The G+C content of the genomic DNA was 44.6 mol%. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain GSD6<SUP>T</SUP> formed a phylogenetic lineage with members of the genus <I>Aliiglaciecola</I> . Strain GSD6<SUP>T</SUP> was most closely related to <I>Aliiglaciecola lipolytica</I> E3<SUP>T</SUP> with a 16S rRNA gene sequence similarity of 97.4 %, but their DNA–DNA hybridization value was 39.1±7.1 %. On the basis of phenotypic, chemotaxonomic and molecular features, strain GSD6<SUP>T</SUP> represents a novel species of the genus <I>Aliiglaciecola</I> , for which the name <I>Aliiglaciecola aliphaticivorans</I> sp. nov. is proposed. The type strain is GSD6<SUP>T</SUP> ( = KACC 18129<SUP>T</SUP> = JCM 30133<SUP>T</SUP>). An emended description of the genus <I>Aliiglaciecola</I> is also proposed.</P>
Jin Hee Ok,Hae Jin Jeong,Hee Chang Kang,Sang Ah Park,Se Hee Eom,Ji Hyun You,Sung Yeon Lee 한국조류학회I 2022 ALGAE Vol.37 No.1
Water temperature affects plankton survival and growth. The dinoflagellate Shimiella gracilenta survives using the plastids of ingested prey, indicating kleptoplastidy. However, studies on the effects of water temperature on kleptoplastidic dinoflagellates are lacking. We explored the growth and ingestion rates of S. gracilenta as a function of water temperature. Furthermore, using data on its spatiotemporal distribution in Korean coastal waters during 2015–2018, we predicted its distribution under elevated temperature conditions of +2, +4, and +6°C. Growth rates of S. gracilenta with and without Teleaulax amphioxeia prey as well as ingestion rates were significantly affected by water temperature. Growth rates of S. gracilenta with and without prey were positive or zero at 5–25°C but were negative at ≥30°C. The maximum growth rate of S. gracilenta with T. amphioxeia was 0.85 d-1, achieved at 25°C, and 0.21 d-1 at 20°C without prey. The ingestion rate of S. gracilenta on T. amphioxeia at 25°C (0.05 ng C predator-1 d-1) was greater than that at 20°C (0.04 ng C predator-1 d-1). Thus, feeding may shift the optimal temperature for the maximum growth rate of S. gracilenta from 20 to 25°C. In spring and winter, the distributions of S. gracilenta under elevated temperature conditions were predicted not to differ from those during 2015–2018. However, S. gracilenta was predicted not to survive at some additional stations under elevated temperature conditions of +2, +4, and +6°C in summer or under elevated temperature conditions of +6°C in autumn. Therefore, global warming may affect the distribution of S. gracilenta.
Jeong, Jin-Woo,Park, Sejin,Park, Cheol,Chang, Young-Chae,Moon, Dong-Oh,Kim, Sung Ok,Kim, Gi-Young,Cha, Hee-Jae,Kim, Heui-Soo,Choi, Young-Whan,Kim, Wun-Jae,Yoo, Young Hyun,Choi, Yung Hyun National Hellenic Research Foundation 2014 ONCOLOGY REPORTS Vol.32 No.1
<P>Epidemiological studies indicate that components of garlic (Allium sativum) have anti-proliferative effects against various types of cancer. In the present study, we investigated the effect of newly isolated phenylamine derivative N-benzyl-N-methyldecan-1-amine (NBNMA) from garlic cloves on the inhibition of the growth and apoptosis of human leukemia U937 cells and its potential anticancer mechanism. NBNMA exhibited an antiproliferative effect in U937 cells by inducing cell cycle arrest at the G2/M phase and apoptotic cell death. Western blot analyses revealed that NBNMA decreased the expression of the regulator genes of G2/M phase progression, cyclin dependent kinase (Cdk) 2 and Cdc2 and elevated the expression of the Cdk inhibitor p21WAF1/CIP1 in a p53-independent manner. In addition, NBNMA activated caspase-8 and caspase-9, initiator caspases of the extrinsic and intrinsic pathways of apoptosis, respectively, which led to activation of executioner caspase-3 along with degradation of poly(ADP-ribose) polymerase. NBNMA-induced apoptosis was observed in parallel with an increased ratio of pro-apoptotic Bax and Bad/anti-apoptotic Bcl-2 and Bcl-xL, and inhibition of inhibitor of apoptosis protein (IAP) family members XIAP and cIAP-1. Furthermore, NBNMA-treated cells displayed enhanced release of cytochrome c from the mitochondria into the cytosol concomitant with a loss of mitochondrial membrane potential and downregulation of Bid, suggesting that NBNMA-induced apoptosis occurred via the extrinsic and intrinsic apoptotic pathways with a possible link to Bid protein activity between the two pathways. These results indicate that NBNMA has promising potential to become a novel anticancer agent for the treatment of leukemia. We provide new insight into the mechanisms underlying the anticancer effect of NBNMA.</P>
Treatment efficacy of alitretinoin in palmoplantar pustular psoriasis
( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Chul Hyun Yun ),( Ji Hoon Kim ),( Jin Ok Baek ),( Jong Rok Lee ),( Joo Young Roh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Palmoplantar Pustular Psoriasis (PPP) is a chronic inflammatory skin disease which is often resistant to therapy. The conventional treatments are topical corticosteroids, phototherapy, retinoids, tetracyclines, dapsone and cyclosporine. No therapeutic standard has yet been defined and no guidelines have been published on the treatment of PPP. Objectives: We performed a pilot study to evaluate the treatment efficacy of alitretinoin in PPP. Methods: Seven patients with PPP who were refractory to conventional treatments were treated with oral alitretinoin 30 mg once daily for 12 weeks. Efficacy was assessed at 12 weeks by modified palmoplantar Pustular Psoriasis area and severity index (mPPPASI), Physician``s Global Assessment (PGA) and Patient``s Global Assessment (PaGA). Results: mPPPASI decreased significantly after 12 weeks of treatment with alitretinoin. The average mPPPASI was 21.6 before treatment and 1.7 after treatment. PGA and PaGA of PPP improved significantly. The limitations of this study are its small sample size of patients and the concomitant usage of topical therapy. Conclusion: Our findings suggest that alitretinoin may represent a new and promising therapy for recalcitrant Palmoplantar Pustular Psoriasis and warrants further controlled studies to confirm efficacy and safety of alitretinoin in this disease.