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Ting Deng,Kaijiang Liu,Liang Chen,Xiao-jun Chen,Hua Wen Li,Hongyan Guo,Huijiao Zhang,Libing Xiang,Xin Feng,Xiaoyu Wang,Hextan Y. S. Ngan,Jianguo Zhao,Dongling Zou,Qing Liu,Jihong Liu 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3
Background: The Lymphadenectomy in Ovarian Neoplasms (LION) study revealed that systemic lymphadenectomy did not bring survival benefit for advanced ovarian cancer patients with clinically normal lymph nodes and was associated with a higher incidence of operative complications. However, there is no consensus on whether lymphadenectomy has survival benefit or not in early epithelial ovarian cancer (EOC). Methods: We designed the LOVE study, a multicenter, randomized controlled, phase III trial to compare the efficacy and safety of comprehensive staging surgery with or without lymphadenectomy in stages IA-IIB EOC and fallopian tube carcinomas (FTC). The hypothesis is that the oncological outcomes provided by comprehensive staging surgery without lymphadenectomy are non-inferior to those of conventional completion staging surgery in early-stage EOC and FTC patients who have indications for post-operative adjuvant chemotherapy. Patients assigned to experimental group will undergo comprehensive staging surgery, but lymphadenectomy. Patients assigned to comparative group will undergo completion staging surgery including systematic pelvic and para-aortic lymphadenectomy. All subjects will receive 3–6 cycles of standard adjuvant chemotherapy. Major inclusion criteria are pathologic confirmed stage IA-IIB EOC or FTC, and patients have indications for adjuvant chemotherapy either confirmed by intraoperative fast frozen section or previous pathology after an incomplete staging surgery. Major exclusion criteria are non-epithelial tumors and low-grade serous carcinoma. Patients with severe rectum involvement which lead to partial rectum resection will be excluded. The sample size is 656 subjects. Primary endpoint is disease-free survival.
A Form-Finding Method of Beam String Structures - Offload by Steps Method
Jihong Ye,Ruo-qiang Feng,Xianbo Zhao,Bin Liu 한국강구조학회 2012 International Journal of Steel Structures Vol.12 No.2
The problem of form-finding of beam string structures was studied, and the method named offload by steps was put forward in accordance with the properties of the mechanical status of the structures. This method was used to find the form of the unstrained state on the basis of the pre-stressed state without the need to assume the unstrained form first. Numerical simulations and experimental research on the form-finding of beam string structures were carried out to verify the offload by steps method and, more importantly, to study the application of the method in engineering practice. The scale of the experimental model was 1/20, and the stretching pattern was the same as that in practical engineering. Comparisons of internal forces and deformations corresponding to unstrained and pre-stressed states of the model were made between experimental and calculation results. The following conclusions were drawn. First, the offload by steps method can be applied to the engineering practice without assuming the form of the unstrained state, and the form of the unstrained state corresponding to that of the pre-stressed state can be obtained directly. Second, the internal forces of the beam string structures in their pre-stressed states can be obtained easily by using the statically-determinate calculation model in the offload by steps method, which can guide design effectively. Third, the method for estimating the cable tension by balancing the deadweight of the beam string truss can be applied to engineering practice.
Jin Liu,Ying Wang,Debi Prasanna Kanungo,Jihong Wei,Yuxia Bai,Ding Li,Zezhuo Song,Yi Lu 한국섬유공학회 2019 Fibers and polymers Vol.20 No.3
The brittleness characteristics of sand reinforced with polypropylene fiber (PF) and polyurethane organic polymer(POP) was investigated in detail using direct tensile and unconfined compression tests. The effects of POP/PF content, curing time and sand density on the brittleness of reinforced sand were studied. The reinforcement mechanism was analyzed with images of scanning electron microscope (SEM) and sample failure mode. The test results indicated that the brittleness of sand increases with curing time, and it has no obvious change after 48 h. The brittleness was decreased obviously with the increase in POP and PF contents. The brittleness of reinforced sand reaches a relative stable state when the POP and fiber contents reach 3 % and 0.6 % respectively. The brittleness also increased with sand density and it reaches a plateau at 1.55 g/cm3. The POP forms a large number of polymer films with water volatilizing in the sand, and the sand particles were wrapped. Fibers improved the compressive strength of reinforced sand and changed it to a more ductile one. Polypropylene fiber plays the role of reinforcing the sand, effectively improving the strength of the sand and reducing the brittleness of the reinforced sand.
Lu, Jingxiong,Sun, Jihong,Li, Fangyuan,Wang, Jin,Liu, Jianan,Kim, Dokyoon,Fan, Chunhai,Hyeon, Taeghwan,Ling, Daishun American Chemical Society 2018 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.140 No.32
<P>Iron oxide nanoparticle (IONP)-based magnetic resonance imaging (MRI) contrast agents have been widely used for the diagnosis of hepatic lesions. However, current IONP-based liver-specific MRI contrast agents rely on single-phase contrast enhancement of the normal liver, which is not sensitive enough to detect early stage small hepatocellular carcinomas (HCCs). We herein report i-motif DNA-assisted pH-responsive iron oxide nanocluster assemblies (termed RIAs), which provide an inverse contrast enhancemt effect to improve the distinction between normal liver and target HCC tissues. The acidic pH of the tumor microenvironment triggers the disassembly of the RIAs, which leads to a drastic decrease in their relaxivity ratio (<I>r</I><SUB>2</SUB>/<I>r</I><SUB>1</SUB>), thus converting the RIAs from a T2 to T1 contrast agent. This inverse contrast enhancement of normal liver darkening and HCC brightening under T1 imaging mode was validated on an orthotopic HCC model. Our design provides a novel strategy for the exploitation of the next-generation intelligent MRI contrast agents.</P> [FIG OMISSION]</BR>
Hu, Xi,Sun, Jihong,Li, Fangyuan,Li, Ruiqing,Wu, Jiahe,He, Jie,Wang, Nan,Liu, Jianan,Wang, Shuaifei,Zhou, Fei,Sun, Xiaolian,Kim, Dokyoon,Hyeon, Taeghwan,Ling, Daishun American Chemical Society 2018 Nano letters Vol.18 No.2
<P>Although metallic nanomaterials with high X-ray attenuation coefficients have been widely used as X-ray computed tomography (CT) contrast agents, their intrinsically poor biodegradability requires them to be cleared from the body to avoid any potential toxicity. On the other hand, extremely small-sized nanomaterials with outstanding renal clearance properties are not much effective for tumor targeting because of their too rapid clearance in vivo. To overcome this dilemma, here we report on the hollow bismuth subcarbonate nanotubes (BNTs) assembled from renal-clearable ultrasmall bismuth subcarbonate nanoclusters for tumor-targeted imaging and chemoradiotherapy. The BNTs could be targeted to tumors with high efficiency and exhibit a high CT contrast effect. Moreover, simultaneous radio- and chemotherapy using drug-loaded BNTs could significantly suppress tumor volumes, highlighting their potential application in CT imaging-guided therapy. Importantly, the elongated nanotubes could be disassembled into isolated small nanoclusters in the acidic tumor microenvironment, accelerating the payload release and kidney excretion. Such body clearable CT contrast agent with high imaging performance and multiple therapeutic functions shall have a substantial potential for biomedical applications.</P>