Exploring the role and mechanisms of diallyl trisulfide and diallyl disulfide in chronic constriction-induced neuropathic pain in rats

( Gang Wang ),( Yan Yang ),( Chunfeng Wang ),( Jianzhong Huang ),( Xiao Wang ),( Ying Liu ),( Hao Wang ) 대한통증학회 2020 The Korean Journal of Pain Vol.33 No.3

Background: Garlic oil is a rich source of organosulfur compounds including diallyl disulfide and diallyl trisulfide. There have been studies showing the neuroprotective actions of these organosulfur compounds. However, the potential of these organosulfur compounds in neuropathic pain has not been explored. The present study was aimed at investigating the pain attenuating potential of diallyl disulfide and diallyl trisulfide in chronic constriction injury (CCI)-induced neuropathic pain in rats. The study also explored their pain-attenuating mechanisms through modulation of H₂S, brain-derived neurotrophin factor (BDNF) and nuclear factor erythroid 2-related factor 2 (Nrf2). Methods: The rats were subjected to CCI injury by ligating the sciatic nerve in four places. The development of neuropathic pain was measured by assessing mechanical hyperalgesia (Randall-Selittotest), mechanical allodynia (Von Frey test), and cold allodynia (acetone drop test) on 14th day after surgery. Results: Administration of diallyl disulfide (25 and 50 mg/kg) and diallyl trisulfide (20 and 40 mg/kg) for 14 days led to a significant reduction in pain in CCI-subjected rats. Moreover, treatment with these organosulfur compounds led to the restoration of H₂S, BDNF and Nrf2 levels in the sciatic nerve and dorsal root ganglia. Coadministration of ANA-12 (BDNF blocker) abolished pain attenuating actions as well as BDNF and the Nrf2 restorative actions of diallyl disulfide and diallyl trisulfide, without modulating H₂S levels. Conclusions: Diallyl disulfide and diallyl trisulfide have the potential to attenuate neuropathic pain in CCI-subjected rats possibly through activation of H₂S-BDNF-Nrf2 signaling pathway.

ZnO Nanorod Array Modified PVDF Membrane with Superhydrophobic Surface for Vacuum Membrane Distillation Application

Wang, Manxiang,Liu, Guicheng,Yu, Hyunjin,Lee, Sang-Hyup,Wang, Lei,Zheng, Jianzhong,Wang, Tao,Yun, Yanbin,Lee, Joong Kee American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.16

<P>The vacuum membrane distillation (VMD) is a promising technology for lots of applications. To solve the membrane fouling and wetting problems, in this paper, a novel ZnO nanorods 1<I>H</I>,1<I>H</I>,2<I>H</I>,2<I>H</I>-perfluorodecyltriethoxysilane (PDTS) modified poly(vinylidene fluoride) (PVDF) membrane with a micro/nanoscale hierarchical structure and a superhydrophobic surface has been prepared and applied to the VMD process for distilling highly salty water, for the first time. Among these, a pyrolysis-adhesion method is created to obtain the ZnO seeds and fasten them on the PVDF substrate firmly. The novel modified membrane shows a stable superhydrophobic surface with a water contact angle of 152°, easy cleaning property, excellent thermal and mechanical stability, because of the Cassie’s state caused by pocketing much air in the hydrophobized ZnO nanorods, the low surface energy of PDTS coating, and the strong adhesion between ZnO nanorods and PVDF membrane, which has built an ideal structure for VMD application. After 8 h VMD of 200 g L<SUP>-1</SUP> NaCl solution, compared to the virgin PVDF membrane, the novel membrane shows a similar permeate flux but a much higher quality permeated liquid because of its unique antifouling and antiwetting caused by the several microns gap between the feed and the membrane. Due to its easy cleaning property, the novel membrane also exhibits an excellent reusability.</P> [FIG OMISSION]</BR>

The Research of Relationship between SICSFCL and Distance Relay Protection of Power Grid

Wang, Jianzhong,Cui, Jibin,Xiong, Zhiquan,Zi, Meirong The Korean Institute of Electrical Engineers 2012 The Journal of International Council on Electrical Vol.2 No.2

A Saturated Iron Core Superconducting Fault Current Limiter (SICSFCL) provides a powerful fault current limitation in high voltage and high capacity power grid. A 35kV/90MVA SICSFCL was installed in a 35 kV network for live-grid operation, in January 2008 at Puji substation, Kunming, China. With deep research on SICSFCL, the matching problem between SICSFCL and relay protection currently needs to be solved. This paper analyzes the influence that SICSFCL brings to the distance relay protection which is used widely in high voltage power grid, and considering the characteristics of microcomputerbased protection, this paper proposes a new algorithm to eliminate the influence.

Rheological and Printable Behavior of Epoxy Resin-based Materials for Extrusion 3D Printing Applications

Jianzhong Shang,Xin Li,Rong Wang,Zhuo Wang 한국고분자학회 2017 폴리머 Vol.41 No.5

This study investigates rheological and extrusion behavior of thermosetting epoxy resins. The purpose is to find the universal property and printing parameters for extrusion based rapid prototyping applications. The thickener proportion greatly influences its viscosity and rheological behavior and therefore plays an important role in the shape of the cross-section of the extrudate. In addition to the effects of the rheological behavior of the composite, shape maintenance and its wettability on the substrate, the cross-sectional geometry of the extrudate is also strongly affected by printing process parameters including the extrusion nozzle height, nozzle moving speed, extrusion rate, and critical nozzle height. Proper combinations of these process parameters are necessary in order to obtain single line extrudates with plump crosssections and 3D objects with dimensional accuracy, uniform wall thickness, good wall uprightness, and no wall slumping. Formulas and procedures for determining these extrusion parameters are proposed and demonstrated in experiments.

Optimizing Oily Wastewater Treatment Via Wet Peroxide Oxidation Using Response Surface Methodology

Shi, Jianzhong,Wang, Xiuqing,Wang, Xiaoyin Korean Chemical Society 2014 대한화학회지 Vol.58 No.1

The process of petroleum involves in a large amount of oily wastewater that contains high levels of chemical oxygen demand (COD) and toxic compounds. So they must be treated before their discharge into the receptor medium. In this paper, wet peroxide oxidation (WPO) was adopted to treat the oily wastewater. Central composite design, an experimental design for response surface methodology (RSM), was used to create a set of 31 experimental runs needed for optimizing of the operating conditions. Quadratic regression models with estimated coefficients were developed to describe the COD removals. The experimental results show that WPO could effectively reduce COD by 96.8% at the optimum conditions of temperature $290^{\circ}C$, $H_2O_2$ excess (HE) 0.8, the initial concentration of oily wastewater 3855 mg/L and reaction time 9 min. RSM could be effectively adopted to optimize the operating multifactors in complex WPO process.

Impact resistance and damage assessment of steel beams with different web openings

Huayan Chen,Jianzhong Huang,Chaojiang Fu,Sixiang Wang,Fengxuan Wang,Caisong Luo,Bizhen Wang 한국강구조학회 2024 International Journal of Steel Structures Vol.24 No.2

To investigate the impact resistance of steel beams with diff erent web openings, falling-hammer impact trials and numerical models analyses were performed, focusing on the impact energy, inter-opening space, and opening diameter. The impact resistance of steel beams with diff erent web openings was analyzed, and damage-assessment curves for web-opening steel beams (WOSBs) under impact loads were established. The results showed that web-hexagonal-opening steel beams (WHOSBs) yielded greater damage-related deformation than web-circular-opening steel beams (WCOSBs) for the same impact energy. The average maximum mid-span displacement of the WCOSBs under the falling-hammer was 86.49% that of the WHOSBs, whereas the average energy absorption rate was 6.07% higher. The WCOSBs were more resistant to impacts than the WHOSBs. The impact velocity and mass were the key damage-assessment parameters, and velocity–mass damage-assessment curves and determination equations were established according to on the WOSBs’ maximum mid-span displacement under hinge-supported restraints at both ends. Thus, this study will serve as a reference for assessing the damages of WOSBs subjected to impacts.

New Structure Design for 126kV HV Vacuum Circuit Breaker

Xie Jiuming,Sun Dengyue,Wang Jianzhong,Cao Jianbo,Liu Wenping 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12

This paper analyzes the advantages of double breaks under series connection for 126kV HV vacuum circuit breaker. It makes efforts in the break designing to avoid hidden danger brought by voltage-sharing capacitor. Voltage is evenly distributed in the shape of ▽ at the basic break that asks for no voltage-sharing capacitors. Permanent magnetic actuator is used to ensure the synchronization of opening and closing of double breaks. Based on this layout, this paper designs a new actuator and motion system for vacuum circuit breaker optimized by virtual prototype software ADAMS and genetic algorithm. Laboratory tests have proved that the opening and closing speed of the breaker meets the speed standard and that the 126kV HV vacuum circuit breaker is feasible.

Accuracy analysis of a parallel positioning mechanism with actuation redundancy

Jianzhong Ding,Chunjie Wang,Hongyu Wu 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1

A forward accuracy analysis method based on Lie-group theory and screw theory is proposed to analyze the pose error of parallel mechanisms with actuation redundancy. Both the input uncertainty and components stiffness were considered. The method was applied to study the accuracy performance of a positioning mechanism, which has the potential to be used for the positioning of satellite antenna, camera, astronomical telescope and so on. The advancement of the method is that it models the elastic deformation and passive joint motions together by motion vector and limb stiffness matrix, which greatly simplifies the constraints modeling process. Mean value and standard deviation of the pose errors under different working conditions were obtained by optimal Latin hypercube sampling method, which reduces the sampling size on the premise of ensuring the precision. Finally, the robust optimization was employed to give further insight into the effects of redundant limb and mechanism structure on the accuracy performance of the actuation-redundant mechanism.

Accuracy analysis and error compensation for Tricept machine tool under load

Jianzhong Ding,Chunjie Wang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.8

This paper provides an efficient way to estimate the accuracy performance of the Tricept machine tool under load. Both joint clearances and link flexibility are considered. Clearances of the spherical joints and universal joint are considered, and the small change in link length arisen from clearances and deformation is modeled with the hyperbolic function. The kinetostatic model for accuracy analysis is obtained by balancing the employed load and the elastic forces provided by limbs. Moreover, an error compensation method for the Tricept machine tool under load is presented. The proposed methods are further illustrated and validated using a study case, and the feasibility of the error compensation method is discussed. This paper gives a deep insight into the effects of clearances, flexibility and loads on the accuracy performance of the Tricept-like mechanisms and instructive conclusions are drawn for accuracy improvement.

Correlation between Heart-type Fatty Acid-binding Protein Gene Polymorphism and mRNA Expression with Intramuscular Fat in Baicheng-oil Chicken

Wang, Yong,He, Jianzhong,Yang, Wenxuan,Muhantay, Gemenggul,Chen, Ying,Xing, Jinming,Liu, Jianzhu Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.10

This study aims to determine the polymorphism and mRNA expression pattern of the heart-type fatty acid-binding protein (H-FABP) gene and their association with intramuscular fat (IMF) content in the breast and leg muscles of Baicheng oil chicken (BOC). A total of 720 chickens, including 240 black Baicheng oil chicken (BBOC), 240 silky Baicheng oil chicken (SBOC), and 240 white Baicheng oil chicken (WBOC) were raised. Three genotypes of H-FABP gene second extron following AA, AB, and BB were detected by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) strategy. The G939A site created AA genotype and G956A site created BB genotype. The content of IMF in AA genotype in breast muscle of BBOC was significantly higher than that of AB (p = 0.0176) and the genotype in leg muscle of WBOC was significantly higher than that of AB (p = 0.0145). The G939A site could be taken as genetic marker for higher IMF content selecting for breast muscle of BBOC and leg muscle of WBOC. The relative mRNA expression of H-FABP was measured by real-time PCR at 30, 60, 90, and 120 d. The IMF content significantly increased with age in both muscles. The mRNA expression level of H-FABP significantly decreased with age in both muscles of the three types of chickens. Moreover, a significant negative correlation between H-FABP abundance and IMF content in the leg muscles of WBOC (p = 0.035) was observed. The mRNA expression of H-FABP negatively correlated with the IMF content in both breast and leg muscles of BOC sat slaughter time.